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Book: Adolescent urology and long-term outcomes

Woodhouse, C. R. J.

2015

Author's details	Christopher Woodhouse
Keywords	Urologic Diseases ; Adolescent
Language	English
Size	IX, 256 S. : Ill., graph. Darst.
Publisher	Wiley Blackwell
Publishing place	Chichester
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT018535494
ISBN	978-1-118-84481-6 ; 1-118-84481-5
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2015 A 1625	available for loan (reading room)	Lesesaal EG

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Article ; Online: Enhanced pan-genomic resources at the maize genetics and genomics database.

Cannon, Ethalinda K / Portwood, John L / Hayford, Rita K / Haley, Olivia C / Gardiner, Jack M / Andorf, Carson M / Woodhouse, Margaret R

Genetics

2024

Abstract: Pan-genomes, encompassing the entirety of genetic sequences found in a collection of genomes within a clade, are more useful than single reference genomes for studying species diversity. This is especially true for a species like Zea mays, which has a ... ...

Abstract	Pan-genomes, encompassing the entirety of genetic sequences found in a collection of genomes within a clade, are more useful than single reference genomes for studying species diversity. This is especially true for a species like Zea mays, which has a particularly diverse and complex genome. Presenting pan-genome data, analyses, and visualization is challenging, especially for a diverse species, but more so when pan-genomic data is linked to extensive gene model and gene data, including classical gene information, markers, insertions, expression and proteomic data, and protein structures as is the case at MaizeGDB. Here, we describe MaizeGDB's expansion to include the genic subset of the Zea pan-genome in a pan-gene data center featuring the maize genomes hosted at MaizeGDB, and the outgroup teosinte Zea genomes from the Pan-Andropoganeae project. The new data center offers a variety of browsing and visualization tools, including sequence alignment visualization, gene trees and other tools, to explore pan-genes in Zea that were calculated by the pipeline Pandagma. Combined, these data will help maize researchers study the complexity and diversity of Zea, and to use the comparative functions to validate pan-gene relationships for a selected gene model.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyae036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Adolescent urology

Woodhouse, C. R. J.

(Book of abstracts / European Society for Paediatric Urology ; 10 ; BJU international ; 83, Suppl. 3)

1999

Author's details	guest ed.: C. R. J. Woodhouse
Series title	Book of abstracts / European Society for Paediatric Urology ; 10 BJU international ; 83, Suppl. 3 Book of abstracts / European Society of Paediatric Urology
Collection	Book of abstracts / European Society of Paediatric Urology
Language	English
Size	IV, 124 S. : Ill., graph. Darst.
Publisher	Blackwell Science
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT010188731
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Ui VI Zs 107 -83,Suppl.3-	verfügbar in Königswinter	Königswinter

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Article: Alternative COVID-19 mitigation measures in school classrooms: analysis using an agent-based model of SARS-CoV-2 transmission.

Woodhouse, M J / Aspinall, W P / Sparks, R S J / Brooks-Pollock, E / Relton, C

Royal Society open science

2022 Volume 9, Issue 8, Page(s) 211985

Abstract: The SARS-CoV-2 epidemic has impacted children's education, with schools required to implement infection control measures that have led to periods of absence and classroom closures. We developed an agent-based epidemiological model of SARS-CoV-2 ... ...

Abstract	The SARS-CoV-2 epidemic has impacted children's education, with schools required to implement infection control measures that have led to periods of absence and classroom closures. We developed an agent-based epidemiological model of SARS-CoV-2 transmission in a school classroom that allows us to quantify projected infection patterns within primary school classrooms, and related uncertainties. Our approach is based on a contact model constructed using random networks, informed by structured expert judgement. The effectiveness of mitigation strategies in suppressing infection outbreaks and limiting pupil absence are considered. COVID-19 infections in primary schools in England in autumn 2020 were re-examined and the model was then used to estimate infection levels in autumn 2021, as the Delta variant was emerging and it was thought likely that school transmission would play a major role in an incipient new wave of the epidemic. Our results were in good agreement with available data. These findings indicate that testing-based surveillance is more effective than bubble quarantine, both for reducing transmission and avoiding pupil absence, even accounting for insensitivity of self-administered tests. Bubble quarantine entails large numbers of absences, with only modest impact on classroom infections. However, maintaining reduced contact rates within the classroom can have a major benefit for managing COVID-19 in school settings.
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.211985
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maize protein structure resources at the maize genetics and genomics database.

Woodhouse, Margaret R / Portwood, John L / Sen, Shatabdi / Hayford, Rita K / Gardiner, Jack M / Cannon, Ethalinda K / Harper, Lisa C / Andorf, Carson M

Genetics

2023 Volume 224, Issue 1

Abstract: Protein structures play an important role in bioinformatics, such as in predicting gene function or validating gene model annotation. However, determining protein structure was, until now, costly and time-consuming, which resulted in a structural biology ...

Abstract	Protein structures play an important role in bioinformatics, such as in predicting gene function or validating gene model annotation. However, determining protein structure was, until now, costly and time-consuming, which resulted in a structural biology bottleneck. With the release of such programs AlphaFold and ESMFold, this bottleneck has been reduced by several orders of magnitude, permitting protein structural comparisons of entire genomes within reasonable timeframes. MaizeGDB has leveraged this technological breakthrough by offering several new tools to accelerate protein structural comparisons between maize and other plants as well as human and yeast outgroups. MaizeGDB also offers bulk downloads of these comparative protein structure data, along with predicted functional annotation information. In this way, MaizeGDB is poised to assist maize researchers in assessing functional homology, gene model annotation quality, and other information unavailable to maize scientists even a few years ago.
MeSH term(s)	Humans ; Zea mays/genetics ; Zea mays/metabolism ; User-Computer Interface ; Databases, Genetic ; Computational Biology/methods ; Genome, Plant ; Molecular Sequence Annotation ; Genomics/methods
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyad016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pre-slaughter factors linked to variation in responses to carbon dioxide gas stunning in pig abattoirs.

Jongman, E C / Woodhouse, R / Rice, M / Rault, J-L

Animal : an international journal of animal bioscience

2020 Volume 15, Issue 2, Page(s) 100134

Abstract: The stunning process is an important component of slaughter with implications for animal welfare due to the potential distress and pain in the case of a sub-effective or lengthy stun. This study examined the factors correlated with variation in responses ...

Abstract	The stunning process is an important component of slaughter with implications for animal welfare due to the potential distress and pain in the case of a sub-effective or lengthy stun. This study examined the factors correlated with variation in responses to carbon dioxide (CO
MeSH term(s)	Abattoirs ; Animal Welfare ; Animals ; Australia ; Carbon Dioxide ; Female ; Hydrocortisone ; Male ; Swine
Chemical Substances	Carbon Dioxide (142M471B3J) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2020.100134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PanEffect: a pan-genome visualization tool for variant effects in maize.

Andorf, Carson M / Haley, Olivia C / Hayford, Rita K / Portwood, John L / Harding, Stephen / Sen, Shatabdi / Cannon, Ethalinda K / Gardiner, Jack M / Kim, Hye-Seon / Woodhouse, Margaret R

Bioinformatics (Oxford, England)

2024 Volume 40, Issue 2

Abstract: Summary: Understanding the effects of genetic variants is crucial for accurately predicting traits and functional outcomes. Recent approaches have utilized artificial intelligence and protein language models to score all possible missense variant ... ...

Abstract	Summary: Understanding the effects of genetic variants is crucial for accurately predicting traits and functional outcomes. Recent approaches have utilized artificial intelligence and protein language models to score all possible missense variant effects at the proteome level for a single genome, but a reliable tool is needed to explore these effects at the pan-genome level. To address this gap, we introduce a new tool called PanEffect. We implemented PanEffect at MaizeGDB to enable a comprehensive examination of the potential effects of coding variants across 50 maize genomes. The tool allows users to visualize over 550 million possible amino acid substitutions in the B73 maize reference genome and to observe the effects of the 2.3 million natural variations in the maize pan-genome. Each variant effect score, calculated from the Evolutionary Scale Modeling (ESM) protein language model, shows the log-likelihood ratio difference between B73 and all variants in the pan-genome. These scores are shown using heatmaps spanning benign outcomes to potential functional consequences. In addition, PanEffect displays secondary structures and functional domains along with the variant effects, offering additional functional and structural context. Using PanEffect, researchers now have a platform to explore protein variants and identify genetic targets for crop enhancement. Availability and implementation: The PanEffect code is freely available on GitHub (https://github.com/Maize-Genetics-and-Genomics-Database/PanEffect). A maize implementation of PanEffect and underlying datasets are available at MaizeGDB (https://www.maizegdb.org/effect/maize/).
MeSH term(s)	Zea mays/genetics ; Databases, Genetic ; Artificial Intelligence ; Genome, Plant ; Phenotype ; Software
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btae073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spatial transcriptional signatures define margin morphogenesis along the proximal-distal and medio-lateral axes in tomato (Solanum lycopersicum) leaves.

Martinez, Ciera C / Li, Siyu / Woodhouse, Margaret R / Sugimoto, Keiko / Sinha, Neelima R

The Plant cell

2021 Volume 33, Issue 1, Page(s) 44–65

Abstract: Leaf morphogenesis involves cell division, expansion, and differentiation in the developing leaf, which take place at different rates and at different positions along the medio-lateral and proximal-distal leaf axes. The gene expression changes that ... ...

Abstract	Leaf morphogenesis involves cell division, expansion, and differentiation in the developing leaf, which take place at different rates and at different positions along the medio-lateral and proximal-distal leaf axes. The gene expression changes that control cell fate along these axes remain elusive due to difficulties in precisely isolating tissues. Here, we combined rigorous early leaf characterization, laser capture microdissection, and transcriptomic sequencing to ask how gene expression patterns regulate early leaf morphogenesis in wild-type tomato (Solanum lycopersicum) and the leaf morphogenesis mutant trifoliate. We observed transcriptional regulation of cell differentiation along the proximal-distal axis and identified molecular signatures delineating the classically defined marginal meristem/blastozone region during early leaf development. We describe the role of endoreduplication during leaf development, when and where leaf cells first achieve photosynthetic competency, and the regulation of auxin transport and signaling along the leaf axes. Knockout mutants of BLADE-ON-PETIOLE2 exhibited ectopic shoot apical meristem formation on leaves, highlighting the role of this gene in regulating margin tissue identity. We mapped gene expression signatures in specific leaf domains and evaluated the role of each domain in conferring indeterminacy and permitting blade outgrowth. Finally, we generated a global gene expression atlas of the early developing compound leaf.
MeSH term(s)	Cell Differentiation/genetics ; Cell Differentiation/physiology ; Gene Expression Regulation, Plant ; Solanum lycopersicum/genetics ; Solanum lycopersicum/metabolism ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism
Chemical Substances	Plant Proteins
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1093/plcell/koaa012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nonoperative Management in Intact Burst Fracture Patient With Thoracolumbar Injury Classification and Severity Score of 5: A Case Report.

Rainone, Gersham J / Patel, Yash / Woodhouse, Cody / Sauber, Ryan / Yu, Alexander

Cureus

2022 Volume 14, Issue 9, Page(s) e29492

Abstract: Thoracolumbar fractures are a common consequence of trauma, often a result of motor vehicle accidents or falls. Burst fractures are a morphology of thoracolumbar fracture in which compressive force causes retropulsion of the posterior elements of the ... ...

Abstract	Thoracolumbar fractures are a common consequence of trauma, often a result of motor vehicle accidents or falls. Burst fractures are a morphology of thoracolumbar fracture in which compressive force causes retropulsion of the posterior elements of the vertebral body, potentially leading to neurological deficits. The Thoracolumbar Injury Classification and Severity (TLICS) score is a decision-making tool to help surgeons decide between nonoperative and operative management. For assigned scores of 4, management is at the discretion of the surgeon, and for scores ≥ 5, operative treatment is recommended. Burst fracture patients that are neurologically intact are given a score of 5 if there is a posterior ligamentous complex (PLC) injury and are recommended to undergo operative management. Here we present a neurologically intact patient with an L4 burst fracture with PLC injury that was managed conservatively and demonstrated successful clinical, functional, and radiographic recovery.
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.29492
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radiologically-guided balloon sialoplasty for benign salivary duct obstruction: a 7-year UK service evaluation.

Cowen, Jake / Ali, Muhammad / Dave, Roma / Woodhouse, Joe / Anand, Rajiv / Repanos, Costa / Brennan, Peter A / Bekker, Jasper

The British journal of oral & maxillofacial surgery

2023 Volume 61, Issue 8, Page(s) 547–552

Abstract: Obstructive sialadenitis is the most common cause of non-malignant salivary gland disorders, with salivary gland strictures being responsible for approximately 23% of all benign obstructive disease. Significant advances in minimally invasive techniques, ... ...

Abstract	Obstructive sialadenitis is the most common cause of non-malignant salivary gland disorders, with salivary gland strictures being responsible for approximately 23% of all benign obstructive disease. Significant advances in minimally invasive techniques, including radiologically-guided balloon sialoplasty, offer the potential for successful treatment with reduced complications. At present there is a paucity of follow-up data regarding patient outcomes and repeat interventions in those undergoing the procedure. Patients with parotid or submandibular gland sialadenitis secondary to gland stricture were identified and underwent radiologically-guided balloon sialoplasty at Queen Alexandra Hospital, Portsmouth, UK between 2015 and 2022. Patient outcomes, complications and reintervention rates were recorded prospectively over the seven-year period and analysed retrospectively. A total of 44 patients underwent radiologically-guided balloon sialoplasty. Forty (89%) underwent sialoplasty for parotid gland disease, with a minority (n = 5) receiving an intervention for submandibular gland strictures. A total of 37 (84%) had their obstruction successfully treated (82% of parotid gland obstructions and 100% of submandibular gland obstructions). Five patients (11%) required a repeat intervention. Seventeen successfully treated patients (85%) who attended follow-up clinic appointments described complete resolution of their symptoms, with the remaining three (15%) describing a partial response. Radiologically-guided balloon sialoplasty for the treatment of benign obstructive sialadenitis secondary to a gland stricture is a safe and effective method of eliminating the obstruction and relieving patients' symptoms. Most patients were symptom free at short-term follow up, with a minority requiring a second sialoplastic intervention.
MeSH term(s)	Humans ; Constriction, Pathologic/surgery ; Constriction, Pathologic/complications ; Constriction, Pathologic/pathology ; Salivary Ducts/surgery ; Salivary Ducts/pathology ; Retrospective Studies ; Salivary Gland Diseases/diagnostic imaging ; Salivary Gland Diseases/surgery ; Sialadenitis/surgery ; Sialadenitis/etiology ; United Kingdom ; Endoscopy/methods
Language	English
Publishing date	2023-08-07
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2023.07.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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