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  1. Article ; Online: Interview with Robert K. Kraft.

    Powers, Brian

    Healthcare (Amsterdam, Netherlands)

    2016  Volume 5, Issue 4, Page(s) 227–228

    MeSH term(s) Delivery of Health Care/economics ; Delivery of Health Care/organization & administration ; Fund Raising/manpower ; Fund Raising/trends ; Humans ; Public Health/manpower ; Public Health/methods ; Public Health/trends ; United States
    Language English
    Publishing date 2016-12-13
    Publishing country Netherlands
    Document type Interview
    ZDB-ID 2724773-9
    ISSN 2213-0772 ; 2213-0764 ; 2213-0772
    ISSN (online) 2213-0772 ; 2213-0764
    ISSN 2213-0772
    DOI 10.1016/j.hjdsi.2016.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Healthy people and the design sciences: the Robert Wood Johnson Foundation advances the frontier.

    McGinnis, J Michael / Powers, Brian W

    American journal of preventive medicine

    2012  Volume 43, Issue 5 Suppl 4, Page(s) S407–9

    MeSH term(s) Environment Design ; Exercise ; Foundations/organization & administration ; Healthy People Programs/methods ; Healthy People Programs/organization & administration ; Humans ; Motor Activity ; Program Evaluation ; United States
    Language English
    Publishing date 2012-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2012.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2096: Show issues Location:
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  3. Book: Forensic toxicology

    Powers, Robert H. / Dean, Dorothy

    mechanisms and pathology

    2016  

    Author's details Robert H. Powers ; Dorothy E. Dean
    Language English
    Size ix, 263 Seiten, Illustrationen
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton ; London ; New York
    Publishing country United States
    Document type Book
    HBZ-ID HT018314557
    ISBN 978-1-4665-8194-4 ; 1-4665-8194-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 501 available for loan (reading room) Lesesaal EG

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  4. Book: International disaster nursing

    Powers, Robert / Daily, Elaine

    a publication of the World Association for Disaster and Emergency Medicine

    2010  

    Institution World Association for Disaster and Emergency Medicine
    Author's details Robert Powers and Elaine Daily ed
    Language English
    Size XXIII, 614 S. : Ill., 26 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016394578
    ISBN 978-0-521-16800-7 ; 0-521-16800-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 2925 order for loan Magazin

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  5. Article ; Online: Multiplatform untargeted metabolomics.

    Jeppesen, Micah J / Powers, Robert

    Magnetic resonance in chemistry : MRC

    2023  Volume 61, Issue 12, Page(s) 628–653

    Abstract: Metabolomics samples like human urine or serum contain upwards of a few thousand metabolites, but individual analytical techniques can only characterize a few hundred metabolites at best. The uncertainty in metabolite identification commonly encountered ... ...

    Abstract Metabolomics samples like human urine or serum contain upwards of a few thousand metabolites, but individual analytical techniques can only characterize a few hundred metabolites at best. The uncertainty in metabolite identification commonly encountered in untargeted metabolomics adds to this low coverage problem. A multiplatform (multiple analytical techniques) approach can improve upon the number of metabolites reliably detected and correctly assigned. This can be further improved by applying synergistic sample preparation along with the use of combinatorial or sequential non-destructive and destructive techniques. Similarly, peak detection and metabolite identification strategies that employ multiple probabilistic approaches have led to better annotation decisions. Applying these techniques also addresses the issues of reproducibility found in single platform methods. Nevertheless, the analysis of large data sets from disparate analytical techniques presents unique challenges. While the general data processing workflow is similar across multiple platforms, many software packages are only fully capable of processing data types from a single analytical instrument. Traditional statistical methods such as principal component analysis were not designed to handle multiple, distinct data sets. Instead, multivariate analysis requires multiblock or other model types for understanding the contribution from multiple instruments. This review summarizes the advantages, limitations, and recent achievements of a multiplatform approach to untargeted metabolomics.
    MeSH term(s) Humans ; Metabolome ; Reproducibility of Results ; Metabolomics/methods ; Multivariate Analysis ; Principal Component Analysis
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.5350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Perspectives of US Adults on Antimicrobial Trials With Noninferiority Designs.

    Morlock, Robert / Rose, John / Powers, John H

    JAMA network open

    2023  Volume 6, Issue 5, Page(s) e2316297

    MeSH term(s) Humans ; Adult ; Anti-Infective Agents ; Research Design
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.16297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frontiers in NMR metabolomics.

    Nagana Gowda, G A / Powers, Robert

    Magnetic resonance in chemistry : MRC

    2023  Volume 61, Issue 12, Page(s) 627

    MeSH term(s) Magnetic Resonance Spectroscopy ; Metabolomics ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Editorial
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.5400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Meta-Analysis Reveals Both the Promises and the Challenges of Clinical Metabolomics.

    Roth, Heidi E / Powers, Robert

    Cancers

    2022  Volume 14, Issue 16

    Abstract: Clinical metabolomics is a rapidly expanding field focused on identifying molecular biomarkers to aid in the efficient diagnosis and treatment of human diseases. Variations in study design, metabolomics methodologies, and investigator protocols raise ... ...

    Abstract Clinical metabolomics is a rapidly expanding field focused on identifying molecular biomarkers to aid in the efficient diagnosis and treatment of human diseases. Variations in study design, metabolomics methodologies, and investigator protocols raise serious concerns about the accuracy and reproducibility of these potential biomarkers. The explosive growth of the field has led to the recent availability of numerous replicate clinical studies, which permits an evaluation of the consistency of biomarkers identified across multiple metabolomics projects. Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related death and has the lowest five-year survival rate primarily due to the lack of an early diagnosis and the limited treatment options. Accordingly, PDAC has been a popular target of clinical metabolomics studies. We compiled 24 PDAC metabolomics studies from the scientific literature for a detailed meta-analysis. A consistent identification across these multiple studies allowed for the validation of potential clinical biomarkers of PDAC while also highlighting variations in study protocols that may explain poor reproducibility. Our meta-analysis identified 10 metabolites that may serve as PDAC biomarkers and warrant further investigation. However, 87% of the 655 metabolites identified as potential biomarkers were identified in single studies. Differences in cohort size and demographics,
    Language English
    Publishing date 2022-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14163992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Flow states of two dimensional active gels driven by external shear.

    Luo, Wan / Baskaran, Aparna / Pelcovits, Robert A / Powers, Thomas R

    Soft matter

    2024  Volume 20, Issue 4, Page(s) 738–753

    Abstract: Using a minimal hydrodynamic model, we theoretically and computationally study the Couette flow of active gels in straight and annular two-dimensional channels subject to an externally imposed shear. The gels are isotropic in the absence of externally- ... ...

    Abstract Using a minimal hydrodynamic model, we theoretically and computationally study the Couette flow of active gels in straight and annular two-dimensional channels subject to an externally imposed shear. The gels are isotropic in the absence of externally- or activity-driven shear, but have nematic order that increases with shear rate. Using the finite element method, we determine the possible flow states for a range of activities and shear rates. Linear stability analysis of an unconfined gel in a straight channel shows that an externally imposed shear flow can stabilize an extensile fluid that would be unstable to spontaneous flow in the absence of the shear flow, and destabilize a contractile fluid that would be stable against spontaneous flow in the absence of shear flow. These results are in rough agreement with the stability boundaries between the base shear flow state and the nonlinear flow states that we find numerically for a confined active gel. For extensile fluids, we find three kinds of nonlinear flow states in the range of parameters we study: unidirectional flows, oscillatory flows, and dancing flows. To highlight the activity-driven spontaneous component of the nonlinear flows, we characterize these states by the average volumetric flow rate and the wall stress. For contractile fluids, we only find the linear shear flow and a nonlinear unidirectional flow in the range of parameters that we studied. For large magnitudes of the activity, the unidirectional contractile flow develops a boundary layer. Our analysis of annular channels shows how curvature of the streamlines in the base flow affects the transitions among flow states.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm00919j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A RANGE-WIDE ECTOPARASITE SURVEY FOR ALLEGHENY WOODRATS (NEOTOMA MAGISTER).

    Powers, Karen E / Eckerlin, Ralph P / Sheehy, Robert R / Reynolds, Richard J

    The Journal of parasitology

    2024  Volume 110, Issue 2, Page(s) 179–185

    Abstract: Allegheny woodrats (Neotoma magister) are karst-specializing rodents that are rare or in conservation need in many states within their current range. Parasitism and habitat fragmentation have been suggested as primary reasons for declining populations. ... ...

    Abstract Allegheny woodrats (Neotoma magister) are karst-specializing rodents that are rare or in conservation need in many states within their current range. Parasitism and habitat fragmentation have been suggested as primary reasons for declining populations. The presence, prevalence, and impact of ectoparasites, including fleas, ticks, and bots, is not fully understood rangewide. We collected Allegheny woodrat ectoparasites across 8 states in their range, identifying parasites via morphological and genetic means. Across contributions from 8 states, we discovered 2 woodrat-specific fleas parasitizing Allegheny woodrats: Orchopeas pennsylvanicus (all contributing states, n = 228) and Epitedia cavernicola (Indiana only, n = 9). The former was a new state record in New Jersey and Ohio. Woodrat specialists Ixodes woodi were morphologically identified as the dominant tick species (n = 38), and our contributions to genetic databases may ease confusion in future efforts. Three generalist species of ticks representing 8 individuals were identified as Dermacentor variabilis, Amblyomma americanum, and Ixodes scapularis. Only 2 bot fly species were recognized in Allegheny woodrats: 1 squirrel bot (Cuterebra emasculator) and 10 individuals of Cuterebra sp. not genetically conspecific to any known eastern U.S. rodent bot. The host specificity for fleas is not surprising, given that previous small-scale surveys and ticks primarily appear to be a mix of genus-specific (Ixodes woodi) and generalist species. There remains uncertainty with bots via morphological and genetic analyses. Our survey presents a wide-ranging baseline survey for Allegheny woodrats across their range, emphasizing the diversity (or specificity) of parasite groups for this species. An understanding of Allegheny woodrats and the health impact of ectoparasites is imperative because they face myriad challenges rangewide, especially considering the bot-driven demise of 1 woodrat in our study. Ectoparasites can have a marked impact on already-declining woodrat populations across their range and should not be overlooked in future surveys.
    MeSH term(s) Animals ; Ixodes ; Parasites ; Indiana ; Sigmodontinae/parasitology ; Siphonaptera
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
    DOI 10.1645/23-118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.76: Show issues Location:
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