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  1. Article ; Online: The another side of COVID-19 in Alzheimer's disease patients: Drug-drug interactions.

    Balli, Nisa / Kara, Emre / Demirkan, Kutay

    International journal of clinical practice

    2020  Volume 74, Issue 10, Page(s) e13596

    MeSH term(s) Alzheimer Disease/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Drug Interactions ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.13596
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  2. Article ; Online: Battle of polymyxin induced nephrotoxicity: Polymyxin B versus colistin.

    Ballı, Fatma Nisa / Ekinci, Pınar Bakır / Kurtaran, Melek / Kara, Emre / Dizman, Gülçin Telli / Sönmezer, Meliha Çağla / Hayran, Mutlu / Demirkan, Kutay / Metan, Gökhan

    International journal of antimicrobial agents

    2023  Volume 63, Issue 2, Page(s) 107035

    Abstract: Objectives: Nephrotoxicity is the most serious and common adverse effect that limits the use of polymyxins. This study compared polymyxin E (colistin) and polymyxin B regarding drug-related nephrotoxicity.: Methods: This study was conducted as a ... ...

    Abstract Objectives: Nephrotoxicity is the most serious and common adverse effect that limits the use of polymyxins. This study compared polymyxin E (colistin) and polymyxin B regarding drug-related nephrotoxicity.
    Methods: This study was conducted as a retrospective cohort study in a university hospital between January 2020 and July 2022. Patients older than 18 years and who received colistin or polymyxin B were identified using electronic hospital records. Kidney disease improving global outcome criteria were used for assessing nephrotoxicity.
    Results: A total of 190 patients, 95 in both groups, were evaluated. The incidence of acute kidney injury during the treatment was higher in the colistin group [52.6% (n = 50) and 34.7% (n = 33), P = 0.013]. In patients who were exposed to high-dose, the rate of nephrotoxicity was higher in patients receiving colistin [25% (n = 3) vs. 76.9% (n = 10); P = 0.017]. Nephrotoxicity was reversible in 64.4% (n = 38) of patients and the reversibility rate was similar (70% and 52.6% for colistin and polymyxin; P = 0.248). In the multivariable analysis, colistin treatment [odds ratio (OR): 3.882, 95% confidence interval (95% CI) = (1.829-8.241)], concomitant vasopressor use (OR = 2.08, CI: 1.036-4.179), and age (OR=1.036, CI: 1.014-1.058) were found to be independent markers of nephrotoxicity.
    Conclusion: Nephrotoxicity was more common in patients receiving high-dose colistin than polymyxin B. Therefore, the use of appropriate doses of colistin is important in terms of preventing nephrotoxicity. In addition, advancing age and concomitant use of vasopressors contribute to polymyxin-related nephrotoxicity.
    MeSH term(s) Humans ; Polymyxin B/adverse effects ; Colistin/adverse effects ; Polymyxins/adverse effects ; Anti-Bacterial Agents/adverse effects ; Retrospective Studies ; Acute Kidney Injury/epidemiology
    Chemical Substances Polymyxin B (J2VZ07J96K) ; Colistin (Z67X93HJG1) ; Polymyxins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.107035
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  3. Article ; Online: The Effect of Therapeutic Plasma Exchange on COVID-19 Therapy

    Cansu GÖNCÜOĞLU / Fatma Nisa BALLI / Aygin BAYRAKTAR EKİNCİOĞLU

    Turkish Journal of Pharmaceutical Sciences, Vol 17, Iss 5, Pp 463-

    2020  Volume 464

    Keywords covid-19 treatment ; therapeutic plasma exchange ; drug removal ; pharmacokinetic ; Pharmacy and materia medica ; RS1-441 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Effect of Therapeutic Plasma Exchange on COVID-19 Therapy.

    GÖncÜoĞlu, Cansu / Balli, Fatma Nisa / Bayraktar EkİncİoĞlu, Aygin

    Turkish journal of pharmaceutical sciences

    2020  Volume 17, Issue 5, Page(s) 463–464

    Keywords covid19
    Language English
    Publishing date 2020-10-30
    Publishing country Turkey
    Document type Journal Article
    ISSN 2148-6247
    ISSN (online) 2148-6247
    DOI 10.4274/tjps.galenos.2020.13845
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  5. Article ; Online: The another side of COVID‐19 in Alzheimer’s disease patients

    Balli, Nisa / Kara, Emre / Demirkan, Kutay

    International Journal of Clinical Practice

    Drug‐drug interactions

    2020  Volume 74, Issue 10

    Keywords General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.13596
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  6. Article ; Online: Effect of clinical pharmacists' interventions on dementia treatment adherence and caregivers' knowledge.

    Balli, Fatma Nisa / Unsal, Pelin / Halil, Meltem Gulhan / Dogu, Burcu Balam / Cankurtaran, Mustafa / Demirkan, Kutay

    Geriatrics & gerontology international

    2021  Volume 21, Issue 6, Page(s) 506–511

    Abstract: Aim: Poor adherence with dementia medications is common among patients and caregivers, owing to the absence of perceived effect, polypharmacy, and adverse effects. The aim of this study was to evaluate the effect of clinical pharmacists' interventions ... ...

    Abstract Aim: Poor adherence with dementia medications is common among patients and caregivers, owing to the absence of perceived effect, polypharmacy, and adverse effects. The aim of this study was to evaluate the effect of clinical pharmacists' interventions on the adherence to dementia treatment and the caregivers' knowledge of dementia.
    Methods: This study was conducted at a geriatric outpatient clinic of the university hospital between October 2018 and April 2019. The Morisky Green Levine Adherence Scale (MGLS) to patients or caregivers and the Dementia Knowledge Assessment Tool Version Two (DKAT2) to caregivers were applied at the beginning of the study and 4 months later by a clinical pharmacist. After the scales were applied in the first interview, verbal information about the importance of adherence to dementia treatment, and incorrect answers of caregivers in DKAT2 were provided by the clinical pharmacist.
    Results: A total of 94 patients and 91 caregivers were included in the study. High adherence to treatment was determined in 70.2% of the patients in the first interview and in 95.7% in the second interview (P < 0.001). The mean score of DKAT2 was 15.53 ± 2.44 in the first interview, while the median score of DKAT2 in the second interview was 19.11 ± 1.25 (P < 0.001).
    Conclusion: The intervention of clinical pharmacists significantly increased the adherence to dementia treatment and the caregivers' knowledge of dementia. Close monitoring of dementia patients and caregivers by clinical pharmacists and collaboration with a multidisciplinary team play an important role in dementia care. Geriatr Gerontol Int 2021; 21: 506-511.
    MeSH term(s) Aged ; Caregivers ; Dementia/drug therapy ; Humans ; Pharmacists ; Polypharmacy ; Treatment Adherence and Compliance
    Language English
    Publishing date 2021-04-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14170
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  7. Article: The Another Side of COVID-19 in Alzheimer's Disease Patients: Drug-Drug Interactions

    Balli, Nisa / Kara, Emre / Demirkan, Kutay

    Int J Clin Pract

    Abstract: Coronavirus Disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major public health problem. The elderly people are the most affected population by the COVID-19 outbreak in terms of ... ...

    Abstract Coronavirus Disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major public health problem. The elderly people are the most affected population by the COVID-19 outbreak in terms of mortality and morbidity. Delirium caused by hypoxia, a prominent clinical feature of COVID-19, may increase the need for treatment of Alzheimer's disease (AD) patients (1). Therefore, drug-drug interactions should be considered in AD patients while receiving COVID-19 treatment.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32593196
    Database COVID19

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  8. Article ; Online: Prevalence of nutrition disorders and nutrition-related conditions in older patients with Alzheimer's disease.

    Unsal, Pelin / Guner, Merve / Ozsurekci, Cemile / Balli, Nisa / Bas, Arzu Okyar / Ozturk, Yelda / Dikmeer, Ayse / Burkuk, Suna / Koca, Meltem / Balci, Cafer / Dogu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2023  Volume 38, Issue 5, Page(s) 1142–1153

    Abstract: Backgrounds: Alzheimer's disease is frequently encountered with nutrition-related conditions such as malnutrition, sarcopenia, frailty, overnutrition, and micronutrient abnormalities in older patients. In this study, we aimed to evaluate the prevalence ... ...

    Abstract Backgrounds: Alzheimer's disease is frequently encountered with nutrition-related conditions such as malnutrition, sarcopenia, frailty, overnutrition, and micronutrient abnormalities in older patients. In this study, we aimed to evaluate the prevalence of nutrition disorders and nutrition-related conditions in the same patient group.
    Methods: A total of 253 older patients with Alzheimer's disease underwent comprehensive geriatric assessment, which included nutrition-related disorders, malnutrition via the Mini Nutritional Assessment-Short Form (MNA-SF), frailty via the Clinical Frailty Scale (CFS), and sarcopenia was diagnosed according to European Working Group on Sarcopenia in Older People-2 criteria.
    Results: The patients' mean age was 79.8 ± 6.5 years, and 58.1% were women. In our patients, 64.8% had malnutrition or were at risk of malnutrition; 38.3% had sarcopenia; 19.8% were prefrail; and 80.2% were frail. Malnutrition, frailty, and sarcopenia prevalence increased as the Alzheimer's disease stage progressed. Malnutrition was found to be significantly related with frailty scores via CFS (odds ratio [OR], 1.397; P = 0.0049) and muscle mass via fat-free mass index (FFMI) (OR, 0.793; P = 0.001). In logistic regression analysis, age, MNA-SF, and CFS were included in the model to detect the independent correlates of probable and confirmed sarcopenia. CFS was independently associated with probable and confirmed sarcopenia (OR, 1.822; P = 0.013; OR, 2.671; P = 0.001, respectively). Frailty was similarly related with FFMI (OR, 0.836; P = 0.031). Obesity was independently related with FFMI (OR, 0.688; P < 0.001).
    Conclusion: In conclusion, nutrition disorders and nutrition-related conditions can present concurrently in patients with all stages of Alzheimer's disease; therefore, these frequent problems should be screened and diagnosed accordingly.
    MeSH term(s) Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Nutritional Status ; Sarcopenia/etiology ; Sarcopenia/complications ; Frailty/epidemiology ; Frailty/etiology ; Prevalence ; Alzheimer Disease/epidemiology ; Alzheimer Disease/complications ; Malnutrition/etiology ; Malnutrition/complications ; Nutrition Assessment
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10995
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  9. Article ; Online: Prevalence of nutrition disorders and nutrition‐related conditions in older patients with Alzheimer's disease

    Unsal, Pelin / Guner, Merve / Ozsurekci, Cemile / Balli, Nisa / Bas, Arzu Okyar / Ozturk, Yelda / Dikmeer, Ayse / Burkuk, Suna / Koca, Meltem / Balci, Cafer / Dogu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem

    Nutrition in Clinical Practice. 2023 Oct., v. 38, no. 5 p.1142-1153

    2023  

    Abstract: BACKGROUNDS: Alzheimer's disease is frequently encountered with nutrition‐related conditions such as malnutrition, sarcopenia, frailty, overnutrition, and micronutrient abnormalities in older patients. In this study, we aimed to evaluate the prevalence ... ...

    Abstract BACKGROUNDS: Alzheimer's disease is frequently encountered with nutrition‐related conditions such as malnutrition, sarcopenia, frailty, overnutrition, and micronutrient abnormalities in older patients. In this study, we aimed to evaluate the prevalence of nutrition disorders and nutrition‐related conditions in the same patient group. METHODS: A total of 253 older patients with Alzheimer's disease underwent comprehensive geriatric assessment, which included nutrition‐related disorders, malnutrition via the Mini Nutritional Assessment‐Short Form (MNA‐SF), frailty via the Clinical Frailty Scale (CFS), and sarcopenia was diagnosed according to European Working Group on Sarcopenia in Older People‐2 criteria. RESULTS: The patients' mean age was 79.8 ± 6.5 years, and 58.1% were women. In our patients, 64.8% had malnutrition or were at risk of malnutrition; 38.3% had sarcopenia; 19.8% were prefrail; and 80.2% were frail. Malnutrition, frailty, and sarcopenia prevalence increased as the Alzheimer's disease stage progressed. Malnutrition was found to be significantly related with frailty scores via CFS (odds ratio [OR], 1.397; P = 0.0049) and muscle mass via fat‐free mass index (FFMI) (OR, 0.793; P = 0.001). In logistic regression analysis, age, MNA‐SF, and CFS were included in the model to detect the independent correlates of probable and confirmed sarcopenia. CFS was independently associated with probable and confirmed sarcopenia (OR, 1.822; P = 0.013; OR, 2.671; P = 0.001, respectively). Frailty was similarly related with FFMI (OR, 0.836; P = 0.031). Obesity was independently related with FFMI (OR, 0.688; P < 0.001). CONCLUSION: In conclusion, nutrition disorders and nutrition‐related conditions can present concurrently in patients with all stages of Alzheimer's disease; therefore, these frequent problems should be screened and diagnosed accordingly.
    Keywords Alzheimer disease ; lean body mass ; malnutrition ; muscle tissues ; nutrition ; obesity ; odds ratio ; overnutrition ; patients ; regression analysis ; risk ; sarcopenia
    Language English
    Dates of publication 2023-10
    Size p. 1142-1153.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10995
    Database NAL-Catalogue (AGRICOLA)

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