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Article ; Online: On arsenic and plague.

Tosetti, Francesca

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2014 Volume 59, Issue 12, Page(s) 1806–1808

MeSH term(s)	Arsenic/therapeutic use ; Drug Resistance, Bacterial ; Humans ; Plague/drug therapy ; Yersinia pestis/drug effects ; Yersinia pestis/pathogenicity
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2014-12-15
Publishing country	United States
Document type	Letter
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciu704
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Article ; Online: ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.

Tosetti, Francesca / Alessio, Massimo / Poggi, Alessandro / Zocchi, Maria Raffaella

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: Enzymes, once considered static molecular machines acting in defined spatial patterns and sites of action, move to different intra- and extracellular locations, changing their function. This topological regulation revealed a close cross-talk between ... ...

Abstract	Enzymes, once considered static molecular machines acting in defined spatial patterns and sites of action, move to different intra- and extracellular locations, changing their function. This topological regulation revealed a close cross-talk between proteases and signaling events involving post-translational modifications, membrane tyrosine kinase receptors and G-protein coupled receptors, motor proteins shuttling cargos in intracellular vesicles, and small-molecule messengers. Here, we highlight recent advances in our knowledge of regulation and function of A Disintegrin And Metalloproteinase (ADAM) endopeptidases at specific subcellular sites, or in multimolecular complexes, with a special focus on ADAM10, and tumor necrosis factor-α convertase (TACE/ADAM17), since these two enzymes belong to the same family, share selected substrates and bioactivity. We will discuss some examples of ADAM10 activity modulated by changing partners and subcellular compartmentalization, with the underlying hypothesis that restraining protease activity by spatial segregation is a complex and powerful regulatory tool.
MeSH term(s)	ADAM10 Protein/metabolism ; Animals ; Humans ; Models, Biological ; Protein Processing, Post-Translational ; Protein Transport ; Signal Transduction ; Substrate Specificity
Chemical Substances	ADAM10 Protein (EC 3.4.24.81)
Language	English
Publishing date	2021-05-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094969
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Article ; Online: SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation.

Costa, Delfina / Venè, Roberta / Coco, Simona / Longo, Luca / Tosetti, Francesca / Scabini, Stefano / Mastracci, Luca / Grillo, Federica / Poggi, Alessandro / Benelli, Roberto

Cells

2023 Volume 12, Issue 4

Abstract: The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 ... ...

Abstract	The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 sustaining organoid proliferation. However, the growth of some colorectal cancer (CRC)-derived organoid cultures is inhibited by this molecule via an unknown mechanism. We biochemically investigated SB202190 activity on a collection of 25 primary human CRC organoids, evaluating EGFR, Akt and Erk1-2 activation using Western blot. We found that Erk1-2 phosphorylation was induced by SB202190 in 20 organoid cultures and inhibited in 5 organoid cultures. A next-generation sequencing (NGS) analysis revealed that the inhibition of p-Erk1-2 signaling corresponded to the cultures with BRAF mutations (with four different hits, one being undescribed), while p-Erk1-2 induction was apparently unrelated to other mutations involving the EGFR pathway (Her2, KRAS and NRAS). We found that SB202190 mirrored the biochemical activity of the BRAF inhibitor Dabrafenib, known to induce the paradoxical activation of p-Erk1-2 signaling in BRAF wild-type cells. SB202190 was a more effective inhibitor of BRAF-mutated organoid growth in the long term than the specific BRAF inhibitors Dabrafenib and PLX8394. Overall, SB202190 can predict BRAF-activating mutations in patient-derived organoids, as well as allowing for the identification of new BRAF variants, preceding and enforcing NGS data.
MeSH term(s)	Humans ; Proto-Oncogene Proteins B-raf/genetics ; Protein Kinase Inhibitors/pharmacology ; Mutation ; Colorectal Neoplasms/genetics ; ErbB Receptors/genetics ; Organoids/metabolism
Chemical Substances	dabrafenib (QGP4HA4G1B) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole (PVX798P8GI) ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1)
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12040664
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Article ; Online: p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer.

Cappello, Angela / Tosetti, Giulia / Smirnov, Artem / Ganini, Carlo / Yang, Xue / Shi, Yufang / Wang, Ying / Melino, Gerry / Bernassola, Francesca / Candi, Eleonora

Biology direct

2023 Volume 18, Issue 1, Page(s) 73

Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of ... ...

Abstract	Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of HNSCC. Physiologically, p63 affects metabolism through the direct transactivation of the enzyme hexokinase 2, and subsequently controls the proliferation of epithelial cells; nonetheless, its role in cancer metabolism is still largely unclear. The high energetic demand of cancer and the consequent needs of a metabolic reshape, also involve the serine and glycine catabolic and anabolic pathways, including the one carbon metabolism (OCM), to produce energetic compounds (purines) and to maintain cellular homeostasis (glutathione and S-adenosylmethionine). Results: The involvement in serine/glycine starvation by other p53 family members has been reported, including HNSCC. Here, we show that in HNSCC p63 controls the expression of the enzymes regulating the serine biosynthesis and one carbon metabolism. p63 binds the promoter region of genes involved in the serine biosynthesis as well as in the one carbon metabolism. p63 silencing in a HNSCC cell line affects the mRNA and protein levels of these selected enzymes. Moreover, the higher expression of TP63 and its target enzymes, negatively impacts on the overall survival of HNSCC patients. Conclusion: These data indicate a direct role of p63 in the metabolic regulation of HNSCC with significant clinical effects.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Carcinoma, Squamous Cell/genetics ; Head and Neck Neoplasms/genetics ; Glycine/genetics ; Glycine/metabolism ; Carbon ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
Chemical Substances	Tumor Suppressor Protein p53 ; Glycine (TE7660XO1C) ; Carbon (7440-44-0)
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2221028-3
ISSN	1745-6150 ; 1745-6150
ISSN (online)	1745-6150
ISSN	1745-6150
DOI	10.1186/s13062-023-00426-1
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Article ; Online: ADAM10 Site-Dependent Biology

Francesca Tosetti / Massimo Alessio / Alessandro Poggi / Maria Raffaella Zocchi

International Journal of Molecular Sciences, Vol 22, Iss 4969, p

Keeping Control of a Pervasive Protease

2021 Volume 4969

Abstract	Enzymes, once considered static molecular machines acting in defined spatial patterns and sites of action, move to different intra- and extracellular locations, changing their function. This topological regulation revealed a close cross-talk between proteases and signaling events involving post-translational modifications, membrane tyrosine kinase receptors and G-protein coupled receptors, motor proteins shuttling cargos in intracellular vesicles, and small-molecule messengers. Here, we highlight recent advances in our knowledge of regulation and function of A Disintegrin And Metalloproteinase (ADAM) endopeptidases at specific subcellular sites, or in multimolecular complexes, with a special focus on ADAM10, and tumor necrosis factor-α convertase (TACE/ADAM17), since these two enzymes belong to the same family, share selected substrates and bioactivity. We will discuss some examples of ADAM10 activity modulated by changing partners and subcellular compartmentalization, with the underlying hypothesis that restraining protease activity by spatial segregation is a complex and powerful regulatory tool.
Keywords	ADAM ; metalloproteinases ; subcellular trafficking ; vesicles ; exosomes ; signaling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy.

Zocchi, Maria Raffaella / Tosetti, Francesca / Benelli, Roberto / Poggi, Alessandro

Cancers

2020 Volume 12, Issue 7

Abstract: Both natural and synthetic nanoparticles have been proposed as drug carriers in cancer treatment, since they can increase drug accumulation in target tissues, optimizing the therapeutic effect. As an example, extracellular vesicles (EV), including ... ...

Abstract	Both natural and synthetic nanoparticles have been proposed as drug carriers in cancer treatment, since they can increase drug accumulation in target tissues, optimizing the therapeutic effect. As an example, extracellular vesicles (EV), including exosomes (Exo), can become drug vehicles through endogenous or exogenous loading, amplifying the anticancer effects at the tumor site. In turn, synthetic nanoparticles (NP) can carry therapeutic molecules inside their core, improving solubility and stability, preventing degradation, and controlling their release. In this review, we summarize the recent advances in nanotechnology applied for theranostic use, distinguishing between passive and active targeting of these vehicles. In addition, examples of these models are reported: EV as transporters of conventional anticancer drugs; Exo or NP as carriers of small molecules that induce an anti-tumor immune response. Finally, we focus on two types of nanoparticles used to stimulate an anticancer immune response: Exo carried with A Disintegrin And Metalloprotease-10 inhibitors and NP loaded with aminobisphosphonates. The former would reduce the release of decoy ligands that impair tumor cell recognition, while the latter would activate the peculiar anti-tumor response exerted by γδ T cells, creating a bridge between innate and adaptive immunity.
Language	English
Publishing date	2020-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12071886
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Article ; Online: p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

Angela Cappello / Giulia Tosetti / Artem Smirnov / Carlo Ganini / Xue Yang / Yufang Shi / Ying Wang / Gerry Melino / Francesca Bernassola / Eleonora Candi

Biology Direct, Vol 18, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the ... ...

Abstract	Abstract Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of HNSCC. Physiologically, p63 affects metabolism through the direct transactivation of the enzyme hexokinase 2, and subsequently controls the proliferation of epithelial cells; nonetheless, its role in cancer metabolism is still largely unclear. The high energetic demand of cancer and the consequent needs of a metabolic reshape, also involve the serine and glycine catabolic and anabolic pathways, including the one carbon metabolism (OCM), to produce energetic compounds (purines) and to maintain cellular homeostasis (glutathione and S-adenosylmethionine). Results The involvement in serine/glycine starvation by other p53 family members has been reported, including HNSCC. Here, we show that in HNSCC p63 controls the expression of the enzymes regulating the serine biosynthesis and one carbon metabolism. p63 binds the promoter region of genes involved in the serine biosynthesis as well as in the one carbon metabolism. p63 silencing in a HNSCC cell line affects the mRNA and protein levels of these selected enzymes. Moreover, the higher expression of TP63 and its target enzymes, negatively impacts on the overall survival of HNSCC patients. Conclusion These data indicate a direct role of p63 in the metabolic regulation of HNSCC with significant clinical effects.
Keywords	Head and neck cancer ; p53 family ; p63 ; Serine ; One carbon metabolism ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Quality assessment, variability and reproducibility of anatomical measurements derived from T1-weighted brain imaging: The RIN-Neuroimaging Network case study.

Bosco, Paolo / Lancione, Marta / Retico, Alessandra / Nigri, Anna / Aquino, Domenico / Baglio, Francesca / Carne, Irene / Ferraro, Stefania / Giulietti, Giovanni / Napolitano, Antonio / Palesi, Fulvia / Pavone, Luigi / Savini, Giovanni / Tagliavini, Fabrizio / Bruzzone, Maria Grazia / Gandini Wheeler-Kingshott, Claudia A M / Tosetti, Michela / Biagi, Laura

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2023 Volume 110, Page(s) 102577

Abstract: Initiatives for the collection of harmonized MRI datasets are growing continuously, opening questions on the reliability of results obtained in multi-site contexts. Here we present the assessment of the brain anatomical variability of MRI-derived ... ...

Abstract	Initiatives for the collection of harmonized MRI datasets are growing continuously, opening questions on the reliability of results obtained in multi-site contexts. Here we present the assessment of the brain anatomical variability of MRI-derived measurements obtained from T1-weighted images, acquired according to the Standard Operating Procedures, promoted by the RIN-Neuroimaging Network. A multicentric dataset composed of 77 brain T1w acquisitions of young healthy volunteers (mean age = 29.7 ± 5.0 years), collected in 15 sites with MRI scanners of three different vendors, was considered. Parallelly, a dataset of 7 "traveling" subjects, each undergoing three acquisitions with scanners from different vendors, was also used. Intra-site, intra-vendor, and inter-site variabilities were evaluated in terms of the percentage standard deviation of volumetric and cortical thickness measures. Image quality metrics such as contrast-to-noise and signal-to-noise ratio in gray and white matter were also assessed for all sites and vendors. The results showed a measured global variability that ranges from 11% to 19% for subcortical volumes and from 3% to 10% for cortical thicknesses. Univariate distributions of the normalized volumes of subcortical regions, as well as the distributions of the thickness of cortical parcels appeared to be significantly different among sites in 8 subcortical (out of 17) and 21 cortical (out of 68) regions of i nterest in the multicentric study. The Bland-Altman analysis on "traveling" brain measurements did not detect systematic scanner biases even though a multivariate classification approach was able to classify the scanner vendor from brain measures with an accuracy of 0.60 ± 0.14 (chance level 0.33).
MeSH term(s)	Humans ; Young Adult ; Adult ; Reproducibility of Results ; Brain/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Signal-To-Noise Ratio
Language	English
Publishing date	2023-04-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2023.102577
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Article ; Online: Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk.

Barboro, Paola / Benelli, Roberto / Tosetti, Francesca / Costa, Delfina / Capaia, Matteo / Astigiano, Simonetta / Venè, Roberta / Poggi, Alessandro / Ferrari, Nicoletta

Carcinogenesis

2020 Volume 41, Issue 9, Page(s) 1246–1252

Abstract: Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associated with the ... ...

Abstract	Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associated with the CRPC phenotype. ASPH is overexpressed in various malignant neoplasms and catalyzes the hydroxylation of aspartyl and asparaginyl residues in the epidermal growth factor (EGF)-like domains of proteins like NOTCH receptors and ligands, enhancing cell motility, invasion and metastatic spread. Bioinformatics analyses of ASPH in prostate cancer (PCa) and CRPC datasets indicate that ASPH gene alterations have prognostic value both in PCa and CRPC patients. In CRPC cells, inhibition of ASPH expression obtained through specific small interfering RNA or culturing cells in hypoxic conditions, reduced cell proliferation, invasion and cyclin D1 expression through modulation of the NOTCH signaling. ASPH and HIF1α crosstalk, within a hydroxylation-regulated signaling pathway, might be transiently driven by the oxidative stress evidenced inside CRPC cells. In addition, increased phosphorylation of GSK3β by ASPH silencing demonstrates that ASPH regulates GSK3β activity inhibiting its interactions with upstream kinases. These findings demonstrate the critical involvement of ASPH in CRPC development and may represent an attractive molecular target for therapy.
MeSH term(s)	Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Calcium-Binding Proteins/antagonists & inhibitors ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mixed Function Oxygenases/antagonists & inhibitors ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Muscle Proteins/antagonists & inhibitors ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Prognosis ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; RNA, Small Interfering/genetics ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Survival Rate ; Tumor Cells, Cultured
Chemical Substances	Biomarkers, Tumor ; Calcium-Binding Proteins ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Membrane Proteins ; Muscle Proteins ; NOTCH1 protein, human ; RNA, Small Interfering ; Receptor, Notch1 ; Mixed Function Oxygenases (EC 1.-) ; ASPH protein, human (EC 1.14.11.16) ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgaa053
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Article ; Online: Autoimmune Lymphoproliferative Syndrome (ALPS) Disease and ALPS Phenotype: Are They Two Distinct Entities?

Palmisani, Elena / Miano, Maurizio / Grossi, Alice / Lanciotti, Marina / Lupia, Michela / Terranova, Paola / Ceccherini, Isabella / Montanari, Eugenia / Calvillo, Michaela / Pierri, Filomena / Micalizzi, Concetta / Maggiore, Rosario / Guardo, Daniela / Zanardi, Sabrina / Facchini, Elena / Maggio, Angela / Mastrodicasa, Elena / Corti, Paola / Russo, Giovanna /

Pillon, Marta / Farruggia, Piero / Cesaro, Simone / Barone, Angelica / Tosetti, Francesca / Ramenghi, Ugo / Crescenzio, Nicoletta / Bleesing, Jack / Dufour, Carlo / Fioredda, Francesca

HemaSphere

2023 Volume 7, Issue 3, Page(s) e845

Abstract: Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder of lymphocyte homeostasis classically due to mutation of FAS, FASL, and CASP10 genes (ALPS-FAS/CASP10). Despite recent progress, about one-third of ALPS patients does not carry ... ...

Abstract	Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder of lymphocyte homeostasis classically due to mutation of FAS, FASL, and CASP10 genes (ALPS-FAS/CASP10). Despite recent progress, about one-third of ALPS patients does not carry classical mutations and still remains gene orphan (ALPS-U, undetermined genetic defects). The aims of the present study were to compare the clinical and immunological features of ALPS-FAS/CASP10 versus those of ALPS-U affected subjects and to deepen the genetic characteristics of this latter group. Demographical, anamnestic, biochemical data were retrieved from medical record of 46 ALPS subjects. An enlarged panel of genes (next-generation sequencing) was applied to the ALPS-U group. ALPS-U subjects showed a more complex phenotype if compared to ALPS-FAS/CASP10 group, characterized by multiorgan involvement (
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000845
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