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Article ; Online: The top 10 research priorities in psoriatic arthritis: a James Lind Alliance Priority Setting Partnership.

Hailey, Louise / Bundy, Chris / Burstow, Helen / Chandler, David / Cowper, Russ / Helliwell, Philip / Joannes, Lucille / Kelly, Andy / Kennedy, Bronagh / Kinsella, Suzannah / McAteer, Helen / Mukherjee, Sandeep / Packham, Jon / Wise, Elspeth / Young, Helen / Coates, Laura C

Rheumatology (Oxford, England)

2022 Volume 62, Issue 8, Page(s) 2716–2723

Abstract: ... of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP ...

Abstract	Objectives: To identify and prioritize the top 10 research questions for PsA. Methods: The British Psoriatic Arthritis Consortium (BritPACT) formed a Priority Setting Partnership (PSP) comprising of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP followed the established three-stage JLA process: first, an online survey of people living with PsA, carers and clinicians to identify PsA questions, asking, 'What do you think are the most important unanswered questions in psoriatic arthritis research?' The questions were checked against existing evidence to establish 'true uncertainties' and grouped as 'indicative questions' reflecting the overarching themes. Then a second online survey ranked the 'true uncertainties' by importance. Finally, a workshop including people living with PsA and clinician stakeholders finalized the top 10 research priorities. Results: The initial survey attracted 317 respondents (69% people living with PsA, 15% carers), with 988 questions. This generated 46 indicative questions. In the second survey, 422 respondents (78% people living with PsA, 4% carers) prioritized these. Eighteen questions were taken forward to the final online workshop. The top unanswered PsA research question was 'What is the best strategy for managing patients with psoriatic arthritis including non-drug and drug treatments?' Other top 10 priorities covered diagnosis, prognosis, outcome assessment, flares, comorbidities and other aspects of treatment (https://www.jla.nihr.ac.uk). Conclusion: The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA.
MeSH term(s)	Humans ; Arthritis, Psoriatic/therapy ; Health Priorities ; Outcome Assessment, Health Care ; Surveys and Questionnaires ; Caregivers ; Biomedical Research
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac676
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Article ; Online: The top 10 research priorities for psoriasis in the U.K.: results of a James Lind Alliance psoriasis Priority Setting Partnership.

Majeed-Ariss, R / McPhee, M / McAteer, H / Griffiths, C E M / Young, H

The British journal of dermatology

2019 Volume 181, Issue 4, Page(s) 871–873

MeSH term(s)	Biomedical Research/organization & administration ; Biomedical Research/statistics & numerical data ; Biomedical Research/trends ; Dermatology/organization & administration ; Dermatology/statistics & numerical data ; Dermatology/trends ; Health Personnel/organization & administration ; Health Personnel/statistics & numerical data ; Humans ; Patient Participation ; Psoriasis/diagnosis ; Psoriasis/epidemiology ; Psoriasis/etiology ; Psoriasis/therapy ; Surveys and Questionnaires/statistics & numerical data ; United Kingdom/epidemiology
Language	English
Publishing date	2019-07-24
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.18209
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Article ; Online: Retention and growth of urinary stones: insights from imaging.

Williams, James C / McAteer, James A

Journal of nephrology

2012 Volume 26, Issue 1, Page(s) 25–31

Abstract: Recent work in nephrolithiasis has benefited from 2 special kinds of imaging: endoscopic study of patient kidneys with high-quality instruments, and examination of stones with microscopic computed tomography (micro CT). The combination of these has ... ...

Abstract	Recent work in nephrolithiasis has benefited from 2 special kinds of imaging: endoscopic study of patient kidneys with high-quality instruments, and examination of stones with microscopic computed tomography (micro CT). The combination of these has provided new evidence that there is more than 1 mechanism by which stones are retained in the kidney until they achieve sizes to be clinically relevant. This review describes what is known about the formation of stones on Randall's plaque, the formation of stones on ductal plugs and the ways in which stones may grow in free solution within the calyceal or pelvic spaces. Studies of urolithiasis need to recognize that any group of "stone formers" likely includes patients who differ fundamentally regarding which mechanism of stone formation is the primary route for their stones. Separation of patients on the basis of which mechanism (or combination of mechanisms) underlies their disease will be important for advancing research in the area of urolithiasis.
MeSH term(s)	Calcinosis/complications ; Endoscopy ; Humans ; Kidney Medulla/pathology ; Kidney Tubules/pathology ; Nephrolithiasis/diagnostic imaging ; Nephrolithiasis/etiology ; Nephrolithiasis/pathology ; X-Ray Microtomography
Language	English
Publishing date	2012-09-14
Publishing country	Italy
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.5301/jn.5000208
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Article: Cavitation-induced streaming in shock wave lithotripsy.

Pishchalnikov, Yuri A / McAteer, James A

Proceedings of meetings on acoustics. Acoustical Society of America

2013 Volume 19, Issue 1

Abstract: Cavitation generated by lithotripter shock waves (SWs) in non-degassed water was studied using a 60 frames-per-second camcorder-recording the migration of microbubbles over successive SWs. Lithotripter SWs were produced using a Dornier DoLi-50 ... ...

Abstract	Cavitation generated by lithotripter shock waves (SWs) in non-degassed water was studied using a 60 frames-per-second camcorder-recording the migration of microbubbles over successive SWs. Lithotripter SWs were produced using a Dornier DoLi-50 electromagnetic lithotripter at 0.5 and 2 Hz pulse repetition frequency (PRF). Cavitation was affected by PRF and by the power level (PL) of the lithotripter. At slow PRF, such as shots fired many seconds apart, cavitation was relatively sparse and bubble clouds flowed in the direction of SW propagation. When PRF was increased, the bubble clouds generated by one SW were amplified by subsequent SWs. Cloud amplification was accompanied by an apparent change in the pattern of bubble migration. Whereas bubbles continued to enter the field of view from the prefocal side, the main bubble cloud remained near the focal point. This was due to a streaming of bubbles opposite to the direction of SW propagation. Increasing the PL grew the cavitation field and enhanced the flow of bubbles opposite to the direction of SW propagation. Stepping up the PL acted to push the broad cloud progressively prefocally (toward the SW source), shifting the position of the plane at which the opposing directional bubble flows collided. (NIH DK43881).
Language	English
Publishing date	2013-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2507198-1
ISSN	1939-800X
ISSN	1939-800X
DOI	10.1121/1.4800374
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Article ; Online: Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides.

Singh, Ravinder K / Malosse, Camille / Davies, Joanne / Malissen, Bernard / Kochba, Efrat / Levin, Yotam / Birchall, James C / Coulman, Sion A / Mous, Jan / McAteer, Martina A / Dayan, Colin M / Henri, Sandrine / Wong, F Susan

Nanomedicine : nanotechnology, biology, and medicine

2020 Volume 32, Page(s) 102321

Abstract: Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble peptide auto-antigen, associated with type 1 diabetes, to modify the peptide pharmacokinetics, following its intradermal delivery. Peptide distribution was characterized, in ...

Abstract	Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble peptide auto-antigen, associated with type 1 diabetes, to modify the peptide pharmacokinetics, following its intradermal delivery. Peptide distribution was characterized, in vivo, after delivery using either conventional intradermal injection or a hollow microneedle device. The poorly-soluble peptide was effectively presented in distant lymph nodes (LN), spleen and draining LN when conjugated to the nanoparticles, whereas peptide alone was only presented in the draining LN. By contrast, nanoparticle conjugation to a highly-soluble peptide did not enhance in vivo distribution. Transfer of both free peptide and peptide-NPs from the skin to LN was reduced in mice lacking lymphoid homing receptor CCR7, suggesting that both are actively transported by migrating dendritic cells to LN. Collectively, these data demonstrate that intradermally administered ultra-small gold nanoparticles can widen the distribution of poorly-soluble auto-antigenic peptides to multiple lymphoid organs, thus enhancing their use as potential therapeutics.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antigens/metabolism ; Cell Proliferation ; Dendritic Cells/drug effects ; Gold/chemistry ; Injections, Intradermal ; Metal Nanoparticles/chemistry ; Mice, Inbred C57BL ; Mice, Transgenic ; Needles ; Peptides/chemistry ; Peptides/pharmacokinetics ; Peptides/pharmacology ; Phenotype ; Skin/drug effects ; Solubility ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Mice
Chemical Substances	Antigens ; Peptides ; Gold (7440-57-5)
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2020.102321
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Article ; Online: High carbonate level of apatite in kidney stones implies infection, but is it predictive?

Englert, Kate M / McAteer, James A / Lingeman, James E / Williams, James C

Urolithiasis

2013 Volume 41, Issue 5, Page(s) 389–394

Abstract: The presence of infectious microorganisms in urinary stones is commonly inferred from stone composition, especially by the presence of struvite in a stone. The presence of highly carbonated apatite has also been proposed as a marker of the presence of ... ...

Abstract	The presence of infectious microorganisms in urinary stones is commonly inferred from stone composition, especially by the presence of struvite in a stone. The presence of highly carbonated apatite has also been proposed as a marker of the presence of bacteria within a stone. We retrospectively studied 368 patients who had undergone percutaneous nephrolithotomy (PCNL), and who also had culture results for both stone and urine. Urine culture showed no association with stone mineral content, but stone culture was more often positive in struvite-containing stones (73 % positive) and majority apatite stones (65 %) than in other stone types (54 %, lower than the others, P < 0.02). In 51 patients in whom the carbonate content of apatite could be measured, carbonate in the apatite was weakly predictive of positive stone culture with an optimal cutoff value of 13.5 % carbonate (sensitivity 0.61, specificity 0.80). In positive cultures of stones (all mineral types combined), organisms that characteristically produce urease were present in 71 % of the cases, with no difference in this proportion among different types of stone. In summary, the type of mineral in the stone was predictive of positive stone culture, but this correlation is imperfect, as over half of non-struvite, non-apatite stones were found to harbor culturable organisms. We conclude that mineral type is an inadequate predictor of whether a stone contains infectious organisms, and that stone culture is more likely to provide information useful to the management of patients undergoing PCNL.
MeSH term(s)	Apatites/analysis ; Humans ; Kidney Calculi/chemistry ; Kidney Calculi/complications ; Kidney Calculi/microbiology ; Magnesium Compounds/analysis ; Nephrostomy, Percutaneous ; Phosphates/analysis ; Retrospective Studies ; Struvite ; Urinary Tract Infections/complications ; Urinary Tract Infections/microbiology
Chemical Substances	Apatites ; Magnesium Compounds ; Phosphates ; carboapatite (55326-60-8) ; Struvite (AW3EJL1462)
Language	English
Publishing date	2013-07-24
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-013-0591-6
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Article ; Online: Effect of the body wall on lithotripter shock waves.

Li, Guangyan / McAteer, James A / Williams, James C / Berwick, Zachary C

Journal of endourology

2014 Volume 28, Issue 4, Page(s) 446–452

Abstract: Purpose: Determine the influence of passage through the body wall on the properties of lithotripter shock waves (SWs) and the characteristics of the acoustic field of an electromagnetic lithotripter.: Methods: Full-thickness ex vivo segments of pig ... ...

Abstract	Purpose: Determine the influence of passage through the body wall on the properties of lithotripter shock waves (SWs) and the characteristics of the acoustic field of an electromagnetic lithotripter. Methods: Full-thickness ex vivo segments of pig abdominal wall were secured against the acoustic window of a test tank coupled to the lithotripter. A fiber-optic probe hydrophone was used to measure SW pressures, determine shock rise time, and map the acoustic field in the focal plane. Results: Peak positive pressure on axis was attenuated roughly proportional to tissue thickness-approximately 6% per cm. Irregularities in the tissue path affected the symmetry of SW focusing, shifting the maximum peak positive pressure laterally by as much as ∼2 mm. Within the time resolution of the hydrophone (7-15 ns), shock rise time was unchanged, measuring ∼17-21 ns with and without tissue present. Mapping of the field showed no effect of the body wall on focal width, regardless of thickness of the body wall. Conclusions: Passage through the body wall has minimal effect on the characteristics of lithotripter SWs. Other than reducing pulse amplitude and having the potential to affect the symmetry of the focused wave, the body wall has little influence on the acoustic field. These findings help to validate laboratory assessment of lithotripter acoustic field and suggest that the properties of SWs in the body are much the same as have been measured in vitro.
MeSH term(s)	Abdominal Wall/anatomy & histology ; Abdominal Wall/physiology ; Acoustics ; Animals ; Electromagnetic Phenomena ; Lithotripsy/instrumentation ; Lithotripsy/methods ; Pressure ; Sus scrofa ; Swine
Language	English
Publishing date	2014-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2013.0662
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Bubble proliferation in the cavitation field of a shock wave lithotripter.

Pishchalnikov, Yuri A / Williams, James C / McAteer, James A

The Journal of the Acoustical Society of America

2011 Volume 130, Issue 2, Page(s) EL87–93

Abstract: Lithotripter shock waves (SWs) generated in non-degassed water at 0.5 and 2 Hz pulse repetition frequency (PRF) were characterized using a fiber-optic hydrophone. High-speed imaging captured the inertial growth-collapse-rebound cycle of cavitation ... ...

Abstract	Lithotripter shock waves (SWs) generated in non-degassed water at 0.5 and 2 Hz pulse repetition frequency (PRF) were characterized using a fiber-optic hydrophone. High-speed imaging captured the inertial growth-collapse-rebound cycle of cavitation bubbles, and continuous recording with a 60 fps camcorder was used to track bubble proliferation over successive SWs. Microbubbles that seeded the generation of bubble clouds formed by the breakup of cavitation jets and by bubble collapse following rebound. Microbubbles that persisted long enough served as cavitation nuclei for subsequent SWs, as such bubble clouds were enhanced at fast PRF. Visual tracking suggests that bubble clouds can originate from single bubbles.
MeSH term(s)	Equipment Design ; High-Energy Shock Waves ; Lithotripsy/instrumentation ; Microbubbles ; Motion ; Signal Processing, Computer-Assisted ; Time Factors ; Video Recording ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2011-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.3609920
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Article ; Online: Research priorities and identification of a health-service delivery model for psoriasis from the UK Psoriasis Priority Setting Partnership.

Ismail, D / McAteer, H / Majeed-Ariss, R / McPhee, M / Griffiths, C E M / Young, H S

Clinical and experimental dermatology

2020 Volume 46, Issue 2, Page(s) 276–285

Abstract: ... by research. We collaborated with the Psoriasis Association and used methodology established by the James Lind ...

Abstract	Background: Psoriasis impacts the health and psychosocial functioning of patients, conferring a significant economic burden on healthcare systems. There remain unmet needs in psoriasis care, which if addressed by research, could improve clinical outcomes. Aim: To research priorities and identify a health service delivery model from the UK Psoriasis Priority Setting Partnership (PsPSP). Methods: Between July 2017 and November 2018, we invited people with lived experience of psoriasis and healthcare professionals to (i) identify unmet needs, and (ii) prioritize the order in which these should be addressed by research. We collaborated with the Psoriasis Association and used methodology established by the James Lind Alliance, which pioneers the joint setting of research priorities by patients and clinicians worldwide. Results: In our initial harvesting survey (Survey 1), 2133 questions were submitted by 805 individuals. Submissions that had not been answered by research (true uncertainties) were supplemented with evidence gaps from systematic reviews/guidelines published in the previous 5 years and refined to produce 55 indicative questions. Voting in Survey 2, by 1154 individuals, enabled a shortlist of questions, which were prioritized during the final workshop to produce a top 20 list of research questions. Submissions on health service delivery (5.8% of the total submissions), which were analysed separately, described a blueprint for psoriasis care. Conclusions: The PsPSP will inform the translational research agenda, ensuring that future research is relevant for the needs of people with psoriasis and those who manage the disease. Submissions on health service delivery describe a model of holistic, patient-focused care providing high-quality, effective management for patients with psoriasis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cost of Illness ; Delivery of Health Care/methods ; Disease Management ; Female ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Humans ; Interdisciplinary Communication ; Life Change Events ; Male ; Middle Aged ; Psoriasis/diagnosis ; Psoriasis/psychology ; Psoriasis/therapy ; Research/organization & administration ; Stakeholder Participation ; Surveys and Questionnaires/statistics & numerical data ; United Kingdom/epidemiology ; Young Adult
Language	English
Publishing date	2020-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14407
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Article ; Online: 4539 Building a Translational Science pipeline

Elmer Sanders / Vanessa Barth / Leigh-Ann Cruz / Ilesha Sherrer / Jacob Olson / Emily Speidell / Elvia Solis / Sharon Harrison / Amy Hinshaw / James A. McAteer

Journal of Clinical and Translational Science, Vol 4, Pp 57-

The Indiana CTSI STEM K-12 Program

2020 Volume 58

Abstract: OBJECTIVES/GOALS: Develop strong network of science teachers interested in promoting scientific research to their students.Place students in an immersive summer research internship that, when possible, matches their career interests.Expose students to ... ...

Abstract	OBJECTIVES/GOALS: Develop strong network of science teachers interested in promoting scientific research to their students.Place students in an immersive summer research internship that, when possible, matches their career interests.Expose students to the numerous career paths within the STEM field.
Keywords	Medicine ; R
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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