LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 220

Search options

  1. Article ; Online: Health Care Workers Online YouTube Content Compared to AUA Prevention of Recurrent Urinary Tract Infections in Women Guidelines: An Integrative Review of Quality and Comprehensiveness Analysis.

    Bondok, Mostafa / Stothers, Lynn / Macnab, Andrew / Bondok, Mohamed / Ackerman, A Lenore / Dixon, Emma / Trochez, Marcia / Petersen, Kelsey / Selvakumar, Rishika

    Urology practice

    2024  Volume 11, Issue 3, Page(s) 498–505

    Abstract: Introduction: We document the quality, veracity, and comprehensiveness of recurrent UTI information on YouTube to increase health care workers' (HCWs') awareness of UTI-related content online, and to identify deficits in understanding, clarify ... ...

    Abstract Introduction: We document the quality, veracity, and comprehensiveness of recurrent UTI information on YouTube to increase health care workers' (HCWs') awareness of UTI-related content online, and to identify deficits in understanding, clarify misconceptions, and reduce stigmatization risk.
    Methods: High-traffic topic search terms were curated by Google Trends to extract 200 videos, of which 45 met inclusion criteria. Five independent reviewers used a standardized questionnaire based on the AUA recurrent UTI guidelines to assess the definition of UTI, marketing content, prophylaxis/prevention strategies, and antibiotic use/stewardship.
    Results: Incongruent or incomplete guideline UTI definitions were found in 78% (35/45) of videos (K = 0.40), despite 80% (36/45) being authored by HCWs. Forty-two percent (19/45) promoted nonguideline-based hygiene practices; 25% (11/45) advocated front-to-back wiping (K = 0.71). Descriptors identified within the videos included the mention of women with UTI as unclean. Only 55% (25/45) discussed increasing fluid intake (K = 0.59), while 33% (15/45) discussed the use of cranberry supplementation (K = 0.81).
    Conclusions: Discussion of hygiene practices which lack a specific guideline statement is particularly evident. Descriptors that characterize women with UTI as "unclean" may create a health equity concern for women experiencing UTIs. These findings should alert HCWs to the scope and emphasis in online education that patients may view to self-educate; both the errors and the issues of equity are problematic. Educational materials on UTI should be based on evidence-based guidelines, such as those by the AUA.
    MeSH term(s) Humans ; Female ; Social Media ; Urinary Tract Infections/prevention & control ; Plant Extracts ; Vaccinium macrocarpon ; Antimicrobial Stewardship
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000537
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review.

    Jalil, Jorge E / Gabrielli, Luigi / Ocaranza, María Paz / MacNab, Paul / Fernández, Rodrigo / Grassi, Bruno / Jofré, Paulina / Verdejo, Hugo / Acevedo, Monica / Cordova, Samuel / Sanhueza, Luis / Greig, Douglas

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: This review examines the impact of obesity on the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF prevention using a glucagon-like peptide-1 receptor agonism (GLP-1 RA). Obesity can lead ...

    Abstract This review examines the impact of obesity on the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF prevention using a glucagon-like peptide-1 receptor agonism (GLP-1 RA). Obesity can lead to HFpEF through various mechanisms, including low-grade systemic inflammation, adipocyte dysfunction, accumulation of visceral adipose tissue, and increased pericardial/epicardial adipose tissue (contributing to an increase in myocardial fat content and interstitial fibrosis). Glucagon-like peptide 1 (GLP-1) is an incretin hormone that is released from the enteroendocrine L-cells in the gut. GLP-1 reduces blood glucose levels by stimulating insulin synthesis, suppressing islet α-cell function, and promoting the proliferation and differentiation of β-cells. GLP-1 regulates gastric emptying and appetite, and GLP-1 RA is currently indicated for treating type 2 diabetes (T2D), obesity, and metabolic syndrome (MS). Recent evidence indicates that GLP-1 RA may play a significant role in preventing HFpEF in patients with obesity, MS, or obese T2D. This effect may be due to activating cardioprotective mechanisms (the endogenous counter-regulatory renin angiotensin system and the AMPK/mTOR pathway) and by inhibiting deleterious remodeling mechanisms (the PKA/RhoA/ROCK pathway, aldosterone levels, and microinflammation). However, there is still a need for further research to validate the impact of these mechanisms on humans.
    MeSH term(s) Humans ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/metabolism ; Heart Failure/metabolism ; Heart Failure/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/drug therapy ; Stroke Volume/drug effects ; Animals ; Glucagon-Like Peptide 1/metabolism ; Obesity/metabolism ; Obesity/complications ; Obesity/drug therapy
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084407
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Running tests on a miniature motor.

    Macnab, R M

    Biophysical journal

    2009  Volume 64, Issue 3, Page(s) 934–935

    Language English
    Publishing date 2009-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/S0006-3495(93)81455-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Advance Care Planning and Chronic Kidney Disease: What Do Patients Know and What Do They Want?

    Phillips, Catherine R / MacNab, Corinne J / Loewen, Lisa M

    Nephrology nursing journal : journal of the American Nephrology Nurses' Association

    2018  Volume 45, Issue 6, Page(s) 513–523

    Abstract: There is a gap in the research literature regarding advance care planning with this population of patients. This article reports on a study about the end-of-life knowledge, needs, and preferences of patients on hemodialysis - as reported by patients - ... ...

    Abstract There is a gap in the research literature regarding advance care planning with this population of patients. This article reports on a study about the end-of-life knowledge, needs, and preferences of patients on hemodialysis - as reported by patients - within a hospital or community-based setting that addresses this gap. Data were collected using a survey method; non-probability, consecutive sampling (n=133) resulted in a high response rate of 64.0%. There were three key findings: 1) patients do not identify themselves as having a progressive health condition, 2) patients are comfortable discussing end-of-life issues, and 3) patients want discussions about end-of-life care when they request to do so or when their health worsens. We report on these findings and discuss three key recommendations: 1) patients with chronic kidney disease be consulted about the appropriate time for advance care planning, 2) symptom management needs greater attention, and 3) the role of family requires more consideration.
    MeSH term(s) Advance Care Planning ; Humans ; Renal Dialysis ; Renal Insufficiency, Chronic/psychology ; Surveys and Questionnaires ; Terminal Care
    Language English
    Publishing date 2018-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008177-7
    ISSN 1526-744X ; 8750-0779
    ISSN 1526-744X ; 8750-0779
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Less radical surgery for women with early stage cervical cancer: Our experience on radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy.

    Rizzuto, I / MacNab, W / Nicholson, R / Nalam, M / Rufford, B

    Gynecologic oncology reports

    2019  Volume 28, Page(s) 65–67

    Abstract: We report the use of radical vaginal trachelectomy (RVT) with pelvic laparoscopic lymphadenectomy (LPL) in patients with early stages cervical cancer (FIGO stage IA2-IB1). This is a case series prospectively collected over a 6-year period (2011-2017) at ... ...

    Abstract We report the use of radical vaginal trachelectomy (RVT) with pelvic laparoscopic lymphadenectomy (LPL) in patients with early stages cervical cancer (FIGO stage IA2-IB1). This is a case series prospectively collected over a 6-year period (2011-2017) at the Ipswich hospital, UK. Cases were compared to a group of women with a similar stage of cervical cancer, but treated with radical hysterectomy (RH) and pelvic lymphadenectomy (PL). A total of 19 patients (group 1) underwent RVT and LPL, and 51 (group 2) had RH and PL. We included: 5/19 (26%) stage IA2 and 14/19 (74%) stage IB1. Among those, we had: 12/19 (63%) cases of squamous cell carcinoma (SCC), 7/19(37%) of adenocarcinoma. Mean hospital stay was 2.7 days (range 2-4) in group 1 versus 4.8 days (range 3-8) group 2 (
    Language English
    Publishing date 2019-03-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2019.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Risk factors and sonographic endometrial thickness as predictors of tumour stage and histological subtype of endometrial cancer.

    Rizzuto, Ivana / Nicholson, Rachel / MacNab, Wendy S / Nalam, Mythili / Sharma, Rohit / Rufford, Barnaby

    Gynecologic oncology reports

    2019  Volume 30, Page(s) 100491

    Abstract: We evaluated the association between risk factors for endometrial cancer (EC) and sonographic endometrial thickness (ET) with FIGO stages at diagnosis. We also reported our experience in reliability of sonographic ET as screening tool for either ... ...

    Abstract We evaluated the association between risk factors for endometrial cancer (EC) and sonographic endometrial thickness (ET) with FIGO stages at diagnosis. We also reported our experience in reliability of sonographic ET as screening tool for either histologic subtype I and II of EC. It was a case series study including 339 patients diagnosed with EC from 2010 to 2017 at the Ipswich Hospital, UK. Women with higher body mass index (BMI) presented at earlier stages when compared to women with lower BMIs (
    Language English
    Publishing date 2019-08-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2019.100491
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Effect of rectus sheath block vs. spinal anaesthesia on time-to-readiness for hospital discharge after trans-peritoneal hand-assisted laparoscopic live donor nephrectomy: A randomised trial.

    Bhatia, Kailash / Columb, Malachy / Wadsworth, Richard / Macnab, William / Jepegnanam, Chandran / Campbell, Tunde / Van Dellen, David

    European journal of anaesthesiology

    2020  Volume 38, Issue 4, Page(s) 374–382

    Abstract: Background: The role of spinal anaesthesia in patients having a transperitoneal hand-assisted laparoscopic donor nephrectomy in an enhanced recovery setting has never been investigated.: Objective: We explored whether substituting a rectus sheath ... ...

    Abstract Background: The role of spinal anaesthesia in patients having a transperitoneal hand-assisted laparoscopic donor nephrectomy in an enhanced recovery setting has never been investigated.
    Objective: We explored whether substituting a rectus sheath block (RSB) with spinal anaesthesia, as an adjunct to a general anaesthetic technique, influenced time-to-readiness for discharge in patients undergoing hand-assisted laparoscopic donor nephrectomy.
    Design: Prospective randomised open blinded end-point (PROBE) study with two parallel groups.
    Setting: Tertiary University Hospital.
    Patients: Ninety-seven patients undergoing a trans-peritoneal hand-assisted laparoscopic donor nephrectomy.
    Intervention: Patients (n=52) were randomly assigned to receive a general anaesthetic and a surgical RSB with 2 mg kg-1 of levobupivacaine at the time of surgical closure or a spinal anaesthetic with hyperbaric bupivacaine 12.5 mg and diamorphine 0.5 mg (n=45) before general anaesthesia.
    Primary outcome: The primary outcome was the time-to-readiness for discharge following surgery.
    Results: Median [IQR] times-to-readiness for discharge were 75 [56 to 83] and 79 [67 to 101] h for RSB and spinal anaesthesia and there was no significant difference in times-to-readiness for discharge (median difference 4 (95% CI, 0 to 20h; P  = 0.07)). There were no significant differences in pain scores at rest (P  = 0.91) or on movement (P = 0.66). Median 24-h oxycodone consumptions were similar (P  = 0.80). Nausea and vomiting scores were similar (P = 0.57) and urinary retention occurred in one vs. four patients with RSB and spinal anaesthesia, respectively (P  = 0.077).
    Conclusion: Substitution of RSB with spinal anaesthesia using 12.5 mg hyperbaric bupivacaine and 0.5 mg diamorphine, together with a general anaesthetic failed to confer any benefit on time-to-discharge readiness following transperitoneal hand-assisted laparoscopic donor nephrectomy. RSB provided similar analgesia in the immediate postoperative period with a low frequency of side-effects in this cohort.
    Trial registration: ClinicalTrial.gov identifier: NCT02700217.
    MeSH term(s) Anesthesia, Spinal ; Anesthetics, Local ; Bupivacaine ; Hand-Assisted Laparoscopy ; Hospitals ; Humans ; Living Donors ; Nephrectomy/adverse effects ; Nerve Block ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Patient Discharge ; Prospective Studies
    Chemical Substances Anesthetics, Local ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2020-10-02
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001337
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Structural biology: Protein crystal mimics reality.

    Macnab, R M

    Nature

    2001  Volume 410, Issue 6826, Page(s) 321–322

    MeSH term(s) Crystallography, X-Ray ; Flagellin/chemistry ; Protein Conformation
    Chemical Substances Flagellin (12777-81-0)
    Language English
    Publishing date 2001-03-15
    Publishing country England
    Document type Comment ; News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/35066677
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Microbiology. Action at a distance--bacterial flagellar assembly.

    Macnab, R M

    Science (New York, N.Y.)

    2000  Volume 290, Issue 5499, Page(s) 2086–2087

    Abstract: ... In a Perspective, Macnab explains how subunits of the protein flagellin flow down a channel inside the flagellum ...

    Abstract The rotating motion of a helical flagellum enables a bacterium to swim toward positive stimuli and away from danger. But how is the flagellum, composed of many different proteins, assembled? In a Perspective, Macnab explains how subunits of the protein flagellin flow down a channel inside the flagellum and are then added to its tip through the action of a rotating pentameric cap complex (Yonekura et al.).
    MeSH term(s) Bacteria/ultrastructure ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Cryoelectron Microscopy ; Diffusion ; Flagella/metabolism ; Flagella/ultrastructure ; Flagellin/chemistry ; Flagellin/metabolism ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Protein Structure, Secondary
    Chemical Substances Bacterial Proteins ; Flagellin (12777-81-0) ; FlaD protein, Bacteria (147757-14-0)
    Language English
    Publishing date 2000-12-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.290.5499.2086
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: The bacterial flagellum: reversible rotary propellor and type III export apparatus.

    Macnab, R M

    Journal of bacteriology

    1999  Volume 181, Issue 23, Page(s) 7149–7153

    MeSH term(s) Bacterial Physiological Phenomena ; Flagella/genetics ; Flagella/physiology ; Models, Biological ; Movement ; Rotation
    Language English
    Publishing date 1999-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.181.23.7149-7153.1999
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top