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  1. Article ; Online: The Author Replies.

    Agarwal, Rajiv

    Kidney international

    2023  Volume 103, Issue 3, Page(s) 638–639

    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.12.008
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    Zs.A 797: Show issues Location:
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  2. Article ; Online: Blocking aldosterone or its receptor-what is the difference?

    Agarwal, Rajiv

    Lancet (London, England)

    2023  Volume 403, Issue 10424, Page(s) 330–332

    MeSH term(s) Humans ; Aldosterone ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Spironolactone
    Chemical Substances Aldosterone (4964P6T9RB) ; Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232)
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02542-4
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  3. Book: The future is now - improving treatment of anaemia in CKD with IV iron

    Agarwal, Rajiv

    (Nephrology, dialysis, transplantation : NDT plus ; 4, Suppl. 1)

    2011  

    Author's details guest ed. Rajiv Agarwal
    Series title Nephrology, dialysis, transplantation : NDT plus ; 4, Suppl. 1
    Nephrology, dialysis, transplantation
    Nephrology, dialysis, transplantation ; NDT plus
    Collection Nephrology, dialysis, transplantation
    Nephrology, dialysis, transplantation ; NDT plus
    Language English
    Size i19 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016903805
    Database Catalogue ZB MED Medicine, Health

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    Zs A 6587 -4,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Should we liberalize potassium intake in CKD? No, we should not.

    Agarwal, Rajiv

    Kidney international

    2022  Volume 102, Issue 4, Page(s) 703–706

    MeSH term(s) Humans ; Potassium ; Potassium, Dietary ; Renal Insufficiency, Chronic/epidemiology
    Chemical Substances Potassium, Dietary ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.07.011
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  5. Article ; Online: Hydrochlorothiazide Versus Chlorthalidone: What Is the Difference?

    Agarwal, Rajiv

    Circulation

    2022  Volume 146, Issue 22, Page(s) 1641–1643

    MeSH term(s) Humans ; Chlorthalidone/adverse effects ; Hydrochlorothiazide/adverse effects ; Antihypertensive Agents/adverse effects ; Hypertension/diagnosis ; Hypertension/drug therapy ; Diuretics/adverse effects ; Blood Pressure
    Chemical Substances Chlorthalidone (Q0MQD1073Q) ; Hydrochlorothiazide (0J48LPH2TH) ; Antihypertensive Agents ; Diuretics
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.061029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Should we CLICK on chlorthalidone for treatment-resistant hypertension in chronic kidney disease?

    Agarwal, Rajiv

    Clinical kidney journal

    2022  Volume 16, Issue 5, Page(s) 793–796

    Abstract: Treatment-resistant hypertension is common among patients with advanced chronic kidney disease (CKD). In people with preserved kidney function, spironolactone is an evidence-based treatment. However, the risk for hyperkalemia limits its use in people ... ...

    Abstract Treatment-resistant hypertension is common among patients with advanced chronic kidney disease (CKD). In people with preserved kidney function, spironolactone is an evidence-based treatment. However, the risk for hyperkalemia limits its use in people with more advanced CKD. In the Chlorthalidone in Chronic Kidney Disease (CLICK) trial, 160 patients with stage 4 CKD and poorly controlled hypertension as confirmed by 24-hour ambulatory blood pressure (ABP) monitoring were randomly assigned to either placebo or chlorthalidone 12.5 mg daily in a 1:1 ratio stratified by prior loop diuretic use. The primary endpoint was the change in 24-hour systolic ABP from baseline to 12 weeks. The trial showed a treatment-induced reduction of 24-hour systolic ABP by 10.5 mmHg. Of the 160 patients randomized, 113 (71%) had resistant hypertension, of which 90 (80%) were on loop diuretics and the mean number of antihypertensive medications prescribed was 4.1 (standard deviation 1.1). In this subgroup of patients with treatment-resistant hypertension, the adjusted change from baseline to 12 weeks in the between-group difference in 24-hour systolic ABP was -13.9 mmHg (95% CI -19.4 to -8.4;
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac272
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  7. Article ; Online: Cardiovascular Benefits of Potassium-Enriched Salt Substitution: Promises and Challenges of Secondary Analyses.

    Tu, Wanzhu / Agarwal, Rajiv

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 1041–1043

    MeSH term(s) Humans ; Potassium ; Cardiovascular System/drug effects ; Stroke
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.124.22690
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    Zs.A 1488: Show issues Location:
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  8. Article ; Online: Spironolactone and chlorthalidone-old drugs, new uses-but approach with caution.

    Agarwal, Rajiv

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2021  Volume 37, Issue 3, Page(s) 407–408

    MeSH term(s) Chlorthalidone/adverse effects ; Diuretics/adverse effects ; Humans ; Hypertension ; Spironolactone/adverse effects
    Chemical Substances Diuretics ; Spironolactone (27O7W4T232) ; Chlorthalidone (Q0MQD1073Q)
    Language English
    Publishing date 2021-12-04
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfab328
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    Zs.A 2198: Show issues Location:
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  9. Article ; Online: Resistant Hypertension in Dialysis: Epidemiology, Diagnosis, and Management.

    Georgianos, Panagiotis I / Agarwal, Rajiv

    Journal of the American Society of Nephrology : JASN

    2024  Volume 35, Issue 4, Page(s) 505–514

    Abstract: Apparent treatment-resistant hypertension is defined as an elevated BP despite the use of ≥3 antihypertensive medications from different classes or the use of ≥4 antihypertensives regardless of BP levels. Among patients receiving maintenance hemodialysis ...

    Abstract Apparent treatment-resistant hypertension is defined as an elevated BP despite the use of ≥3 antihypertensive medications from different classes or the use of ≥4 antihypertensives regardless of BP levels. Among patients receiving maintenance hemodialysis or peritoneal dialysis, using this definition, the prevalence of apparent treatment-resistant hypertension is estimated to be between 18% and 42%. Owing to the lack of a rigorous assessment of some common causes of pseudoresistance, the burden of true resistant hypertension in the dialysis population remains unknown. What distinguishes apparent treatment-resistance from true resistance is white-coat hypertension and adherence to medications. Accordingly, the diagnostic workup of a dialysis patient with apparent treatment-resistant hypertension on dialysis includes the accurate determination of BP control status with the use of home or ambulatory BP monitoring and exclusion of nonadherence to the prescribed antihypertensive regimen. In a patient on dialysis with inadequately controlled BP, despite adherence to therapy with maximally tolerated doses of a β -blocker, a long-acting dihydropyridine calcium channel blocker, and a renin-angiotensin system inhibitor, volume-mediated hypertension is the most important treatable cause of resistance. In daily clinical practice, such patients are often managed with intensification of antihypertensive therapy. However, this therapeutic strategy is likely to fail if volume overload is not adequately recognized or treated. Instead of increasing the number of prescribed BP-lowering medications, we recommend diet and dialysate restricted in sodium to facilitate achievement of dry weight. The achievement of dry weight is facilitated by an adequate time on dialysis of at least 4 hours for delivering an adequate dialysis dose. In this article, we review the epidemiology, diagnosis, and management of resistant hypertension among patients on dialysis.
    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Renal Dialysis/adverse effects ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Calcium Channel Blockers/therapeutic use ; Calcium Channel Blockers/pharmacology ; White Coat Hypertension ; Blood Pressure
    Chemical Substances Antihypertensive Agents ; Calcium Channel Blockers
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000315
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  10. Article ; Online: Much to Fear about MUCH.

    Agarwal, Rajiv

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 11, Page(s) 2496–2499

    MeSH term(s) Blood Pressure Monitoring, Ambulatory ; Cohort Studies ; Fear ; Humans ; Prognosis ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020091270
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