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Article ; Online: Diagnosi e terapia dell’insufficienza mitralica ischemica: l’arte delle incertezze.

Carpenito, Myriam / Cammalleri, Valeria / Melfi, Rosetta / Nusca, Annunziata / Mega, Simona / Ussia, Gian Paolo / Grigioni, Francesco

Giornale italiano di cardiologia (2006)

2022 Volume 23, Issue 4, Page(s) 247–253

Title translation	Diagnosis and treatment of ischemic mitral regurgitation: the art of uncertainties.
MeSH term(s)	Humans ; Mitral Valve ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/therapy
Language	Italian
Publishing date	2022-03-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3766.37532
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Zs.A 6738: Show issues

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Article ; Online: Sinonasal teratocarcinosarcoma treated with surgery and proton beam therapy: clinical, histological aspects and differential diagnosis of a new case.

Belotti, Alessia / Carpenito, Laura / Bulfamante, Antonio Mario / Maccari, Alberto / Bulfamante, Gaetano

Pathologica

2022 Volume 113, Issue 6, Page(s) 469–474

Abstract: Sinonasal teratocarcinosarcoma is a rare aggressive malignant tumor with a primary setting involving the nasal cavity followed by the ethmoid sinus and maxillary sinus. It accounts for approximately 3% of all head and neck cancers and less than 1% of all ...

Abstract	Sinonasal teratocarcinosarcoma is a rare aggressive malignant tumor with a primary setting involving the nasal cavity followed by the ethmoid sinus and maxillary sinus. It accounts for approximately 3% of all head and neck cancers and less than 1% of all tumors. Nasal obstruction, recurrent epistaxis and headache represent the typical clinical presentation. Imaging shows the presence of a mass in the nasal cavity. The treatment usually consists of surgery and adjuvant intensity modulated radiotherapy. The rarity and the variability of the histological features make its diagnosis particularly difficult. In this paper, we report a case of sinonasal teratocarcinosarcoma in a 62-year-old male treated with a multidisciplinary approach. As an alternative to intensity modulated radiotherapy, we proposed proton beam therapy for the first time. The patient benefited from the new and personalized protocol that provided excellent results and few adverse effects. At 45 months follow-up there is no evidence of relapse and the patient is in good health.
MeSH term(s)	Carcinosarcoma ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Nose Neoplasms/diagnostic imaging ; Nose Neoplasms/radiotherapy ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/radiotherapy ; Proton Therapy ; Teratoma
Language	English
Publishing date	2022-01-01
Publishing country	Italy
Document type	Case Reports
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
DOI	10.32074/1591-951X-215
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Zs.B 369: Show issues

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Article ; Online: Predictors of Service Utilization of Young Children and Families Enrolled in a Pediatric Primary Care Mental Health Promotion and Prevention Program.

Nayak, Sameera S / Carpenito, Thomas / Zamechek, Lynn / Roper, Kate / Méndez-Peñate, Larisa / Arty, Malika / Moulin, Christy / Mirand, Daphney / Molnar, Beth E

Community mental health journal

2022 Volume 58, Issue 6, Page(s) 1191–1206

Abstract: Understanding early childhood mental health service utilization in community-based clinical settings is important. Project Linking Actions for Unmet Needs in Children's Health (Project LAUNCH) provided mental health-related services for young children ... ...

Abstract	Understanding early childhood mental health service utilization in community-based clinical settings is important. Project Linking Actions for Unmet Needs in Children's Health (Project LAUNCH) provided mental health-related services for young children and families within pediatric medical homes. Using data from the Project LAUNCH evaluation (n = 106), we implemented negative binomial regression models to determine if baseline variables were associated with service utilization, defined as the number of encounters between the family and the team. Past-year homelessness emerged as a significant predictor of service utilization. Encounters for families with children who experienced homelessness within the last 12 months occurred at a rate 34.5% lower than those who had not experienced homelessness. Results highlight the importance of addressing homelessness as a barrier to mental health service utilization for families. Screening for recent housing insecurity and developing interventions that integrate housing support services into mental health programs may inform strategies to increase attendance for families with young children.
MeSH term(s)	Child ; Child, Preschool ; Health Promotion ; Homeless Persons ; Housing ; Humans ; Mental Health Services ; Primary Health Care
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-021-00929-z
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Zs.B 557: Show issues

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Article ; Online: Total embedding of spermatic cord and hilar soft tissue in orchiectomy for seminoma: does the extensive sampling improve pathologic risk factors?

Colecchia, Maurizio / Paolini, Biagio / Pini, Giacomo Maria / Carpenito, Laura / Maghini, Beatrice / Avuzzi, Barbara / Paganoni, Anna Maria / Nicolai, Nicola

Virchows Archiv : an international journal of pathology

2022 Volume 481, Issue 5, Page(s) 695–701

Abstract: Pure seminomas represent the majority of testicular germ cell tumors and accurate diagnosis and staging require an accurate sampling of radical orchiectomy specimens. The aim of our study is to find the most informative gross sampling method for ... ...

Abstract	Pure seminomas represent the majority of testicular germ cell tumors and accurate diagnosis and staging require an accurate sampling of radical orchiectomy specimens. The aim of our study is to find the most informative gross sampling method for orchiectomy specimens. We performed the extensive sampling of 88 radical orchiectomy specimens embedding in their entirety testicular hilum, rete testis, hilar soft tissue, and spermatic cord. We examined the impact of this procedure on tumor stage, prognostic parameters (lymphovascular invasion and infiltration of rete testis, epididymis, tunica vaginalis, and spermatic cord), and their relationship with recurrence. Eighty-eight seminomas from 88 radical orchiectomies were sampled. Seventy-seven cases (87.5%) presented as clinical stage I and 11 cases (12.5%) as clinical stage II. The follow-up period range was 18-54 months and 82 patients (93.2%) had a minimum of 2-year follow-up. Tumor size ranged from 0.4 to 16 cm (mean 3.6) requiring a mean of 7.1 sections for entire tumoral sampling. Epididymis required 2 to 8 sections (mean 3.3), and hilum and hilar soft tissues 2 to 9 sections (mean 3.4). Epididymal infiltration and lymphovascular invasion resulted significant at multivariate analysis generating a receiver operating characteristic (ROC) curve with area under curve of 0.778. All the other parameters (except for pagetoid rete testis infiltration) were significant to predict metastasis only at univariate analysis. Extensive sampling of radical orchiectomy specimens does not improve the accuracy of staging in pure seminomas. Lymphovascular invasion and epididymal infiltration are useful to predict metastasis.
MeSH term(s)	Male ; Humans ; Seminoma/diagnosis ; Orchiectomy ; Spermatic Cord/surgery ; Spermatic Cord/pathology ; Neoplasm Staging ; Neoplasm Invasiveness/pathology ; Testicular Neoplasms/diagnosis ; Risk Factors
Language	English
Publishing date	2022-07-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-022-03370-z
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Article ; Online: Iodine intake among children: Letter.

Carpenito, Fiore / De Marco, Margot / Cavallo, Pierpaolo / Turco, Maria Caterina / Marzullo, Liberato

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2020 Volume 62, Page(s) 126610

MeSH term(s)	Adolescent ; Child ; Humans ; Iodine/administration & dosage ; Iodine/deficiency ; Italy ; Sodium Chloride, Dietary/administration & dosage ; Thyroid Diseases/etiology
Chemical Substances	Sodium Chloride, Dietary ; iodized salt ; Iodine (9679TC07X4)
Language	English
Publishing date	2020-07-04
Publishing country	Germany
Document type	Letter
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2020.126610
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Zs.A 2279: Show issues

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Article: Robotic Hepatectomy plus Biliary Reconstruction for Bismuth Type III and Type IV Hilar Cholangiocarcinoma: State of the Art and Literature Review.

Guadagni, Simone / Comandatore, Annalisa / Furbetta, Niccolò / Di Franco, Gregorio / Carpenito, Cristina / Bechini, Bianca / Vagelli, Filippo / Ramacciotti, Niccolò / Palmeri, Matteo / Di Candio, Giulio / Morelli, Luca

Journal of personalized medicine

2023 Volume 14, Issue 1

Abstract: Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this ... ...

Abstract	Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this setting, the aim of this study is to evaluate the potential benefits of RAS in III-IV HC in terms of post-operative outcomes. Methods: We conducted a systematic review using the PRISMA checklist for article selection. We searched the PubMed database and included only studies with clinical data about the treatment of III-IV HC using RAS. Results: A total of 12 papers involving 50 patients were included. All cases were Bismuth IIIa ( Conclusions: RAS for III-IV HC is safe and feasible, at least if performed by experienced surgeons on selected cases. The oncological outcomes appear acceptable, given the aggressiveness of this pathology, but further studies are needed to fully elucidate the exact role of robotics in this setting.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010012
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Article ; Online: Initial 50 consecutive full-robotic pancreatoduodenectomies without conversion by a single surgeon: a learning curve analysis from a tertiary referral high-volume center.

Morelli, Luca / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Di Franco, Gregorio / Gianardi, Desirée / Cervelli, Rosa / Lorenzoni, Valentina / Comandatore, Annalisa / Carpenito, Cristina / Di Candio, Giulio / Cuschieri, Alfred

Surgical endoscopy

2023 Volume 37, Issue 5, Page(s) 3531–3539

Abstract: Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic ... ...

Abstract	Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic experiences and do not take into account the previous surgical background in pancreatic surgery (PS) and in robotic-assisted surgery (RAS), the center's volume, as well as the platform used, we aimed to perform a surgical outcomes analysis with a particular view to these aspects. Methods: Intraoperative and perioperative outcomes of the first 50 consecutive R-PD performed with the da Vinci Xi by the same surgeon, within a tertiary referral high-volume center, between January 2018 and March 2022, were analyzed. The surgeon was previously experienced in both PS and RAS. Shewhart control chart and cumulative sum (CUSUM) analysis were used to evaluate the learning curve of R-PD. Results: All the operations were performed with a full-robotic technique, without any conversion to open surgery. Twenty of 50 patients (40%) had a BMI ≥ 25 kg/m Conclusions: An extensive prior experience in both PS and RAS, within a tertiary referral high-volume center with availability of the da Vinci Xi platform, can significantly flatten the learning curve and, therefore, enable safe performance of challenging operations, i.e., pancreatoduodenectomies with a minimally invasive approach, with very low risk of conversion to open surgery, even in the first 50 operations.
MeSH term(s)	Humans ; Learning Curve ; Pancreaticoduodenectomy ; Referral and Consultation ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Surgeons/education
Language	English
Publishing date	2023-01-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-022-09784-9
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Article ; Online: Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy: Comparison between traditional open surgery and full-robotic approach with da Vinci Xi.

Morelli, Luca / Di Franco, Gregorio / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Gianardi, Desirée / Carpenito, Cristina / Comandatore, Annalisa / Giovannetti, Elisa / Di Candio, Giulio / Cuschieri, Alfred

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 , Page(s) e2571

Abstract: Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD.: Methods: Open ... ...

Abstract	Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD. Methods: Open and robotic PDs were performed in 353 and 50 cases, respectively, from January 2009 to March 2022. We compared the clinical outcomes and incidence of clinically relevant DGE between robotic PpPD (R-PpPD) and open PpPD after one-to-one case-control matching. Results: Each group consisted of 30 patients. Clinically relevant DGE was less common after R-PpPD (3/30 [10%] vs. 10/30 cases [33.3%], p = 0.028). The median length of hospital stay (LoS) was significantly lower in the R-PpPD group (10 vs. 15 days, p = 0.013). Conclusion: The reduced tissue trauma by the minimally invasive robotic approach is associated with a lower incidence of DGE, reducing the LoS and encouraging PpPD performed using the fully robotic approach.
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2571
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Article ; Online: The autopsy at the time of SARS-CoV-2: Protocol and lessons.

Carpenito, L / D'Ercole, M / Porta, F / Di Blasi, E / Doi, P / Fagara, G Redolfi / Rey, R / Bulfamante, G

Annals of diagnostic pathology

2020 Volume 48, Page(s) 151562

Abstract: A new viral disease named COVID-19 has recently turned into a pandemic. Compared to a common viral pneumonia it may evolve in an atypical way, causing the rapid death of the patient. For over two centuries, autopsy has been recognized as a fundamental ... ...

Abstract	A new viral disease named COVID-19 has recently turned into a pandemic. Compared to a common viral pneumonia it may evolve in an atypical way, causing the rapid death of the patient. For over two centuries, autopsy has been recognized as a fundamental diagnostic technique, particularly for new or little-known diseases. To date, it is often considered obsolete giving the inadequacy to provide samples of a quality appropriate to the sophisticated diagnostic techniques available today. This is probably one of the reasons why during this pandemic autopsies were often requested only in few cases, late and discouraged, if not prohibited, by more than one nation. This is in contrast with our firm conviction: to understand the unknown we must look at it directly and with our own eyes. This has led us to implement an autopsy procedure that allows the beginning of the autopsy shortly after death (within 1-2 h) and its rapid execution, also including sampling for ultrastructural and molecular investigations. In our experience, the tissue sample collected for diagnosis and research were of quality similar to biopsy or surgical resections. This procedure was performed ensuring staff and environmental safety. We want to propose our experience, our main qualitative results and a few general considerations, hoping that they can be an incentive to use autopsy with a new procedure adjusted to match the diagnostic challenges of the third millennium.
MeSH term(s)	Autopsy/methods ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Humans ; Infection Control/methods ; Pandemics ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Specimen Handling/methods ; Time Factors
Keywords	covid19
Language	English
Publishing date	2020-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2020.151562
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Zs.A 5463: Show issues

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Article ; Online: Effect of water composition and timing of ingestion on urinary lithogenic profile in healthy volunteers: a randomized crossover trial.

Ferraro, Pietro Manuel / Baccaro, Rocco / Baroni, Silvia / D'Alessandri, Ludovica / Carpenito, Claudio / Di Daniele, Nicola / Urbani, Andrea / Gambaro, Giovanni

Journal of nephrology

2020 Volume 34, Issue 3, Page(s) 875–881

Abstract: ... assigned to a different sequence of four combined interventions (1 L of water consumed during fasting and 1 ... L of water consumed with meals): CBW/OW; OW/CBW; CBW/CBW; OW/OW. Participants were instructed ...

Abstract	Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bicarbonate water (CBW) and oligomineral water (OW)] consumed at different times during the day on urine composition in a group of healthy volunteers. In a cross-over randomized trial, 12 healthy volunteers were assigned to a different sequence of four combined interventions (1 L of water consumed during fasting and 1 L of water consumed with meals): CBW/OW; OW/CBW; CBW/CBW; OW/OW. Participants were instructed to follow the same diet and to avoid smoking, caffeine and other beverages during the day of intervention, and to collect their urine every 2 h during the day, followed by a single overnight collection. The relative supersaturation for calcium oxalate was higher for CBW/CBW compared with all other interventions, while relative supersaturation for calcium phosphate was lower for the combination OW/CBW with meals. Urinary excretion of oxalate was lower in all interventions including CBW, while no significant differences were found for urinary calcium. Water composition and timing of ingestion have complex and interacting effects on lithogenic risk. Depending on individual characteristics, a strategy involving either OW or a mix of CBW during meals and OW outside of meals could be effective in modulating the lithogenic profile.Trial registered at clinicaltrial.gov: Protocol ID NCT03447847.
MeSH term(s)	Calcium Oxalate/metabolism ; Cross-Over Studies ; Eating/physiology ; Humans ; Kidney Calculi/metabolism ; Water/analysis
Chemical Substances	Water (059QF0KO0R) ; Calcium Oxalate (2612HC57YE)
Language	English
Publishing date	2020-06-08
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-020-00769-2
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