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  1. Article ; Online: The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations.

    Tuminello, Elizabeth R / Han, S Duke

    International journal of Alzheimer's disease

    2011  Volume 2011, Page(s) 726197

    Abstract: Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD). However, research with younger populations of ε4 carriers has suggested that the APOE ε4 ... ...

    Abstract Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD). However, research with younger populations of ε4 carriers has suggested that the APOE ε4 allele may in fact be beneficial in earlier ages and may only confer risk of cognitive decline later in life. Accordingly, we and others have proposed that APOE may represent an example of antagonistic pleiotropy. Antagonistic pleiotropy is an evolutionary biology concept that proposes certain genes or alleles that may differentially impact fitness during different life stages. We critically review this hypothesis in light of new research of the impact of APOE on cognition and neural integrity across the lifespan. We provide recommendations for the revision of the antagonistic pleiotropy hypothesis of APOE and suggest important avenues for future research in this area.
    Language English
    Publishing date 2011-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573333-3
    ISSN 2090-0252 ; 2090-8024
    ISSN (online) 2090-0252
    ISSN 2090-8024
    DOI 10.4061/2011/726197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What the face and body reveal: in-group emotion effects and stereotyping of emotion in African American and European American children.

    Tuminello, Elizabeth R / Davidson, Denise

    Journal of experimental child psychology

    2011  Volume 110, Issue 2, Page(s) 258–274

    Abstract: This study examined whether 3- to 7-year-old African American and European American children's assessment of emotion in face-only, face+body, and body-only photographic stimuli was affected by in-group emotion recognition effects and racial or gender ... ...

    Abstract This study examined whether 3- to 7-year-old African American and European American children's assessment of emotion in face-only, face+body, and body-only photographic stimuli was affected by in-group emotion recognition effects and racial or gender stereotyping of emotion. Evidence for racial in-group effects was found, with European American children being more accurate when assessing emotion in European American photographs than African American photographs for some emotions. African American children were either equally proficient in recognizing emotion in African American and European American photographs or were more accurate with European American photographs for some emotions. Stereotyping of emotion was also found, with boys being more often labeled with "masculine" emotions (e.g., mad) and at least some girls being more often labeled with "feminine" emotions (e.g., happy). However, stereotyping effects were found only when the face was present in the stimuli and were not found with body-only stimuli. In-group effects, however, were not affected by type of photograph (face-only, body-only, or face+body), with children being unable to recognize at least some emotions from just the body postures alone (mad). These results have important implications for how future studies assess emotion recognition in children, particularly in terms of how emotion stimuli are constructed, the diversity of the stimuli, and who judges the stimuli.
    MeSH term(s) Adult ; African Americans/psychology ; Child ; Child, Preschool ; Emotions ; European Continental Ancestry Group/psychology ; Facial Expression ; Female ; Gender Identity ; Humans ; Judgment ; Male ; Nonverbal Communication ; Pattern Recognition, Visual ; Posture ; Recognition (Psychology) ; Sex Factors ; Stereotyping
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 218137-x
    ISSN 1096-0457 ; 0022-0965
    ISSN (online) 1096-0457
    ISSN 0022-0965
    DOI 10.1016/j.jecp.2011.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 670: Show issues Location:
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  3. Article ; Online: Executive functions in adolescents with spina bifida: relations with autonomy development and parental intrusiveness.

    Tuminello, Elizabeth R / Holmbeck, Grayson N / Olson, Rick

    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

    2011  Volume 18, Issue 2, Page(s) 105–124

    Abstract: The current study was part of a larger longitudinal investigation and examined the relation of parent-report and performance measures of executive functioning (EF) with measures of behavioral and emotional autonomy and parental intrusiveness in ... ...

    Abstract The current study was part of a larger longitudinal investigation and examined the relation of parent-report and performance measures of executive functioning (EF) with measures of behavioral and emotional autonomy and parental intrusiveness in adolescents with and without spina bifida (SB; n=65 in a comparison sample and 61 in an SB sample; M age=14.55, SD=0.63). For both groups, higher levels of parent-reported EF problems predicted higher levels of observed child dependency and lower levels of teacher-reported intrinsic motivation. Higher scores on performance EF measures predicted lower levels of observed child dependency and observed maternal intrusiveness for both groups. In adolescents with SB only, higher performance EF scores predicted higher intrinsic motivation and emotional autonomy from both mother and father and predicted lower levels of observed paternal intrusiveness. While causal conclusions cannot be drawn, EFs appear to be closely related to autonomy development and parental intrusiveness, particularly for adolescents with SB. These results suggest that the inclusion of EF training in interventions targeting adolescents with SB may be beneficial for autonomy development.
    MeSH term(s) Adolescent ; Emotions ; Executive Function ; Humans ; Longitudinal Studies ; Motivation ; Neuropsychological Tests ; Parent-Child Relations ; Parents/psychology ; Personal Autonomy ; Spinal Dysraphism/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2011-07-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1262599-1
    ISSN 1744-4136 ; 0929-7049
    ISSN (online) 1744-4136
    ISSN 0929-7049
    DOI 10.1080/09297049.2011.590470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5753: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Functional neuroimaging studies in normal aging.

    Guidotti Breting, Leslie M / Tuminello, Elizabeth R / Duke Han, S

    Current topics in behavioral neurosciences

    2012  Volume 10, Page(s) 91–111

    Abstract: With an expanding aging population, it is increasingly important to gain a better understanding of the changes in cognition and neural integrity that occur in normal aging. The advent of non-invasive functional neuroimaging techniques has spurred ... ...

    Abstract With an expanding aging population, it is increasingly important to gain a better understanding of the changes in cognition and neural integrity that occur in normal aging. The advent of non-invasive functional neuroimaging techniques has spurred researchers to examine cognition and neural functioning in healthy older adults. A significant amount of research has been produced since this time and has led to influential theories of aging such as the hemispheric asymmetry reduction for older adults (HAROLD) model and the compensatory recruitment hypothesis. This chapter discusses advances in our understanding of normal aging achieved through the use of functional neuroimaging. Research examining age-related changes in domains such as attention, memory, and executive functioning, as well as imaging of the resting-state and the influences of genetic risk factors (e.g., APOE genotype), are discussed. In conclusion, limitations of the current literature and important avenues for future research are proposed.
    MeSH term(s) Aging ; Apolipoproteins E/genetics ; Attention/physiology ; Brain/blood supply ; Brain/physiology ; Cognition/physiology ; Humans ; Image Processing, Computer-Assisted ; Learning ; Magnetic Resonance Imaging ; Oxygen/blood ; Visual Perception
    Chemical Substances Apolipoproteins E ; Oxygen (S88TT14065)
    Language English
    Publishing date 2012
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2011_139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Apolipoprotein E Antagonistic Pleiotropy Hypothesis

    Elizabeth R. Tuminello / S. Duke Han

    International Journal of Alzheimer's Disease, Vol

    Review and Recommendations

    2011  Volume 2011

    Keywords Geriatrics ; RC952-954.6 ; Special situations and conditions ; RC952-1245 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; DOAJ:Neurology
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Functional connectivity variations in mild cognitive impairment: associations with cognitive function.

    Han, S Duke / Arfanakis, Konstantinos / Fleischman, Debra A / Leurgans, Sue E / Tuminello, Elizabeth R / Edmonds, Emily C / Bennett, David A

    Journal of the International Neuropsychological Society : JINS

    2011  Volume 18, Issue 1, Page(s) 39–48

    Abstract: Participants with mild cognitive impairment (MCI) have a higher likelihood of developing Alzheimer's disease (AD) compared to those without MCI, and functional magnetic resonance neuroimaging (fMRI) used with MCI participants may prove to be an important ...

    Abstract Participants with mild cognitive impairment (MCI) have a higher likelihood of developing Alzheimer's disease (AD) compared to those without MCI, and functional magnetic resonance neuroimaging (fMRI) used with MCI participants may prove to be an important tool in identifying early biomarkers for AD. We tested the hypothesis that functional connectivity differences exist between older adults with and without MCI using resting-state fMRI. Data were collected on over 200 participants of the Rush Memory and Aging Project, a community-based, clinical-pathological cohort study of aging. From the cohort, 40 participants were identified as having MCI, and were compared to 40 demographically matched participants without cognitive impairment. MCI participants showed lesser functional connectivity between the posterior cingulate cortex and right and left orbital frontal, right middle frontal, left putamen, right caudate, left superior temporal, and right posterior cingulate regions; and greater connectivity with right inferior frontal, left fusiform, left rectal, and left precentral regions. Furthermore, in an alternate sample of 113, connectivity values in regions of difference correlated with episodic memory and processing speed. Results suggest functional connectivity values in regions of difference are associated with cognitive function and may reflect the presence of AD pathology and increased risk of developing clinical AD.
    MeSH term(s) Aged ; Aged, 80 and over ; Brain/blood supply ; Brain/pathology ; Brain Mapping ; Cognitive Dysfunction/pathology ; Cohort Studies ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mental Status Schedule ; Neural Pathways/blood supply ; Neural Pathways/physiology ; Neuropsychological Tests ; Oxygen/blood ; Statistics as Topic
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2011-10-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1230632-0
    ISSN 1469-7661 ; 1355-6177
    ISSN (online) 1469-7661
    ISSN 1355-6177
    DOI 10.1017/S1355617711001299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4440: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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