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Article ; Online: Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential.

Singh, Amit Kumar / Singla, Rajeev Kumar / Pandey, Abhay Kumar

2022 Volume 30, Issue 34, Page(s) 3905–3926

Abstract: Phenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine ... ...

Abstract	Phenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine is chlorogenic acid (CGA). It is one of the most readily available phytochemicals that can be isolated from the leaves and fruits of plants, such as coffee beans (Coffea arabica L.), apples (Malus spp.), artichoke (Cynara cardunculus L.), carrots (Daucus carota L.), betel (Piper betle L.), burdock (Arctium spp.), etc. Despite its low oral bioavailability (about 33%), CGA has drawn considerable attention due to its wide range of biological activities and numerous molecular targets. Several studies have reported that the antioxidant and anti-inflammatory potentials of CGA mainly account for its broad-spectrum pharmacological attributes. CGA has been implicated in exerting a beneficial role against dysbiosis by encouraging the growth of beneficial GUT microbes. At the biochemical level, its therapeutic action is mediated by free radical scavenging efficacy, modulation of glucose and lipid metabolism, down-regulation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-1β, and interferon-gamma (IFN-γ), upregulation of nuclear factor erythroid 2-related factor 2 (Nrf-2), and inhibition of the activity of nuclear factor- κβ (NF-κβ), thus helping in the management of diabetes, cardiovascular diseases, neurodegenerative disorders, cancer, hypertension etc. This review highlights the natural sources of CGA, its bioavailability, metabolism, pharmacotherapeutic potential, and underlying mechanisms of action for the clinical usefulness of CGA in the management of health disorders.
MeSH term(s)	Humans ; Chlorogenic Acid/pharmacology ; Chlorogenic Acid/therapeutic use ; Chlorogenic Acid/chemistry ; Diet ; Hydroxybenzoates ; Diabetes Mellitus/drug therapy
Chemical Substances	Chlorogenic Acid (318ADP12RI) ; phenolic acid (I3P9R8317T) ; Hydroxybenzoates
Language	English
Publishing date	2022-08-11
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867329666220816154634
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Article ; Online: Pancreatic tuberculosis mimicking as pancreatic malignancy: Surgeon's dilemma.

T Siddeek, Rohik Anjum / Gupta, Amit / Singla, Tanuj / Rajput, Deepak / Ahmed, Shaik Sameer / Jeladharan, Reshma

Indian journal of pathology & microbiology

2023 Volume 66, Issue 3, Page(s) 614–617

Abstract: Pancreatic tuberculosis is a rare form of Tuberculosis (TB) which requires a high index of suspicion to diagnose. Here, we report a case of middle-aged gentleman presenting with abdominal pain and constitutional symptoms who was diagnosed with pancreatic ...

Abstract	Pancreatic tuberculosis is a rare form of Tuberculosis (TB) which requires a high index of suspicion to diagnose. Here, we report a case of middle-aged gentleman presenting with abdominal pain and constitutional symptoms who was diagnosed with pancreatic tuberculosis on imaging, which was confirmed by Fine Needle Aspiration (FNA) from the lesion. The patient was given Anti-Tubercular Treatment (ATT) as per conventional protocol. Follow-up showed recovery from the entity. A review of patient presentation, patho-physiology, diagnosis, and management of pancreatic tuberculosis is mentioned in this article.
MeSH term(s)	Middle Aged ; Humans ; Pancreatic Diseases/diagnosis ; Pancreatic Diseases/pathology ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/pathology ; Surgeons ; Pancreatic Neoplasms
Language	English
Publishing date	2023-08-02
Publishing country	India
Document type	Review ; Case Reports
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_874_21
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Article ; Online: A comprehensive study of radon in drinking waters of Hanumangarh district and the assessment of resulting dose to local population

Singla, Amit Kumar / Kanse, Sandeep / Kansal, Sandeep / Rani, Supriya / Mehra, Rohit

Environ Geochem Health. 2023 Feb., v. 45, no. 2 p.443-455

2023

Abstract: Study of radon concentration in drinking water from different sources (groundwater and surface water) used across the Hanumangarh district of Rajasthan, India, was done using scintillation-based detector. The concentration of radon in surface water ... ...

Abstract	Study of radon concentration in drinking water from different sources (groundwater and surface water) used across the Hanumangarh district of Rajasthan, India, was done using scintillation-based detector. The concentration of radon in surface water varied from 0.12 to 2.07 Bq/l with an average value of 0.62 Bq/l and a standard deviation of 0.55 Bq/l and in groundwater samples varied from 1.61 to 8.73 Bq/l with an average value of 4.8 Bq/l and a standard deviation of 2.24 Bq/l. The ingestion and inhalation dose were calculated to assess the health risk for infants, children and adults. The resulting average annual effective dose has been found to be considerably lower than the recommended safe limit of 0.1 msv/y (WHO, In: Incorporating first and second addenda, third ed. WHO Press, Geneva. 3rd ed. World Health Organisation, Geneva, Switzerland, 2008). It can be concluded that radon in water does not pose a significant radiological health risk to the population of the studied area.
Keywords	breathing ; groundwater ; ingestion ; radon ; risk ; standard deviation ; surface water ; India
Language	English
Dates of publication	2023-02
Size	p. 443-455.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01304-x
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Article ; Online: Musculoskeletal Tumors.

Singla, Amit / Geller, David S

Pediatric clinics of North America

2019 Volume 67, Issue 1, Page(s) 227–245

Abstract: Pediatric musculoskeletal tumors can arise in both bone and soft tissues. The overwhelming majority of these are benign; however, rarely, malignant neoplasms do occur. These are collectively termed sarcomas, indicating their mesenchymal origin. Sarcoma ... ...

Abstract	Pediatric musculoskeletal tumors can arise in both bone and soft tissues. The overwhelming majority of these are benign; however, rarely, malignant neoplasms do occur. These are collectively termed sarcomas, indicating their mesenchymal origin. Sarcoma management requires careful adherence to the well-described tenets of tumor management. This article summarizes the basic principles and recent advances in the management of soft tissue and bone tumors.
MeSH term(s)	Bone Neoplasms/diagnosis ; Bone Neoplasms/therapy ; Child ; Humans ; Sarcoma/diagnosis ; Sarcoma/therapy ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/therapy
Language	English
Publishing date	2019-11-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215711-1
ISSN	1557-8240 ; 0031-3955
ISSN (online)	1557-8240
ISSN	0031-3955
DOI	10.1016/j.pcl.2019.09.014
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Article ; Online: Using Biceps Tendon Autograft as a Patch in the Treatment of Massive Irreparable Rotator Cuff Tears Improves Patient-reported Outcome Scores: A Systematic Review.

Cheppalli, Naga Suresh / Purudappa, Prabhudev Prasad / Metikala, Sreenivasulu / Goel, Akshay / Singla, Amit / Sambandam, Senthil

Arthroscopy, sports medicine, and rehabilitation

2023 Volume 5, Issue 2, Page(s) e529–e536

Abstract: Purpose: To review the clinical studies describing the use of ipsilateral biceps tendon autograft for bridging irreparable massive rotator cuff tears (MRCTs).: Methods: A systematic review was conducted of MEDLINE, Embase, Cochrane, CINAHL, and ... ...

Abstract	Purpose: To review the clinical studies describing the use of ipsilateral biceps tendon autograft for bridging irreparable massive rotator cuff tears (MRCTs). Methods: A systematic review was conducted of MEDLINE, Embase, Cochrane, CINAHL, and Scopus databases using search terms "massive rotator cuff tear," "irreparable rotator cuff tear," and "long head of the biceps tendon." Only clinical human studies in which the biceps tendon was used as a bridging graft in MRCTs were included. All review studies, technique papers, and studies describing the use of biceps tendon as superior capsular reconstruction equivalent or rotator cable were excluded. Results: A total of 45 studies were initially identified, of which only 6 studies met the inclusion criterion. All studies were retrospective in nature, with a total of 176 patients. All studies reported a clinically significant improvement in postoperative functional outcomes, although this was not compared to a control group in all the studies. Pain was assessed using the visual analog scale (VAS) in 4 studies, and all reported an improvement in postoperative VAS ranging from 5 to 6 points. One study reported an improvement in pain scale from Japanese Orthopedic Association from 13.1 to 22.5 (9 points). One study did not report a VAS score as this study was published before the VAS score was developed. All the reported studies saw improvements in range of motion. Conclusions: The use of the long head of the biceps tendon as an interposition/bridging patch to augment the MRCT repair can reduce the VAS score, improve elevation and external rotation, and improve clinical and functional outcomes. Level of evidence: IV, systematic review of Level III and IV studies.
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-061X
ISSN (online)	2666-061X
DOI	10.1016/j.asmr.2023.01.016
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Article ; Online: Arteritic anterior ischemic optic neuropathy with hypotony, an alarming sign of severe form of giant cell arteritis.

Chopra, Amit / Sharma, Rajan / Singla, Kritika / Saroya, Arnav S / Verma, Shaina / Nagesha, C K

Indian journal of ophthalmology

2022 Volume 70, Issue 9, Page(s) 3426–3427

MeSH term(s)	Giant Cell Arteritis ; Humans ; Optic Disk ; Optic Neuropathy, Ischemic
Language	English
Publishing date	2022-08-26
Publishing country	India
Document type	Letter
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_521_22
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Article: Role of

Sowmya, S Durga / Gupta, Amit / Narayan, Manishi L / Chauhan, Udit / Jain, Jaydeep / Singla, Tanuj / Chennatt, Jaine John

World journal of nuclear medicine

2022 Volume 21, Issue 3, Page(s) 231–235

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0042-1751038
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Article ; Online: Correlation of multiparametric MRI with histopathological grade of peripheral zone prostate carcinoma.

Singla, Amit / Deep, Nerbadyswari / Naik, Suprava / Mohakud, Sudipta / Nayak, Prasant / Sable, Mukund

Journal of cancer research and therapeutics

2023 Volume 19, Issue Suppl 2, Page(s) S569–S576

Abstract: Background: Prostatic cancer is the second most common malignant tumor in men. Preoperative grading of prostate cancer is important for its management. Our objective is to compare individual and combined detection rates of T2-weighted imaging (T2WI), ... ...

Abstract	Background: Prostatic cancer is the second most common malignant tumor in men. Preoperative grading of prostate cancer is important for its management. Our objective is to compare individual and combined detection rates of T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI), and magnetic resonance spectroscopy (MRS) for prostate cancer with histopathological diagnosis as its golden standard. Methods: Forty-four patients with positive digital rectal examination (DRE) findings and elevated prostate specific antigen (PSA), underwent multiparametric MRI (Mp-MRI). T2WI, DWI, DCE-MRI and MRS were done in all the patients. Cognitive magnetic resonance-transrectal ultrasound (MR-TRUS) fusion biopsy was done in all the patients. Sensitivity and specificity of T2WI, DWI, DCE-MRI, and Prostate Imaging - Reporting and Data System PIRADS version 2 was obtained. Apparent diffusion coefficient (ADC) value and choline/citrate ratio were obtained for each lesion and correlated with histopathological grade. Results: The mean age of the patients was 68.7 ± 10.1 years, and the mean serum PSA level was 58.1 ± 22.4 ng/dL. Of the 38 lesions in peripheral zone, 33 (87%) had histopathologically proven prostate cancer. T2WI had a sensitivity and specificity of 75.8% and 80% and DWI had a sensitivity and specificity of 90.9% and 80%, respectively, for detection of malignant prostatic lesion. The mean ADC values for prostate cancer, prostatitis, and normal prostatic parenchyma were 0.702 ± 0.094 × 10-3 mm2/sec, 0.959 ± 0.171 × 10-3 mm2/sec, and 1.31 ± 0.223 × 10-3 mm2/sec, respectively. Type 3 curve has lower sensitivity (45.5%) but high specificity (80%) for diagnosing prostate cancer. Conclusion: DWI can be useful to differentiate benign from malignant prostatic lesions, and low-grade from high-grade prostate carcinoma. ADC value has a positive correlation with histopathological grade of prostate cancer.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Prostate/diagnostic imaging ; Prostate/pathology ; Multiparametric Magnetic Resonance Imaging ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Sensitivity and Specificity ; Image-Guided Biopsy ; Carcinoma/pathology ; Retrospective Studies
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-04-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_280_22
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Article: Stentolith in Bile Duct: A Neglected Entity-Case Report with Review of Literature.

Gupta, Amit / Rajput, Deepak / Chennat, Jaine John / Singla, Tanuj / Ahmed, Shaik Sameer

Surgery journal (New York, N.Y.)

2022 Volume 8, Issue 1, Page(s) e86–e89

Abstract: Stentolith is a forgotten stent that acts as a nidus for stone formation leading to a stone-stent complex. Once the planned procedure is completed, these stents should be removed within 4 to 6 weeks, but if they are required for a longer period, then ... ...

Abstract	Stentolith is a forgotten stent that acts as a nidus for stone formation leading to a stone-stent complex. Once the planned procedure is completed, these stents should be removed within 4 to 6 weeks, but if they are required for a longer period, then they should be replaced every 3 to 6 months. Devastating complications may ensue -such as cholangitis, biliary stricture, or secondary biliary cirrhosis. Management primarily comprises surgical intervention with common bile duct exploration or endoscopic clearance. The majority of patients eventually develop symptoms that lead to their diagnosis and subsequent management. This article, however, details the case of a silent stentolith and how it may have led to disastrous complications if surgical intervention was not done promptly.
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2864275-2
ISSN	2378-5136 ; 2378-5128
ISSN (online)	2378-5136
ISSN	2378-5128
DOI	10.1055/s-0042-1743521
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Article: The Surgeon and the Smartphone - is the Association Really Smart?

Gupta, Amit / Chennatt, Jaine John / Singla, Tanuj / Barabari, Geetha Sindhuri

Hellenike cheirourgike. Acta chirurgica Hellenica

2021 Volume 92, Issue 5, Page(s) 177–181

Abstract: The aim of this literature review is to encompass the importance of integrating smartphones in the life of a surgeon especially in the era of the COVID-19 pandemic. With the progression of technology, telesurgery, remote pre and postoperative care, ... ...

Abstract	The aim of this literature review is to encompass the importance of integrating smartphones in the life of a surgeon especially in the era of the COVID-19 pandemic. With the progression of technology, telesurgery, remote pre and postoperative care, smartphone-assisted intraoperative navigation and transcontinental education can be made a reality. Nonetheless, rates of nosocomial infections have been raised and the increased use of a smartphone can compound this issue. Similarly, there is a greater potential for operator distraction, medical equipment interference and increased radiation exposure for the user. All the above create a new set of problems for the surgeon. We hereby attempt a review of the advantages and harmful effects from the usage of smartphones.
Language	English
Publishing date	2021-03-22
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	2546225-8
ISSN	1868-8845 ; 0018-0092
ISSN (online)	1868-8845
ISSN	0018-0092
DOI	10.1007/s13126-020-0571-6
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