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  1. Article ; Online: Accessible computing platforms democratize neuroimaging data analysis.

    Uddin, Lucina Q

    Nature methods

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-024-02238-1
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  2. Article ; Online: A Brain Network by Any Other Name.

    Uddin, Lucina Q

    Journal of cognitive neuroscience

    2022  Volume 35, Issue 3, Page(s) 363–364

    Abstract: Network neuroscientists generally agree with Pessoa's contention that human brain function is context-dependent and interactionally complex, and that we should embrace brain networks as the functional units of interest. The more contentious issue for the ...

    Abstract Network neuroscientists generally agree with Pessoa's contention that human brain function is context-dependent and interactionally complex, and that we should embrace brain networks as the functional units of interest. The more contentious issue for the field is how to define brain networks in ways that will facilitate further discovery. A group including members from the Organization for Human Brain Mapping is working toward cataloging best practices and providing concrete reporting guidelines for the scientific community.
    MeSH term(s) Humans ; Brain ; Brain Mapping ; Nerve Net
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_01925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exceptional abilities in autism: Theories and open questions.

    Uddin, Lucina Q

    Current directions in psychological science

    2022  Volume 31, Issue 6, Page(s) 509–517

    Abstract: The vast majority of research on autism spectrum disorder (ASD) focuses on characterizing and addressing the social communication deficits and restricted, repetitive patterns of behavior that constitute the diagnostic criteria for the disorder. Yet, a ... ...

    Abstract The vast majority of research on autism spectrum disorder (ASD) focuses on characterizing and addressing the social communication deficits and restricted, repetitive patterns of behavior that constitute the diagnostic criteria for the disorder. Yet, a small but significant portion of individuals diagnosed with ASD exhibit exceptional cognitive abilities in one or more domains. These "twice-exceptional" individuals often have unique skills that enable them to make significant contributions to the workforce, while at the same time facing unique challenges during the transition to independent living due to a lack of services and broad public misperceptions regarding their condition. Here we review the current literature on cognitive divergence in ASD, focusing on cognitive theories, neural substrates, and clinical and societal implications for increasing understanding of this phenomenon.
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026362-4
    ISSN 1467-8721 ; 0963-7214
    ISSN (online) 1467-8721
    ISSN 0963-7214
    DOI 10.1177/09637214221113760
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  4. Article ; Online: An 'edgy' new look.

    Uddin, Lucina Q

    Nature neuroscience

    2020  Volume 23, Issue 12, Page(s) 1471–1472

    MeSH term(s) Cerebral Cortex ; Humans
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-020-00741-0
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  5. Article ; Online: Cognitive and behavioural flexibility: neural mechanisms and clinical considerations.

    Uddin, Lucina Q

    Nature reviews. Neuroscience

    2021  Volume 22, Issue 3, Page(s) 167–179

    Abstract: Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and behaviours in response to changing environmental demands. Brain mechanisms enabling flexibility have been examined using non-invasive neuroimaging and behavioural ... ...

    Abstract Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and behaviours in response to changing environmental demands. Brain mechanisms enabling flexibility have been examined using non-invasive neuroimaging and behavioural approaches in humans alongside pharmacological and lesion studies in animals. This work has identified large-scale functional brain networks encompassing lateral and orbital frontoparietal, midcingulo-insular and frontostriatal regions that support flexibility across the lifespan. Flexibility can be compromised in early-life neurodevelopmental disorders, clinical conditions that emerge during adolescence and late-life dementias. We critically evaluate evidence for the enhancement of flexibility through cognitive training, physical activity and bilingual experience.
    MeSH term(s) Animals ; Behavior/physiology ; Behavioral Symptoms/physiopathology ; Cognition/physiology ; Cognition Disorders/physiopathology ; Humans ; Nerve Net/physiology ; Nerve Net/physiopathology ; Nervous System Physiological Phenomena ; Neural Pathways/physiology
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-021-00428-w
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  6. Article: Stability and plasticity of functional brain networks after hemispherectomy: implications for consciousness research.

    Uddin, Lucina Q

    Quantitative imaging in medicine and surgery

    2020  Volume 10, Issue 6, Page(s) 1408–1412

    Language English
    Publishing date 2020-06-09
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-20-554
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  7. Article ; Online: The end game: respecting major sources of population diversity.

    Kopal, Jakub / Uddin, Lucina Q / Bzdok, Danilo

    Nature methods

    2023  Volume 20, Issue 8, Page(s) 1122–1128

    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-023-01812-3
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  8. Article ; Online: Bring the Noise: Reconceptualizing Spontaneous Neural Activity.

    Uddin, Lucina Q

    Trends in cognitive sciences

    2020  Volume 24, Issue 9, Page(s) 734–746

    Abstract: Definitions of what constitutes the 'signal of interest' in neuroscience can be controversial, due in part to continuously evolving notions regarding the significance of spontaneous neural activity. This review highlights how the challenge of separating ... ...

    Abstract Definitions of what constitutes the 'signal of interest' in neuroscience can be controversial, due in part to continuously evolving notions regarding the significance of spontaneous neural activity. This review highlights how the challenge of separating brain signal from noise has led to new conceptualizations of brain functional organization at both the micro- and macroscopic level. Recent debates in the functional neuroimaging community surrounding artifact removal processes have revived earlier discussions surrounding how to appropriately isolate and measure neuronal signals against a background of noise from various sources. Insights from electrophysiological studies and computational modeling can inform current theory and data analytic practices in human functional neuroimaging, given that signal and noise may be inextricably linked in the brain.
    MeSH term(s) Artifacts ; Brain ; Brain Mapping ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2020-06-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2020.06.003
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  9. Article ; Online: Effects of Participant Functioning Level on Brain Functional Connectivity in Autism.

    Uddin, Lucina Q

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2019  Volume 4, Issue 3, Page(s) 216–217

    MeSH term(s) Autistic Disorder ; Brain ; Brain Mapping ; Humans
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2019.01.004
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  10. Article ; Online: Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder.

    Uddin, Lucina Q

    Biological psychiatry

    2020  Volume 89, Issue 2, Page(s) 172–183

    Abstract: Cognitive flexibility enables appropriate responses to a changing environment and is associated with positive life outcomes. Adolescence, with its increased focus on transitioning to independent living, presents particular challenges for youths with ... ...

    Abstract Cognitive flexibility enables appropriate responses to a changing environment and is associated with positive life outcomes. Adolescence, with its increased focus on transitioning to independent living, presents particular challenges for youths with autism spectrum disorder (ASD) who often struggle to behave in a flexible way when faced with challenges. This review focuses on brain mechanisms underlying the development of flexible cognition during adolescence and how these neural systems are affected in ASD. Neuroimaging studies of task switching and set-shifting provide evidence for atypical lateral frontoparietal and midcingulo-insular network activation during cognitive flexibility task performance in individuals with ASD. Recent work also examines how intrinsic brain network dynamics support flexible cognition. These dynamic functional connectivity studies provide evidence for alterations in the number of transitions between brain states, as well as hypervariability of functional connections in adolescents with ASD. Future directions for the field include addressing issues related to measurement of cognitive flexibility using a combination of metrics with ecological and construct validity. Heterogeneity of executive function ability in ASD must also be parsed to determine which individuals will benefit most from targeted training to improve flexibility. The influence of pubertal hormones on brain network development and cognitive maturation in adolescents with ASD is another area requiring further exploration. Finally, the intriguing possibility that bilingualism might be associated with preserved cognitive flexibility in ASD should be further examined. Addressing these open questions will be critical for future translational neuroscience investigations of cognitive and behavioral flexibility in adolescents with ASD.
    MeSH term(s) Adolescent ; Autism Spectrum Disorder ; Brain/diagnostic imaging ; Brain Mapping ; Cognition ; Executive Function ; Humans ; Magnetic Resonance Imaging
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.05.010
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