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  1. Article ; Online: Inadvertent transmission of polycystic kidney disease in kidney transplantation.

    Langote, Amit / Mazarova, Andrea / Mahoney, John / Blew, Brian / Knoll, Greg A

    The American journal of case reports

    2015  Volume 16, Page(s) 115–118

    Abstract: Background: Although organ donors are rigorously tested, occasionally an unidentified donor disease can be transmitted to the recipient. These conditions include malignancies, infections, and, rarely, congenital diseases.: Case report: We report a ... ...

    Abstract Background: Although organ donors are rigorously tested, occasionally an unidentified donor disease can be transmitted to the recipient. These conditions include malignancies, infections, and, rarely, congenital diseases.
    Case report: We report a case of an inadvertent transmission of polycystic kidney disease from a 40-year-old trauma victim to both kidney recipients. There was no family history of renal disease in the donor. The renal allografts gradually increased in size with the development of cysts and functioned for 10 and 14 years.
    Conclusions: We report a case of inadvertent transmission of polycystic kidney disease from an unsuspecting deceased donor to both the recipients through renal allograft. Both the grafts lasted long enough to suggest that polycystic kidneys from deceased donors can be considered for transplantation.
    MeSH term(s) Adult ; Allografts/diagnostic imaging ; Allografts/pathology ; Humans ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Polycystic Kidney Diseases/diagnosis ; Polycystic Kidney Diseases/etiology ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2015-02-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.892456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hemodialysis Access Choice: Impact of Health Literacy.

    Mazarova, Andrea / Hiremath, Swapnil / Sood, Manish M / Clark, Edward G / Brown, Pierre Antoine / Bugeja, Ann L / England, Grant L / Zimmerman, Deborah

    Health literacy research and practice

    2017  Volume 1, Issue 3, Page(s) e136–e144

    Abstract: Background: Hemodialysis patients need to make decisions about vascular access and diet that they may not fully understand. In this study, we hypothesized that patients with low health literacy are likely to choose a central venous catheter (CVC) and ... ...

    Abstract Background: Hemodialysis patients need to make decisions about vascular access and diet that they may not fully understand. In this study, we hypothesized that patients with low health literacy are likely to choose a central venous catheter (CVC) and have higher serum potassium (K), serum phosphate (P), and inter-dialysis weight gains (IDWG).
    Objective: Primarily, the study sought to describe the health literacy of patients treated with hemodialysis in a Canadian tertiary care center. The secondary objective was to describe the association between health literacy and permanent vascular access choice, hyperkalemia, hyperphosphatemia, and IDWG.
    Methods: Adult patients receiving hemodialysis for more than 6 months were included. Health literacy was assessed with the Newest Vital Sign (NVS) test. Vascular access type and reasons for CVC use were determined. Serum K, P, and IDWG were collected retrospectively for 6 months. Student's
    Key results: Fifty-six patients were involved. The average NVS score was 2.9. Overall, 66% of the patients had a CVC; one-third had chosen this access themselves. Poor control of K, P, and IDWG was experienced by 27%, 55%, and 36% of patients, respectively. The average NVS score was lower for patients choosing a CVC (
    Conclusions: Patients with low health literacy, who are eligible for both surgically created vascular access (fistula or graft) and CVC, are more likely to refuse fistula/graft creation compared to patients with adequate health literacy. Different educational strategies for such patients may help in appropriate decision-making.
    Plain language summary: This study suggests that more than one-half of patients who receive hemodialysis may not understand all the information provided by their health care team. Despite a higher risk of complications with a central venous catheter, patients with lower health literacy prefer the catheter over fistula as their blood access for hemodialysis. We need to explore patient education to ensure that information is easy to understand.
    Language English
    Publishing date 2017-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 2474-8307
    ISSN (online) 2474-8307
    DOI 10.3928/24748307-20170711-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The association of urinary sodium excretion and the need for renal replacement therapy in advanced chronic kidney disease: a cohort study.

    Mazarova, Andrea / Molnar, Amber O / Akbari, Ayub / Sood, Manish M / Hiremath, Swapnil / Burns, Kevin D / Ramsay, Timothy O / Mallick, Ranjeeta / Knoll, Gregory A / Ruzicka, Marcel

    BMC nephrology

    2016  Volume 17, Issue 1, Page(s) 123

    Abstract: Background: Restriction of dietary sodium is routinely recommended for patients with chronic kidney disease (CKD). Whether or not sodium intake is associated with the progression of CKD and mortality remains controversial. We evaluated the association ... ...

    Abstract Background: Restriction of dietary sodium is routinely recommended for patients with chronic kidney disease (CKD). Whether or not sodium intake is associated with the progression of CKD and mortality remains controversial. We evaluated the association of urinary sodium excretion (as a surrogate for sodium intake) on the need for renal replacement therapy and mortality in patients with advanced CKD.
    Methods: We conducted a retrospective study of patients followed at a CKD clinic of a tertiary care hospital from January 2010 to December 2012. Adult patients with advanced CKD (estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m(2)) were included. Using a time-to-event analysis, we examined the association of urinary sodium excretion as a continuous and also as a categorical variable (categorized as low sodium diet - LSD (<100 mEq/day), medium sodium diet - MSD (100-150 mEq/day), and high sodium diet - HSD (>150 mEq/day) and the outcomes of interest. The primary outcome was defined as composite of progression to end-stage renal disease requiring any type of renal replacement therapy and mortality. The secondary outcome was change in eGFR/year.
    Results: 341 patients (82 LSD, 116 MSD and 143 HSD) were included in the study (mean follow up of 1.5 years) with a mean eGFR decline of 2.7 ml/min/1.73 m(2)/year. 105 patients (31 %) required renal replacement therapy and 10 (3 %) died. There was no association between urinary sodium excretion and change in the eGFR or need for renal replacement therapy and mortality in crude or adjusted models (unadjusted HR 1.002; 95%CI 1.000-1.004, adjusted HR 1.001; 95%CI 0.998-1.004).
    Conclusion: In patients with advanced CKD (eGFR < 30 ml/min/1.73 m(2)), sodium intake does not appear to impact the progression of CKD to end-stage renal disease; however, more definitive studies are needed.
    MeSH term(s) Aged ; Aged, 80 and over ; Diet, Sodium-Restricted ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Renal Replacement Therapy ; Retrospective Studies ; Sodium/urine ; Sodium, Dietary/administration & dosage ; Survival Rate
    Chemical Substances Sodium, Dietary ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2016--05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-016-0338-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hemodialysis Access Choice

    Andrea Mazarova / Swapnil Hiremath / Manish M. Sood / Edward G. Clark / Pierre Antoine Brown / Ann L. Bugeja / Grant L. England / Deborah Zimmerman

    Health Literacy Research and Practice, Vol 1, Iss 3, Pp e136-e

    Impact of Health Literacy

    2017  Volume 144

    Abstract: Background: Hemodialysis patients need to make decisions about vascular access and diet that they may not fully understand. In this study, we hypothesized that patients with low health literacy are likely to choose a central venous catheter (CVC) and ... ...

    Abstract Background: Hemodialysis patients need to make decisions about vascular access and diet that they may not fully understand. In this study, we hypothesized that patients with low health literacy are likely to choose a central venous catheter (CVC) and have higher serum potassium (K), serum phosphate (P), and inter-dialysis weight gains (IDWG). Objective: Primarily, the study sought to describe the health literacy of patients treated with hemodialysis in a Canadian tertiary care center. The secondary objective was to describe the association between health literacy and permanent vascular access choice, hyperkalemia, hyperphosphatemia, and IDWG. Methods: Adult patients receiving hemodialysis for more than 6 months were included. Health literacy was assessed with the Newest Vital Sign (NVS) test. Vascular access type and reasons for CVC use were determined. Serum K, P, and IDWG were collected retrospectively for 6 months. Student's t test and logistic regression were used to determine the association between health literacy (NVS score < 4 versus ≥ 4) and CVC choice, hyperkalemia, hyperphosphatemia, and high IDWG. Key Results: Fifty-six patients were involved. The average NVS score was 2.9. Overall, 66% of the patients had a CVC; one-third had chosen this access themselves. Poor control of K, P, and IDWG was experienced by 27%, 55%, and 36% of patients, respectively. The average NVS score was lower for patients choosing a CVC (p = .001), but not different for those with higher K, P, or IDWG. None of the patients who chose a CVC had adequate health literacy (NVS ≥ 4). Conclusions: Patients with low health literacy, who are eligible for both surgically created vascular access (fistula or graft) and CVC, are more likely to refuse fistula/graft creation compared to patients with adequate health literacy. Different educational strategies for such patients may help in appropriate decision-making.
    Keywords hemodialysis ; health literacy ; patient education ; public health ; Public aspects of medicine ; RA1-1270
    Subject code 616
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher SLACK Incorporated
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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