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  1. Article: Dendritic pathology: an overview of Golgi studies in man.

    Jagadha, V / Becker, L E

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    1989  Volume 16, Issue 1, Page(s) 41–50

    Abstract: Study of dendritic morphology through Golgi impregnation techniques has significantly furthered our understanding of neuronal development, maturation, and senescence. It has also provided insight into the pathogenesis of a wide spectrum of disease ... ...

    Abstract Study of dendritic morphology through Golgi impregnation techniques has significantly furthered our understanding of neuronal development, maturation, and senescence. It has also provided insight into the pathogenesis of a wide spectrum of disease processes ranging from brain malformations to degenerative disorders. Golgi impregnation remains virtually the only method for demonstrating dendritic morphology. It delineates the profile of the individual neuron and its dendritic ramifications with unsurpassed clarity. Although it has been widely applied to experimental neuroscience involving animal tissue, its application to human material has been limited. This review summarizes the information on dendritic development and pathology in the human brain revealed by the use of the Golgi method.
    MeSH term(s) Brain Diseases/pathology ; Dendrites/pathology ; Humans
    Language English
    Publishing date 1989-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/s0317167100028493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Brain morphology in Duchenne muscular dystrophy: a Golgi study.

    Jagadha, V / Becker, L E

    Pediatric neurology

    1988  Volume 4, Issue 2, Page(s) 87–92

    Abstract: Intellectual impairment associated with Duchenne muscular dystrophy is well recognized, although no consistent anatomic central nervous system lesions have been reported. The autopsy findings of 13 patients, ages 13-18 years, were reviewed. Intelligence ... ...

    Abstract Intellectual impairment associated with Duchenne muscular dystrophy is well recognized, although no consistent anatomic central nervous system lesions have been reported. The autopsy findings of 13 patients, ages 13-18 years, were reviewed. Intelligence quotients, ascertained in 5 patients, ranged from 46-79. Gross and microscopic examinations of brain and spinal cord revealed no consistent pattern of abnormalities. Neuropathology included neuronal loss and gliosis in spinal gray matter and tegmental brainstem, extensive Purkinje cell loss, mononuclear perivascular cuffing with cortical and subcortical gliosis, and cerebral heterotopia. Quantitative analysis of rapid Golgi impregnations of the visual cortex revealed significantly reduced dendritic length and branching of apical and basal dendrites from pyramidal neurons in 1 patient and less striking attenuation of dendritic arborization in 2 others. The literature suggests that the intellectual deficit in Duchenne muscular dystrophy is nonprogressive and unrelated to age or severity of muscle disease, although performance intelligence quotient may deteriorate with progressive muscle weakness. Golgi analysis suggested that abnormal dendritic development and arborization may underlie intellectual impairment. Although the pathogenesis of the cellular defect is not fully known, the coexistence of central nervous system and muscle pathology raises the possibility of a common molecular mechanism.
    MeSH term(s) Adolescent ; Brain/pathology ; Dendrites/ultrastructure ; Humans ; Muscular Dystrophies/pathology ; Neurons/pathology ; Retrospective Studies
    Language English
    Publishing date 1988-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/0887-8994(88)90047-1
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  3. Article: Massive cerebral edema associated with meningioma.

    Jagadha, V / Deck, J H

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    1987  Volume 14, Issue 1, Page(s) 55–58

    Abstract: Cerebral edema is a well-known complication of malignant astrocytoma and metastatic brain tumour. Though far less frequent, the association of cerebral edema with meningioma is also recognized; this is unpredictable and sometimes out of proportion to ... ...

    Abstract Cerebral edema is a well-known complication of malignant astrocytoma and metastatic brain tumour. Though far less frequent, the association of cerebral edema with meningioma is also recognized; this is unpredictable and sometimes out of proportion to tumour size. We describe three cases where the mass effect was due to severe edema, rather than the tumour itself and was responsible for a catastrophic clinical presentation. The mechanisms responsible for the development of severe edema with meningioma which have been previously proposed are reviewed. They include tumour size, location, histologic subtype, cellularity, mitotic activity, vascularity and the presence of excretory-secretory activity. None of these consistently correlate with cerebral edema. Our cases suggest that spontaneous hemorrhage into the tumour may be the common factor responsible for severe cerebral edema. It is stressed that though a decidedly rare complication, cerebral edema secondary to meningioma should be entertained in the differential diagnosis of acute neurologic deterioration of these patients.
    MeSH term(s) Adult ; Brain Edema/etiology ; Brain Edema/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/pathology ; Female ; Humans ; Meningeal Neoplasms/complications ; Meningeal Neoplasms/pathology ; Meningioma/complications ; Meningioma/pathology ; Middle Aged
    Language English
    Publishing date 1987-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/s0317167100026184
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  4. Article: Fatal subarachnoid hemorrhage due to traumatic rupture of the vertebral artery.

    Deck, J H / Jagadha, V

    Archives of pathology & laboratory medicine

    1986  Volume 110, Issue 6, Page(s) 489–493

    Abstract: Massive fatal subarachnoid hemorrhage maximal in the posterior fossa following minor trauma to the head and neck was first attributed to rupture of a vertebral artery (VA) in 1971. Typically, a young, healthy, but intoxicated man receives a minor blow ... ...

    Abstract Massive fatal subarachnoid hemorrhage maximal in the posterior fossa following minor trauma to the head and neck was first attributed to rupture of a vertebral artery (VA) in 1971. Typically, a young, healthy, but intoxicated man receives a minor blow and immediately collapses and dies within minutes. Early reports suggested an extracranial site of rupture with upward tracking of blood into the subarachnoid space. In few cases has this site of rupture been histologically verified, and more recent reports have drawn attention to intracranial rupture of the VA. We describe herein six cases in which the intracranial segment of the VA was the site of traumatic rupture, a site which can be demonstrated by careful examination of the most proximal segment of the VA attached to the brain in the course of routine brain removal.
    MeSH term(s) Adolescent ; Adult ; Humans ; Male ; Rupture ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/pathology ; Vertebral Artery/injuries ; Vertebral Artery/pathology
    Language English
    Publishing date 1986-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0003-9985 ; 0363-0153 ; 0096-8528
    ISSN (online) 1543-2165
    ISSN 0003-9985 ; 0363-0153 ; 0096-8528
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  5. Article: Extra-adrenal myelolipoma.

    Jagadha, V / Ramaswamy, G

    New York state journal of medicine

    1985  Volume 85, Issue 2, Page(s) 60

    MeSH term(s) Aged ; Female ; Humans ; Lipoma/diagnosis ; Sacrococcygeal Region
    Language English
    Publishing date 1985-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82066-0
    ISSN 0028-7628
    ISSN 0028-7628
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  6. Article: Epidermoid cysts of the cranium.

    Jagadha, V / Poon, T

    New York state journal of medicine

    1985  Volume 85, Issue 10, Page(s) 596–597

    MeSH term(s) Adult ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Epidermal Cyst/diagnostic imaging ; Epidermal Cyst/pathology ; Female ; Humans ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 1985-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82066-0
    ISSN 0028-7628
    ISSN 0028-7628
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  7. Article: Benign infiltrative lipomatous lesions.

    Jagadha, V / Ramaswamy, G

    New York state journal of medicine

    1984  Volume 84, Issue 12, Page(s) 591–592

    MeSH term(s) Adult ; Axilla ; Child, Preschool ; Humans ; Lipoma/pathology ; Male ; Maxillary Neoplasms/pathology
    Language English
    Publishing date 1984-12
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 82066-0
    ISSN 0028-7628
    ISSN 0028-7628
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  8. Article: Rapidly progressive fulminating tuberculosis.

    Jagadha, V / Ramaswamy, G

    New York state journal of medicine

    1984  Volume 84, Issue 10, Page(s) 497–501

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Tuberculosis/pathology
    Language English
    Publishing date 1984-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82066-0
    ISSN 0028-7628
    ISSN 0028-7628
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  9. Article: An unusual case of thymolipoma with hamartomatous changes.

    Jagadha, V / Ramaswamy, G

    Archives of pathology & laboratory medicine

    1984  Volume 108, Issue 8, Page(s) 611–612

    MeSH term(s) Humans ; Lipoma/pathology ; Male ; Middle Aged ; Thymus Neoplasms/pathology
    Language English
    Publishing date 1984-08
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0003-9985 ; 0363-0153 ; 0096-8528
    ISSN (online) 1543-2165
    ISSN 0003-9985 ; 0363-0153 ; 0096-8528
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  10. Article: Amylase in serous ovarian neoplasms.

    Ramaswamy, G / Jagadha, V / Tchertkoff, V

    New York state journal of medicine

    1985  Volume 85, Issue 3, Page(s) 113–115

    MeSH term(s) Amylases/blood ; Clinical Enzyme Tests ; Cystadenocarcinoma/diagnosis ; Cystadenocarcinoma/pathology ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Ovary/pathology
    Chemical Substances Amylases (EC 3.2.1.-)
    Language English
    Publishing date 1985-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82066-0
    ISSN 0028-7628
    ISSN 0028-7628
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