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  1. Article: Obesity: a review of pathogenesis and management strategies.

    Kaila, Brinderjit / Raman, Maitreyi

    Canadian journal of gastroenterology = Journal canadien de gastroenterologie

    2008  Volume 22, Issue 1, Page(s) 61–68

    Abstract: The prevalence of obesity in the developed world is increasing. Approximately 23% of adult Canadians (5.5 million people) are obese. Obesity is associated with an increased risk of developing several comorbid diseases, ranging from cardiovascular ... ...

    Abstract The prevalence of obesity in the developed world is increasing. Approximately 23% of adult Canadians (5.5 million people) are obese. Obesity is associated with an increased risk of developing several comorbid diseases, ranging from cardiovascular diseases to cholelithiasis and nonalcoholic fatty liver disease. The etiology of obesity is multifactorial, involving a complex interaction among genetics, hormones and the environment. The available evidence and recommendations for nonpharmacological management of obesity, including dietary therapy, physical activity and behavioural therapy, in addition to pharmacotherapy are discussed. A brief discussion on endoscopic and surgical procedures is undertaken. Several antiobesity treatment options are available and may be indicated in appropriate situations. Selecting obesity therapy may be guided by body mass index measurements, comorbid illnesses and patient preference.
    MeSH term(s) Anti-Obesity Agents/therapeutic use ; Bariatric Surgery/methods ; Behavior Therapy ; Caloric Restriction/methods ; Cyclobutanes/therapeutic use ; Dietary Carbohydrates/metabolism ; Dietary Fats/metabolism ; Exercise/physiology ; Humans ; Lactones/therapeutic use ; Obesity/etiology ; Obesity/physiopathology ; Obesity/therapy ; Orlistat ; Piperidines/therapeutic use ; Pyrazoles/therapeutic use ; Rimonabant ; Weight Loss/physiology
    Chemical Substances Anti-Obesity Agents ; Cyclobutanes ; Dietary Carbohydrates ; Dietary Fats ; Lactones ; Piperidines ; Pyrazoles ; Orlistat (95M8R751W8) ; Rimonabant (RML78EN3XE) ; sibutramine (WV5EC51866)
    Language English
    Publishing date 2008-01-22
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 639439-5
    ISSN 1916-7237 ; 0835-7900
    ISSN (online) 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2008/609039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The anti-Saccharomyces cerevisiae antibody assay in a province-wide practice: accurate in identifying cases of Crohn's disease and predicting inflammatory disease.

    Kaila, Brinderjit / Orr, Kenneth / Bernstein, Charles N

    Canadian journal of gastroenterology = Journal canadien de gastroenterologie

    2005  Volume 19, Issue 12, Page(s) 717–721

    Abstract: Objective: To determine the utility of the anti-Saccharomyces cerevisiae antibody (ASCA) ELISA test developed in Manitoba in 2001 in a population-wide sample referred from physicians across Manitoba in their investigation of patients with ... ...

    Abstract Objective: To determine the utility of the anti-Saccharomyces cerevisiae antibody (ASCA) ELISA test developed in Manitoba in 2001 in a population-wide sample referred from physicians across Manitoba in their investigation of patients with gastrointestinal symptoms.
    Methods: Patients whose serum was referred for ASCA testing in 2001 and 2002 were eligible for the present study. ELISA was performed by a technologist, blind to patient diagnoses. A single investigator contacted physicians to facilitate chart review. Data collected included demographics, final diagnoses and tests used to substantiate the final diagnosis.
    Results: Of 482 subjects identified, 410 charts were available for review and 29 of those were unavailable for follow-up or had incomplete charts. The present study population included Crohn's disease (CD, n=114), ulcerative colitis (n=74), indeterminate colitis (n=31), celiac disease (n=9), irritable bowel syndrome (n=75), other diagnoses (n=33) and no disease (n=45). ASCA had a sensitivity of 37% (95% CI 27.8 to 46.8) and specificity of 97% (95% CI 93.8 to 98.6) for diagnosing CD and an odds ratio for a diagnosis of CD of 18.4 (95% CI 8.2 to 41.3). The 47 ASCA-positive patients included the following diagnoses: CD=39, ulcerative colitis=3, indeterminate colitis=1, celiac disease=3 and no disease=1. The likelihood of having an inflammatory disease if ASCA is positive was nearly 40-fold.
    Conclusion: A positive ASCA test using this assay nearly clinches a diagnosis of some form of inflammatory intestinal disease, which is highly likely to be CD. In symptomatic patients, a positive ASCA test should encourage the clinician to pursue further investigations.
    MeSH term(s) Adolescent ; Adult ; Antibodies, Antineutrophil Cytoplasmic/analysis ; Antibodies, Fungal/analysis ; Antibody Specificity/immunology ; Child ; Crohn Disease/diagnosis ; Crohn Disease/immunology ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/immunology ; Male ; Manitoba ; Middle Aged ; Retrospective Studies ; Saccharomyces cerevisiae/immunology ; Sensitivity and Specificity
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Fungal
    Language English
    Publishing date 2005-12-12
    Publishing country Canada
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639439-5
    ISSN 1916-7237 ; 0835-7900
    ISSN (online) 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2005/147681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Crohn's disease recurrence in a small bowel transplant.

    Kaila, Brinderjit / Grant, David / Pettigrew, Norman / Greenberg, Howard / Bernstein, Charles N

    The American journal of gastroenterology

    2003  Volume 99, Issue 1, Page(s) 158–162

    Abstract: This is a report of a patient with short-bowel syndrome secondary to recurrent surgeries for Crohn's disease who ultimately required small bowel transplantation in 1994. Eight years posttransplantation he developed recurrent Crohn's disease that was ... ...

    Abstract This is a report of a patient with short-bowel syndrome secondary to recurrent surgeries for Crohn's disease who ultimately required small bowel transplantation in 1994. Eight years posttransplantation he developed recurrent Crohn's disease that was responsive to prednisone. From the perspective of advancing our understanding of Crohn's disease pathogenesis this case suggests that intestine-specific antigens may be more important than the classical MHC antigens for the development of Crohn's disease, since this man developed Crohn's disease in both the native intestine and also in the engrafted one.
    MeSH term(s) Adult ; Crohn Disease/diagnosis ; Crohn Disease/pathology ; Crohn Disease/surgery ; Humans ; Intestine, Small/transplantation ; Male ; Recurrence
    Language English
    Publishing date 2003-11-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1046/j.1572-0241.2003.04004.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
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