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Article ; Online: Galea vs periosteum: impact of excision depth on outcomes for cutaneous squamous cell carcinoma of the scalp.

Brewer, Christopher F / Chawla, Reema / Patel, Animesh J K

Journal of plastic surgery and hand surgery

2022 Volume 57, Issue 1-6, Page(s) 253–256

Abstract: Cutaneous squamous-cell carcinoma (cSCC) is the second most common skin cancer, with local recurrence rates of up to 10% in the scalp. To date there have been no direct comparisons of recurrence rates or deep margin involvement for surgical excision to ... ...

Abstract	Cutaneous squamous-cell carcinoma (cSCC) is the second most common skin cancer, with local recurrence rates of up to 10% in the scalp. To date there have been no direct comparisons of recurrence rates or deep margin involvement for surgical excision to different anatomical layers of the scalp. A multi-centre retrospective study of all cSCC excised from the scalp from 2015 to 2020 was conducted. Two hundred and seventy nine patients (17-female, 262-male) met the inclusion criteria (median age 82.2 years), incorporating a total of 302 cSCC's. Primary excision depth was galea in 80 cases and periosteum in 222 (26.5% and 73.5% respectively). A significantly greater proportion of lesions excised to galea had involved or close (<1mm) deep margins (
MeSH term(s)	Humans ; Male ; Female ; Aged, 80 and over ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Scalp/surgery ; Retrospective Studies ; Periosteum/surgery ; Neoplasm Recurrence, Local/epidemiology
Language	English
Publishing date	2022-04-12
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	2551921-9
ISSN	2000-6764 ; 2000-656X
ISSN (online)	2000-6764
ISSN	2000-656X
DOI	10.1080/2000656X.2022.2060993
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Article ; Online: Is radiation therapy as a primary treatment modality for squamous cell carcinoma of the hand the best choice? Case series and review of the literature.

Brewer, Christopher F / Deutsch, Christopher J / Jemec, Barbara

Dermatology online journal

2020 Volume 26, Issue 6

Abstract: Background: Squamous cell carcinoma (SCC) is the most common malignancy of the upper limb, and can pose a significant therapeutic challenge. Early treatment needs to be radical whilst maintaining function.: Methods: We describe two cases of upper ... ...

Abstract	Background: Squamous cell carcinoma (SCC) is the most common malignancy of the upper limb, and can pose a significant therapeutic challenge. Early treatment needs to be radical whilst maintaining function. Methods: We describe two cases of upper limb squamous cell carcinoma treated with radiotherapy, review the literature on radiotherapy as a primary treatment modality, and discuss the specific difficulties treating SCC in the hand. Results: Radiation therapy was inadequate in tumor clearance in both cases, with recurrence both extensive and distal to the initial focus. Moreover, both patients developed progressive functional loss related to pain, swelling, and stiffness. Conclusion: The evidence basis for radiation therapy as a primary modality is limited, although clearance rates are comparable to surgery. Both radiotherapy and surgery can be utilized to treat SCC. However, we make the case for the hand being especially susceptible to the unwanted side effects of radiotherapy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brachytherapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Hand/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Radiation Injuries/pathology ; Radiotherapy/adverse effects ; Skin Neoplasms/pathology ; Skin Neoplasms/radiotherapy
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2026239-5
ISSN	1087-2108 ; 1087-2108
ISSN (online)	1087-2108
ISSN	1087-2108
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Article ; Online: Inhibition of vibrational energy flow within an aromatic scaffold via heavy atom effect.

Hassani, Majid / Mallon, Christopher J / Monzy, Judith N / Schmitz, Andrew J / Brewer, Scott H / Fenlon, Edward E / Tucker, Matthew J

The Journal of chemical physics

2023 Volume 158, Issue 22

Abstract: ... followed by energy relaxation into the solvent [Schmitz et al., J. Phys. Chem. A 123, 10571 (2019 ...

Abstract	The regulation of intramolecular vibrational energy redistribution (IVR) to influence energy flow within molecular scaffolds provides a way to steer fundamental processes of chemistry, such as chemical reactivity in proteins and design of molecular diodes. Using two-dimensional infrared (2D IR) spectroscopy, changes in the intensity of vibrational cross-peaks are often used to evaluate different energy transfer pathways present in small molecules. Previous 2D IR studies of para-azidobenzonitrile (PAB) demonstrated that several possible energy pathways from the N3 to the cyano-vibrational reporters were modulated by Fermi resonance, followed by energy relaxation into the solvent [Schmitz et al., J. Phys. Chem. A 123, 10571 (2019)]. In this work, the mechanisms of IVR were hindered via the introduction of a heavy atom, selenium, into the molecular scaffold. This effectively eliminated the energy transfer pathway and resulted in the dissipation of the energy into the bath and direct dipole-dipole coupling between the two vibrational reporters. Several structural variations of the aforementioned molecular scaffold were employed to assess how each interrupted the energy transfer pathways, and the evolution of 2D IR cross-peaks was measured to assess the changes in the energy flow. By eliminating the energy transfer pathways through isolation of specific vibrational transitions, through-space vibrational coupling between an azido (N3) and a selenocyanato (SeCN) probe is facilitated and observed for the first time. Thus, the rectification of this molecular circuitry is accomplished through the inhibition of energy flow using heavy atoms to suppress the anharmonic coupling and, instead, favor a vibrational coupling pathway.
Language	English
Publishing date	2023-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0153760
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Article ; Online: Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA.

Martin, Rebecca / Espinoza, Claudia Y / Large, Christopher R L / Rosswork, Joshua / Van Bruinisse, Cole / Miller, Aaron W / Sanchez, Joseph C / Miller, Madison / Paskvan, Samantha / Alvino, Gina M / Dunham, Maitreya J / Raghuraman, M K / Brewer, Bonita J

PLoS genetics

2024 Volume 20, Issue 1, Page(s) e1010850

Abstract: Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generation ... ...

Abstract	Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generation of these gross chromosomal rearrangements. We proposed a model of template switching (ODIRA-origin dependent inverted repeat amplification) in which simultaneous ligation of the leading and lagging strands at diverging replication forks could generate segmental inverted triplications through an extrachromosomal inverted circular intermediate. Here, we created a genetic assay using split-ura3 cassettes to trap the proposed inverted intermediate. However, instead of recovering circular inverted intermediates, we found inverted linear chromosomal fragments ending in native telomeres-suggesting that a template switch had occurred at the centromere-proximal fork of a replication bubble. As telomeric inverted hairpin fragments can also be created through double strand breaks we tested whether replication errors or repair of double stranded DNA breaks were the most likely initiating event. The results from CRISPR/Cas9 cleavage experiments and growth in the replication inhibitor hydroxyurea indicate that it is a replication error, not a double stranded break that creates the inverted junctions. Since inverted amplicons of the SUL1 gene occur during long-term growth in sulfate-limited chemostats, we sequenced evolved populations to look for evidence of linear intermediates formed by an error in replication. All of the data are compatible with a two-step version of the ODIRA model in which sequential template switching at short inverted repeats between the leading and lagging strands at a replication fork, followed by integration via homologous recombination, generates inverted interstitial triplications.
MeSH term(s)	Humans ; DNA Replication/genetics ; DNA Copy Number Variations/genetics ; Chromosome Aberrations ; DNA Breaks, Double-Stranded ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010850
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Article: ECM-Focused Proteomic Analysis of Ear Punch Regeneration in

McCabe, Maxwell C / Okamura, Daryl M / Erickson, Christopher B / Perry, Blair W / Brewer, Chris M / Nguyen, Elizabeth D / Saviola, Anthony J / Majesky, Mark W / Hansen, Kirk C

bioRxiv : the preprint server for biology

2023

Abstract: In mammals, significant injury is generally followed by the formation of a fibrotic scar which provides structural integrity but fails to functionally restore damaged tissue. Spiny mice of the ... ...

Abstract	In mammals, significant injury is generally followed by the formation of a fibrotic scar which provides structural integrity but fails to functionally restore damaged tissue. Spiny mice of the genus
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.11.561940
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Article ; Online: Local Recurrence of Melanoma Is Higher After Wide Local Excision Versus Mohs Micrographic Surgery or Staged Excision: A Systematic Review and Meta-analysis.

Pride, Renee L D / Miller, Christopher J / Murad, M Hassan / Erwin, Patricia J / Brewer, Jerry D

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2021 Volume 48, Issue 2, Page(s) 164–170

Abstract: Background: Complete removal of melanoma is a primary goal of excision, and local recurrence is one measure to evaluate the efficacy of surgical technique.: Objective: To compare published local recurrence rates for melanoma treated with Mohs ... ...

Abstract	Background: Complete removal of melanoma is a primary goal of excision, and local recurrence is one measure to evaluate the efficacy of surgical technique. Objective: To compare published local recurrence rates for melanoma treated with Mohs micrographic surgery (MMS) or staged excision versus wide local excision (WLE). Methods and materials: Search of 6 databases identified comparative and noncomparative studies that reported local recurrence rates after MMS, staged excision, or WLE for melanoma. Random-effects meta-analysis was used to estimate odds ratios and 95% confidence interval (CI) from comparative studies and event rates from noncomparative studies. Results: Of the 71 studies included (16,575 patients), 12 were comparative studies (2,683 patients) and 56 were noncomparative studies (13,698 patients). Comparative studies showed increased recurrence after WLE compared with MMS or staged excision (odds ratio [OR], 2.5; 95% CI, 1.4-4.6) and compared with MMS alone (OR, 3.3; 95% CI, 1.8-5.9). Pooled data from comparative and noncomparative studies showed a local recurrence rate of 7% after WLE (95% CI, 5%-11%), 3% after staged excision (95% CI, 2%-4%), and less than 1% after MMS (95% CI, 0%-1%). Statistical heterogeneity was moderate to high. Conclusion: Local recurrence of melanoma is significantly lower after MMS (<1%) and staged excision (3%) compared with WLE (7%).
MeSH term(s)	Databases, Factual ; Humans ; Melanoma/surgery ; Mohs Surgery/methods ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies ; Skin Neoplasms/surgery
Language	English
Publishing date	2021-11-25
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003309
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Zs.A 1212: Show issues

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Article ; Online: Commentary on "Limitations in the literature regarding Mohs surgery and staged excision for melanoma: A critical review of quality and data reporting".

Miller, Christopher J / Etzkorn, Jeremy R / Leitenberger, Justin J / Bar, Anna / Baum, Christian L / Brewer, Jerry D / Srivastava, Divya / Nijhawan, Rajiv I

Journal of the American Academy of Dermatology

2021 Volume 88, Issue 2, Page(s) 511–512

MeSH term(s)	Humans ; Melanoma/surgery ; Mohs Surgery ; Research Design ; Skin Neoplasms/surgery
Language	English
Publishing date	2021-04-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2021.03.117
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Zs.A 1540: Show issues

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Article ; Online: Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US.

Jiang, Jialing / Warren, Christopher M / Brewer, Audrey / Soffer, Gary / Gupta, Ruchi S

JAMA network open

2023 Volume 6, Issue 6, Page(s) e2318162

Abstract: Importance: Food allergies affect approximately 8% of children and 11% of adults in the US. Racial differences in food allergy outcomes have previously been explored among Black and White children, but little is known about the distribution of food ... ...

Abstract	Importance: Food allergies affect approximately 8% of children and 11% of adults in the US. Racial differences in food allergy outcomes have previously been explored among Black and White children, but little is known about the distribution of food allergies across other racial, ethnic, and socioeconomic subpopulations. Objective: To estimate the national distribution of food allergies across racial, ethnic, and socioeconomic groups in the US. Design, setting, and participants: In this cross-sectional survey study, conducted from October 9, 2015, to September 18, 2016, a population-based survey was administered online and via telephone. A US nationally representative sample was surveyed. Participants were recruited using both probability- and nonprobability-based survey panels. Statistical analysis was performed from September 1, 2022, through April 10, 2023. Exposures: Demographic and food allergy-related participant characteristics. Main outcomes and measures: Stringent symptom criteria were developed to distinguish respondents with a "convincing" food allergy from those with similar symptom presentations (ie, food intolerance or oral allergy syndrome), with or without physician diagnosis. The prevalence of food allergies and their clinical outcomes, such as emergency department visits, epinephrine autoinjector use, and severe reactions, were measured across race (Asian, Black, White, and >1 race or other race), ethnicity (Hispanic and non-Hispanic), and household income. Complex survey-weighted proportions were used to estimate prevalence rates. Results: The survey was administered to 51 819 households comprising 78 851 individuals (40 443 adults and parents of 38 408 children; 51.1% women [95% CI, 50.5%-51.6%]; mean [SD] age of adults, 46.8 [24.0] years; mean [SD] age of children, 8.7 [5.2] years): 3.7% Asian individuals, 12.0% Black individuals, 17.4% Hispanic individuals, 62.2% White individuals, and 4.7% individuals of more than 1 race or other race. Non-Hispanic White individuals across all ages had the lowest rate of self-reported or parent-reported food allergies (9.5% [95% CI, 9.2%-9.9%]) compared with Asian (10.5% [95% CI, 9.1%-12.0%]), Hispanic (10.6% [95% CI, 9.7%-11.5%]), and non-Hispanic Black (10.6% [95% CI, 9.8%-11.5%]) individuals. The prevalence of common food allergens varied by race and ethnicity. Non-Hispanic Black individuals were most likely to report allergies to multiple foods (50.6% [95% CI, 46.1%-55.1%]). Asian and non-Hispanic White individuals had the lowest rates of severe food allergy reactions (Asian individuals, 46.9% [95% CI, 39.8%-54.1%] and non-Hispanic White individuals, 47.8% [95% CI, 45.9%-49.7%]) compared with individuals of other races and ethnicities. The prevalence of self-reported or parent-reported food allergies was lowest within households earning more than $150 000 per year (8.3% [95% CI, 7.4%-9.2%]). Conclusions and relevance: This survey study of a US nationally representative sample suggests that the prevalence of food allergies was highest among Asian, Hispanic, and non-Hispanic Black individuals compared with non-Hispanic White individuals in the US. Further assessment of socioeconomic factors and corresponding environmental exposures may better explain the causes of food allergy and inform targeted management and interventions to reduce the burden of food allergies and disparities in outcomes.
MeSH term(s)	Adult ; Child ; Child, Preschool ; Female ; Humans ; Male ; Young Adult ; Cross-Sectional Studies ; Ethnicity ; Food ; Food Hypersensitivity/ethnology ; Hispanic or Latino ; Asian ; White ; Black or African American ; United States/epidemiology ; Middle Aged ; Aged
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.18162
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Article ; Online: Ultrasensitive Detection of Circulating Tumour DNA enriches for Patients with a Greater Risk of Recurrence of Clinically Localised Prostate Cancer.

European urology

2024 Volume 85, Issue 4, Page(s) 407–410

MeSH term(s)	Male ; Humans ; Circulating Tumor DNA/genetics ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/diagnosis ; Prostatectomy
Chemical Substances	Circulating Tumor DNA ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2024.01.002
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Fluorescent probes for imaging formaldehyde in biological systems.

Bruemmer, Kevin J / Brewer, Thomas F / Chang, Christopher J

Current opinion in chemical biology

2017 Volume 39, Page(s) 17–23

Abstract: Formaldehyde (FA) is a common environmental toxin but is also endogenously produced through a diverse array of essential biological processes, including mitochondrial one-carbon metabolism, metabolite oxidation, and nuclear epigenetic modifications. Its ... ...

Abstract	Formaldehyde (FA) is a common environmental toxin but is also endogenously produced through a diverse array of essential biological processes, including mitochondrial one-carbon metabolism, metabolite oxidation, and nuclear epigenetic modifications. Its high electrophilicity enables reactivity with a wide variety of biological nucleophiles, which can be beneficial or detrimental to cellular function depending on the context. New methods that enable detection of FA in living systems can help disentangle the signal/stress dichotomy of this simplest reactive carbonyl species (RCS), and fluorescent probes for FA with high selectivity and sensitivity have emerged as promising chemical tools in this regard.
MeSH term(s)	Animals ; Fluorescent Dyes/chemistry ; Formaldehyde/chemistry ; Formaldehyde/metabolism ; Humans ; Molecular Imaging/methods
Chemical Substances	Fluorescent Dyes ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2017-05-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1439176-4
ISSN	1879-0402 ; 1367-5931
ISSN (online)	1879-0402
ISSN	1367-5931
DOI	10.1016/j.cbpa.2017.04.010
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Zs.A 4986: Show issues

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