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  1. Article ; Online: Evaluation of three brands of Mueller-Hinton media for broth microdilution method to determine the susceptibility of multidrug-resistant Gram-negative bacilli against eravacycline.

    Hsu, Chi-Kuei / Lai, Chih-Cheng / Chen, Chi-Chung / Chen, Hung-Jui / Tang, Hung-Jen

    International journal of antimicrobial agents

    2024  Volume 63, Issue 5, Page(s) 107117

    MeSH term(s) Microbial Sensitivity Tests/methods ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Tetracyclines/pharmacology ; Gram-Negative Bacteria/drug effects ; Humans ; Culture Media/chemistry
    Chemical Substances Anti-Bacterial Agents ; Tetracyclines ; eravacycline (07896928ZC) ; Culture Media
    Language English
    Publishing date 2024-02-24
    Publishing country Netherlands
    Document type Letter ; Evaluation Study
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Impact of Monthly Prophylactic Antibiotics Use in Patients with Recurrent Cellulitis: A 20-Year Population-Based Cohort Study in a Medical Center.

    Huang, Yu-Fen / Tang, Hung-Jen / Hsu, Hung-Lin

    Infection and drug resistance

    2023  Volume 16, Page(s) 3819–3827

    Abstract: Purpose: The vicious cycle of recurrent cellulitis ultimately results in a high risk of relapse, which facilitates the use of antibiotic prophylaxis with monthly intramuscular benzathine penicillin G (BPG) to prevent recurrence. However, several ... ...

    Abstract Purpose: The vicious cycle of recurrent cellulitis ultimately results in a high risk of relapse, which facilitates the use of antibiotic prophylaxis with monthly intramuscular benzathine penicillin G (BPG) to prevent recurrence. However, several clinical situations hinder the guideline recommendations in daily practice. Therefore, intramuscular clindamycin has been used as an alternative in our institution for years. This study aims to elucidate the effectiveness of monthly intramuscular antibiotics in preventing further cellulitis recurrence and evaluate the applicability of intramuscular clindamycin as an alternative to BPG.
    Patients and methods: A retrospective cohort study was conducted at a medical center in Taiwan from January 2000 to October 2020. Adult patients with recurrent cellulitis were enrolled to receive monthly intramuscular antibiotic prophylaxis (including 1.2-2.4MU BPG or 300-600mg intramuscular clindamycin) or to be observed without prophylaxis. The decision to administer prophylaxis or observe was made at the discretion of the examining infectious disease specialists. Cox proportional-hazards regressions were performed to estimate hazard ratios (HR) and adjust for variables between groups. The Kaplan-Meier method was used to estimate survival curves.
    Results: Enrollment in the study consisted of 426 patients, with 222 receiving BPG, 106 receiving intramuscular clindamycin, and 98 being observed without prophylaxis. Both types of antibiotics resulted in a significantly lower recurrence rate than observation alone (27.9% for BPG, 32.1% for intramuscular clindamycin, and 82.7% for observation, P < 0.001). After adjusting for multiple variables, antibiotic prophylaxis continued to significantly reduce the risk of cellulitis recurrence by 82% (HR 0.18, 95% CI 0.13 to 0.26), by 86% (HR 0.14, 95% CI 0.09 to 0.20) with BPG, and by 77% (HR 0.23, 95% CI 0.14 to 0.38) with intramuscular clindamycin.
    Conclusion: Monthly intramuscular antibiotic prophylaxis was demonstrated to be effective in reducing cellulitis recurrence. Moreover, in the real-world practice, intramuscular clindamycin may serve as a reasonable alternative option to BPG.
    Language English
    Publishing date 2023-06-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S393919
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  3. Article: Changing Epidemiology of Respiratory Tract Infection during COVID-19 Pandemic.

    Tang, Hung-Jen / Lai, Chih-Cheng / Chao, Chien-Ming

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: The outbreak of COVID-19 has significantly changed the epidemiology of respiratory tract infection in several ways. The implementation of non-pharmaceutical interventions (NPIs) including universal masking, hand hygiene, and social distancing not only ... ...

    Abstract The outbreak of COVID-19 has significantly changed the epidemiology of respiratory tract infection in several ways. The implementation of non-pharmaceutical interventions (NPIs) including universal masking, hand hygiene, and social distancing not only resulted in a decline in reported SARS-CoV-2 cases but also contributed to the decline in the non-COVID-19 respiratory tract infection-related hospital utilization. Moreover, it also led to the decreased incidence of previous commonly encountered respiratory pathogens, such as influenza and
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11030315
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  4. Article ; Online: The association between corticosteroid uses and mortality among severe COVID-19 patients.

    Tang, Hung-Jen / Lai, Chih-Cheng

    The Journal of infection

    2020  Volume 82, Issue 2, Page(s) e24

    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Keywords covid19
    Language English
    Publishing date 2020-09-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.09.005
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  5. Article: The Collateral Effect of COVID-19 on the Epidemiology of Airborne/Droplet-Transmitted Notifiable Infectious Diseases in Taiwan.

    Tang, Hung-Jen / Lai, Chih-Cheng / Chao, Chien-Ming

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: This study was conducted to compare the number of cases of airborne/droplet-transmitted notifiable infectious disease (NID) between the pandemic period (defined as from January 2020 to December 2021) and the pre-pandemic period (defined as the period ... ...

    Abstract This study was conducted to compare the number of cases of airborne/droplet-transmitted notifiable infectious disease (NID) between the pandemic period (defined as from January 2020 to December 2021) and the pre-pandemic period (defined as the period from January 2018 to December 2019). The annual case numbers of airborne/droplet-transmitted NIDs from 2018 to 2021 were collected for comparison. Fourteen airborne/droplet-transmitted NIDs including measles, rubella, pertussis, influenza with severe complications, invasive pneumococcal diseases (IPD), Q fever, mumps, meningococcal meningitis, varicella, legionellosis, invasive Haemophilus influenzae type b infection, hantavirus syndrome, TB, and multidrug-resistant TB (MDRTB), were included for the analysis. Overall, the annual case number of these 14 airborne/droplet-transmitted NID was 11,930, 12,747, 9477, and 8268 in 2018, 2019, 2020, and 2021, respectively, and the overall incidence was 50.3, 53.6, 39.8, 34.6 per 100,000 populations in in 2018, 2019, 2020, and 2021. The case number of influenza with severe complications had the largest reduction from the pre-pandemic period to the pandemic period, with a reduction of 3076 cases, followed by TB (-2904), IPD (-490), mumps (-292), measles (-292), pertussis (-57), MDRTB (-43), rubella (-35), Q fever (-20), varicella (-12), meningococcal meningitis (-5), invasive
    Language English
    Publishing date 2022-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11040478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical Outcomes and Adverse Effects in Septic Patients with Impaired Renal Function Who Received Different Dosages of Cefoperazone-Sulbactam.

    Tai, Chien-Hsiang / Tang, Hung-Jen / Lee, Chen-Hsiang

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: This study aimed to compare clinical outcomes and adverse effects in septic patients with impaired renal function who received different dosages of cefoperazone-sulbactam (CFP-SUL 1 g/1 g or 2 g/2 g every 12 h). The retrospective study was conducted ... ...

    Abstract This study aimed to compare clinical outcomes and adverse effects in septic patients with impaired renal function who received different dosages of cefoperazone-sulbactam (CFP-SUL 1 g/1 g or 2 g/2 g every 12 h). The retrospective study was conducted using the Chang Gung Research Database to include adult patients who had renal insufficiency presented with septicemia caused by Gram-negative organisms and had received CFP-SUL for more than 1 week. A total of 265 patients (44 in the CFP-SUL 1 g/1 g group and 221 in the CFP-SUL 2 g/2 g group) were eligible to be included in this study. After 1:3 propensity score matching, 41 and 123 patients in the CFP-SUL 1 g/1 g and CFP-SUL 2 g/2 g groups, respectively, were included for analyses. There were no significant between-group differences in all-cause mortality rates and adverse effects, including prolonged prothrombin time. A logistic regression model showed that the Pitt bacteremia score was related to all-cause mortality rate and prolonged prothrombin time was associated with renal replacement therapy. The adverse effects of CFP-SUL did not increase in septic patients with impaired renal function receiving CFP-SUL 2 g/2 g Q12H. However, this study may be underpowered to reveal a difference in all-cause mortality.
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11040460
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  7. Article: In vitro

    Su, Bo-An / Chen, Chi-Chung / Chen, Hung-Jui / Lai, Hsin-Yu / Tsai, Chia-Hung / Lai, Chih-Cheng / Tang, Hung-Jen / Chao, Chien-Ming

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1186669

    Abstract: Objectives: To investigate the : Methods: Thirty-two : Results: The susceptibility rates of levofloxacin (LVX), fosfomycin (FOS), tigecycline (TGC) and sulfamethoxazole-trimethoprim (SXT) against 32 : Conclusion: S. ... ...

    Abstract Objectives: To investigate the
    Methods: Thirty-two
    Results: The susceptibility rates of levofloxacin (LVX), fosfomycin (FOS), tigecycline (TGC) and sulfamethoxazole-trimethoprim (SXT) against 32
    Conclusion: S. maltophilia
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1186669
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  8. Article ; Online: Oral Janus kinase inhibitors for treating hospitalized patients with COVID-19: An updated systematic review and meta-analysis of randomized controlled trials.

    Tang, Hung-Jen / Weng, Teng-Song / Chen, Yu-Hung / Chao, Chien-Ming

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2022  

    Abstract: Objectives: This study investigated the clinical efficacy and safety of oral Janus kinase inhibitors (JAKis) in the treatment of hospitalized patients with COVID-19.: Methods: The PubMed, Embase, Cochrane Central Register of Controlled Trials, and ... ...

    Abstract Objectives: This study investigated the clinical efficacy and safety of oral Janus kinase inhibitors (JAKis) in the treatment of hospitalized patients with COVID-19.
    Methods: The PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases were searched for relevant articles written before January 29, 2022. Only randomized controlled trials (RCTs) that assessed the clinical efficacy and safety of oral JAKis in patients with COVID-19 were included.
    Results: In the pooled analysis of the 7 RCTs, the all-cause 28-day mortality rate in the study group receiving JAKis was significantly lower than that in the control group (9.4% [183/1941] vs. 10.9% [184/1687], risk ratio [RR] = 0.69, 95% confidence interval [CI], 0.58-0.81, I
    Conclusions: Oral JAKis can significantly reduce the risk of death among patients with COVID-19. In addition, JAKis are tolerable for hospitalized patients with COVID-19.
    Language English
    Publishing date 2022-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2022.08.005
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  9. Article ; Online: The Safety of Eravacycline in the Treatment of Acute Bacterial Infection.

    Tang, Hung-Jen / Lai, Chih-Cheng

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 70, Issue 12, Page(s) 2750–2751

    MeSH term(s) Bacterial Infections/drug therapy ; Humans ; Intraabdominal Infections ; Meropenem ; Prospective Studies ; Tetracyclines
    Chemical Substances Tetracyclines ; eravacycline (07896928ZC) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2019-09-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz855
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  10. Article ; Online: Plazomicin-associated Nephrotoxicity.

    Tang, Hung-Jen / Lai, Chih-Cheng

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 71, Issue 4, Page(s) 1130–1131

    MeSH term(s) Aminoglycosides ; Anti-Bacterial Agents/adverse effects ; Humans ; Sisomicin/analogs & derivatives
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; plazomicin (LYO9XZ250J) ; Sisomicin (X55XSL74YQ)
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz1064
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