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  1. Article ; Online: Clinical manifestations of Behçet's syndrome: A single-center cohort of 777 patients.

    Gürbüz, Cemal / Yalçın Kehribar, Demet / Özgen, Metin

    European journal of rheumatology

    2022  Volume 8, Issue 4, Page(s) 211–216

    Abstract: Objective: Behçet's syndrome (BS) is a multisystem variable vessel vasculitis characterized by skin-mucosal lesions. It can also involve the eyes, blood vessels, joints, gastrointestinal system, urogenital system, and central nervous system. BS starts ... ...

    Abstract Objective: Behçet's syndrome (BS) is a multisystem variable vessel vasculitis characterized by skin-mucosal lesions. It can also involve the eyes, blood vessels, joints, gastrointestinal system, urogenital system, and central nervous system. BS starts in the third or fourth decade and affects both genders equally. The disease is more severe in young men. Although the sensitivity of the pathergy test (PT) is decreasing today, it is still an important clue in the diagnosis of BS. We describe the characteristics of BS in our region, retrospectively. We also analyzed the effect of gender, age, family history, and skin PT positivity status on the difference of clinical involvement.
    Methods: A total of 777 BS patients (391 women and 386 men; 40.0 ± 11.6 years old) who applied to our Rheumatology Department between January 2010 and June 2020 were included in the study.
    Results: Of the 777 patients, 391 were female (50.3%) and 386 were male (49.7%). The mean age at diagnosis was 30.3 ± 9.8 years. The proportion of patients with BS in their family was 10.2%. Of the 777 patients, 310 (39.9%) had only mucocutaneous symptoms. Other 467 patients (60.1%) had at least one of the ocular, musculoskeletal, vascular, neurologic, intestinal, or genitourinary involvement. Serious involvements such as eye, cardiovascular, and neurologic involvement were more common in male patients.
    Conclusion: BS has the different clinical phenotypes according to gender, age of onset, and skin PT positivity status. Gender influences on the major organ involvements such as eye, neurologic, and vascular.
    Language English
    Publishing date 2022-02-03
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.21199
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  2. Article: Efficacy of anti-interleukin-1 treatment in colchicine-resistant arthritis in patients with familial Mediterranean fever.

    Kehribar, Demet Yalçın / Özgen, Metin

    European journal of rheumatology

    2020  Volume 8, Issue 1, Page(s) 16–19

    Abstract: Objective: In the familial Mediterranean fever (FMF) clinic, arthritis is among the most common symptoms, and it generally responds well to colchicine treatment. However, cases of patients with chronic prolonged colchicine-resistant arthritis have been ... ...

    Abstract Objective: In the familial Mediterranean fever (FMF) clinic, arthritis is among the most common symptoms, and it generally responds well to colchicine treatment. However, cases of patients with chronic prolonged colchicine-resistant arthritis have been reported, and there are inadequate studies on the treatments to be used for such patients.
    Methods: This study included 18 patients diagnosed with FMF who had colchicine-resistant chronic arthritis and received anti-interleukin (IL)-1 treatment for at least 1 year. The clinical and laboratory data of the patients were retrospectively retrieved from the database of our hospital.
    Results: Remission was achieved in arthritis attacks in 16 of 18 patients who started anti-IL-1 therapy because of colchicine-resistant chronic arthritis. The clinical and laboratory values of the other 2 patients improved, but complete remission could not be achieved. The treatment dose of colchicine was reduced with anti-IL-1 therapy. In addition to the improvement in arthritis symptoms, remission was achieved in other clinical findings of FMF by anti-IL-1 therapy. In this study, with an average follow-up time of 33 months, no adverse effects requiring discontinuation were observed in any patient.
    Conclusion: Anti-IL-1 therapy is effective and reliable in the treatment of colchicine-resistant chronic FMF arthritis. The efficacy of anti-IL-1 therapy was realized without concomitant disease-modifying antirheumatic drug therapy, despite the reduction in colchicine dose.
    Language English
    Publishing date 2020-09-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.20126
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  3. Article: The importance of Mediterranean fever gene in familial Mediterranean fever.

    Kehribar, Demet Yalçın / Özgen, Metin

    European journal of rheumatology

    2020  

    Abstract: Objective: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent serositis attacks and fever. The discovery of the Mediterranean fever (MEFV) gene has been a milestone in FMF etiopathogenesis. Our ... ...

    Abstract Objective: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent serositis attacks and fever. The discovery of the Mediterranean fever (MEFV) gene has been a milestone in FMF etiopathogenesis. Our knowledge about the relationship between the MEFV gene and FMF phenotype increases each day. This study aims to investigate the relationship between MEFV gene mutations and the FMF clinical findings of a single-center FMF cohort.
    Methods: Gender, age, age at symptom onset, age at diagnosis, clinical characteristics, and MEFV gene analysis of the patients were recorded.
    Results: A total of 837 FMF patients were included in this study. There were 515 females and 322 males. The age at symptom onset was 18.3±10.9 years, while the age at diagnosis was 24.4±10.9 years. The most common symptom that accompanied fever was peritonitis (91.1%), while the other common clinical findings were pleuritis (45%), myalgia (44%), and arthritis (36%). A total of 47 patients developed amyloidosis. A total of 553 (66%) FMF patients had M694V mutation, 221 (26%) of which were homozygous, while 332 (40%) were heterozygous. Exon 10 mutation frequency was 759 (91%), while the non-exon 10 mutation frequency was 78 (9%). There was no wild type among the patients.
    Conclusion: In conclusion, the fact that a vast majority of the disease burden was constituted by the exon 10, especially M694V mutations and that none of the 837 patients from our cohort had a wild-type FMF proved the significance of MEFV gene mutation analysis. Therefore, we speculate that it is necessary to examine the MEFV gene mutations in each FMF suspected case. It seems plausible to re-evaluate the FMF diagnosis for cases in which a wild type MEFV gene mutation occurs.
    Language English
    Publishing date 2020-07-21
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.20107
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  4. Article ; Online: Infliximab treatment in refractory vascular Behcet's disease: A single-center experience.

    Kehribar, Demet Yalçın / Ozgen, Metin

    Vascular

    2020  Volume 28, Issue 6, Page(s) 829–833

    Abstract: Objective: This study aims to investigate the efficacy and reliability of infliximab treatment in Behcet's disease with vascular involvement.: Methods: This single-center retrospective study included a total of 18 patients diagnosed with Behcet's ... ...

    Abstract Objective: This study aims to investigate the efficacy and reliability of infliximab treatment in Behcet's disease with vascular involvement.
    Methods: This single-center retrospective study included a total of 18 patients diagnosed with Behcet's disease with vascular involvement who were initiated infliximab treatment after exhibiting resistance to conventional immunosuppressive treatments.
    Results: Seventeen patients achieved remission with infliximab treatment. While 18 patients were receiving a median of 50 (IQR: 20-61) mg/day equivalent of methylprednisolone before infliximab treatment, after infliximab treatment, only four patients were receiving 4 mg/day equivalent of methylprednisolone (
    Conclusion: Infliximab seems to be an effective and reliable treatment in Behcet's disease with vascular involvement and may also allow reduced dosage or even the discontinuation of corticosteroids. The results of our study suggest that oral anticoagulant use is unnecessary in Behcet's disease with vascular involvement. However, further long-term randomized controlled studies are needed to investigate the length of infliximab regimen, whether or not it should be discontinued, and if so, whether or not immunosuppressants should be given as maintenance after discontinuation.
    MeSH term(s) Adult ; Aged ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Behcet Syndrome/immunology ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infliximab/adverse effects ; Infliximab/therapeutic use ; Male ; Middle Aged ; Remission Induction ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Turkey ; Young Adult
    Chemical Substances Immunosuppressive Agents ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2020-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/1708538120927701
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  5. Article ; Online: Adult-onset Still's Disease Detected in Ankylosing Spondylitis Patient using Adalimumab.

    Duran, Tugba Izci / Kehribar, Demet Yalcin / Ozgen, Metin

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 30, Issue 12, Page(s) 1364

    MeSH term(s) Adalimumab/adverse effects ; Adult ; Humans ; Spondylitis, Ankylosing/drug therapy ; Still's Disease, Adult-Onset/diagnosis ; Still's Disease, Adult-Onset/drug therapy
    Chemical Substances Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2021-01-04
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.12.1364
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  6. Article: Ovarian Reserve and Pelvic Ultrasound Assessment in Familial Mediterranean Fever.

    Okuyucu, Muhammed / Ozdemir, Ayse Zehra / Yalcin Kehribar, Demet / Ozgen, Metin

    Cureus

    2022  Volume 14, Issue 8, Page(s) e28027

    Abstract: Introduction Familial Mediterranean fever (FMF) is an inflammatory rheumatic disease that affects people in their reproductive period. The aim of this study was to investigate the number of gravida, ovarian reserve, and ovarian doppler characteristics in ...

    Abstract Introduction Familial Mediterranean fever (FMF) is an inflammatory rheumatic disease that affects people in their reproductive period. The aim of this study was to investigate the number of gravida, ovarian reserve, and ovarian doppler characteristics in FMF patients. Methods The study design is cross-sectional. Between November 1, 2018, and October 31, 2019, 40 FMF patients, and 40 age-matched volunteers were included in the study. Early follicular phase follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), progesterone, and anti-Mullerian hormone (AMH) levels, as well as ovarian volume, antral follicle count (AFC), ovarian stromal artery doppler findings, and pelvic pathologies, were evaluated. Results The number of gravida, and the AFC was significantly higher in the control group (16.00 ± 5.22) compared to the patients with FMF (13.00 ± 4.09) (p = 0.026). LH values were significantly higher in the FMF group. Thirteen patients (32.5%) received anakinra and colchicine, and 27 patients (67.5%) received only colchicine. There was no significant difference between the patients receiving anakinra, and the patients receiving colchicine in terms of AMH, FSH, AFC, and E2 values. Conclusion FMF patients were found to have low gravida and AFC, and a significant portion was observed to have pelvic fluid and hydrosalpinx. In conclusion, the presence of pelvic fluid, hydrosalpinx, and low AFC persist in FMF patients despite colchicine and/or anti-interleukin-1 treatments. The low gravida may be related to these pathologies detected in patients with FMF.
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.28027
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  7. Article ; Online: Molecularly imprinted polymers in toxicology: a literature survey for the last 5 years.

    Köse, Kazım / Kehribar, Demet Yalçın / Uzun, Lokman

    Environmental science and pollution research international

    2021  Volume 28, Issue 27, Page(s) 35437–35471

    Abstract: The science of toxicology dates back almost to the beginning of human history. Toxic chemicals, which are encountered in different forms, are always among the chemicals that should be investigated in criminal field, environmental application, ... ...

    Abstract The science of toxicology dates back almost to the beginning of human history. Toxic chemicals, which are encountered in different forms, are always among the chemicals that should be investigated in criminal field, environmental application, pharmaceutic, and even industry, where many researches have been carried out studies for years. Almost all of not only drugs but also industrial dyes have toxic side and direct effects. Environmental micropollutants accumulate in the tissues of all living things, especially plants, and show short- or long-term toxic symptoms. Chemicals in forensic science can be known by detecting the effect they cause to the body with the similar mechanism. It is clear that the best tracking tool among analysis methods is molecularly printed polymer-based analytical setups. Different polymeric combinations of molecularly imprinted polymers allow further study on detection or extraction using chromatographic and spectroscopic instruments. In particular, methods used in forensic medicine can detect trace amounts of poison or biological residues on the scene. Molecularly imprinted polymers are still in their infancy and have many variables that need to be developed. In this review, we summarized how molecular imprinted polymers and toxicology intersect and what has been done about molecular imprinted polymers in toxicology by looking at the studies conducted in the last 5 years.
    MeSH term(s) Humans ; Molecular Imprinting ; Molecularly Imprinted Polymers ; Polymers ; Spectrum Analysis
    Chemical Substances Molecularly Imprinted Polymers ; Polymers
    Language English
    Publishing date 2021-05-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-14510-4
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  8. Article ; Online: Infliximab therapy in parenchymal neuro-Behçet's disease: A single-center experience.

    Yalcin Kehribar, Demet / Gunaydin, Serkan / Ozgen, Metin

    International journal of rheumatic diseases

    2021  Volume 24, Issue 10, Page(s) 1302–1307

    Abstract: Background: Parenchymal neuro-Behçet's disease involvement is the most serious complication of Behçet's disease, and no sufficient data on its treatment exists. This study aims to investigate the efficacy and safety of infliximab treatment in neuro- ... ...

    Abstract Background: Parenchymal neuro-Behçet's disease involvement is the most serious complication of Behçet's disease, and no sufficient data on its treatment exists. This study aims to investigate the efficacy and safety of infliximab treatment in neuro-Behçet's disease patients with parenchymal involvement.
    Materials and methods: Patients who were diagnosed with Behçet's disease with parenchymal neurological involvement and underwent infliximab treatment for at least 12 months were included in the study. Demographic, clinical, and radiological data of the patients were accessed through the electronic database of our hospital.
    Results: This study comprises 19 patients who were diagnosed with neuro-Behçet's disease and used infliximab: 12 male and 7 female patients. The mean age of the patients was 36.5 ± 11.7 years, and the diagnostic age was 26.3 ± 10.8 years. The duration of treatment with infliximab was 32.3 months (minimum 11, max 79). In the 19 patients receiving infliximab treatment, 11 (58%) patients achieved remission (complete disappearance of neurological symptoms) and 7 (37%) patients achieved disease stability (no new neurological findings); steroid treatments were discontinued for these 18 patients. In addition, only 5 patients were concomitantly taking immunosuppressive drugs with the infliximab. Infliximab was discontinued after the development of a new parenchymal attack in the 9th month of infliximab treatment.
    Conclusion: In conclusion, parenchymal neurological involvement in Behçet's disease is an important cause of disability, and no sufficient data exists in literature on its treatment. The results of our study suggest that infliximab treatment was effective and safe in neuro-Behçet's disease parenchymal involvement for preventing long-term neurological attacks and discontinuing corticosteroid treatment.
    MeSH term(s) Adolescent ; Adult ; Aged ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Behcet Syndrome/immunology ; Central Nervous System Diseases/diagnosis ; Central Nervous System Diseases/drug therapy ; Central Nervous System Diseases/immunology ; Child ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infliximab/adverse effects ; Infliximab/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Turkey ; Young Adult
    Chemical Substances Immunosuppressive Agents ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2021-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14209
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    Zs.A 6098: Show issues Location:
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  9. Article ; Online: EGFR blocker lapatinib inhibits the synthesis of matrix metalloproteinases from synovial fibroblasts.

    Kehribar, Demet Yalçın / Emmungil, Hakan / Türkmen, Neşe Başak / Çiftçi, Osman / Salva, Emine / Özgen, Metin

    Turkish journal of medical sciences

    2022  Volume 52, Issue 4, Page(s) 1355–1361

    Abstract: Background: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This ... ...

    Abstract Background: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro.
    Methods: Synovial fibroblast cell culture was obtained from a patient with rheumatoid arthritis who underwent knee arthroplasty. Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were added to the cell culture to stimulate synovial fibroblast cells and create an inflammatory character. Understimulated and nonstimulated conditions, lapatinib was applied to the culture in four different concentrations of 25, 50, 100, and 200 µmol. Then, matrix metalloproteinase -1, -3, and, -13 levels were assessed.
    Results: When stimulated with IL-1β and TNF-α, the synthesis of matrix metalloproteinases from synovial fibroblast was increased significantly. When lapatinib is added to the stimulated synovial fibroblasts, matrix metalloproteinases synthesis is significantly suppressed.
    Discussion: Inhibition of the EGFR pathway with lapatinib suppresses matrix metalloproteinases synthesis. Our results suggest EGFR pathway inhibition may be a promising option to prevent joint destruction in the treatment of rheumatoid arthritis.
    MeSH term(s) Humans ; Synovial Membrane/metabolism ; Synovial Membrane/pathology ; Tumor Necrosis Factor-alpha ; Lapatinib/pharmacology ; Lapatinib/metabolism ; Matrix Metalloproteinases/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Arthritis, Rheumatoid/pathology ; ErbB Receptors/metabolism ; Cells, Cultured
    Chemical Substances Tumor Necrosis Factor-alpha ; Lapatinib (0VUA21238F) ; Matrix Metalloproteinases (EC 3.4.24.-) ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-08-10
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.55730/1300-0144.5442
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  10. Article: Molecularly imprinted polymers in toxicology: a literature survey for the last 5 years

    Köse, Kazım / Kehribar, Demet Yalçın / Uzun, Lokman

    Environmental science and pollution research. 2021 July, v. 28, no. 27

    2021  

    Abstract: The science of toxicology dates back almost to the beginning of human history. Toxic chemicals, which are encountered in different forms, are always among the chemicals that should be investigated in criminal field, environmental application, ... ...

    Abstract The science of toxicology dates back almost to the beginning of human history. Toxic chemicals, which are encountered in different forms, are always among the chemicals that should be investigated in criminal field, environmental application, pharmaceutic, and even industry, where many researches have been carried out studies for years. Almost all of not only drugs but also industrial dyes have toxic side and direct effects. Environmental micropollutants accumulate in the tissues of all living things, especially plants, and show short- or long-term toxic symptoms. Chemicals in forensic science can be known by detecting the effect they cause to the body with the similar mechanism. It is clear that the best tracking tool among analysis methods is molecularly printed polymer-based analytical setups. Different polymeric combinations of molecularly imprinted polymers allow further study on detection or extraction using chromatographic and spectroscopic instruments. In particular, methods used in forensic medicine can detect trace amounts of poison or biological residues on the scene. Molecularly imprinted polymers are still in their infancy and have many variables that need to be developed. In this review, we summarized how molecular imprinted polymers and toxicology intersect and what has been done about molecular imprinted polymers in toxicology by looking at the studies conducted in the last 5 years.
    Keywords chromatography ; forensic sciences ; humans ; industry ; medicine ; molecular imprinting ; pollutants ; pollution ; polymers ; research ; spectroscopy ; surveys ; toxicity ; toxicology
    Language English
    Dates of publication 2021-07
    Size p. 35437-35471.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-14510-4
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