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Article ; Online: Innovative governance systems and green innovations of agriculture-related enterprises based on the approach of fuzzy-set qualitative comparative analysis

Huricha Bao / Chibo Chen / Yuemin Liu

Frontiers in Environmental Science, Vol

2022 Volume 10

Abstract: The green innovation (GI) of agriculture-related enterprises has been an important factor to the ecological and sustainable development of agriculture. This research integrates the eight elements of the internally and externally governing mechanisms in ... ...

Abstract	The green innovation (GI) of agriculture-related enterprises has been an important factor to the ecological and sustainable development of agriculture. This research integrates the eight elements of the internally and externally governing mechanisms in the innovative governance system (IGS), adopts the fuzzy-set qualitative comparative analysis (fsQCA) from the configuration perspective, taking the data of A-shares’ listed agricultural companies in Shanghai and Shenzhen stock markets from 2007 to 2019 as samples, and explores the configuration effects of highly green innovations (GIs) from the collaborative matching of various elements of the enterprises’ IGS. The research results showed that 1) a single element of this IGS was unable to become a requisite for agriculture-related enterprises to generate highly GIs, but government subsidies played a more universal role in such a process; 2) the “multiple synergies” of various elements in the enterprises’ IGS formed six different configurations to drive highly GIs, namely, three major models of internal and external supervision with an external incentive, internal supervision with internal and external incentives, and internal and external supervision with internal and external incentives; 3) there were five different paths for the IGS of agriculture-related enterprises to generate non-highly GIs, which were in asymmetry with the configuration paths to generate the highly GIs.
Keywords	external governance ; internal governance ; synergistic matching ; highly green innovations ; fsQCA ; Environmental sciences ; GE1-350
Subject code	320
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic roles of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, and cancer antigen 125 for ovarian cancer

Liuqing Ye / Guoming Zhou / Lingling Zhou / Dongguo Wang / Shunqiang Xiong / Chibo Liu / Guobing Zhang

Journal of International Medical Research, Vol

2023 Volume 51

Abstract: Objective To compare the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP) level, and cancer antigen 125 (CA125) level for ovarian cancer (OC). ... ...

Abstract	Objective To compare the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP) level, and cancer antigen 125 (CA125) level for ovarian cancer (OC). Methods Data of 72 patients with OC, 50 patients with benign ovarian disease, and 46 healthy controls were retrospectively analyzed, and receiver operating characteristic analysis was performed. Results The platelet count was higher in patients with a tumor diameter of ≥10 vs. <10 cm. The absolute lymphocyte count was significantly higher in patients with stage I/II OC than in those with multiple and stage III/IV OC. The absolute monocyte count, NLR, MLR, and CA125 were significantly higher in patients with multiple and stage III/IV OC than in those with single and stage I/II OC. The NLR, PLR, MLR, fibrinogen, D-dimer, CRP, and CA125 were useful for distinguishing between the OC and healthy control groups. Conclusions Our analysis showed that the following combinations have practical diagnostic value in OC: NLR + PLR + MLR + CA125, NLR + PLR + MLR + CA125 + CRP, NLR + MLR +PLR + CA125 + CRP + fibrinogen, and NLR + MLR + PLR + CA125 + CRP + fibrinogen + D-dimer.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clustering of cardio-metabolic risk factors and pre-diabetes among U.S. adolescents

Chibo Liu / Susu Wu / Xiao Pan

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 7

Abstract: Abstract Few studies have assessed the association between clustering of cardio-metabolic risk factors (CMRFs) and pre-diabetes in children or adolescents. We aimed to examine the association between clustering of CMRFs and pre-diabetes among U.S. ... ...

Abstract	Abstract Few studies have assessed the association between clustering of cardio-metabolic risk factors (CMRFs) and pre-diabetes in children or adolescents. We aimed to examine the association between clustering of CMRFs and pre-diabetes among U.S. adolescents. Data were available for 5,633 U.S. adolescents aged 12–19 years from the National Health and Nutrition Examination Surveys 1999–2014. Pre-diabetes was defined as impaired fasting glucose (IFG) (fasting plasma glucose 100–125 mg/dL), impaired glucose tolerance (IGT) (2-h plasma glucose 140–199 mg/dL) or elevated hemoglobin A1c (HbA1c) (HbA1c 5.7–6.4%). The individual CMRFs considered in the present study were as follows: waist-to-height ratio, blood pressure, triglycerides, and high-density lipoprotein cholesterol. CMRFs were defined based on the modified National Cholesterol Education Program (NCEP) criteria or the modified International Diabetes Federation (IDF) criteria. Logistic regression analysis was used to examine the association between clustering of CMRFs and pre-diabetes with adjustment for potential covariates. Among 5633 adolescents, 11.4% had IFG, 4.7% had IGT, 4.5% had elevated HbA1c and 16.1% had pre-diabetes. Compared with adolescents with no CMRFs, the odds ratios (ORs) with 95% confidence intervals (CIs) for pre-diabetes across the clustering of CMRFs (i.e., 1, 2, 3, and 4) were 1.32 (1.03–1.68), 2.07 (1.55–2.76), 2.52 (1.69–3.76), and 5.41 (3.14–9.32), respectively, based on the modified NCEP criteria. The corresponding ORs with 95% CIs were 1.16 (0.89–1.51), 1.78 (1.35–2.36), 3.07 (1.89–4.98) and 12.20 (3.93–37.89), respectively, based on the modified IDF criteria. The present study suggests that the clustering of CMRFs is associated with increased pre-diabetes among U.S. adolescents. It might be necessary for effective strategies and measures targeting adolescents with clustering of CMRFs, including those with less than 3 risk factors.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic roles of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein, and cancer antigen 125 for ovarian cancer.

Ye, Liuqing / Zhou, Guoming / Zhou, Lingling / Wang, Dongguo / Xiong, Shunqiang / Liu, Chibo / Zhang, Guobing

The Journal of international medical research

2023 Volume 51, Issue 12, Page(s) 3000605231218557

Abstract: Objective: To compare the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP) level, and cancer antigen 125 (CA125) level for ovarian cancer (OC).! ...

Abstract	Objective: To compare the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP) level, and cancer antigen 125 (CA125) level for ovarian cancer (OC). Methods: Data of 72 patients with OC, 50 patients with benign ovarian disease, and 46 healthy controls were retrospectively analyzed, and receiver operating characteristic analysis was performed. Results: The platelet count was higher in patients with a tumor diameter of ≥10 vs. <10 cm. The absolute lymphocyte count was significantly higher in patients with stage I/II OC than in those with multiple and stage III/IV OC. The absolute monocyte count, NLR, MLR, and CA125 were significantly higher in patients with multiple and stage III/IV OC than in those with single and stage I/II OC. The NLR, PLR, MLR, fibrinogen, D-dimer, CRP, and CA125 were useful for distinguishing between the OC and healthy control groups. Conclusions: Our analysis showed that the following combinations have practical diagnostic value in OC: NLR + PLR + MLR + CA125, NLR + PLR + MLR + CA125 + CRP, NLR + MLR +PLR + CA125 + CRP + fibrinogen, and NLR + MLR + PLR + CA125 + CRP + fibrinogen + D-dimer.
MeSH term(s)	Humans ; Female ; Neutrophils ; Monocytes ; C-Reactive Protein ; CA-125 Antigen ; Retrospective Studies ; Lymphocytes ; Blood Platelets ; Ovarian Neoplasms/diagnosis ; Fibrinogen
Chemical Substances	C-Reactive Protein (9007-41-4) ; CA-125 Antigen ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231218557
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Article ; Online: Is interleukin-6 circulating levels associated with coronary artery disease?

Liu, Chibo

International journal of cardiology

2012 Volume 157, Issue 2, Page(s) 270; author reply 253–4

MeSH term(s)	Coronary Artery Disease/blood ; Coronary Artery Disease/genetics ; Genetic Variation/genetics ; Humans ; Interleukin-6/blood ; Interleukin-6/genetics ; Mendelian Randomization Analysis/methods
Chemical Substances	Interleukin-6
Language	English
Publishing date	2012-05-31
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2012.03.015
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Article ; Online: Clustering of cardio-metabolic risk factors and pre-diabetes among U.S. adolescents.

Liu, Chibo / Wu, Susu / Pan, Xiao

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5015

Abstract: Few studies have assessed the association between clustering of cardio-metabolic risk factors (CMRFs) and pre-diabetes in children or adolescents. We aimed to examine the association between clustering of CMRFs and pre-diabetes among U.S. adolescents. ... ...

Abstract	Few studies have assessed the association between clustering of cardio-metabolic risk factors (CMRFs) and pre-diabetes in children or adolescents. We aimed to examine the association between clustering of CMRFs and pre-diabetes among U.S. adolescents. Data were available for 5,633 U.S. adolescents aged 12-19 years from the National Health and Nutrition Examination Surveys 1999-2014. Pre-diabetes was defined as impaired fasting glucose (IFG) (fasting plasma glucose 100-125 mg/dL), impaired glucose tolerance (IGT) (2-h plasma glucose 140-199 mg/dL) or elevated hemoglobin A1c (HbA1c) (HbA1c 5.7-6.4%). The individual CMRFs considered in the present study were as follows: waist-to-height ratio, blood pressure, triglycerides, and high-density lipoprotein cholesterol. CMRFs were defined based on the modified National Cholesterol Education Program (NCEP) criteria or the modified International Diabetes Federation (IDF) criteria. Logistic regression analysis was used to examine the association between clustering of CMRFs and pre-diabetes with adjustment for potential covariates. Among 5633 adolescents, 11.4% had IFG, 4.7% had IGT, 4.5% had elevated HbA1c and 16.1% had pre-diabetes. Compared with adolescents with no CMRFs, the odds ratios (ORs) with 95% confidence intervals (CIs) for pre-diabetes across the clustering of CMRFs (i.e., 1, 2, 3, and 4) were 1.32 (1.03-1.68), 2.07 (1.55-2.76), 2.52 (1.69-3.76), and 5.41 (3.14-9.32), respectively, based on the modified NCEP criteria. The corresponding ORs with 95% CIs were 1.16 (0.89-1.51), 1.78 (1.35-2.36), 3.07 (1.89-4.98) and 12.20 (3.93-37.89), respectively, based on the modified IDF criteria. The present study suggests that the clustering of CMRFs is associated with increased pre-diabetes among U.S. adolescents. It might be necessary for effective strategies and measures targeting adolescents with clustering of CMRFs, including those with less than 3 risk factors.
MeSH term(s)	Adolescent ; Blood Glucose/metabolism ; Blood Pressure/physiology ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Child ; Cholesterol, HDL/blood ; Cluster Analysis ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Fasting ; Female ; Glucose Intolerance/blood ; Glucose Intolerance/epidemiology ; Glucose Intolerance/physiopathology ; Glycated Hemoglobin A/metabolism ; Humans ; Logistic Models ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/physiopathology ; Nutrition Surveys ; Odds Ratio ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Prediabetic State/physiopathology ; Risk Factors ; Triglycerides/blood ; United States/epidemiology ; Waist-Height Ratio ; Young Adult
Chemical Substances	Blood Glucose ; Cholesterol, HDL ; Glycated Hemoglobin A ; Triglycerides ; hemoglobin A1c protein, human
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84128-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Application of SELDI-TOF-MS in Clinical Diagnosis of Cancers

Chibo Liu

Journal of Biomedicine and Biotechnology, Vol

2011 Volume 2011

Abstract: Cancer diagnosis is important, and the early diagnosis of cancers could predict a more successful treatment. The proteomic studies emerged to be useful in combined analyses of samples from patients and provide more accurate diagnosis when compared to the ...

Abstract	Cancer diagnosis is important, and the early diagnosis of cancers could predict a more successful treatment. The proteomic studies emerged to be useful in combined analyses of samples from patients and provide more accurate diagnosis when compared to the single-factor-based diagnosis. In recent years, cancer detection with surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) is flourishing and brought significant progress in this area. This paper summarizes some recent results with this technique for cancer diagnosis.
Keywords	Biotechnology ; TP248.13-248.65 ; Medicine ; R
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Associations between polymorphisms of tumor necrosis factor-α gene and breast cancer risk.

Liu, Chibo

Breast cancer research and treatment

2011 Volume 129, Issue 3, Page(s) 1015–1017

MeSH term(s)	Breast Neoplasms/genetics ; Female ; Humans ; Polymorphism, Genetic ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	2011-10
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-011-1580-5
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Article ; Online: The association between AURKA T91A polymorphism and breast cancer risk.

Liu, Chibo

Breast cancer research and treatment

2011 Volume 129, Issue 1, Page(s) 281–283

MeSH term(s)	Breast Neoplasms/genetics ; Female ; Humans ; Polymorphism, Single Nucleotide ; Protein-Serine-Threonine Kinases/genetics
Chemical Substances	Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2011-08
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-011-1497-z
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Article ; Online: Adaptation of Droplet Digital PCR-Based HIV Transcription Profiling to Digital PCR and Association of HIV Transcription and Total or Intact HIV DNA.

Tumpach, Carolin / Rhodes, Ajantha / Kim, Youry / Ong, Jesslyn / Liu, Haoming / Chibo, Doris / Druce, Julian / Williamson, Deborah / Hoh, Rebecca / Deeks, Steven G / Yukl, Steven A / Roche, Michael / Lewin, Sharon R / Telwatte, Sushama

Viruses

2023 Volume 15, Issue 7

Abstract: In most people living with HIV (PLWH) on effective antiretroviral therapy (ART), cell-associated viral transcripts are readily detectable in CD4+ T cells despite the absence of viremia. Quantification of HIV RNA species provides insights into the ... ...

Abstract	In most people living with HIV (PLWH) on effective antiretroviral therapy (ART), cell-associated viral transcripts are readily detectable in CD4+ T cells despite the absence of viremia. Quantification of HIV RNA species provides insights into the transcriptional activity of proviruses that persist in cells and tissues throughout the body during ART ('HIV reservoir'). One such technique for HIV RNA quantitation, 'HIV transcription profiling', developed in the Yukl laboratory, measures a series of HIV RNA species using droplet digital PCR. To take advantage of advances in digital (d)PCR, we adapted the 'HIV transcription profiling' technique to Qiagen's dPCR platform (QIAcuity) and compared its performance to droplet digital (dd)PCR (Bio-Rad QX200 system). Using RNA standards, the two technologies were tested in parallel and assessed for multiple parameters including sensitivity, specificity, linearity, and intra- and inter-assay variability. The newly validated dPCR assays were then applied to samples from PLWH to determine HIV transcriptional activity relative to HIV reservoir size. We report that HIV transcriptional profiling was readily adapted to dPCR and assays performed similarly to ddPCR, with no differences in assay characteristics. We applied these assays in a cohort of 23 PLWH and found that HIV reservoir size, based on genetically intact proviral DNA, does not predict HIV transcriptional activity. In contrast, levels of total DNA correlated with levels of most HIV transcripts (initiated, proximally and distally elongated, unspliced, and completed, but not multiply spliced), suggesting that a considerable proportion of HIV transcripts likely originate from defective proviruses. These findings may have implications for measuring and assessing curative strategies and clinical trial outcomes.
MeSH term(s)	Humans ; DNA, Viral/genetics ; DNA, Viral/analysis ; HIV-1/genetics ; Polymerase Chain Reaction ; Proviruses/genetics ; CD4-Positive T-Lymphocytes ; HIV Infections ; RNA, Viral/analysis ; Viral Load/methods
Chemical Substances	DNA, Viral ; RNA, Viral
Language	English
Publishing date	2023-07-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15071606
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