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Article ; Online: Multiple sclerosis: assay of free immunoglobulin light chains.

Ramsden, D B

2017 Volume 54, Issue 1, Page(s) 5–13

Abstract: Over the past five years, a number of papers have appeared describing the assay of free immunoglobulin light chains in cerebrospinal fluid to assist in the diagnosis of multiple sclerosis. The assay of kappa free immunoglobulin chains is being advocated ... ...

Abstract	Over the past five years, a number of papers have appeared describing the assay of free immunoglobulin light chains in cerebrospinal fluid to assist in the diagnosis of multiple sclerosis. The assay of kappa free immunoglobulin chains is being advocated as a technically simpler and cheaper quantitative alternative to the qualitative detection of oligoclonal bands. This article reviews the analytical and clinical characteristics of these immunoglobulin free light chain assays and places them in their historical context and possible future developments.
MeSH term(s)	Biological Assay ; Humans ; Immunoglobulin G/cerebrospinal fluid ; Immunoglobulin kappa-Chains/cerebrospinal fluid ; Immunoglobulin lambda-Chains/cerebrospinal fluid ; Limit of Detection ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/pathology
Chemical Substances	Immunoglobulin G ; Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/0004563216652175
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Zs.A 889: Show issues

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Article ; Online: Innovations, Opportunities, and Challenges for Predicting Alteration in Drug-Metabolizing Enzyme and Transporter Activity in Specific Populations.

Chothe, Paresh P / Arya, Vikram / Prasad, Bhagwat / Ramsden, Diane / Taskar, Kunal

Drug metabolism and disposition: the biological fate of chemicals

2023 Volume 51, Issue 12, Page(s) 1547–1550

Abstract: Drug-metabolizing enzymes and transporters (DMETs) are key regulators of the pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades, significant advancements in in vitro methodologies, targeted proteomics, in vitro to in vivo ...

Abstract	Drug-metabolizing enzymes and transporters (DMETs) are key regulators of the pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades, significant advancements in in vitro methodologies, targeted proteomics, in vitro to in vivo extrapolation methods, and integrated computational approaches such as physiologically based pharmacokinetic modeling have unequivocally contributed to improving our ability to quantitatively predict the role of DMETs in absorption, distribution, metabolism, and excretion and drug-drug interactions. However, the paucity of data regarding alterations in DMET activity in specific populations such as pregnant individuals, lactation, pediatrics, geriatrics, organ impairment, and disease states such as, cancer, kidney, and liver diseases and inflammation has restricted our ability to realize the full potential of these recent advancements. We envision that a series of carefully curated articles in a special supplementary issue of
MeSH term(s)	Pregnancy ; Female ; Humans ; Child ; Membrane Transport Proteins/metabolism ; Liver Diseases ; Drug Interactions ; Inflammation ; Metabolic Clearance Rate
Chemical Substances	Membrane Transport Proteins
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	186795-7
ISSN	1521-009X ; 0090-9556
ISSN (online)	1521-009X
ISSN	0090-9556
DOI	10.1124/dmd.123.001453
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Zs.A 1014: Show issues

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Article ; Online: Empowering Ontario's long-term care residents to shape the place they call home: a codesign protocol.

Lee, Chloe / Tripp, Dee / McVie, Melissa / Fineczko, Julia / Ramsden, Gale / Hothi, Sobhneek / Langston, Jennifer / Gilhuly, Jim / Collingwood, Beryl / McAiney, Carrie / McGilton, Katherine S / Bethell, Jennifer

BMJ open

2024 Volume 14, Issue 2, Page(s) e077791

Abstract: Background: Canada's long-term care (LTC) homes were founded on an institutional model that viewed residents as passive recipients of care. Many homes continue to follow this model leaving residents removed from operational decision-making within their ... ...

Abstract	Background: Canada's long-term care (LTC) homes were founded on an institutional model that viewed residents as passive recipients of care. Many homes continue to follow this model leaving residents removed from operational decision-making within their homes. However, involving residents in the design of their LTC home's environment, programmes and operations can improve the residents' quality of life and other outcomes. This codesign project creates a toolkit/resource for LTC homes to facilitate meaningful resident engagement in their home's organisational design and governance. Method: This three-part project consists of a scoping review, qualitative interviews, toolkit/resource development and prototyping. In part 1, we conduct a scoping review to synthesise existing knowledge on approaches to engaging LTC home residents in organisational design and governance of their LTC homes, as well as explore barriers, challenges and facilitators of engagement, considerations for diversity and cognitive change, and approaches to evaluation. In part 2, we will have interviews and focus groups with residents, team members (staff) and administrators to assess community capacity to implement and sustain a programme to engage LTC residents in organisational design and governance of their LTC homes. The third part of our project uses these findings to help codesign toolkit(s)/resource(s) to enable the engagement of LTC residents in the organisational design and governance of their LTC homes. Ethics and dissemination: The project is conducted in partnership with the Ontario Association of Residents' Councils. We will leverage their communication to disseminate findings and support the use of the codesigned toolkit(s)/resource(S) with knowledge users. We will also publish the study results in an academic journal and present at conferences, webinars and workshops. These results can influence practices within LTC homes by inspiring an organisational culture where residents help shape the place they call home. The interviews and focus groups, conducted in part 2, have been submitted to the University Health Network Research Ethics Board.
MeSH term(s)	Humans ; Long-Term Care/psychology ; Ontario ; Quality of Life ; Palliative Care ; Power, Psychological ; Review Literature as Topic
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-077791
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Article ; Online: Nurturing a culture of curiosity in family medicine and primary care: The Section of Researchers' Blueprint 2 (2018-2023).

Fortin, Martin / Pereira, José / Hutchison, Brian / Ramsden, Vivian R / Menear, Matthew / Snelgrove, Deirdre

Canadian family physician Medecin de famille canadien

2021 Volume 67, Issue 5, Page(s) 333–338

Abstract: Objective: To describe Blueprint 2 (2018-2023), the 5-year strategic plan launched in 2018 by the Section of Researchers (SOR), as well as its guiding principles and the process used to develop it.: Composition of the committee: Blueprint 2 was co- ... ...

Abstract	Objective: To describe Blueprint 2 (2018-2023), the 5-year strategic plan launched in 2018 by the Section of Researchers (SOR), as well as its guiding principles and the process used to develop it. Composition of the committee: Blueprint 2 was co-created by many stakeholders from across Canada and led by the SOR Council (SORC). The process started with an external, commissioned program evaluation in 2017 of the effect of the first SOR Blueprint (2012-2017). The findings and recommendations arising from the evaluation were presented in a day-long facilitated invitational retreat, hosted by the SORC in September 2017 and involving 40 key stakeholders. Methods: Blueprint 2 was created using a multi-pronged, participatory, and iterative process to ensure broad input and alignment with current and future opportunities and priorities. Report: Blueprint 2 incorporates 4 strategic priority areas, each supported by objectives and actions. The strategic priority areas are membership, capacity building, advocacy, and partnerships. This updated Blueprint provides a useful, membership-driven strategic plan specifically for the SOR. The implementation of its objectives will promote research and quality improvement and contribute to building a culture of curiosity. Blueprint 2 emphasizes research and quality improvement that emanate from the realities of everyday practice and are rooted in everyday work. At its core are patient- and community-oriented approaches; it also contributes to achieving the Quadruple Aim. These outcomes will further the integration of the scholar role into daily practice for family physicians and primary care clinicians and teams. Conclusion: The ability of family physicians to identify, study, and cite their own evidence is essential to establishing the value and effect of primary care, including family medicine, in relation to Canadians' health and the Canadian health care system.
MeSH term(s)	Canada ; Exploratory Behavior ; Family Practice ; Humans ; Primary Health Care ; Research Personnel
Language	English
Publishing date	2021-05-13
Publishing country	Canada
Document type	Journal Article
ZDB-ID	603565-6
ISSN	1715-5258 ; 0008-350X
ISSN (online)	1715-5258
ISSN	0008-350X
DOI	10.46747/cfp.6705333
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Zs.B 2236: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 5: Show issues

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Article ; Online: Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans.

Chen, Daniel K / Metherel, Adam H / Rezaei, Kimia / Parzanini, Camilla / Chen, Chuck T / Ramsden, Christopher E / Horowitz, Mark / Faurot, Keturah R / MacIntosh, Beth / Zamora, Daisy / Bazinet, Richard P

Journal of lipid research

2023 Volume 64, Issue 9, Page(s) 100424

Abstract: Natural variations in ... ...

Abstract	Natural variations in the
MeSH term(s)	Adult ; Animals ; Humans ; Female ; Male ; Fatty Acids, Omega-6 ; Fatty Acids, Omega-3 ; Eicosapentaenoic Acid/metabolism ; Fatty Acids ; Phospholipids ; Docosahexaenoic Acids/metabolism
Chemical Substances	Fatty Acids, Omega-6 ; Fatty Acids, Omega-3 ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Fatty Acids ; Phospholipids ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2023.100424
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Zs.A 175: Show issues

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Article ; Online: IPM Decisions – eine neue europäische Plattform für Entscheidungshilfen im integrierten Pflanzenschutz

Weigand, Stephan / Paveley, Neil / Ffoulkes, Charles / Nordskog, Berit / Skirvin, Dave / Nistrup Jørgensen, Lise / Georgantzis, Nikos / Brinks, Harm / Ramsden, Mark

2023

Keywords	Text ; abstract_or_summary ; ddc:630
Language	German
Publisher	Julius Kühn-Institut
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human amylase gene copy number variation as a determinant of metabolic state.

Elder, Patrick J D / Ramsden, David B / Burnett, David / Weickert, Martin O / Barber, Thomas M

Expert review of endocrinology & metabolism

2018 Volume 13, Issue 4, Page(s) 193–205

Abstract: Introduction: Humans have multiple genes encoding amylase that are broadly divided into salivary (AMY1) and pancreatic (AMY2) genes. They exhibit some of the greatest copy numbers of any human gene, an expansion possibly driven by increased dietary ... ...

Abstract	Introduction: Humans have multiple genes encoding amylase that are broadly divided into salivary (AMY1) and pancreatic (AMY2) genes. They exhibit some of the greatest copy numbers of any human gene, an expansion possibly driven by increased dietary starch intake. Within the population, amylase gene copy number is highly variable and there is evidence of an inverse association between AMY1 copy number and BMI. Areas covered: We examine the evidence for the link between AMY1 and BMI, its potential mechanisms, and the metabolic effects of salivary and pancreatic amylase, both in the gastrointestinal tract and the blood Expert commentary: Salivary amylase may influence postprandial 'cephalic phase' insulin release, which improves glucose tolerance, while serum amylase may have insulin-sensitizing properties. This could explain the favorable metabolic status associated with higher AMY1 copy number. The association with BMI is harder to explain and is potentially mediated by increased flux of undigested starch into the ileum, with resultant effects on short-chain fatty acids (SCFAs), changes in gut microbiota and effects on appetite and energy expenditure in those with low copy number. Future research on the role of amylase as a determinant of metabolic health and BMI may lead to novel therapies to target obesity.
MeSH term(s)	Biological Evolution ; Body Mass Index ; DNA Copy Number Variations ; Glucose/metabolism ; Homeostasis ; Humans ; Obesity/enzymology ; Obesity/genetics ; Salivary alpha-Amylases/genetics
Chemical Substances	Salivary alpha-Amylases (EC 3.2.1.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-07-25
Publishing country	England
Document type	Journal Article ; Review
ISSN	1744-8417
ISSN (online)	1744-8417
DOI	10.1080/17446651.2018.1499466
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Article ; Online: Speech-language pathology telehealth in rural and remote schools: the experience of school executive and therapy assistants.

Fairweather, Glenn C / Lincoln, Michelle A / Ramsden, Robyn

Rural and remote health

2017 Volume 17, Issue 3, Page(s) 4225

Abstract: ... relationships in the data.: Results: Emergent themes related to (a) unmet speech pathology needs, (b ... building relationships, (c) telehealth's advantages, (d) telehealth's disadvantages, (e) anxiety replaced ...

Abstract	Introduction: Difficulties in accessing allied health services, especially in rural and remote areas, appear to be driving the use of telehealth services to children in schools. The objectives of this study were to investigate the experiences and views of school executive staff and therapy assistants regarding the feasibility and acceptability of a speech-language pathology telehealth program for children attending schools in rural and remote New South Wales, Australia. The program, called Come N See, provided therapy interventions remotely via low-bandwidth videoconferencing, with email follow-up. Over a 12-week period, children were offered therapy blocks of six fortnightly sessions, each lasting a maximum of 30 minutes. Methods: School executives (n=5) and therapy assistants (n=6) described factors that promoted or threatened the program's feasibility and acceptability, during semistructured interviews. Thematic content analysis with constant comparison was applied to the transcribed interviews to identify relationships in the data. Results: Emergent themes related to (a) unmet speech pathology needs, (b) building relationships, (c) telehealth's advantages, (d) telehealth's disadvantages, (e) anxiety replaced by joy and confidence in growing skills, and (f) supports. Conclusions: School executive staff and therapy assistants verified that the delivery of the school-based telehealth service was feasible and acceptable. However, the participants saw significant opportunities to enhance this acceptability through building into the program stronger working relationships and supports for stakeholders. These findings are important for the future development of allied health telehealth programs that are sustainable as well as effective and fit the needs of all crucial stakeholders. The results have significant implications for speech pathology clinical practice relating to technology, program planning and teamwork within telehealth programs.
Language	English
Publishing date	2017-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2105620-1
ISSN	1445-6354 ; 1445-6354
ISSN (online)	1445-6354
ISSN	1445-6354
DOI	10.22605/RRH4225
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Article: Themed issue: neurodegenerative diseases.

Ramsden, D B

Molecular pathology : MP

2001 Volume 54, Issue 6, Page(s) 361

Language	English
Publishing date	2001-12
Publishing country	England
Document type	Editorial
ZDB-ID	1363384-3
ISSN	1472-4154 ; 1366-8714 ; 1355-2910
ISSN (online)	1472-4154
ISSN	1366-8714 ; 1355-2910
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Zs.A 4279: Show issues

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Article ; Online: Sub-lethal effects of titanium dioxide nanoparticles on the physiology and reproduction of zebrafish.

Ramsden, C S / Henry, T B / Handy, R D

Aquatic toxicology (Amsterdam, Netherlands)

2013 Volume 126, Page(s) 404–413

Abstract: ... also unclear. This study aimed to examine the sub-lethal effects of a 14-d aqueous TiO(2) (TiO(2) NP, 0 ... of zebrafish. After the 14-d exposure, fish were examined for haematology, whole body electrolyte and trace ... metal profiles, biochemistry, and histopathology. Then, during a 21-d post exposure recovery period ...

Abstract	There are limited data on the sub-lethal physiological effects of titanium dioxide nanoparticles (TiO(2) NPs) in adult fishes, and the consequences of TiO(2) NP exposure on reproductive success are also unclear. This study aimed to examine the sub-lethal effects of a 14-d aqueous TiO(2) (TiO(2) NP, 0.1 or 1.0 mg l(-1); TiO(2) bulk, 1.0 mg l(-1)) exposure on the physiology and reproductive health of zebrafish. After the 14-d exposure, fish were examined for haematology, whole body electrolyte and trace metal profiles, biochemistry, and histopathology. Then, during a 21-d post exposure recovery period, effects of the TiO(2) exposure on reproductive success were evaluated. Whole body Ti concentrations increased significantly in fish exposed to both the 1.0 mg l(-1) TiO(2) NP and bulk TiO(2) compared to controls, but concentrations returned to control levels by the end of the recovery period. No change in erythrocyte counts were observed, but there was a two-fold decline in leukocyte counts in all TiO(2) treatment groups relative to time-matched controls. Whole body electrolyte and trace metal profiles were not affected by exposure to TiO(2), and there were no changes in Na(+)K(+)-ATPase activity in brain, gill or liver tissues. Total glutathione (GSH) levels in brain, gill and liver tissues were higher in fish exposed to TiO(2) NP (both 0.1 and 1.0 mg l(-1)) compared to bulk TiO(2) and control fish. Histological examination of gill, liver, brain and gonad tissues showed little evidence of treatment-related morphological change. At the end of the 14-d exposure adult zebrafish were able to reproduce; however, the cumulative number of viable embryos produced was lower in fish exposed to 1.0 mg l(-1) TiO(2) (both NP and bulk) by the end of the 21-d recovery period. Overall, this study showed limited toxicity of bulk or nano scale TiO(2) during the exposure; however reproduction was affected in both bulk and NP 1.0 mg l(-1) groups.
MeSH term(s)	Animals ; Blood Cell Count ; Breeding ; Metal Nanoparticles/toxicity ; Metals/analysis ; Reproduction/drug effects ; Sodium-Potassium-Exchanging ATPase/metabolism ; Titanium/toxicity ; Water Pollutants, Chemical/toxicity ; Zebrafish
Chemical Substances	Metals ; Water Pollutants, Chemical ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9)
Language	English
Publishing date	2013-01-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2012.08.021
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