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  1. Article ; Online: Reclaiming the 'person' and advocacy for good clinical care in psychiatric residency training through medical humanities.

    Rajagopalan, Arvind / Sim, Kang

    Medical education

    2024  Volume 58, Issue 5, Page(s) 623–624

    MeSH term(s) Humans ; Internship and Residency ; Humanities ; Education, Medical ; Curriculum
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.15327
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 312: Show issues Location:
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  2. Article ; Online: Bane or boon regarding urbanicity and psychotic spectrum disorders: a scoping review of current evidence.

    Chew, Qian Hui / Sim, Kang

    Current opinion in psychiatry

    2024  Volume 37, Issue 3, Page(s) 212–224

    Abstract: Purpose of review: This review aims to provide an update on the association between urbanization and psychotic spectrum disorders, focusing on specific aspects of the urban environment that could be a bane or boon for the risk of psychosis.: Recent ... ...

    Abstract Purpose of review: This review aims to provide an update on the association between urbanization and psychotic spectrum disorders, focusing on specific aspects of the urban environment that could be a bane or boon for the risk of psychosis.
    Recent findings: Majority of the included studies support previous evidence suggesting that urbanization is linked to a higher risk of psychotic experiences and psychotic spectrum disorders. A small minority, however, have also found specific factors in the urban environment that could give rise to positive outcomes, such as better social functioning and lower mortality rates in psychotic spectrum disorders, or mitigate the risks associated with urbanization. The perception of the urban environment was also an important factor that increased or mitigated stress levels in patients with psychosis, which in turn affected their susceptibility to psychotic symptoms.
    Summary: Specific aspects of the urban environment such as the availability and density of greenspaces are crucial for mitigating the effect of urbanization on risk of psychotic spectrum disorders, and should be incorporated into urban planning. At the same time, there is a need to further explore how modifiable risk factors of the urban environment such as air and noise pollution can be minimized to allow for more liveable cities in the context of psychotic spectrum conditions.
    MeSH term(s) Humans ; Psychotic Disorders/etiology ; Urbanization ; Cities ; Risk Factors
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645162-7
    ISSN 1473-6578 ; 0951-7367
    ISSN (online) 1473-6578
    ISSN 0951-7367
    DOI 10.1097/YCO.0000000000000928
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2532: Show issues Location:
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  3. Article: International Trends in Lithium Use for Pharmacotherapy and Clinical Correlates in Bipolar Disorder: A Scoping Review.

    Shuy, Yao Kang / Santharan, Sanjana / Chew, Qian Hui / Sim, Kang

    Brain sciences

    2024  Volume 14, Issue 1

    Abstract: Lithium remains an effective option in the treatment of bipolar disorder (BD). Thus, we aim to characterize the pharmaco-epidemiological patterns of lithium use internationally over time and elucidate clinical correlates associated with BD using a ... ...

    Abstract Lithium remains an effective option in the treatment of bipolar disorder (BD). Thus, we aim to characterize the pharmaco-epidemiological patterns of lithium use internationally over time and elucidate clinical correlates associated with BD using a scoping review, which was conducted using the methodological framework by Arksey and O'Malley (2005). We searched several databases for studies that examined the prescriptions for lithium and clinical associations in BD from inception until December 2023. This review included 55 articles from 1967 to 2023, which collected data from North America (
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010102
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  4. Article ; Online: Inter-Professional Education Interventions, and Practice Outcomes Related to Healthcare Setting and Patients Within Mental Healthcare: A Scoping Review.

    Chew, Qian Hui / Maniam, Ethan Jian-Hui / Sim, Kang

    Perspectives on medical education

    2024  Volume 13, Issue 1, Page(s) 108–118

    Abstract: Introduction: This scoping review aimed to examine 1) types of inter-professional (IPE) interventions using Strosahl's typology framework, 2) practice outcomes related to healthcare setting and patients using Kirkpatrick's model of training evaluation, ... ...

    Abstract Introduction: This scoping review aimed to examine 1) types of inter-professional (IPE) interventions using Strosahl's typology framework, 2) practice outcomes related to healthcare setting and patients using Kirkpatrick's model of training evaluation, and 3) enablers and challenges related to the effectiveness of IPE interventions specific to the mental healthcare setting in order to guide the development of such future programs.
    Methods: This scoping review was conducted in accordance with the methodology of the Joanna Briggs Institute for scoping reviews. Several databases were searched for relevant studies from database inception until December 2023. Articles were included if it 1) involved IPE interventions within mental healthcare, 2) reported practice outcomes related to healthcare setting and patients, and 3) was published in English. Variables of interest included the mode of IPE intervention using Strosahl's typology, enablers, and challenges related to IPE interventions.
    Results: Overall, 16 studies were included. IPE intervention outcomes within healthcare setting related to shifts in practice culture, engagement with family members, and increased collaborations with other inter-professional groups. Reported patient outcomes included clinical improvements (e.g., reduced depression and anxiety, psychotropic drug use, better psychosocial functioning), patient empowerment, satisfaction, and confidence in treatment. The enablers and challenges included resource limitations, inter-professional group and individual participation, and pedagogy.
    Discussion: Future efforts in IPE mental healthcare practice can focus on garnering sustained institutional support, identifying and investing in committed faculty, encouraging greater learner participation, and making iterative changes to the IPE program structure to facilitate involvement of inter-professional disciplines for better patient care.
    MeSH term(s) Humans ; Education, Professional ; Patient Care Team ; Delivery of Health Care ; Mental Health Services
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2670231-9
    ISSN 2212-277X ; 2212-277X
    ISSN (online) 2212-277X
    ISSN 2212-277X
    DOI 10.5334/pme.1084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparative studies of psychotropic drug use over the last seven decades: Gaps and goals in global ethnopsychopharmacology.

    Sim, Kang / Baldessarini, Ross J

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2022  Volume 60, Page(s) 19–21

    MeSH term(s) Goals ; Humans ; Mental Disorders/drug therapy ; Psychotropic Drugs/therapeutic use
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2022-05-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2022.03.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3288: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 630: Show issues

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  6. Article ; Online: Resilience in Bipolar Disorder and Interrelationships With Psychopathology, Clinical Features, Psychosocial Functioning, and Mediational Roles: A Systematic Review.

    Chan, Min Kai / Chew, Qian Hui / Sim, Kang

    The Journal of clinical psychiatry

    2023  Volume 84, Issue 2

    Abstract: Objective:: Data Sources:: Study Selection:: Data Extraction:: Results:: Conclusions: ...

    Abstract Objective:
    Data Sources:
    Study Selection:
    Data Extraction:
    Results:
    Conclusions:
    MeSH term(s) Humans ; Bipolar Disorder/psychology ; Quality of Life ; Psychosocial Functioning ; Psychotic Disorders/psychology ; Impulsive Behavior
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.22r14431
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 108: Show issues Location:
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    Zs.MO 247: Show issues

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  7. Article: Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice.

    Park, Sin-Hye / Sim, Young Eun / Kang, Min-Kyung / Kim, Dong Yeon / Kang, Il-Jun / Lim, Soon Sung / Kang, Young-Hee

    Nutrition research and practice

    2023  Volume 17, Issue 6, Page(s) 1099–1112

    Abstract: Background/objectives: Dyslipidemia causes metabolic disorders such as atherosclerosis and fatty liver syndrome due to abnormally high blood lipids. Purple perilla frutescens extract (PPE) possesses various bioactive compounds such as α-asarone, ... ...

    Abstract Background/objectives: Dyslipidemia causes metabolic disorders such as atherosclerosis and fatty liver syndrome due to abnormally high blood lipids. Purple perilla frutescens extract (PPE) possesses various bioactive compounds such as α-asarone, chlorogenic acid and rosmarinic acid. This study examined whether PPE and α-asarone improved dyslipidemia-associated inflammation and inhibited atheroma formation in apolipoprotein E (apoE)-deficient mice, an experimental animal model of atherosclerosis.
    Materials/methods: ApoE-deficient mice were fed on high cholesterol-diet (Paigen's diet) and orally administrated with 10-20 mg/kg PPE and α-asarone for 10 wk.
    Results: The Paigen's diet reduced body weight gain in apoE-deficient mice, which was not restored by PPE or α-asarone. PPE or α-asarone improved the plasma lipid profiles in Paigen's diet-fed apoE-deficient mice, and despite a small increase in high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL)-cholesterol, and very LDL were significantly reduced. Paigen's diet-induced systemic inflammation was reduced in PPE or α-asarone-treated apoE-deficient mice. Supplying PPE or α-asarone to mice lacking apoE suppressed aorta atherogenesis induced by atherogenic diet. PPE or α-asarone diminished aorta accumulation of CD68- and/or F4/80-positive macrophages induced by atherogenic diet in apoE-deficient mice. Treatment of apoE-deficient mice with PPE and α-asarone resulted in a significant decrease in plasma cholesteryl ester transfer protein level and an increase in lecithin:cholesterol acyltransferase reduced by supply of Paigen's diet. Supplementation of PPE and α-asarone enhanced the transcription of hepatic apoA1 and SR-B1 reduced by Paigen's diet in apoE-deficient mice.
    Conclusions: α-Asarone in PPE inhibited inflammation-associated atheroma formation and promoted hepatic HDL-C trafficking in dyslipidemic mice.
    Language English
    Publishing date 2023-08-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2387946-4
    ISSN 2005-6168 ; 1976-1457
    ISSN (online) 2005-6168
    ISSN 1976-1457
    DOI 10.4162/nrp.2023.17.6.1099
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    In stock of ZB MED Bonn / Germany

    Z 7762: Show issues

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  8. Article ; Online: Change in Weight Status Among Children Who Do and Do Not Participate in Intensive Health Behavior and Lifestyle Treatment for Obesity.

    Chen, Cathy / Eichen, Dawn / Kang Sim, D Eastern / Strong, David / Boutelle, Kerri N / Rhee, Kyung E

    Childhood obesity (Print)

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2639910-6
    ISSN 2153-2176 ; 2153-2168
    ISSN (online) 2153-2176
    ISSN 2153-2168
    DOI 10.1089/chi.2023.0114
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  9. Article ; Online: Cirsium Setidens Water Extracts Containing Linarin Block Estrogen Deprivation-Induced Bone Loss in Mice.

    Oh, Moon-Sik / Kim, Soo-Il / Sim, Young Eun / Park, Sin-Hye / Kang, Min-Kyung / Kang, Il-Jun / Lim, Soon Sung / Kang, Young-Hee

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Osteoporosis is evident in postmenopausal women and is an osteolytic disease characterized by bone loss that further increases the susceptibility to bone fractures and frailty. The use of complementary therapies to alleviate postmenopausal osteoporosis ... ...

    Abstract Osteoporosis is evident in postmenopausal women and is an osteolytic disease characterized by bone loss that further increases the susceptibility to bone fractures and frailty. The use of complementary therapies to alleviate postmenopausal osteoporosis is fairly widespread among women. Edible Cirsium setidens contains various polyphenols of linarin, pectolinarin, and apigenin with antioxidant and hepatoprotective effects. This study aimed to determine whether Cirsium setidens water extracts (CSEs), the component linarin, and its aglycone acacetin blocked ovariectomy (OVX)-induced bone loss. This study employed OVX C57BL/6 female mice as a model for postmenopausal osteoporosis. CSEs, acacetin, or linarin was orally administrated to OVX mice at a dose of 20 mg/kg for 8 weeks. Surgical estrogen loss in mice for 8 weeks reduced bone mineral density (BMD) of mouse femur and serum 17β-estradiol level and enhanced the serum receptor activator of NF-κB ligand/osteoprotegerin ratio with uterine atrophy. CSEs and linarin reversed such adverse effects and enhanced femoral BMD in OVX mice. Oral administration of CSEs and linarin attenuated tartrate-resistant acid phosphate activity and the induction of αvβ3 integrins and proton suppliers in resorption lacunae in femoral bone tissue of OVX mice. In addition, CSEs and linarin curtailed the bone levels of cathepsin K and matrix metalloproteinase-9 responsible for osteoclastic bone resorption. On the other hand, CSEs and linarin enhanced the formation of trabecular bones in estrogen-deficient femur with increased induction of osteocalcin and osteopontin. Further, treatment with CSEs and linarin enhanced the collagen formation-responsive propeptide levels in the circulation along with the increase in the tissue non-specific alkaline phosphatase level in bone exposed to OVX. Supplementing CSEs, acacetin, or linarin to OVX mice elevated the formation of collagen fibers in OVX trabecular bone, evidenced using Picrosirius red staining. Accordingly, CSEs and linarin were effective in retarding osteoclastic bone resorption and promoting osteoblastic bone matrix mineralization under OVX conditions. Therefore, linarin, which is abundant in CSEs, may be a natural compound for targeting postmenopausal osteoporosis and pathological osteoresorptive disorders.
    MeSH term(s) Animals ; Female ; Mice ; Bone Density ; Bone Resorption/drug therapy ; Bone Resorption/etiology ; Cirsium ; Collagen/pharmacology ; Estrogens/pharmacology ; Mice, Inbred C57BL ; Osteoporosis, Postmenopausal/drug therapy ; Ovariectomy/adverse effects
    Chemical Substances Collagen (9007-34-5) ; Estrogens ; linarin (HBH2I685IU)
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021620
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  10. Article ; Online: Understanding Resilience: No Place to Rest on Our Laurels-Reply to Modesto-Lowe et al.

    Sim, Kang / Chew, Qian Hui

    The Journal of clinical psychiatry

    2021  Volume 82, Issue 5

    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.21lr14035a
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 108: Show issues Location:
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