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  1. Article ; Online: Guillain-Barré syndrome and COVID-19 vaccines: focus on adenoviral vectors.

    Rzymski, Piotr

    Frontiers in immunology

    2023  Volume 14, Page(s) 1183258

    Abstract: COVID-19 vaccination is a life-saving intervention. However, it does not come up without a risk of rare adverse events, which frequency varies between vaccines developed using different technological platforms. The increased risk of Guillain-Barré ... ...

    Abstract COVID-19 vaccination is a life-saving intervention. However, it does not come up without a risk of rare adverse events, which frequency varies between vaccines developed using different technological platforms. The increased risk of Guillain-Barré syndrome (GBS) has been reported for selected adenoviral vector vaccines but not for other vaccine types, including more widely used mRNA preparations. Therefore, it is unlikely that GBS results from the cross-reactivity of antibodies against the SARS-CoV-2 spike protein generated after the COVID-19 vaccination. This paper outlines two hypotheses according to which increased risk of GBS following adenoviral vaccination is due to (1) generation of anti-vector antibodies that may cross-react with proteins involved in biological processes related to myelin and axons, or (2) neuroinvasion of selected adenovirus vectors to the peripheral nervous system, infection of neurons and subsequent inflammation and neuropathies. The rationale behind these hypotheses is outlined, advocating further epidemiological and experimental research to verify them. This is particularly important given the ongoing interest in using adenoviruses in developing vaccines against various infectious diseases and cancer immunotherapeutics.
    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; Guillain-Barre Syndrome/etiology ; COVID-19/prevention & control ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1183258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Avian influenza outbreaks in domestic cats: another reason to consider slaughter-free cell-cultured poultry?

    Rzymski, Piotr

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1283361

    Abstract: Avian influenza causes substantial economic loss in the poultry industry and potentially threatens human health. Over recent years, the highly pathogenic avian influenza A/H5N1 virus has led to devastating losses in poultry flocks and wild birds. At the ... ...

    Abstract Avian influenza causes substantial economic loss in the poultry industry and potentially threatens human health. Over recent years, the highly pathogenic avian influenza A/H5N1 virus has led to devastating losses in poultry flocks and wild birds. At the same time, the number of mammalian species identified to be infected with A/H5N1 is increasing, with recent outbreaks in domestic cats, including household individuals, evidenced in July 2023 in Poland, ultimately creating opportunities for the virus to adapt better to mammalian hosts, including humans. Overall, between 2003 and 2023, over 10 outbreaks in felids have been documented globally, and in six of them, feed based on raw chicken was suspected as a potential source of A/H5N1, fuelling a debate on threats posed by A/H5N1 and methods to decrease the associated risks. This article debates that technology allowing the production of slaughter-free meat, including poultry, from cell and tissue cultures could be considered as a part of a mitigation strategy to decrease the overall burden and threat of adaptation of avian influenza viruses to human hosts. By shifting poultry production to the cultured meat industry, the frequency of A/H5N1 outbreaks in farmed birds may be decreased, leading to a reduced risk of virus acquisition by wild and domesticated mammals that have direct contact with birds or eat raw poultry and have close contact with human (including domestic cats), ultimately minimizing the potential of A/H5N1 to adapt better to mammalian host, including humans. This adds to the list of other benefits of cultured meat that are also reviewed in this paper, including decreased antibiotic use, risk of microbial contamination and parasite transmission, and environmental and ethical advantages over conventional slaughtered meat. In conclusion, further development and implementation of this technology, also in the context of poultry production, is strongly advocated. Although cultured poultry is unlikely to replace the conventional process in the near future due to challenges with scaling up the production and meeting the continuously increased demand for poultry meat, it may still decrease the pressures and threats related to the transmission of highly pathogenic avian influenza in selected world regions.
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1283361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The pivotal role of uridine modifications in the development of mRNA technology

    Piotr Rzymski

    Journal of Medical Science (2023)

    2023  

    Abstract: In 2023, Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine for their nucleoside base modifications research that later enabled mRNA vaccine development against COVID-19. This paper briefly reviews these achievements ... ...

    Abstract In 2023, Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine for their nucleoside base modifications research that later enabled mRNA vaccine development against COVID-19. This paper briefly reviews these achievements in the context of the development of mRNA technology and its enormous potential for medicine in the prevention of various infectious diseases and cancer treatment, including personalized therapies. It is beyond any doubt that discoveries made by Karikó and Weissman were pivotal in overcoming one of the major hurdles in the practical application of mRNA molecules, i.e., their recognition by endosomal Toll-like receptors and downstream innate immune response, ultimately leading to the decreased translational activity of exogenous mRNA molecules and their degradation. Although the Nobel Prize for Karikó and Weissman is fully justified, it must be stressed that the mRNA technology would never unfold its potential for public health without a collective scientific effort encompassing over 40 years of research.
    Keywords mRNA vaccines ; infectious diseases ; cancer treatment ; pseudouridine ; Nobel Prize ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Poznan University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Comment on "Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005-2016".

    Rzymski, Piotr

    Journal of affective disorders

    2021  Volume 295, Page(s) 937–938

    Abstract: The collection of wild mushrooms for consumption remain highly popular in different populations and is also practiced in the US. It cannot be ruled out that the decreased (not dose-dependent) odd of depression in mushroom consumers is, at least partially, ...

    Abstract The collection of wild mushrooms for consumption remain highly popular in different populations and is also practiced in the US. It cannot be ruled out that the decreased (not dose-dependent) odd of depression in mushroom consumers is, at least partially, due to their exposure to the natural environment and associated lifestyle factors. Therefore, further research focusing on depression rates in groups of mushroom hunters is encouraged.
    MeSH term(s) Agaricales ; Depression/epidemiology ; Humans ; Nutrition Surveys
    Language English
    Publishing date 2021-09-09
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2021.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Respiratory syncytial virus immunoprophylaxis: Novel opportunities and a call for equity.

    Rzymski, Piotr / Gwenzi, Willis

    Journal of medical virology

    2024  Volume 96, Issue 2, Page(s) e29453

    Abstract: With the approval of the first vaccines against respiratory syncytial virus (RSV) and a novel RSV-neutralizing antibody, 2023 has been perceived as a game-changing year in preventing severe outcomes of RSV infections in infants and the elderly. However, ... ...

    Abstract With the approval of the first vaccines against respiratory syncytial virus (RSV) and a novel RSV-neutralizing antibody, 2023 has been perceived as a game-changing year in preventing severe outcomes of RSV infections in infants and the elderly. However, the costs of these pharmaceuticals are high, while RSV disproportionately impacts populations of low-to-middle-income regions, which may continue to suffer from a lack of pharmaceutical measures for RSV prevention under health and socioeconomic disparities. This paper presents an overview of the characteristics, clinical results, and approval status of various RSV vaccines and anti-RSV antibodies. It posits that wealthy nations cannot monopolize RSV immunoprophylaxis and should work jointly to make it available to lower-income countries. An approach toward RSV immunoprophylaxis equity based on five points is offered: (1) integration of RSV vaccines and antibodies into the existing global humanitarian distribution systems, (2) using affordable RSV vaccine pricing models, (3) enforcing equity as a part of national and global public health strategy, (4) implementing equitable allocation frameworks for RSV immunoprophylaxis, and (5) promoting local manufacturing. Such a plan needs to be put into action as soon as possible to avoid delays in serving the populations with the highest needs related to RSV burden.
    MeSH term(s) Infant ; Humans ; Aged ; Respiratory Syncytial Virus Vaccines ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/prevention & control ; Immunization ; Antibodies, Viral
    Chemical Substances Respiratory Syncytial Virus Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Epstein-Barr virus and autoimmunity: effective preventive and therapeutic strategies are urgently needed.

    Rzymski, Piotr / Szuster-Ciesielska, Agnieszka

    Reumatologia

    2023  Volume 61, Issue 5, Page(s) 327–330

    Language English
    Publishing date 2023-10-10
    Publishing country Poland
    Document type Editorial
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum/171506
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 676: Show issues Location:
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  7. Article ; Online: The Heat about Cultured Meat in Poland: A Cross-Sectional Acceptance Study.

    Sikora, Dominika / Rzymski, Piotr

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: Cultured meat, produced by culturing animal cells in vitro, is gaining increasing interest. The first products obtained using this technology were authorized for human consumption in Singapore and the United States, and more are likely to follow in other ...

    Abstract Cultured meat, produced by culturing animal cells in vitro, is gaining increasing interest. The first products obtained using this technology were authorized for human consumption in Singapore and the United States, and more are likely to follow in other parts of the world. Therefore, it is important to assess the attitudes toward such meat in various populations and understand the grounds for its acceptance and rejection. The present cross-sectional online study of adult Poles (
    MeSH term(s) Adult ; Animals ; Humans ; Female ; Poland ; Hot Temperature ; Cross-Sectional Studies ; Food Preferences ; Meat ; Consumer Behavior ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214649
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  8. Article: Long-Term Survivability of Tardigrade

    Wilanowska, Paulina Anna / Rzymski, Piotr / Kaczmarek, Łukasz

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: Perchlorate salts, including magnesium perchlorate, are highly toxic compounds that occur on Mars at levels far surpassing those on Earth and pose a significant challenge to the survival of life on this planet. Tardigrades are commonly known for their ... ...

    Abstract Perchlorate salts, including magnesium perchlorate, are highly toxic compounds that occur on Mars at levels far surpassing those on Earth and pose a significant challenge to the survival of life on this planet. Tardigrades are commonly known for their extraordinary resistance to extreme environmental conditions and are considered model organisms for space and astrobiological research. However, their long-term tolerance to perchlorate salts has not been the subject of any previous studies. Therefore, the present study aimed to assess whether the tardigrade species
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030335
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  9. Article ; Online: Limnological Review: Opening a New Chapter

    Rzymski, Piotr / Klimaszyk, Piotr / Marszelewski, Włodzimierz

    Limnol Rev. 2023 Apr. 21, v. 22, no. 1 p.2-3

    2023  

    Abstract: Limnology is the study of inland water ecosystems, which are major contributors to biospheric diversity, structure, and function, even though they represent a small fraction of surface waters [ ... ] ...

    Abstract Limnology is the study of inland water ecosystems, which are major contributors to biospheric diversity, structure, and function, even though they represent a small fraction of surface waters [...]
    Keywords biosphere ; inland waters ; limnology
    Language English
    Dates of publication 2023-0421
    Size p. 2-3.
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2759409-9
    ISSN 2300-7575
    ISSN 2300-7575
    DOI 10.3390/limnolrev22010002
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Beethoven's deafness more likely linked to viral infection than lead poisoning.

    Rzymski, Piotr / Zarębska-Michaluk, Dorota / Flisiak, Robert

    The Journal of infection

    2023  Volume 88, Issue 2, Page(s) 210

    MeSH term(s) Humans ; Deafness ; Lead Poisoning/complications ; Virus Diseases ; Germany
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.12.011
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