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  1. Article ; Online: Acute hydrocephalus after aneurysmal subarachnoid hemorrhage: The controversial role of lumbar puncture.

    Perrini, Paolo

    Journal of the neurological sciences

    2023  Volume 446, Page(s) 120567

    MeSH term(s) Humans ; Subarachnoid Hemorrhage ; Spinal Puncture ; Hydrocephalus
    Language English
    Publishing date 2023-01-29
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2023.120567
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    Zs.A 308: Show issues Location:
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  2. Article ; Online: Commentary: Comparison of Pericranial Autograft and AlloDerm for Duraplasty in Patients With Type I Chiari Malformation: Retrospective Cohort Analysis.

    Perrini, Paolo

    Operative neurosurgery (Hagerstown, Md.)

    2021  Volume 21, Issue 6, Page(s) E467–E468

    MeSH term(s) Arnold-Chiari Malformation/surgery ; Autografts ; Collagen ; Humans ; Retrospective Studies
    Chemical Substances Alloderm ; Collagen (9007-34-5)
    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opab350
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  3. Article ; Online: Successful Treatment of

    Perrotta, Francesco / Perrini, Marco Paolo

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 5

    Abstract: Carbapenem- ... ...

    Abstract Carbapenem-resistant
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/therapeutic use ; Aztreonam/therapeutic use ; COVID-19 ; Ceftazidime/therapeutic use ; Cross Infection/drug therapy ; Drug Combinations ; Humans ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Purpura, Thrombotic Thrombocytopenic/drug therapy ; RNA, Viral ; SARS-CoV-2 ; Sepsis/drug therapy ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations ; RNA, Viral ; avibactam (7352665165) ; Ceftazidime (9M416Z9QNR) ; beta-Lactamases (EC 3.5.2.6) ; Aztreonam (G2B4VE5GH8)
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57050424
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    Zs.A 6270: Show issues Location:
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  4. Article ; Online: Bartolomeo Panizza (1785-1867) and his contribution to the discovery of the visual cortex.

    Perrini, Paolo / DI Carlo, Davide T / Fava, Arianna / Montemurro, Nicola

    Journal of neurosurgical sciences

    2023  Volume 67, Issue 6, Page(s) 767–772

    Abstract: Bartolomeo Panizza (1785-1867) was an eminent anatomist and a pupil of Antonio Scarpa (1752-1832) at the University of Pavia. In 1855, before the revolutionary studies of Paul Broca (1824-1880) on aphasia that supported the theory of cortical ... ...

    Abstract Bartolomeo Panizza (1785-1867) was an eminent anatomist and a pupil of Antonio Scarpa (1752-1832) at the University of Pavia. In 1855, before the revolutionary studies of Paul Broca (1824-1880) on aphasia that supported the theory of cortical localizations, Panizza delivered a lecture in Milan on the anatomy of the visual system, Osservazioni sul Nervo Ottico ("Observations on the optic nerve"). This lecture contains the first description of the cortical projection of the visual pathways in the occipital lobe, anticipating the revolutionary studies performed by Hermann Munk (1839-1912) in the late 19
    MeSH term(s) Humans ; Visual Cortex ; History, 18th Century ; Anatomy/history ; Italy
    Language English
    Publishing date 2023-05-09
    Publishing country Italy
    Document type Biography ; Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.22.05696-X
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  5. Article ; Online: Will COVID-19 change neurosurgical clinical practice?

    Montemurro, Nicola / Perrini, Paolo

    British journal of neurosurgery

    2020  Volume 36, Issue 1, Page(s) 117–118

    MeSH term(s) COVID-19 ; Humans ; Neurosurgery ; Neurosurgical Procedures
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Letter
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2020.1773399
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  6. Article ; Online: Syringopleural shunt for refractory syringomyelia: how I do it.

    Perrini, Paolo / Benedetto, Nicola / Vercelli, Alberto / Di Carlo, Davide Tiziano

    Acta neurochirurgica

    2023  Volume 165, Issue 10, Page(s) 3039–3043

    Abstract: Background: Surgical treatment of syringomyelia is directed at the reconstruction of the subarachnoid space and restoration normal cerebrospinal fluid flow. Direct intervention on the syrinx is a rescue procedure and should be offered to patients with ... ...

    Abstract Background: Surgical treatment of syringomyelia is directed at the reconstruction of the subarachnoid space and restoration normal cerebrospinal fluid flow. Direct intervention on the syrinx is a rescue procedure and should be offered to patients with refractory syringomyelia.
    Methods: We provide an overview on indications and technique of syringopleural shunt (SPS). The procedure involves the connection of syrinx with the pleural space using a lumboperitoneal shunt. The occurrence of a negative pressure inside the pleural compartment offers an appropriate gradient for drainage from the syrinx.
    Conclusions: The SPS allows for a safe and effective treatment of persistent syringomyelia when management of the underlying cause does not yield substantial improvement.
    MeSH term(s) Humans ; Syringomyelia/diagnostic imaging ; Syringomyelia/surgery ; Syringomyelia/etiology ; Magnetic Resonance Imaging/methods ; Subarachnoid Space/diagnostic imaging ; Subarachnoid Space/surgery ; Treatment Outcome ; Drainage/adverse effects ; Cerebrospinal Fluid Shunts/adverse effects ; Arnold-Chiari Malformation/surgery
    Language English
    Publishing date 2023-06-19
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-023-05654-y
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  7. Article ; Online: Unsuccessful bypass and trapping of a giant dolichoectatic thrombotic basilar trunk aneurysm. What went wrong?

    Montemurro, Nicola / Perrini, Paolo / Lawton, Michael T

    British journal of neurosurgery

    2022  , Page(s) 1–4

    Abstract: Aneurysms of the basilar trunk represent an exceptional challenge to the neurosurgeon, due to high mortality and surgical morbidity. We present a 69-year-old man with a giant dolichoectatic thrombotic basilar trunk aneurysm (BTA), who underwent right ... ...

    Abstract Aneurysms of the basilar trunk represent an exceptional challenge to the neurosurgeon, due to high mortality and surgical morbidity. We present a 69-year-old man with a giant dolichoectatic thrombotic basilar trunk aneurysm (BTA), who underwent right orbitozygomatic craniotomy, posterior cerebral artery (PCA) to right middle cerebral artery (MCA) bypass and trapping of the BTA. Unfortunately, patient died after surgery due to multiple foci of intraparenchymal haemorrhage and thrombosis of a short segment proximal to aneurysm trapped and his body was donated to the hospital, giving us the unique opportunity to compare intraoperative details with anatomical dissection findings, according to our previously published cadaveric neurosurgical research. The great and unique opportunity of this reported case, to learn by watching and watching again what has been done during surgery, to observe small vessels and brainstem perforators and to look at stiches of the bypass, SVG and the position of the clips, permits to refine the theoretical and practical skills for the treatment of complex aneurysms such as that one reported.
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2077306
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    Zs.A 2210: Show issues Location:
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  8. Article ; Online: Clinical outcome after microvascular decompression for trigeminal neuralgia: a systematic review and meta-analysis.

    Di Carlo, Davide Tiziano / Benedetto, Nicola / Perrini, Paolo

    Neurosurgical review

    2022  Volume 46, Issue 1, Page(s) 8

    Abstract: Microvascular decompression (MVD) is considered an effective treatment for trigeminal neuralgia (TN). However, the anatomical and clinical variables associated with a better outcome are not fully examined. The authors performed a systematic review and ... ...

    Abstract Microvascular decompression (MVD) is considered an effective treatment for trigeminal neuralgia (TN). However, the anatomical and clinical variables associated with a better outcome are not fully examined. The authors performed a systematic review and meta-analysis of the literature investigating the immediate and long-term clinical results of MVD for TN, and the impact of the anatomical features of the neurovascular conflict on the outcome. The systematic search of three databases was performed for studies published between January 1990 and November 2021. PRISMA guidelines were followed. Random-effects meta-analysis was used to pool the analyzed outcomes, and random-effect meta-regression was used to examine the association between the effect size and potential confounders. A funnel plot followed by Egger's linear regression was used to test publication bias. A total of 9 studies were included in this analysis, including 2102 patients with trigeminal neuralgia. The immediate post-operative rate of BNI I was 82.9%, whereas surgical failure (BNI IV-V) was reported in approximately 2.6% of patients. CSF leak was the most common postoperative complication (2.4%). The rate of BNI I at last follow up was 64.7% (p < 0.01), showing a significant negative correlation after multiple meta-regression with the rate of patients with isolated venous conflict (p < 0.01). On the other hand, the evidence of an arterial conflict proved is positive association with a favorable outcome (p < 0.01). At the last follow-up, BNI IV-V was reported in 19.2% (95% CI 8.9-29.5%, p < 0.01, I
    MeSH term(s) Humans ; Trigeminal Neuralgia/surgery
    Language English
    Publishing date 2022-12-08
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-022-01922-0
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  9. Article ; Online: Successful Treatment of Klebsiella pneumoniae NDM Sepsis and Intestinal Decolonization with Ceftazidime/Avibactam Plus Aztreonam Combination in a Patient with TTP Complicated by SARSCoV-2 Nosocomial Infection

    Francesco Perrotta / Marco Paolo Perrini

    Medicina, Vol 57, Iss 424, p

    2021  Volume 424

    Abstract: Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat. Infections due to these organisms are associated with significant morbidity and mortality. Among them, metallo-β-lactamases (MBLs)-producing Klebsiella pneumoniae are of ... ...

    Abstract Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat. Infections due to these organisms are associated with significant morbidity and mortality. Among them, metallo-β-lactamases (MBLs)-producing Klebsiella pneumoniae are of global concern today. The ceftazidime/avibactam combination and the ceftazidime/avibactam + aztreonam combination currently represent the most promising antibiotic strategies to stave off these kinds of infections. We describe the case of a patient affected by thrombotic thrombocytopenic purpura (TTP) admitted in our ICU after developing a hospital-acquired SarsCoV2 interstitial pneumonia during his stay in the hematology department. His medical conditions during his ICU stay were further complicated by a K. Pneumoniae NDM sepsis. To our knowledge, the patient had no risk factors for multidrug-resistant bacteria exposure or contamination during his stay in the hematology department. During his stay in the ICU, we treated the sepsis with a combination therapy of ceftazidime/avibactam + aztreonam. The therapy solved his septic state, allowing for a progressive improvement in his general condition. Moreover, we noticed that the negativization of the hemocultures was also associated to a decontamination of his known rectal colonization. The ceftazidime/avibactam + aztreonam treatment could not only be a valid therapeutic option for these kinds of infections, but it could also be considered as a useful tool in selected patients’ intestinal decolonizations.
    Keywords multidrug-resistant bacteria ; Klebsiella NDM ; ceftazidime-avibactam ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Post-Operative Complications after Foramen Magnum Decompression with Duraplasty Using Different Graft Materials in Adults Patients with Chiari I Malformation: A Systematic Review and Meta-Analysis.

    Perrini, Paolo / Lorenzini, Daniele / Vercelli, Alberto / Perrone, Alessandra / Di Carlo, Davide Tiziano

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: Despite extensive investigations, the choice of graft material for reconstructive duraplasty after foramen magnum decompression for Chiari type I malformation (CMI) is still a topic of discussion. The authors performed a systematic review and meta- ... ...

    Abstract Despite extensive investigations, the choice of graft material for reconstructive duraplasty after foramen magnum decompression for Chiari type I malformation (CMI) is still a topic of discussion. The authors performed a systematic review and meta-analysis of the literature examining the post-operative complications in adult patients with CMI after foramen magnum decompression and duraplasty (FMDD) using different graft materials. Our systematic review included 23 studies with a total of 1563 patients with CMI who underwent FMDD with different dural substitutes. The most common complications were pseudomeningocele (2.7%, 95% CI 1.5-3.9%,
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103382
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