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Article: Agrobacteria deploy two classes of His-Me finger superfamily nuclease effectors exerting different antibacterial capacities against specific bacterial competitors.

Santos, Mary Nia M / Pintor, Katherine L / Hsieh, Pei-Yu / Cheung, Yee-Wai / Sung, Li-Kang / Shih, Yu-Ling / Lai, Erh-Min

Frontiers in microbiology

2024 Volume 15, Page(s) 1351590

Abstract: The type VI secretion system (T6SS) assembles into a contractile nanomachine to inject effectors across bacterial membranes for secretion. ... ...

Abstract	The type VI secretion system (T6SS) assembles into a contractile nanomachine to inject effectors across bacterial membranes for secretion. The
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1351590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Invasive lobular carcinoma enclosed by a benign phyllodes tumor: A case report.

Chen, Yu-Hsuan / Tu, Yu-Ling / Chen, Han-Ku / Shih, Shen-Liang

International journal of surgery case reports

2022 Volume 91, Page(s) 106804

Abstract: Introduction and importance: Phyllodes tumors (PT) account for approximately 1% of all breast tumors. The coexistence of phyllodes tumor and invasive lobular carcinoma in the ipsilateral breast is extremely rare with fewer than six cases reported ... ...

Abstract	Introduction and importance: Phyllodes tumors (PT) account for approximately 1% of all breast tumors. The coexistence of phyllodes tumor and invasive lobular carcinoma in the ipsilateral breast is extremely rare with fewer than six cases reported worldwide in the last 20 years. We hereby present the first in Taiwan. Case presentation: A 43-year-old female was presented with a protruding tumor with bleeding tendency over left breast in 2016. Breast sonography revealed highly suspected malignancy (ACR BI-RADS category 5). Computed tomography scan disclosed a protruding mass occupying the left breast. Core needle biopsy showed a fibroepithelial lesion favoring fibroadenoma. Considering clinicopathological discrepancy, a nipple-sparing mastectomy was conducted. Pathology report revealed a benign PT with an incidental finding of invasive lobular carcinoma (pT1cN0) within the tumor. Due to tumor recurrence, the patient received re-operation of total mastectomy in 2017, and is under regular adjuvant hormonal therapy without cancer recurrence to date. Clinical discussion: Physicians could easily overlook carcinomas enclosed by PTs due to its occult property. However, when carcinomatous changes arise from within or along with the PT, the proposed therapeutical course may be altered. Moreover, invasive carcinoma components in PTs possess potential for lymph node metastasis. Multidisciplinary cooperation is key in detecting and managing PT with synchronous carcinomatosis. Conclusion: Thorough examination of the excised tumor specimen and ensuring an adequate surgical margin is necessary. Sentinel lymph node biopsy (SLNB) should be considered whenever suspicious clinical features occur in PT patients. This may aid in the detection of microscopic invasive carcinomatous change.
Language	English
Publishing date	2022-02-02
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.106804
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Article ; Online: One-pot tandem reduction and site-selective halogenation of nitroarenes.

Dhandabani, Ganesh Kumar / Chang, Li-Te / Hsieh, Hao-Yu / Shih, Chia-Ling / Hsin, Ling-Wei

Organic & biomolecular chemistry

2024 Volume 22, Issue 5, Page(s) 976–981

Abstract: Halogenated aryl amines are a widely used chemical feedstock in the pharmaceutical and agrochemical industries. Achieving a single regioselective product from ... ...

Abstract	Halogenated aryl amines are a widely used chemical feedstock in the pharmaceutical and agrochemical industries. Achieving a single regioselective product from the
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01732j
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Article ; Online: A machine learning-based ensemble model for estimating diurnal variations of nitrogen oxide concentrations in Taiwan.

Asri, Aji Kusumaning / Lee, Hsiao-Yun / Chen, Yu-Ling / Wong, Pei-Yi / Hsu, Chin-Yu / Chen, Pau-Chung / Lung, Shih-Chun Candice / Chen, Yu-Cheng / Wu, Chih-Da

The Science of the total environment

2024 Volume 916, Page(s) 170209

Abstract: Air pollution is inextricable from human activity patterns. This is especially true for nitrogen oxide ( ... ...

Abstract	Air pollution is inextricable from human activity patterns. This is especially true for nitrogen oxide (NO
MeSH term(s)	Humans ; Air Pollutants/analysis ; Environmental Monitoring/methods ; Taiwan ; Reproducibility of Results ; Air Pollution/analysis ; Nitrogen Oxides/analysis ; Nitric Oxide ; Machine Learning ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Nitrogen Oxides ; Nitric Oxide (31C4KY9ESH) ; Particulate Matter
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170209
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Zs.A 949: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Changes in employment status and income before and after newly diagnosed depressive disorders in Taiwan: a matched cohort study using controlled interrupted time series analysis.

Chen, Yu-Ling / Liao, Wei-Hsiang / Wang, Shih-Heng / Lien, Yin-Ju / Chang, Chia-Ming / Liao, Shih-Cheng / Huang, Wei-Lieh / Wu, Chi-Shin

Epidemiology and psychiatric sciences

2023 Volume 32, Page(s) e41

Abstract: Aims: We explored long-term employment status and income before and after depression diagnosis among men and women and at different working ages in Taiwan.: Methods: Data from 2006 to 2019 were obtained from the National Health Insurance Research ... ...

Abstract	Aims: We explored long-term employment status and income before and after depression diagnosis among men and women and at different working ages in Taiwan. Methods: Data from 2006 to 2019 were obtained from the National Health Insurance Research Database (NHIRD). Individuals with newly diagnosed depressive disorder aged 15 to 64 years during the study period were identified. An equal number of individuals without depression were matched for their demographic and clinical characteristics. Employment outcomes included employment status, which was categorized into employed or unemployed, and annual income. Based on the occupation categories and monthly insurance salary recorded in the Registry for Beneficiaries of the NHIRD, a subject was defined as unemployed if he or she differed from the income earner or the occupation category was unemployed. Monthly income was defined as zero for unemployed subjects and proxied as monthly insurance salary for others. Annual income was the sum of monthly income in each observation year. Results: A total of 420,935 individuals with depressive disorder were included in the study, and an equal number of individuals with not diagnosed depression served as controls. Employment rate and income were lower in the depression group than in the control group before the year of diagnosis, with a difference of 5.7% in employment rate and USD 1,173 in annual income. This gap increased considerably after the year of diagnosis (7.3% in employment rate and USD 1,573 in annual incomes) and further widened in the subsequent years (8.1% in employment rate and USD 2,006 in annual incomes in the 5th following year). The drops in the employment rate and income caused by depression were more evident in men and older age groups than in women and younger age groups, respectively. However, the reduction in employment rate and income in the following years after the diagnosis was more considerable among younger age groups. Conclusions: The effect of depression on employment status and income was significant during the year of diagnosis and continued afterwards. The effect on employment outcomes varied between genders and across all age groups.
MeSH term(s)	Female ; Humans ; Male ; Aged ; Interrupted Time Series Analysis ; Taiwan/epidemiology ; Cohort Studies ; Unemployment ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2607964-1
ISSN	2045-7979 ; 2045-7960
ISSN (online)	2045-7979
ISSN	2045-7960
DOI	10.1017/S2045796023000562
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Zs.A 5143: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes.

Yen, Ling-Jung / Chen, Ying-Chin / Wang, Kai-Chun / Shih, Meng-Chieh / Li, Chia-Ling / Yu, Sheng-Jie / Lu, Ling-Ying

Immunopharmacology and immunotoxicology

2024 Volume 46, Issue 1, Page(s) 128–137

Abstract: Objective: Hydroxychloroquine (HCQ) is a US Food and Drug Administration (FDA)-approved treatment for systemic lupus erythematosus (SLE) through inhibition of antigen presentation and subsequent reduction in T cell activation. Psoriasis relapse after ... ...

Abstract	Objective: Hydroxychloroquine (HCQ) is a US Food and Drug Administration (FDA)-approved treatment for systemic lupus erythematosus (SLE) through inhibition of antigen presentation and subsequent reduction in T cell activation. Psoriasis relapse after antimalarial therapy have been reported in up to 18% of patients with psoriasis. Here, we explored the role of HCQ on exacerbating dermatitis utilizing an imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model. Methods: Thirty-six C57BL/6 female mice were divided into six groups: wild-type control, IMQ-Only, pre-treat HCQ (30 mg/kg and 60 mg/kg HCQ), and co-treat HCQ with IMQ (30 mg/kg and 60 mg/kg HCQ). Besides control, all were topically treated with IMQ for 5 days. Pharmacological effects and mechanisms of HCQ were assessed by clinical severity of dermatitis, histopathology, and flow cytometry. HaCaT cells were co-treated with both HCQ and recombinant IL-17A, followed by the detection of proinflammatory cytokine expression and gene profiles through enzyme-linked immunosorbent assay and next-generation sequencing. Results: In the pre-treated and co-treated HCQ groups, skin redness and scaling were significantly increased compared to the IMQ-Only group, and Th17 cell expression was also upregulated. Acanthosis and CD11b Conclusions: HCQ exacerbates psoriasis-like skin inflammation by increasing the expression of IL-6, stimulating DC infiltration, and promoting Th17 expression in the microenvironment of the skin. Key messages: This study provided possible mechanisms for inducing psoriasis during HCQ treatment through an animal model.
MeSH term(s)	Humans ; Female ; Animals ; Mice ; Imiquimod/adverse effects ; Interleukin-17 ; Hydroxychloroquine/adverse effects ; Interleukin-6/metabolism ; Mice, Inbred C57BL ; Psoriasis/chemically induced ; Keratinocytes ; Skin ; Dermatitis/metabolism ; Dermatitis/pathology ; Disease Models, Animal ; Mice, Inbred BALB C
Chemical Substances	Imiquimod (P1QW714R7M) ; Interleukin-17 ; Hydroxychloroquine (4QWG6N8QKH) ; Interleukin-6
Language	English
Publishing date	2024-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2023.2281283
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Zs.A 1481: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Developing an intelligent virtual reality interactive system based on the ADDIE model for learning pour-over coffee brewing

Shih-Jou Yu / Yu-Ling Hsueh / Jerry Chih-Yuan Sun / Hao-Ze Liu

Computers and Education: Artificial Intelligence, Vol 2, Iss , Pp 100030- (2021)

2021

Abstract: This study aims to use the analysis, design, development, implementation, and evaluation (ADDIE) model to develop an intelligent virtual reality (VR) interactive system for learning pour-over coffee brewing. The operation of pour-over coffee brewing is ... ...

Abstract	This study aims to use the analysis, design, development, implementation, and evaluation (ADDIE) model to develop an intelligent virtual reality (VR) interactive system for learning pour-over coffee brewing. The operation of pour-over coffee brewing is complex. An intelligent system is a concrete actuator that realizes artificial intelligence (AI) decisions. When learners face the challenge of learning complex skills, an intelligent system can actively analyze their learning behaviors and provide corresponding intelligent feedback to correct them. Furthermore, head-mounted-display VR can structure an immersive environment to improve the learning experience and knowledge transfer. This research integrates these two techniques into an intelligent VR interactive system and utilizes the ADDIE model to enable the system to achieve the ideal educational framework. The participants were 103 students who experienced and evaluated this system. The results indicated that the intelligent VR interactive system matched the participants' learning requirements and enhanced their learning performance. In addition, the learners proposed some suggestions to optimize the system, such as adding detailed content to the intelligent feedback and note function. Overall, this system increases the effectiveness of learning. The study suggests that instructors can use an intelligent VR interactive system to strengthen learners’ manipulative ability and knowledge.
Keywords	ADDIE model ; Coffee brewing ; Intelligent system ; Learning performance ; Manipulative ability ; Virtual reality ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	004
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Development of a petal protoplast transfection system for

Pan, Zhao-Jun / Hung, Yu-Ling / Chen, Tsun-Ying / Shih, Yu-An / Lin, Ying-Chung Jimmy / Wang, Chun-Neng

Applications in plant sciences

2022 Volume 10, Issue 3, Page(s) e11476

Abstract: Premise: Transient gene expression systems are powerful tools for studying gene interactions in plant species without available or stable genetic transformation protocols. We optimized a petal protoplast transformation protocol for : Methods and ... ...

Abstract	Premise: Transient gene expression systems are powerful tools for studying gene interactions in plant species without available or stable genetic transformation protocols. We optimized a petal protoplast transformation protocol for Methods and results: A high yield of petal protoplasts was obtained using a 6-h enzyme digestion in a solution of 1.5% cellulase and 0.4% macerozyme. Modest transfection efficiency (average 41.4%) was achieved. The viability of the transfected protoplasts remained at more than 90%. A fusion of green fluorescent protein and CYCLOIDEA (SsCYC), the Teosinte branched 1 Conclusions: The transient transfection system presented herein can be effectively used to study gene-regulatory interactions in Gesneriaceae species.
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2699923-7
ISSN	2168-0450
ISSN	2168-0450
DOI	10.1002/aps3.11476
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Article ; Online: Associations between antenatal education program and mental health outcomes in Taiwan: A population-based cohort study.

Chen, Yu-Ling / Tseng, Ching-Hsuan / Cheong, Mei-Leng / Lien, Yin-Ju / Wang, Shi-Heng / Chang, Chia-Ming / Liao, Shih-Cheng / Wu, Chi-Shin

Psychiatry research

2023 Volume 322, Page(s) 115128

Abstract: Universal antenatal education has been offered to expectant mothers in Taiwan since 2014. Depression screening is included in the offered education sessions. This study aimed to examine the association of antennal education and depression screening with ... ...

Abstract	Universal antenatal education has been offered to expectant mothers in Taiwan since 2014. Depression screening is included in the offered education sessions. This study aimed to examine the association of antennal education and depression screening with mental health outcomes, including perinatal depression diagnosis and psychiatrist visits. Data was obtained from the antenatal education records and Taiwan's National Health Insurance claims database. A total of 789,763 eligible pregnant women were included in the current study. The psychiatric-related outcomes were measured between antenatal education and the six-month after delivery. It was found that the antenatal education was widely used in Taiwan, and the attendance rate has increased to 82.6% since its launch. The attenders were more likely to be from disadvantaged backgrounds, and 5.3% of them were screened positive for depressive symptoms. They were also more likely to visit a psychiatrist but less likely to be diagnosed with depression than the non-attenders. Factors including young age, high healthcare utilization, and comorbid psychiatric disorder history were consistently associated with depression symptoms, perinatal depression diagnoses and psychiatrist visits. Further research is needed to understand the reasons for the nonattendance at antenatal education programmes and the barriers to utilizing mental health services.
MeSH term(s)	Taiwan/epidemiology ; Cohort Studies ; Prenatal Education ; Mental Health ; Humans ; Female ; Adult ; Depression/diagnosis ; Depression/epidemiology ; Pregnancy ; Psychiatry ; Pregnancy Complications/diagnosis ; Pregnancy Complications/epidemiology ; Pregnancy Complications/psychology ; Perinatal Care ; Adolescent ; Young Adult ; Middle Aged ; Mass Screening ; Outpatients ; Treatment Outcome
Language	English
Publishing date	2023-02-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115128
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Zs.A 1541: Show issues

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Article ; Online: Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome

Hong Thuy Vy Nguyen / Xiaorui Chen / Claudia Parada / An-Chi Luo / Orion Shih / U-Ser Jeng / Chia-Ying Huang / Yu-Ling Shih / Che Ma

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 13

Abstract: The FtsB-FtsL-FtsQ complex is essential for regulating cell wall synthesis during bacterial cell division. Here, authors report the full-length trimeric structure showing a tilted V-shaped conformation and suggest an allosteric regulatory mechanism. ...

Abstract	The FtsB-FtsL-FtsQ complex is essential for regulating cell wall synthesis during bacterial cell division. Here, authors report the full-length trimeric structure showing a tilted V-shaped conformation and suggest an allosteric regulatory mechanism.
Keywords	Science ; Q
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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