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Article: Metastase d’un adenocarcinome prostatique au sein d’un polype colique. À propos d’un cas et revue de la littérature.

Abitbol, Guillaume / Barthomeuf, Clémence / Varennes, Olivier / Clement, Marine / Hakim, Sami / Chatelain, Denis

2023 Volume 43, Issue 4, Page(s) 342–344

Title translation	Metastasis of a prostatic adenocarcinoma within a colonic polyp. A case report and review of the literature.
MeSH term(s)	Male ; Humans ; Colonic Polyps/diagnosis ; Colonic Polyps/pathology ; Colonic Neoplasms/complications ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/pathology ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology ; Adenocarcinoma/complications ; Adenocarcinoma/diagnosis ; Adenocarcinoma/surgery
Language	French
Publishing date	2023-02-23
Publishing country	France
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	225720-8
ISSN	0242-6498
ISSN	0242-6498
DOI	10.1016/j.annpat.2023.01.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association of Protein Tyrosine Phosphatase Receptor Type D and Serine Racemase Genetic Variants with Type 2 Diabetes in Malaysian Indians.

Saif-Ali, Riyadh / Al-Hamodi, Zaid / Salem, Sameer D / Al-Habori, Molham / Al-Dubai, Sami A / Ismail, Ikram S

Indian journal of endocrinology and metabolism

2024 Volume 28, Issue 1, Page(s) 55–59

Abstract: Introduction: Type 2 diabetes (T2D) candidate genes, protein tyrosine phosphatase receptor type D ...

Abstract	Introduction: Type 2 diabetes (T2D) candidate genes, protein tyrosine phosphatase receptor type D (PTPRD), and serine racemase (SRR) were suggested by a genome-wide association study (GWAS) in the Chinese population. Association studies have been replicated among East Asian populations. The association of PTPRD and SRR genetic variants with T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of PTPRD and SSR genetic variants with T2D in Malaysian Indian subjects. Methods: The single nucleotide polymorphisms (SNPs) of PTPRD (rs649891 and rs17584499) and SRR (rs4523957, rs391300, and rs8081273) were genotyped in 397 T2D and 285 normal Malaysian Indian subjects. Results: The homozygous dominant genotype of rs17584499 is frequent in diabetic patients (56.5%) compared to normal subjects (47.3%). In contrast, the homozygous recessive genotype of rs8081273 is more frequent among normal subjects (12.5%) than diabetic patients (5.6%). The dominant genetic model showed that PTPRD rs17584499 (CC) is a risk factor for T2D (OR = 1.42, Conclusion: This study confirmed the association of PTPRD rs17584499 genetic variations with T2D in Malaysian Indians. While the SRR rs8081273 (TT) genotype showed protection against T2D, more investigation in different populations is required to confirm this protection.
Language	English
Publishing date	2024-02-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.ijem_209_23
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Article ; Online: The Effect of Weekly 50,000 IU Vitamin D

Bader, Dana A / Abed, Anas / Mohammad, Beisan A / Aljaberi, Ahmad / Sundookah, Ahmad / Habash, Maha / Alsayed, Ahmad R / Abusamak, Mohammad / Al-Shakhshir, Sami / Abu-Samak, Mahmoud

Nutrients

2023 Volume 15, Issue 5

Abstract: This research aimed to evaluate the effects of high-dose cholecalciferol ( ... ...

Abstract	This research aimed to evaluate the effects of high-dose cholecalciferol (VD
MeSH term(s)	Adult ; Humans ; Cholecalciferol ; Interleukin-10 ; Cytokines ; Leptin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Cytokine Release Syndrome ; Dietary Supplements ; Vitamin D Deficiency ; Vitamin D ; Double-Blind Method
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Interleukin-10 (130068-27-8) ; Cytokines ; Leptin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15051188
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Article ; Online: Determinants of Vitamin D deficiency among type 2 diabetes mellitus patients: A retrospective study.

Alzahrani, Sami Hamdan / Baig, Mukhtiar / Yaghmour, Khaled A / Al Muammar, Sarah

Medicine

2024 Volume 103, Issue 8, Page(s) e37291

Abstract: Recent studies have shown an association between vitamin D deficiency (VDD) and type 2 ... were selected from electronic records and checked for vitamin D levels, glycosylated hemoglobin (HbA1c ... VDD was common, with an incidence of 723 (83.7%) subjects. A significantly lower vitamin D level was ...

Abstract	Recent studies have shown an association between vitamin D deficiency (VDD) and type 2 diabetes mellitus patients (T2DM), but the precise relationship between these conditions has yet to be clarified. In this study, we aimed to estimate the incidence of VDD among diabetic patients and identify any relationship between diabetes and the determinants of VDD among T2DM individuals. A retrospective cross-sectional study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Patients of either gender were selected from electronic records and checked for vitamin D levels, glycosylated hemoglobin (HbA1c), and other parameters. A total of 864 subjects were enrolled. Subjects were grouped according to HbA1c levels, with < 5.7%, 5.7% to 6.49%, and > 6.5% considered normal, impaired, and diabetic, respectively. VDD was common, with an incidence of 723 (83.7%) subjects. A significantly lower vitamin D level was found in diabetic subjects than in nondiabetic subjects (29.1 ± 12.0 vs 44.0 ± 28.3, P < .001). A total of 207/209 (99%) subjects with impaired HbA1c and 179/183 (97.8%) people with diabetes had VDD. Interestingly, none of the diabetic or impaired HbA1c subjects had normal vitamin D levels. A significant association was found between VDD and being > 50 years old, overweight, or obese, as well as HbA1c, fasting plasma glucose, calcium, and total cholesterol (TC) levels. A high rate of VDD and significantly lower vitamin D levels were found in diabetic subjects. Age, being overweight, obesity, HbA1c, and fasting plasma glucose were the few determinants of VDD among T2DM patients. These findings highlight the importance of addressing vitamin D status in managing and preventing T2DM, particularly in those over the age of 50, those who have higher body weight, and those with raised HbA1c and fasting plasma glucose levels.
MeSH term(s)	Humans ; Middle Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Retrospective Studies ; Glycated Hemoglobin ; Blood Glucose ; Overweight ; Cross-Sectional Studies ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D ; Obesity/complications ; Obesity/epidemiology ; Vitamins
Chemical Substances	Glycated Hemoglobin ; Blood Glucose ; Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037291
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Article ; Online: Association of vitamin D deficiency and vitamin D receptor (VDR) gene single-nucleotide polymorphism (rs7975232) with risk of preeclampsia.

Aziz, Asma / Shah, Mohsin / Siraj, Sami / Iqbal, Waheed / Jan, Amin / Khan, Imran / Ahmed, Sajjad / Vitale, Salvatore Giovanni / Angioni, Stefano

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2022 Volume 39, Issue 1, Page(s) 2146089

Abstract: ... between preeclampsia and vitamin D (VD) metabolic axis. Genetic variations like ... single-nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) gene can alter the metabolic role of VD, which have been shown ... pregnant women were compared for VD status and VDR gene polymorphism. Serum 25-hydroxyvitamin-D [25(OH) D] level ...

Abstract	Background: Preeclampsia has a multifactorial-yet-elusive etiology. Recent reports suggest a link between preeclampsia and vitamin D (VD) metabolic axis. Genetic variations like single-nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) gene can alter the metabolic role of VD, which have been shown by several genetic association studies. However, there is discordance among these studies. Objective: The current study aimed to investigate the association of VDR gene polymorphism (ApaI) and VD deficiency with risk of developing preeclampsia. Patients and method: In this case-control study, 40 preeclamptic and 40 normotensive pregnant women were compared for VD status and VDR gene polymorphism. Serum 25-hydroxyvitamin-D [25(OH) D] level was determined by enzyme-linked immunosorbent assay (ELISA) and VDR gene polymorphism Apa1 was analyzed by Allele specific polymerase chain reaction (AS-PCR) using sequence specific primers. Results: Serum levels of 25(OH) D were very low but comparable in both preeclamptic and normotensive pregnant women. The difference between the two groups were not statistically significant ( Conclusion: This study showed that VDR gene polymorphism (ApaI) and VD deficiency are not associated with the risk of preeclampsia.
MeSH term(s)	Female ; Humans ; Pregnancy ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Pre-Eclampsia/genetics ; Case-Control Studies ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/genetics ; Genotype ; Genetic Predisposition to Disease
Chemical Substances	methyl 4-azidophenylacetimidate (73710-32-4) ; Receptors, Calcitriol ; Vitamin D (1406-16-2) ; VDR protein, human
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2022.2146089
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Zs.A 2284: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 608: Show issues

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Article: Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action.

Talib, Wamidh H / Ahmed Jum'AH, Dima Abdulraheem / Attallah, Zeena Shamil / Jallad, Mohanned Sami / Al Kury, Lina T / Hadi, Rawan Wamidh / Mahmod, Asma Ismail

Frontiers in nutrition

2024 Volume 10, Page(s) 1281879

Abstract: ... as promising candidates for cancer prevention and treatment. This review focuses on Vitamins A, C, E, and D ...

Abstract	Cancer, a leading global cause of mortality, arises from intricate interactions between genetic and environmental factors, fueling uncontrolled cell growth. Amidst existing treatment limitations, vitamins have emerged as promising candidates for cancer prevention and treatment. This review focuses on Vitamins A, C, E, and D because of their protective activity against various types of cancer. They are essential as human metabolic coenzymes. Through a critical exploration of preclinical and clinical studies via PubMed and Google Scholar, the impact of these vitamins on cancer therapy was analyzed, unraveling their complicated mechanisms of action. Interestingly, vitamins impact immune function, antioxidant defense, inflammation, and epigenetic regulation, potentially enhancing outcomes by influencing cell behavior and countering stress and DNA damage. Encouraging clinical trial results have been observed; however, further well-controlled studies are imperative to validate their effectiveness, determine optimal dosages, and formulate comprehensive cancer prevention and treatment strategies. Personalized supplementation strategies, informed by medical expertise, are pivotal for optimal outcomes in both clinical and preclinical contexts. Nevertheless, conclusive evidence regarding the efficacy of vitamins in cancer prevention and treatment is still pending, urging further research and exploration in this compelling area of study.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1281879
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Article: Revealing the association between vitamin D metabolic pathway gene variants and lung cancer risk: a systematic review and meta-analysis.

Elsalahaty, Mohamed I / Alkafaas, Samar Sami / Bashir, Aya O / El-Tarabily, Khaled A / El-Saadony, Mohamed T / Yousef, Eman H

Frontiers in genetics

2024 Volume 15, Page(s) 1302527

Abstract: ... in vitamin D pathway genes have also been studied in regards to lung cancer, but the findings have been ...

Abstract	Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been studied in regards to lung cancer, but the findings have been inconclusive. We here present a systematic review and meta-analysis of seven genes in this pathway:
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1302527
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Article ; Online: The association of coffee consumption rate with serum 25-hydroxyvitamin D, non-HDL levels, and TC/HDL ratio in females with vitamin D deficiency.

Habash, Maha / Al-Shakhshir, Sami / Abusamak, Mohammad / Mohammad, Mohammad Yasin / AbuSamak, Mahmoud

Women's health (London, England)

2022 Volume 18, Page(s) 17455057221112268

Abstract: ... with serum 25-hydroxyvitamin D, non-high-density lipoprotein cholesterol levels, and total cholesterol ... to high-density lipoprotein cholesterol ratio in females with vitamin D deficiency.: Methods ... years with varying degrees of vitamin D deficiency. Following completion of the questionnaire regarding ...

Abstract	Objectives: The purpose of this study was to evaluate the association of coffee consumption rate with serum 25-hydroxyvitamin D, non-high-density lipoprotein cholesterol levels, and total cholesterol to high-density lipoprotein cholesterol ratio in females with vitamin D deficiency. Methods: This retrospective cross-sectional study was carried out by studying the records of 270 Jordanian females aged 18-65 years with varying degrees of vitamin D deficiency. Following completion of the questionnaire regarding their anthropometric characteristics and coffee consumption rate during the preceding 3 months, the participants were required to provide blood samples for analysis to measure 25-hydroxyvitamin D and lipid profile levels including non-high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol ratio. Results: The current study demonstrated that coffee consumption rate and vitamin D deficiency were significantly positively connected with the total cholesterol to high-density lipoprotein cholesterol ratio ( Conclusion: Higher coffee consumption rate among women with vitamin D deficiency significantly elevated total cholesterol to high-density lipoprotein cholesterol ratio that may increase woman's risk of hyperlipidemia.
MeSH term(s)	Cholesterol ; Cholesterol, HDL ; Coffee ; Cross-Sectional Studies ; Female ; Humans ; Retrospective Studies ; Vitamin D/analogs & derivatives ; Vitamin D Deficiency/epidemiology
Chemical Substances	Cholesterol, HDL ; Coffee ; Vitamin D (1406-16-2) ; Cholesterol (97C5T2UQ7J) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274503-8
ISSN	1745-5065 ; 1745-5057
ISSN (online)	1745-5065
ISSN	1745-5057
DOI	10.1177/17455057221112268
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Article ; Online: La participation comme objet intermédiaire d’apprentissages

Seguin Laura / Barataud Fabienne / Guichard Laurence / Bonifazi Mathilde / Souchère Véronique / Bouarfa Sami / Tournebize Julien

Natures Sciences Sociétés, Vol 29, Iss 3, Pp 299-

leçons d’une démarche participative sur les pollutions diffuses agricoles

2021 Volume 311

Abstract: Cet article propose d’analyser la manière dont la construction transdisciplinaire d’un projet ... de recherche, puis la mise en œuvre d’une démarche participative sur l’enjeu des pollutions diffuses agricoles ... de l’eau (nitrates et pesticides), constituent des espaces d’apprentissages. L’étude s’appuie ...

Abstract	Cet article propose d’analyser la manière dont la construction transdisciplinaire d’un projet de recherche, puis la mise en œuvre d’une démarche participative sur l’enjeu des pollutions diffuses agricoles de l’eau (nitrates et pesticides), constituent des espaces d’apprentissages. L’étude s’appuie sur une recherche participative menée sur le territoire de la Brie, en Seine-et-Marne, analysée en tant que processus permettant de transgresser les frontières disciplinaires, qui opposent de manière souvent arbitraire chercheurs et acteurs, et les frontières qui divisent les différentes parties prenantes d’un problème public. Les perceptions et les connaissances initiales des chercheurs et acteurs s’enrichissent à travers la participation. Les limites de ce processus et des inégalités d’apprentissages sont également identifiées.
Keywords	agriculture ; environnement ; transdisciplinarité ; participation ; apprentissage ; gestion de l’eau ; Science ; Q ; Social Sciences ; H
Language	French
Publishing date	2021-07-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plasma 25-Hydroxyvitamin D Level at Admission Predicts Unfavorable Outcome in Intensive Care Unit Patients.

Maamer, Dhouha / Trifi, Ahlem / Ben Fradj, Mohamed Kacem / Daly, Foued / Hammami, Mohamed Bassem / Abdellatif, Sami / Feki, Moncef / Ben Lakhal, Salah

Biological research for nursing

2020 Volume 22, Issue 3, Page(s) 388–396

Abstract: ... Considering the role of vitamin D (Vit D) in cardiovascular and immune functions, Vit D deficiency ... could affect ICU patients' outcomes. This study aimed to evaluate Vit D status and its predictive value ... hydroxyvitamin D (25(OH)D) was assessed by immunoassay. Multivariate Cox regression analyses were performed ...

Abstract	Introduction: Patients in intensive care units (ICUs) are at high risk of unfavorable outcomes. Considering the role of vitamin D (Vit D) in cardiovascular and immune functions, Vit D deficiency could affect ICU patients' outcomes. This study aimed to evaluate Vit D status and its predictive value for outcome in ICU patients. Patients and methods: A total of 169 ICU patients were followed during ICU stay. Primary outcome was the occurrence of at least one major adverse event; secondary outcomes were organ failure, septic shock, ICU-acquired infection, other adverse events, and ICU mortality. Plasma 25-hydroxyvitamin D (25(OH)D) was assessed by immunoassay. Multivariate Cox regression analyses were performed to test the associations of low 25(OH)D levels with poor outcomes. Results: Around 75% of patients had 25(OH)D levels <12 ng/ml. During their ICU stay, 114 patients experienced a major adverse event, 85 patients presented an ICU-acquired infection, and 22 patients died. Plasma 25(OH)D levels <12 ng/ml were associated with higher risk of major adverse events, Hazard ratio [95% CI], 4.47 [1.77, 11.3], Conclusions: Hypovitaminosis D is very common in ICU patients. Results of the present study show that low plasma 25(OH)D levels are associated with increased risk of unfavorable outcomes in these patients. Additional research is needed to investigate the impact of Vit D status and effect of Vit D supplementation in ICU patients.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Patient Admission/statistics & numerical data ; Plasma/chemistry ; Predictive Value of Tests ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/therapy
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145107-2
ISSN	1552-4175 ; 1099-8004
ISSN (online)	1552-4175
ISSN	1099-8004
DOI	10.1177/1099800420923746
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