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  1. Book: Histology and cell biology

    Kierszenbaum, Abraham L. / Tres, Laura L.

    an introduction to pathology

    2020  

    Author's details Abraham L. Kierszenbaum, Laura L. Tres
    Language English
    Size xvi, 804 Seiten, Illustrationen
    Edition Fifth edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020209482
    ISBN 978-0-323-67321-1 ; 0-323-67321-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1653 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: Histology and cell biology

    Kierszenbaum, Abraham L.

    an introduction to pathology

    2007  

    Author's details Abraham L. Kierszenbaum
    Keywords Pathology ; Histology ; Cytology
    Language English
    Size XIV, 671 S. : zahlr. Ill.
    Edition 2. ed
    Publisher Mosby Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note Previous ed.: St. Louis, Mo.; London: Mosby, 2002. - Includes Internet access
    HBZ-ID HT014927924
    ISBN 0-323-04527-8 ; 978-0-323-04527-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 1690 order for loan Magazin
    Internetausgabe nicht erworben

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  3. Book: Histology and cell biology

    Kierszenbaum, Abraham L. / Tres, Laura L.

    an introduction to pathology

    (Student consult)

    2012  

    Author's details Abraham L. Kierszenbaum ; Laura L. Tres
    Series title Student consult
    Keywords Pathologie ; Histologie ; Cytologie
    Subject Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle ; Gewebelehre ; Mikroskopische Anatomie ; Mikroanatomie ; Allgemeine Pathologie ; Spezielle Pathologie ; Klinische Pathologie ; Allgemeine Krankheitslehre
    Language English
    Size XIV, 701 S. : zahlr. Ill.
    Edition 3. ed.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT016920442
    ISBN 978-0-323-07842-9 ; 0-323-07842-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3253 order for loan Magazin
    Zugang zu Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Book: Histology and cell biology

    Kierszenbaum, Abraham L / Tres, Laura L

    an introduction to pathology

    2016  

    Author's details Abraham L. Kierszenbaum, Laura L. Tres
    MeSH term(s) Histology ; Pathologic Processes ; Cell Biology ; Pathology
    Language English
    Size xiv, 734 pages :, illustrations
    Edition Fourth edition.
    Document type Book
    Note Includes index.
    ISBN 9780323313308 ; 0323313302
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Tyrosine protein kinases and spermatogenesis: truncation matters.

    Kierszenbaum, Abraham L

    Molecular reproduction and development

    2006  Volume 73, Issue 4, Page(s) 399–403

    Abstract: Protein phosphorylation on serine/threonine or tyrosine residues represents a significant regulatory mechanism in signal transduction during spermatogenesis, oogenesis, and fertilization. There are several families of tyrosine protein kinases operating ... ...

    Abstract Protein phosphorylation on serine/threonine or tyrosine residues represents a significant regulatory mechanism in signal transduction during spermatogenesis, oogenesis, and fertilization. There are several families of tyrosine protein kinases operating during spermatogenesis: the Src family of tyrosine protein kinases; the Fujinami poultry sarcoma/feline sarcoma (Fps/Fes) and Fes-related protein (Fer) subfamily of non-receptor proteins; and c-kit, the transmembrane tyrosine kinase receptor that belongs to the family of the PDGF receptor. A remarkable characteristic is the coexistence of full-length and truncated tyrosine kinases in testis. Most of the truncated forms are present during spermiogenesis. Examples include the truncated forms of Src tyrosine kinase hematopoietic cell kinase (Hck), FerT, and tr-kit. A feature of FerT and tr-kit is the kinase domain that ensures the functional properties of the truncated protein. FerT, a regulator of actin assembly/disassembly mediated by cortactin phosphorylation, is present in the acroplaxome, a cytoskeletal plate containing an F-actin network and linking the acrosome to the spermatid nuclear envelope. This finding suggests that Fer kinase represents one of the tyrosine protein kinases that may contribute to spermatid head shaping. The c-kit ligand, stem cell factor (SCF), which induces c-kit dimerization and autophosphorylation, exists as both membrane-associated and soluble. Although tyrosine protein kinases are prominent in spermatogenesis, a remarkable observation is the paucity of phenotypic alterations in spermatogenic cells in male mice targeted with Fer kinase-inactivating mutation. It is possible that the redundant functions of the tyrosine protein kinase pool present during spermatogenesis may explain the limited phenotypes of single mutant mice. The production of compound and viable mutant mice, lacking the expression of two or more tyrosine kinases, may shed light on this intriguing issue.
    MeSH term(s) Animals ; Humans ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/physiology ; Male ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/physiology ; Sequence Deletion/physiology ; Spermatogenesis/genetics ; Spermatogenesis/physiology ; Testis/enzymology
    Chemical Substances Isoenzymes ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2006-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.20456
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Cell-cycle regulation and mammalian gametogenesis: a lesson from the unexpected.

    Kierszenbaum, Abraham L

    Molecular reproduction and development

    2006  Volume 73, Issue 8, Page(s) 939–942

    Abstract: The progression of mammalian gametogenesis requires a precise balance between cell-cycle activities and elimination of defective gametogenic cells to ensure the perpetuation of species. Both spermatogonia and oogonia are stem cell populations committed ... ...

    Abstract The progression of mammalian gametogenesis requires a precise balance between cell-cycle activities and elimination of defective gametogenic cells to ensure the perpetuation of species. Both spermatogonia and oogonia are stem cell populations committed to meiosis with the aim of generating haploid gametes for fertilization. At puberty, mitotically dividing spermatogonial cell cohorts maintain the ability of cell renewal and occupy niches in the seminiferous tubule. In contrast, mitotically dividing oogonial cell cohorts produced in the fetal ovary, are exclusively committed to meiosis and produce primordial follicles housing a primary oocyte surrounded by somatic follicular cells. A consistent physiological event during mammalian gametogenesis is the disposal of spermatogenic cells by apoptosis and ovarian follicles by atresia. Cyclin-dependent kinases (Cdks) and their cyclin partners coordinate the activities of the cell cycle. An additional cell-cycle regulatory component is the centrosome. The centrosome harbors regulatory proteins controlling the normal progression of the cell cycle. Changes in individual centrosome proteins can lead to cell-cycle arrest and a decrease in the genomic protective function of p53 that promotes apoptosis. Disruption of cyclin A1, Cdk2, and Cdk4 expression in transgenic mice results in infertility and gonadal atrophy. Cdk-cyclin complexes interact with regulatory proteins, which may fine-tune the activities of the complex. One of the many regulatory proteins is p12, a 115 amino acid growth suppressor polypeptide designated p12(CDK2AP1), partner of Cdk2 and with binding affinity to DNA polymerase alpha/primase. Overexpression of p12 is associated with testicular and ovarian atrophy without affecting fertility. Ectopic expression of p12 was driven by the keratin 14 promoter. Keratin 14 is the pairing partner of keratin 5 and both keratins are expressed in testis. The efficiency of keratin promoters in driving ectopic gonadal gene expression, the association of gonadal atrophy with the ectopic expression of a Cdk2 regulatory protein and the centrosome, as a reservoir of cell-cycle regulatory proteins, open new experimental opportunities to address still lingering questions concerning cell differentiation and division during mammalian gametogenesis.
    MeSH term(s) Animals ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Gametogenesis/physiology
    Chemical Substances Cell Cycle Proteins
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.20536
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: Histology and cell biology

    Kierszenbaum, Abraham L

    an introduction to pathology

    2007  

    Author's details Abraham L. Kierszenbaum
    MeSH term(s) Histology ; Cell Biology ; Pathology
    Language English
    Size xiv, 671 p. :, ill.
    Edition 2nd ed.
    Publisher Mosby Elsevier
    Publishing place Philadelphia, PA
    Document type Book
    Note Includes index.
    ISBN 9780323045278 ; 0323045278
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Polycystins: what polycystic kidney disease tells us about sperm.

    Kierszenbaum, Abraham L

    Molecular reproduction and development

    2004  Volume 67, Issue 4, Page(s) 385–388

    Abstract: Experimental evidence indicates that the membrane-associated proteins polycystin-1 and polycystin-2 operate as a receptor-calcium channel complex that regulates signaling pathways essential for modulation of renal tubulogenesis. Polycystic kidney disease ...

    Abstract Experimental evidence indicates that the membrane-associated proteins polycystin-1 and polycystin-2 operate as a receptor-calcium channel complex that regulates signaling pathways essential for modulation of renal tubulogenesis. Polycystic kidney disease is characterized by defective renal tubular structure and results from mutations in either PKD1 or PKD2 genes. Recent data suggest that polycystin-1 and polycystin-2 might localize to primary cilium in principal cells of renal collecting tubules and are thought to act as mechanosensors of fluid flow and contents. Ciliary bending by fluid flow or mechanical stimulation induce Ca(2+) release from intracellular stores, presumably to modulate ion influx in response to tubular fluid flow. Polycystins are also emerging as playing a significant role in sperm development and function. Drosophila polycystin-2 is associated with the head and tail of mature sperm. Targeted disruption of the PKD2 homolog results in nearly complete male sterility without disrupting spermatogenesis. Mutant sperm are motile but are unable to reach the female storage organs (seminal receptacles and spermathecae). The sea urchin polycystin-1-equivalent suPC2 colocalizes with the polycystin-1 homolog REJ3 to the plasma membrane over the acrosomal vesicle. This localization site suggests that the suPC2-REJ3 complex may function as a cation channel mediating acrosome reaction when sperm contact the jelly layer surrounding the egg at fertilization. Future studies leading to the identification of specific ligands for polycystins, including the signaling pathways, might define the puzzling relationship between renal tubular morphogenesis and sperm development and function.
    MeSH term(s) Acrosome/metabolism ; Animals ; Calcium/metabolism ; Cilia/genetics ; Cilia/metabolism ; Disease Models, Animal ; Drosophila/genetics ; Humans ; Infertility, Male/genetics ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Polycystic Kidney, Autosomal Dominant/genetics ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Recessive/genetics ; Polycystic Kidney, Autosomal Recessive/metabolism ; Proteins/genetics ; Proteins/metabolism ; Sea Urchins/genetics ; Sperm Tail/metabolism ; Spermatogenesis/genetics ; TRPP Cation Channels
    Chemical Substances Membrane Proteins ; Proteins ; TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2004-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.20042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Histology and cell biology

    Kierszenbaum, Abraham L / Tres, Laura L

    an introduction to pathology

    2012  

    Author's details Abraham L. Kierszenbaum, Laura L. Tres
    MeSH term(s) Histology ; Cell Biology ; Pathology
    Language English
    Size xiv, 701 p. :, ill.
    Edition 3rd ed.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Document type Book
    ISBN 9780323078429 ; 0323078427
    Database Catalogue of the US National Library of Medicine (NLM)

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    Kategorien

    Order via subito

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    Inter-library loan at ZB MED

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  10. Book: Histology and cell biology

    Kierszenbaum, Abraham L / Tres, Laura L

    an introduction to pathology

    2012  

    Author's details Abraham L. Kierszenbaum, Laura L. Tres
    MeSH term(s) Cell Biology ; Histology ; Pathology
    Keywords Histology, Pathological ; Pathology, Cellular ; Histopathologie ; Cytopathologie
    Language English
    Size XIV, 701 S., 28 cm
    Edition 3. ed
    Publisher Elsevier Saunders
    Publishing place Philadelphia, PA
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9780323078429 ; 0323078427
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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