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  1. Article ; Online: Correction to: Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology.

    Sato, Shigeharu

    Journal of physiological anthropology

    2021  Volume 40, Issue 1, Page(s) 3

    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2248072-9
    ISSN 1880-6805 ; 1880-6791 ; 1345-3475
    ISSN (online) 1880-6805
    ISSN 1880-6791 ; 1345-3475
    DOI 10.1186/s40101-021-00254-0
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  2. Article ; Online: Correction to

    Shigeharu Sato

    Journal of Physiological Anthropology, Vol 40, Iss 1, Pp 1-

    Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

    2021  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via the original article. ...

    Abstract An amendment to this paper has been published and can be accessed via the original article.
    Keywords Physical anthropology. Somatology ; GN49-298
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  3. Article ; Online: Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

    Shigeharu Sato

    Journal of Physiological Anthropology, Vol 40, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Abstract Malaria is one of the most devastating infectious diseases of humans. It is problematic clinically and economically as it prevails in poorer countries and regions, strongly hindering socioeconomic development. The causative agents of malaria are ...

    Abstract Abstract Malaria is one of the most devastating infectious diseases of humans. It is problematic clinically and economically as it prevails in poorer countries and regions, strongly hindering socioeconomic development. The causative agents of malaria are unicellular protozoan parasites belonging to the genus Plasmodium. These parasites infect not only humans but also other vertebrates, from reptiles and birds to mammals. To date, over 200 species of Plasmodium have been formally described, and each species infects a certain range of hosts. Plasmodium species that naturally infect humans and cause malaria in large areas of the world are limited to five—P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. The first four are specific for humans, while P. knowlesi is naturally maintained in macaque monkeys and causes zoonotic malaria widely in South East Asia. Transmission of Plasmodium species between vertebrate hosts depends on an insect vector, which is usually the mosquito. The vector is not just a carrier but the definitive host, where sexual reproduction of Plasmodium species occurs, and the parasite’s development in the insect is essential for transmission to the next vertebrate host. The range of insect species that can support the critical development of Plasmodium depends on the individual parasite species, but all five Plasmodium species causing malaria in humans are transmitted exclusively by anopheline mosquitoes. Plasmodium species have remarkable genetic flexibility which lets them adapt to alterations in the environment, giving them the potential to quickly develop resistance to therapeutics such as antimalarials and to change host specificity. In this article, selected topics involving the Plasmodium species that cause malaria in humans are reviewed.
    Keywords Antimalarial ; Asymptomatic carrier ; Drug resistance ; Host specificity ; Host switch ; Malaria ; Physical anthropology. Somatology ; GN49-298
    Subject code 572
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  4. Article ; Online: Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology.

    Sato, Shigeharu

    Journal of physiological anthropology

    2021  Volume 40, Issue 1, Page(s) 1

    Abstract: Malaria is one of the most devastating infectious diseases of humans. It is problematic clinically and economically as it prevails in poorer countries and regions, strongly hindering socioeconomic development. The causative agents of malaria are ... ...

    Abstract Malaria is one of the most devastating infectious diseases of humans. It is problematic clinically and economically as it prevails in poorer countries and regions, strongly hindering socioeconomic development. The causative agents of malaria are unicellular protozoan parasites belonging to the genus Plasmodium. These parasites infect not only humans but also other vertebrates, from reptiles and birds to mammals. To date, over 200 species of Plasmodium have been formally described, and each species infects a certain range of hosts. Plasmodium species that naturally infect humans and cause malaria in large areas of the world are limited to five-P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. The first four are specific for humans, while P. knowlesi is naturally maintained in macaque monkeys and causes zoonotic malaria widely in South East Asia. Transmission of Plasmodium species between vertebrate hosts depends on an insect vector, which is usually the mosquito. The vector is not just a carrier but the definitive host, where sexual reproduction of Plasmodium species occurs, and the parasite's development in the insect is essential for transmission to the next vertebrate host. The range of insect species that can support the critical development of Plasmodium depends on the individual parasite species, but all five Plasmodium species causing malaria in humans are transmitted exclusively by anopheline mosquitoes. Plasmodium species have remarkable genetic flexibility which lets them adapt to alterations in the environment, giving them the potential to quickly develop resistance to therapeutics such as antimalarials and to change host specificity. In this article, selected topics involving the Plasmodium species that cause malaria in humans are reviewed.
    MeSH term(s) Animals ; Antimalarials ; Culicidae ; Host Specificity ; Humans ; Insect Vectors ; Malaria ; Plasmodium
    Chemical Substances Antimalarials
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2248072-9
    ISSN 1880-6805 ; 1880-6791 ; 1345-3475
    ISSN (online) 1880-6805
    ISSN 1880-6791 ; 1345-3475
    DOI 10.1186/s40101-020-00251-9
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  5. Article ; Online: Does self-reported physical activity relate to physical function and walking ability in female patients with hip osteoarthritis? A cross-sectional multicenter study.

    Shinonaga, Atsushi / Tanaka, Shigeharu / Tsuru, Takashi / Sato, Yuya / Taguchi, Masahiro / Takane, Ryosuke

    Physiotherapy theory and practice

    2024  , Page(s) 1–10

    Abstract: Background: The effectiveness of a high level of physical activity in maintaining physical function in patients with hip osteoarthritis has not been adequately examined.: Objective: This study aimed to determine whether self-reported physical ... ...

    Abstract Background: The effectiveness of a high level of physical activity in maintaining physical function in patients with hip osteoarthritis has not been adequately examined.
    Objective: This study aimed to determine whether self-reported physical activity is associated with physical function and walking ability in female patients with hip osteoarthritis.
    Methods: This was a multicenter cross-sectional study. The dependent variables were the lower-limb range of motion and muscle strength, and walking ability. Self-reported physical activity was assessed according to the guidelines of the Japanese Ministry of Health, Labor, and Welfare. Multiple regression models were used to determine whether physical activity was significantly related to the dependent variables after adjusting for confounding factors (age, body mass index, hip pain, comorbidity, and severity of hip osteoarthritis).
    Results: A total of 167 participants were included in the study. Physical activity was associated with muscle strength in hip flexion (affected/unaffected, β = 0.18/β = 0.16), abduction (β = 0.19/β = 0.26), knee extension (β = 0.22/β = 0.26), Timed Up-and-Go test (β = -0.16), and 5-m walking time test (β = -0.15).
    Conclusion: In female patients with hip osteoarthritis, greater physical activity was associated with greater lower extremity muscle strength and walking ability.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1045333-7
    ISSN 1532-5040 ; 0959-3985
    ISSN (online) 1532-5040
    ISSN 0959-3985
    DOI 10.1080/09593985.2024.2334761
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  6. Article: Voting for secession and siting nuisance facilities in a federation

    Sato, Shigeharu

    Applied approaches to societal institutions and economics : essays in honor of Moriki Hosoe , p. 333-347

    2017  , Page(s) 333–347

    Author's details Shigeharu Sato
    Language English
    Publisher Springer
    Publishing place Singapore
    Document type Article
    ISBN 978-981-10-5662-8 ; 981-10-5662-5
    Database ECONomics Information System

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  7. Article: Referendums for secession domino and redistribution

    Sato, Shigeharu

    Asia-Pacific journal of regional science Vol. 1, No. 2 , p. 451-469

    2017  Volume 1, Issue 2, Page(s) 451–469

    Author's details Shigeharu Sato
    Keywords Secession domino ; Referendum ; Voting ; Redistribution ; Fiscal policy ; Local public good ; Downs-Hotelling model
    Language English
    Publisher Springer
    Publishing place Tokyo, Japan
    Document type Article
    ZDB-ID 2915927-1 ; 2882268-7
    ISSN 2509-7954 ; 2509-7946
    ISSN (online) 2509-7954
    ISSN 2509-7946
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  8. Article ; Online: Coordination of apicoplast transcription in a malaria parasite by internal and host cues.

    Kobayashi, Yuki / Komatsuya, Keisuke / Imamura, Sousuke / Nozaki, Tomoyoshi / Watanabe, Yoh-Ichi / Sato, Shigeharu / Dodd, Antony N / Kita, Kiyoshi / Tanaka, Kan

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 28, Page(s) e2214765120

    Abstract: The malaria ... ...

    Abstract The malaria parasite
    MeSH term(s) Animals ; Apicoplasts/genetics ; Apicoplasts/metabolism ; Parasites/genetics ; Parasites/metabolism ; Cues ; Plasmodium falciparum/genetics ; Plasmodium falciparum/metabolism ; Malaria/metabolism ; Protozoan Proteins/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2214765120
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    Zs.A 1148: Show issues Location:
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  9. Article ; Online: Rapidly progressive mucus plugs in allergic bronchopulmonary mycosis.

    Miyazaki, Osamu / Igarashi, Akira / Sato, Kento / Inoue, Sumito / Yokoyama, Ryuto / Nakane, Masaki / Kodama, Sahoko / Hasegawa, Ryo / Ueki, Shigeharu / Yaguchi, Takashi / Watanabe, Akira / Watanabe, Masafumi

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2024  , Page(s) 1–6

    Abstract: Introduction: Allergic bronchopulmonary mycosis (ABPM) is a chronic airway disease characterized by the presence of fungi that trigger allergic reactions and airway obstruction. Here, we present a unique case of ABPM in which a patient experienced ... ...

    Abstract Introduction: Allergic bronchopulmonary mycosis (ABPM) is a chronic airway disease characterized by the presence of fungi that trigger allergic reactions and airway obstruction. Here, we present a unique case of ABPM in which a patient experienced sudden respiratory failure due to mucus plug-induced airway obstruction. The patient's life was saved by venovenous extracorporeal membrane oxygenation (VV-ECMO) and bronchoscopic removal of the plug. This case emphasizes the clinical significance of mucus plug-induced airway obstruction in the differential diagnosis of respiratory failure in patients with ABPM.
    Case study: A 52-year-old female clerical worker with no smoking history, presented with dyspnea. CT scan revealed mucus plugs in both lungs. Despite treatment, the dyspnea progressed rapidly to respiratory failure, leading to VV-ECMO placement.
    Results: CT revealed bronchial wall thickening, obstruction, and extensive atelectasis. Bronchoscopy revealed extensive mucus plugs that were successfully removed within two days. The patient's respiratory status significantly improved. Follow-up CT revealed no recurrence. Fungal cultures identified
    Conclusion: Differentiating between asthma exacerbation and mucus plug-induced airway obstruction in patients with ABPM and those with acute respiratory failure is challenging. Prompt evaluation of mucous plugs and atelectasis using CT and timely decision to introduce ECMO and bronchoscopic mucous plug removal are required.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2024.2312429
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  10. Article ; Online: Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters.

    Sato, Takahiko / Chiba, Takahito / Nakahara, Takeshi / Watanabe, Ken / Sakai, Sawako / Noguchi, Natsuko / Noto, Mai / Ueki, Shigeharu / Kono, Michihiro

    Journal of dermatological science

    2023  Volume 112, Issue 1, Page(s) 6–14

    Abstract: Background: Bullous pemphigoid (BP) is an autoimmune bullous disease in which abundant eosinophils accumulate in the blisters. Galectin-10 abounds in the cytoplasm of eosinophils and is released as a result of eosinophil extracellular trap cell death ( ... ...

    Abstract Background: Bullous pemphigoid (BP) is an autoimmune bullous disease in which abundant eosinophils accumulate in the blisters. Galectin-10 abounds in the cytoplasm of eosinophils and is released as a result of eosinophil extracellular trap cell death (EETosis).
    Objective: To identify EETosis and the pathological roles of galectin-10 in BP.
    Methods: EETosis and galectin-10 in BP blisters were confirmed by immunofluorescence and transmission electron microscopy. The concentrations of galectin-10 in serum and blister fluid from BP patients were studied by ELISA. The matrix metalloproteinase (MMP) expression in BP blisters was immunohistochemically compared to that in healthy controls. As an in vitro assay, normal human epidermal keratinocytes (NHEKs) and normal human dermal fibroblasts (NHDFs) were stimulated with galectin-10, followed by MMP expression measurement by real-time PCR and ELISA. The signaling pathways activated by galectin-10 were studied using Western blotting and confirmed by inhibition assays.
    Results: Galectin-10-containing eosinophil infiltration and the extracellular deposition of major basic protein were observed in BP blisters. The ultrastructural characteristics of tissue eosinophils indicated piecemeal degranulation and EETosis. In the BP patients, the concentration of galectin-10 was higher in the blister fluid than in the serum. Several types of MMPs were upregulated in BP blisters. Galectin-10 upregulated the production of MMPs through the pathways of p38 MAPK, ERK and JNK in NHEKs and NHDFs.
    Conclusion: In the BP blisters, the eosinophils underwent EETosis and released galectin-10. Galectin-10 might contribute to BP blister formation through the production of MMPs by keratinocytes and fibroblasts.
    MeSH term(s) Humans ; Blister/pathology ; Pemphigoid, Bullous ; Eosinophils ; Matrix Metalloproteinases ; Galectins
    Chemical Substances Matrix Metalloproteinases (EC 3.4.24.-) ; Galectins
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2023.07.008
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