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Article ; Online: Go V.I.R.A.L.: Social Media Engagement Strategies in Infectious Diseases.

Langford, Bradley J / Laguio-Vila, Maryrose / Gauthier, Timothy P / Shah, Aditya

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 74, Issue Suppl_3, Page(s) e10–e13

Abstract: Social media has emerged as a tool to facilitate communication and dissemination of information for both patients and healthcare professionals. We describe 3 social media engagement strategies used to reach a broad and diverse audience on the topics of ... ...

Abstract	Social media has emerged as a tool to facilitate communication and dissemination of information for both patients and healthcare professionals. We describe 3 social media engagement strategies used to reach a broad and diverse audience on the topics of infectious diseases and antimicrobial stewardship, including the use of memes, a clue-based knowledge assessment quiz, and a personality quiz. We describe a novel acronym "VIRAL" to guide engaging social media strategies in healthcare, including eye catching Visuals, Interactive content, showing Respect and empathy for the audience, Adapting to new technology, and making Learning fun.
MeSH term(s)	Antimicrobial Stewardship ; Communicable Diseases/drug therapy ; Communication ; Humans ; Social Media
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac051
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficient Cleaning with Warm Water.

Bradley, R L

Journal of food protection

2019 Volume 45, Issue 11, Page(s) 1010–1012

Abstract: A prototype chlorinated alkaline cleaner (Diversey-Wyandotte PX 1704) functioned satisfactorily in recirculating water with temperatures as low as 30°C (85°F), whereas typical cleaner formulations currently in use require that water be at least at 60°C ( ... ...

Abstract	A prototype chlorinated alkaline cleaner (Diversey-Wyandotte PX 1704) functioned satisfactorily in recirculating water with temperatures as low as 30°C (85°F), whereas typical cleaner formulations currently in use require that water be at least at 60°C (140°F). On-farm experiments for periods up to 1 year with both hard (342 ppm) and softened water gave results similar to those of control periods before water temperature reduction. At each milk delivery to the University of Wisconsin Dairy, collected samples were evaluated for Standard Plate Count and for coliform and psychrotroph populations. Routine inspections with partial disassembly of the equipment showed no evidence of insanitary conditions, accumulation of deposits or conditions which would cause bacteria counts to increase. Evidence shows the importance of this cleaner in that dairy farmers can reduce use of hot water and thus markedly reduce expenditures for energy without sacrificing product quality.
Language	English
Publishing date	2019-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-45.11.1010
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Article ; Online: Effect of Light on Alteration of Nutritional Value and Flavor of Milk: A Review

Bradley, R L

Journal of food protection

2019 Volume 43, Issue 4, Page(s) 314–320

Abstract: Milk in glass, polycarbonate, high density polyethylene, blow-molded polyethylene, plastic bags and paperboard containers, when exposed to fluorescent light or sunlight, will develop a characteristic off-flavor described synonomously by many researchers ... ...

Abstract	Milk in glass, polycarbonate, high density polyethylene, blow-molded polyethylene, plastic bags and paperboard containers, when exposed to fluorescent light or sunlight, will develop a characteristic off-flavor described synonomously by many researchers as activated, sunlight or oxidized flavor. The extent of flavor development is related to the exposure interval, strength of the light and amount of milk surface exposed. Paperboard containers. particularly those with large printed areas of dark ink or foil in the laminate, offer the best protecton to milk, while the remaining containers offered limited protection at best. Characteristic flavor is produced prinicipally by conversion of methionine to methional. Partial loss of vitamins B
Language	English
Publishing date	2019-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-43.4.314
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Article ; Online: Pharmacometabolomics in Drug Disposition, Toxicity and Precision Medicine

Trevor, George R / Lim, Yong Jin / Urquhart, Bradley L

Drug metabolism and disposition: the biological fate of chemicals

2024

Abstract: The precision medicine initiative has driven a substantial change in the way scientists and health care practitioners think about diagnosing and treating disease. While it has long been recognized that drug response is determined by the intersection of ... ...

Abstract	The precision medicine initiative has driven a substantial change in the way scientists and health care practitioners think about diagnosing and treating disease. While it has long been recognized that drug response is determined by the intersection of genetic, environmental and disease factors, improvements in technology have afforded precision medicine guided dosing of drugs to improve efficacy and reduce toxicity. Pharmacometabolomics aims to evaluate small molecule metabolites in plasma and/or urine to help evaluate mechanisms that predict and/or reflect drug efficacy and toxicity. In this mini review, we provide an overview of pharmacometabolomic approaches and methodologies. Relevant examples where metabolomic techniques have been used to better understand drug efficacy and toxicity in major depressive disorder and cancer chemotherapy are discussed. In addition, the utility of metabolomics in drug development and understanding drug metabolism, transport and pharmacokinetics is reviewed. Pharmacometabolomic approaches can help understand factors mediating drug disposition, efficacy and toxicity. While important advancements in this area have been made, their remain several challenges that must be overcome before this approach can be fully implemented into clinical drug therapy.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	186795-7
ISSN	1521-009X ; 0090-9556
ISSN (online)	1521-009X
ISSN	0090-9556
DOI	10.1124/dmd.123.001074
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Article ; Online: Economic impacts of marine debris encounters on commercial shrimping.

Posadas, Benedict C / Sparks, Eric L / Cunningham, Sarah R / Rodolfich, Alyssa E / Wessel, Caitlin / Bradley, Ryan

Marine pollution bulletin

2024 Volume 200, Page(s) 116038

Abstract: The commercial shrimping industry is subjected to myriad stressors that have led to financial hardships among industry members. One of these stressors is marine debris; however, there is limited understanding of the type and magnitude of impacts. ... ...

Abstract	The commercial shrimping industry is subjected to myriad stressors that have led to financial hardships among industry members. One of these stressors is marine debris; however, there is limited understanding of the type and magnitude of impacts. Quantitative methods of estimating the economic impacts of marine debris on the commercial shrimping industry were developed. From June to December 2019, participating shrimpers submitted 393 daily summaries, including shrimping activities, marine debris encounters, damages, and impacts. The impacts of marine debris encounters were assessed from reports of daily damages to fishing assets, daily lost fishing time, daily loss-catch ratios, and daily catch losses. The results of this study demonstrate substantial negative economic impacts on commercial shrimpers related to marine debris encounters. About 17 % of shrimp caught were lost due to marine debris encounters, resulting in foregone total sales and job impacts of $3.2 million and 33 jobs in shrimping and associated businesses.
MeSH term(s)	Animals ; Fisheries ; Environmental Monitoring/methods ; Brachyura ; Seafood
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2024.116038
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Article ; Online: Transforming health care delivery: The role of primary health care nurses in rural and remote Australia.

Robinson, Tracy / Govan, Linda / Bradley, Cressida / Rossiter, Rachel

The Australian journal of rural health

2024

Abstract: Aim: This paper describes the policy context and approaches taken to improve access to primary health care in Australia by supporting nurses to deliver improved integrated care meeting community needs.: Context: In Primary Health Care (PHC), the ... ...

Abstract	Aim: This paper describes the policy context and approaches taken to improve access to primary health care in Australia by supporting nurses to deliver improved integrated care meeting community needs. Context: In Primary Health Care (PHC), the nursing workforce are predominantly employed in the general practice sector. Despite evidence that nurse-led models of care can bridge traditional treatment silos in the provision of specialised and coordinated care, PHC nurses' scope of practice varies dramatically. Nurse-led models of care are imperative for rural and remote populations that experience workforce shortages and barriers to accessing health care. Existing barriers include policy constraints, limited organisational structures, education and financing models. Approach: The Australian Primary Health Care Nurses Association (APNA) received funding to implement nurse-led clinics as demonstration projects. The clinics enable PHC nurses to work to their full scope of practice, improve continuity of care and increase access to health care in under serviced locations. We reviewed a range of peer-reviewed literature, policy documents, grey literature and APNA provided sources, particularly those relevant to rural and remote populations. We argue more focus is needed on how to address variations in the scope of practice of the rural and remote PHC nursing workforce. Conclusion: Despite growing evidence for the effectiveness of nurse-led models of care, significant policy and financial barriers continue to inhibit PHC nurses working to their full scope of practice. If their potential to transform health care and increase access to health services is to be realised these barriers must be addressed.
Language	English
Publishing date	2024-04-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/ajr.13120
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Article: Distinct hippocampal mechanisms support concept formation and updating.

Mack, Michael L / Love, Bradley C / Preston, Alison R

bioRxiv : the preprint server for biology

2024

Abstract: Learning systems must constantly decide whether to create new representations or update existing ones. For example, a child learning that a bat is a mammal and not a bird would be best served by creating a new representation, whereas updating may be best ...

Abstract	Learning systems must constantly decide whether to create new representations or update existing ones. For example, a child learning that a bat is a mammal and not a bird would be best served by creating a new representation, whereas updating may be best when encountering a second similar bat. Characterizing the neural dynamics that underlie these complementary memory operations requires identifying the exact moments when each operation occurs. We address this challenge by interrogating fMRI brain activation with a computational learning model that predicts trial-by-trial when memories are created versus updated. We found distinct neural engagement in anterior hippocampus and ventral striatum for model-predicted memory create and update events during early learning. Notably, the degree of this effect in hippocampus, but not ventral striatum, significantly related to learning outcome. Hippocampus additionally showed distinct patterns of functional coactivation with ventromedial prefrontal cortex and angular gyrus during memory creation and premotor cortex during memory updating. These findings suggest that complementary memory functions, as formalized in computational learning models, underlie the rapid formation of novel conceptual knowledge, with the hippocampus and its interactions with frontoparietal circuits playing a crucial role in successful learning. Significance statement: How do we reconcile new experiences with existing knowledge? Prominent theories suggest that novel information is either captured by creating new memories or leveraged to update existing memories, yet empirical support of how these distinct memory operations unfold during learning is limited. Here, we combine computational modeling of human learning behaviour with functional neuroimaging to identify moments of memory formation and updating and characterize their neural signatures. We find that both hippocampus and ventral striatum are distinctly engaged when memories are created versus updated; however, it is only hippocampus activation that is associated with learning outcomes. Our findings motivate a key theoretical revision that positions hippocampus is a key player in building organized memories from the earliest moments of learning.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.14.580181
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Article ; Online: Remote magnetic navigation enables precision telesurgery.

Nelson, Bradley J / Bendok, Bernard R / Turcotte, Evelyn L / Batjer, H Hunt

Science robotics

2024 Volume 9, Issue 87, Page(s) eado3187

Abstract: Medical devices actuated by external magnetic fields can create opportunities for clinical adoption of precision telesurgery. ...

Abstract	Medical devices actuated by external magnetic fields can create opportunities for clinical adoption of precision telesurgery.
MeSH term(s)	Robotics ; Magnetic Fields ; Magnetics ; Equipment Design
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-9476
ISSN (online)	2470-9476
DOI	10.1126/scirobotics.ado3187
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Article ; Online: A Novel Approach to Tally Aculops cannabicola (Acari: Eriophyidae) for Field and Laboratory Studies.

Falcon-Brindis, A / Villanueva, R T / Viloria, Z / Bradley, C L

Journal of economic entomology

2023 Volume 116, Issue 2, Page(s) 591–598

Abstract: The hemp russet mite, Aculops cannabicola (Farkas) is a key pest of hemp (Cannabis sativa L ...

Abstract	The hemp russet mite, Aculops cannabicola (Farkas) is a key pest of hemp (Cannabis sativa L.). Given its microscopic size, estimating the size of its populations can be a major limitation to control this pest. Here, we describe a method to count A. cannabicola using photographs taken with a handheld digital microscope. We compared the consistency and strength of the relationship between photographic- and microscope-based counts of mites from infested plants. Among the three sections of the leaflet, the maximum consistency levels were observed in the proximal (50%) and middle photographs (50%). However, it reached from 64% to 100% when the three sections were considered. Photographic and a microscope-based counts were positively correlated (>0.7). A single photograph can be a good predictor of the total mites per leaflet, however, using two pictures (proximal and middle sections) will increase the consistency of the abundance of A. cannabicola per leaflet. A minimum of 22 leaflets per sampling event can support a strong correlation between the microscope and photographic counts. Our method requires low budget and training and takes short time (0.4 to 1.3 min per leaflet) to count mites per sample. Additionally, photographs can be stored on a smartphone, computer, or tablet, allowing users to share, store and process the photos. This method simplifies counts of A. cannabicola on hemp for research purposes and provides a practical tool for growers to assess mite populations for management decisions. In addition, it may be useful for monitoring eriophyid mites on cultivated plants.
MeSH term(s)	Animals ; Mites
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3031-4
ISSN	1938-291X ; 0022-0493
ISSN (online)	1938-291X
ISSN	0022-0493
DOI	10.1093/jee/toad004
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Article ; Online: Effect of antenatal micronutrient or antidepressant exposure on Brazelton neonatal behavioral assessment scale (NBAS) performance within one-month of birth.

Campbell, S A / Bradley, H A / Mulder, R T / Henderson, J M T / Dixon, L / Haslett, L C / Rucklidge, J J

Early human development

2024 Volume 190, Page(s) 105948

Abstract: ... to antidepressant-exposed. There was an association between micronutrient exposure length and better habituation (r ...

Abstract	Background: Antenatal depression is a risk factor for poor infant outcomes. Broad-spectrum-micronutrients (vitamins and minerals) have shown efficacy in treating psychiatric symptoms in non-pregnant populations and are associated with reduced incidence of adverse birth outcomes, and improvements in neonatal development. We investigated the effects of treatment of antenatal depression with micronutrients above the Recommended Dietary Allowance on infant development compared to treatment with antidepressant medications and controls. Method: One-hundred-and-three infants were assessed using the Brazelton Neonatal Behavioral Assessment Scale (NBAS) within 28 days of birth: 37 exposed to micronutrients in-utero (50-182 days exposure), 18 to antidepressants in-utero (exposure for full gestation), and 48 controls whose mothers received neither treatment nor experienced depressive symptoms. Results: Controlling for gestational age and parity, there were significant group differences on habituation, orientation, motor, state regulation, autonomic stability and reflexes (p < .05). Micronutrient-exposed performed better than antidepressant-exposed and controls on habituation, motor and autonomic stability (p < .05), effect sizes ranged 1.0-1.7 and 0.5-1.0, respectively. Antidepressant-exposed performed significantly worse on orientation and reflexes compared to micronutrient-exposed and controls. Micronutrient-exposed had significantly better state regulation compared to antidepressant-exposed. There was an association between micronutrient exposure length and better habituation (r = 0.41, p = .028). Micronutrient exposure was generally identified as a stronger predictor of neonatal performance over maternal depression, social adversity, gestational age and infant sex. Conclusion: In-utero micronutrient exposure appears to mitigate risks of depression on infant outcomes showing positive effects on infant behavior, on par with or better than typical pregnancies and superior to antidepressants. Limitations include differential exposure to micronutrients/antidepressants and lack of group blinding.
MeSH term(s)	Infant, Newborn ; Infant ; Child ; Pregnancy ; Humans ; Female ; Micronutrients ; Vitamins ; Antidepressive Agents/adverse effects ; Trace Elements ; Mothers
Chemical Substances	Micronutrients ; Vitamins ; Antidepressive Agents ; Trace Elements
Language	English
Publishing date	2024-01-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2024.105948
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