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  1. Article ; Online: Editorial: Chagas disease novel drug targets and treatments.

    Duschak, Vilma G / Paniz Mondolfi, Alberto E / Benaim, Gustavo

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1199715

    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1199715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas' Disease and Leishmaniasis.

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Sordillo, Emilia Mia

    Current pharmaceutical design

    2020  Volume 27, Issue 15, Page(s) 1825–1833

    Abstract: The repurposing or repositioning of previously-approved drugs has become an accepted strategy for the expansion of the pharmacopeia for neglected diseases. Accordingly, amiodarone, an inexpensive and extensively- used class III antiarrhythmic has been ... ...

    Abstract The repurposing or repositioning of previously-approved drugs has become an accepted strategy for the expansion of the pharmacopeia for neglected diseases. Accordingly, amiodarone, an inexpensive and extensively- used class III antiarrhythmic has been proposed as a treatment for Chagas' disease and leishmaniasis. Amiodarone has a potent trypanocidal and leishmanicidal action, mainly acting through the disruption of parasite intracellular Ca
    MeSH term(s) Amiodarone/pharmacology ; Amiodarone/therapeutic use ; Animals ; Calcium ; Chagas Disease/drug therapy ; Dogs ; Leishmaniasis/drug therapy ; Trypanocidal Agents ; Trypanosoma cruzi
    Chemical Substances Trypanocidal Agents ; Amiodarone (N3RQ532IUT) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-09-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666200928161403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Laboratory Diagnosis of SARS-CoV-2 Pneumonia.

    Gitman, Melissa R / Shaban, Maryia V / Paniz-Mondolfi, Alberto E / Sordillo, Emilia M

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 7

    Abstract: The emergence and rapid proliferation of Coronavirus Disease-2019, throughout the past year, has put an unprecedented strain on the global schema of health infrastructure and health economy. The time-sensitive agenda of identifying the virus in humans ... ...

    Abstract The emergence and rapid proliferation of Coronavirus Disease-2019, throughout the past year, has put an unprecedented strain on the global schema of health infrastructure and health economy. The time-sensitive agenda of identifying the virus in humans and delivering a vaccine to the public constituted an effort to flatten the statistical curve of viral spread as it grew exponentially. At the forefront of this effort was an exigency of developing rapid and accurate diagnostic strategies. These have emerged in various forms over the past year-each with strengths and weaknesses. To date, they fall into three categories: (1) those isolating and replicating viral RNA in patient samples from the respiratory tract (Nucleic Acid Amplification Tests; NAATs), (2) those detecting the presence of viral proteins (Rapid Antigen Tests; RATs) and serology-based exams identifying antibodies to the virus in whole blood and serum. The latter vary in their detection of immunoglobulins of known prevalence in early-stage and late-stage infection. With this review, we delineate the categories of testing measures developed to date, analyze the efficacy of collecting patient specimens from diverse regions of the respiratory tract, and present the up and coming technologies which have made pathogen identification easier and more accessible to the public.
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11071270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies.

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Ramírez, Juan David / Sordillo, Emilia Mia

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 777008

    MeSH term(s) Chagas Disease ; Humans ; Leishmaniasis ; Molecular Biology ; Trypanosoma cruzi
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.777008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Florid

    Shea, Stephanie / Paniz-Mondolfi, Alberto / Sordillo, Emilia / Nowak, Michael / Dekio, Fumiko

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2021  Volume 24, Issue 4, Page(s) 361–365

    Abstract: ... Bacillus ... ...

    Abstract Bacillus cereus
    MeSH term(s) Adult ; Bacillus cereus/isolation & purification ; Chorioamnionitis/diagnosis ; Chorioamnionitis/microbiology ; Chorioamnionitis/pathology ; Female ; Fetal Death/etiology ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/pathology ; Humans ; Male ; Placenta/microbiology ; Placenta/pathology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/pathology ; Pregnancy, Twin
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/1093526621999026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5063: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Concerns about influenza H5N8 outbreaks in humans and birds: Facing the next airborne pandemic?

    Rodriguez-Morales, Alfonso J / Bonilla-Aldana, D Katterine / Paniz-Mondolfi, Alberto E

    Travel medicine and infectious disease

    2021  Volume 41, Page(s) 102054

    MeSH term(s) Animals ; Animals, Wild ; Birds ; Disease Outbreaks/prevention & control ; Humans ; Influenza A Virus, H5N8 Subtype ; Influenza in Birds/epidemiology ; Influenza in Birds/prevention & control ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics/prevention & control ; Phylogeny
    Language English
    Publishing date 2021-04-03
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2021.102054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cutaneous leishmaniosis due to Leishmania mexicana in a cat treated with cryotherapy.

    Mendoza, Yeimar / Colmenares, Alegria / Hernández-Pereira, Carlos E / Shaban, Maryia V / Mogollón, Alexander / Morales-Panza, R J / Suarez-Alvarado, Maria Jose / Sordillo, Emilia M / Kato, Hirotomo / Paniz-Mondolfi, Alberto E

    Veterinary dermatology

    2022  Volume 33, Issue 5, Page(s) 450–453

    Abstract: We report the novel use of cryosurgery to treat cutaneous feline leishmaniosis (FeL) in a domestic cat from mid-western Venezuela. Amastigotes, evident by microscopy in aspirates from the nodular, erythematous nose lesions, were identified as Leishmania ... ...

    Abstract We report the novel use of cryosurgery to treat cutaneous feline leishmaniosis (FeL) in a domestic cat from mid-western Venezuela. Amastigotes, evident by microscopy in aspirates from the nodular, erythematous nose lesions, were identified as Leishmania mexicana by cytochrome b gene sequence analysis. Lesions resolved completely without relapse after 14 months.
    MeSH term(s) Animals ; Cat Diseases/surgery ; Cats ; Cryotherapy/veterinary ; Leishmania mexicana ; Leishmaniasis, Cutaneous/therapy ; Leishmaniasis, Cutaneous/veterinary
    Language English
    Publishing date 2022-05-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2011122-8
    ISSN 1365-3164 ; 0959-4493
    ISSN (online) 1365-3164
    ISSN 0959-4493
    DOI 10.1111/vde.13083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Sordillo, Emilia Mia / Martinez-Sotillo, Nathalia

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 46

    Abstract: There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite, ...

    Abstract There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite,
    MeSH term(s) Amiodarone ; Calcium ; Chagas Disease/drug therapy ; Homeostasis ; Humans ; Trypanosoma cruzi
    Chemical Substances Amiodarone (N3RQ532IUT) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Microbiome Alterations Driven by

    Castañeda, Sergio / Muñoz, Marina / Hotez, Peter J / Bottazzi, Maria Elena / Paniz-Mondolfi, Alberto E / Jones, Kathryn M / Mejia, Rojelio / Poveda, Cristina / Ramírez, Juan David

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0019923

    Abstract: Alterations caused by Trypanosoma cruzi in the composition of gut microbiome may play a vital role in the host-parasite interactions that shapes physiology and immune responses against infection. Thus, a better understanding of this parasite-host- ... ...

    Abstract Alterations caused by Trypanosoma cruzi in the composition of gut microbiome may play a vital role in the host-parasite interactions that shapes physiology and immune responses against infection. Thus, a better understanding of this parasite-host-microbiome interaction may yield relevant information in the comprehension of the pathophysiology of the disease and the development of new prophylactic and therapeutic alternatives. Therefore, we implemented a murine model with two mice strains (BALB/c and C57BL/6) to evaluate the impact of Trypanosoma cruzi (Tulahuen strain) infection on the gut microbiome utilizing cytokine profiling and shotgun metagenomics. Higher parasite burdens were observed in cardiac and intestinal tissues, including changes in anti-inflammatory (interleukin-4 [IL-4] and IL-10) and proinflammatory (gamma interferon, tumor necrosis factor alpha, and IL-6) cytokines. Bacterial species such as Bacteroides thetaiotaomicron, Faecalibaculum rodentium, and Lactobacillus johnsonii showed a decrease in relative abundance, while Akkermansia muciniphila and Staphylococcus xylosus increased. Likewise, as infection progressed, there was a decrease in gene abundances related to metabolic processes such as lipid synthesis (including short-chain fatty acids) and amino acid synthesis (including branched-chain amino acids). High-quality metagenomic assembled genomes of L. johnsonii and A. muciniphila among other species were reconstructed, confirming, functional changes associated with metabolic pathways that are directly affected by the loss of abundance of specific bacterial taxa.
    MeSH term(s) Mice ; Animals ; Disease Models, Animal ; Mice, Inbred C57BL ; Chagas Disease/parasitology ; Trypanosoma cruzi ; Microbiota
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00199-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Utility of liquid biopsy in diagnosing isolated cerebral phaeohyphomycosis: illustrative case.

    Arrighi-Allisan, Annie E / Vidaurrazaga, Monica M / De Chavez, Vincent B / Bryce, Clare H / Rutland, John W / Paniz-Mondolfi, Alberto E / Sordillo, Emilia M / Nowak, Michael D / Gitman, Melissa R / Fuller, Risa / Baneman, Emily / Yong, Raymund L

    Journal of neurosurgery. Case lessons

    2022  Volume 3, Issue 5

    Abstract: Background: Cladophialophora bantiana is a dematiaceous, saprophytic fungus and a rare but reported cause of intracranial abscesses due to its strong neurotropism. Although it predominantly affects immunocompetent individuals with environmental exposure, ...

    Abstract Background: Cladophialophora bantiana is a dematiaceous, saprophytic fungus and a rare but reported cause of intracranial abscesses due to its strong neurotropism. Although it predominantly affects immunocompetent individuals with environmental exposure, more recently, its significance as a highly lethal opportunistic infection in transplant recipients has been recognized. Successful treatment requires timely but often challenging diagnosis, followed by complete surgical excision. Next-generation sequencing of microbial cell-free DNA (cfDNA) from plasma is a novel diagnostic method with the potential to identify invasive fungal infections more rapidly and less invasively than conventional microbiological testing, including brain biopsy.
    Observations: The authors described the case of a recipient of a liver transplant who presented with seizures and was found to have innumerable ring-enhancing intracranial lesions. The Karius Test, a commercially available method of next-generation sequencing of cfDNA, was used to determine the causative organism. Samples from the patient's plasma identified C. bantiana 6 days before culture results of the surgical specimen, allowing optimization of the empirical antifungal regimen, which led to a reduction in the size of the abscesses.
    Lessons: The authors' findings suggest that microbial cfDNA sequencing may be particularly impactful in improving the management of brain abscesses in which the differential diagnosis is wide because of immunosuppression.
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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