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Article ; Online: Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.

Padgett, Claire L / Lalive, Arnaud L / Tan, Kelly R / Terunuma, Miho / Munoz, Michaelanne B / Pangalos, Menelas N / Martínez-Hernández, José / Watanabe, Masahiko / Moss, Stephen J / Luján, Rafael / Lüscher, Christian / Slesinger, Paul A

Neuron

2012 Volume 73, Issue 5, Page(s) 978–989

Abstract: ... mediated by GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK/Kir(3)) channels ... both synaptically evoked and baclofen-activated GABA(B)R-GIRK currents were significantly depressed in VTA GABA ... neurons and remained depressed for 7 days. Presynaptic inhibition mediated by GABA(B)Rs on GABA terminals ...

Abstract	Psychostimulants induce neuroadaptations in excitatory and fast inhibitory transmission in the ventral tegmental area (VTA). Mechanisms underlying drug-evoked synaptic plasticity of slow inhibitory transmission mediated by GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK/Kir(3)) channels, however, are poorly understood. Here, we show that 1 day after methamphetamine (METH) or cocaine exposure both synaptically evoked and baclofen-activated GABA(B)R-GIRK currents were significantly depressed in VTA GABA neurons and remained depressed for 7 days. Presynaptic inhibition mediated by GABA(B)Rs on GABA terminals was also weakened. Quantitative immunoelectron microscopy revealed internalization of GABA(B1) and GIRK2, which occurred coincident with dephosphorylation of serine 783 (S783) in GABA(B2), a site implicated in regulating GABA(B)R surface expression. Inhibition of protein phosphatases recovered GABA(B)R-GIRK currents in VTA GABA neurons of METH-injected mice. This psychostimulant-evoked impairment in GABA(B)R signaling removes an intrinsic brake on GABA neuron spiking, which may augment GABA transmission in the mesocorticolimbic system.
MeSH term(s)	Action Potentials/drug effects ; Action Potentials/genetics ; Animals ; Animals, Newborn ; Baclofen/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Central Nervous System Stimulants/pharmacology ; Channelrhodopsins ; Dopamine/pharmacology ; Dopamine Agents/pharmacology ; Down-Regulation/drug effects ; Drug Interactions ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/ultrastructure ; GABA-B Receptor Agonists/pharmacology ; Glutamate Decarboxylase/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Homeodomain Proteins/genetics ; In Vitro Techniques ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/genetics ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Methamphetamine/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Immunoelectron/methods ; Neurons/drug effects ; Neurons/metabolism ; Neurons/ultrastructure ; Organophosphorus Compounds/pharmacology ; Phosphorylation ; Receptors, GABA-A/metabolism ; Receptors, GABA-A/ultrastructure ; Transcription Factors/genetics ; Ventral Tegmental Area/cytology ; Ventral Tegmental Area/drug effects ; gamma-Aminobutyric Acid/metabolism ; gamma-Aminobutyric Acid/pharmacology
Chemical Substances	Bacterial Proteins ; Central Nervous System Stimulants ; Channelrhodopsins ; Dopamine Agents ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; GABA-B Receptor Agonists ; Homeodomain Proteins ; Kcnj6 protein, mouse ; Luminescent Proteins ; Organophosphorus Compounds ; Receptors, GABA-A ; Transcription Factors ; homeobox protein PITX3 ; yellow fluorescent protein, Bacteria ; Green Fluorescent Proteins (147336-22-9) ; CGP 54626 (149184-21-4) ; Methamphetamine (44RAL3456C) ; gamma-Aminobutyric Acid (56-12-2) ; Glutamate Decarboxylase (EC 4.1.1.15) ; glutamate decarboxylase 1 (EC 4.1.1.15) ; Baclofen (H789N3FKE8) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2012-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2011.12.031
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: Yersinia enterocolitica YopT and Clostridium difficile toxin B induce expression of GILZ in epithelial cells.

Köberle, Martin / Göppel, David / Grandl, Tanja / Gaentzsch, Peer / Manncke, Birgit / Berchtold, Susanne / Müller, Steffen / Lüscher, Bernhard / Asselin-Labat, Marie-Liesse / Pallardy, Marc / Sorg, Isabel / Langer, Simon / Barth, Holger / Zumbihl, Robert / Autenrieth, Ingo B / Bohn, Erwin

PloS one

2012 Volume 7, Issue 7, Page(s) e40730

Abstract: ... expression. Similarly, Clostridium difficile toxin B, another bacterial inhibitor of Rho GTPases induced GILZ ... expression. YopT and toxin B both increased transcriptional activity of the GILZ promoter in HeLa cells. GILZ ... proved necessary for profound GILZ induction by toxin B. Promoter studies and gel shift analyses defined ...

Abstract	Glucocorticoid induced-leucine zipper (GILZ) has been shown to be induced in cells by different stimuli such as glucocorticoids, IL-10 or deprivation of IL-2. GILZ has anti-inflammatory properties and may be involved in signalling modulating apoptosis. Herein we demonstrate that wildtype Yersinia enterocolitica which carry the pYV plasmid upregulated GILZ mRNA levels and protein expression in epithelial cells. Infection of HeLa cells with different Yersinia mutant strains revealed that the protease activity of YopT, which cleaves the membrane-bound form of Rho GTPases was sufficient to induce GILZ expression. Similarly, Clostridium difficile toxin B, another bacterial inhibitor of Rho GTPases induced GILZ expression. YopT and toxin B both increased transcriptional activity of the GILZ promoter in HeLa cells. GILZ expression could not be linked to the inactivation of an individual Rho GTPase by these toxins. However, forced expression of RhoA and RhoB decreased basal GILZ promoter activity. Furthermore, MAPK activation proved necessary for profound GILZ induction by toxin B. Promoter studies and gel shift analyses defined binding of upstream stimulatory factor (USF) 1 and 2 to a canonical c-Myc binding site (E-box) in the GILZ promoter as a crucial step of its trans-activation. In addition we could show that USF-1 and USF-2 are essential for basal as well as toxin B induced GILZ expression. These findings define a novel way of GILZ promoter trans-activation mediated by bacterial toxins and differentiate it from those mediated by dexamethasone or deprivation of IL-2.
MeSH term(s)	Apoptosis ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Base Sequence ; Cysteine Endopeptidases/metabolism ; E-Box Elements ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Gene Expression ; Gene Expression Profiling ; HeLa Cells ; Humans ; Inflammation/genetics ; Inflammation Mediators/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; Signal Transduction ; Transcription Factors/genetics ; Transcription, Genetic ; Transcriptional Activation ; Upstream Stimulatory Factors/metabolism ; rho GTP-Binding Proteins/metabolism
Chemical Substances	Bacterial Proteins ; Bacterial Toxins ; Inflammation Mediators ; NF-kappa B ; TSC22D3 protein, human ; Transcription Factors ; USF1 protein, human ; USF2 protein, human ; Upstream Stimulatory Factors ; YopT protein, Yersinia ; toxB protein, Clostridium difficile ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Cysteine Endopeptidases (EC 3.4.22.-) ; rho GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2012-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0040730
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Article ; Online: Heart failure and respiratory tract infection: Cause and consequence of acute decompensation?

Heidecker, Bettina / Pagnesi, Matteo / Lüscher, Thomas F

European journal of heart failure

2024

Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Editorial
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.3209
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Article ; Online: Ultraviolet-B radiation and water deficit interact to alter flavonol and anthocyanin profiles in grapevine berries through transcriptomic regulation.

Martínez-Lüscher, Johann / Sánchez-Díaz, Manuel / Delrot, Serge / Aguirreolea, Jone / Pascual, Inmaculada / Gomès, Eric

Plant & cell physiology

2014 Volume 55, Issue 11, Page(s) 1925–1936

Abstract: UV-B radiation and water deficit may trigger flavonol and anthocyanin biosynthesis in plant tissues ... anthocyanin profiles in response to UV-B and water deficit. The aim of this study is to identify ... to separate and combined UV-B and water deficit. Grapevines (Vitis vinifera L. cv. Tempranillo) were exposed ...

Abstract	UV-B radiation and water deficit may trigger flavonol and anthocyanin biosynthesis in plant tissues. In addition, previous research has showed strong qualitative effects on grape berry skin flavonol and anthocyanin profiles in response to UV-B and water deficit. The aim of this study is to identify the mechanisms leading to quantitative and qualitative changes in flavonol and anthocyanin profiles, in response to separate and combined UV-B and water deficit. Grapevines (Vitis vinifera L. cv. Tempranillo) were exposed to three levels of UV-B radiation (0, 5.98 and 9.66 kJ m(-2) day(-1)) and subjected to two water regimes. A strong effect of UV-B on flavonol and anthocyanin biosynthesis was found, resulting in an increased anthocyanin concentration and a change in their profile. Concomitantly, two key biosynthetic genes (FLS1 and UFGT) were up-regulated by UV-B, leading to increased flavonol and anthocyanin skin concentration. Changes in flavonol and anthocyanin composition were explained to a large extend by transcript levels of F3'H, F3'5'H and OMT2. A significant interaction between UV-B and water deficit was found in the relative abundance of 3'4' and 3'4'5' substituted flavonols, but not in their anthocyanin homologues. The ratio between 3'4'5' and 3'4' substituted flavonols was linearly related to the ratios of F3'5'H and FLS1 transcription, two steps up-regulated independently by water deficit and UV-B radiation, respectively. Our results indicate that changes in flavonol profiles in response to environmental conditions are not only a consequence of changes in the expression of flavonoid hydroxylases; but also the result of the competition of FLS, F3'5'H and F3'H enzymes for the same flavonol substrates.
MeSH term(s)	Anthocyanins/analysis ; Anthocyanins/genetics ; Anthocyanins/metabolism ; Flavonols/analysis ; Flavonols/genetics ; Flavonols/metabolism ; Fruit/genetics ; Fruit/metabolism ; Gene Expression Regulation, Plant ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Principal Component Analysis ; Transcriptome ; Ultraviolet Rays ; Vitis/genetics ; Vitis/metabolism ; Vitis/radiation effects ; Water/metabolism
Chemical Substances	Anthocyanins ; Flavonols ; Plant Proteins ; Water (059QF0KO0R) ; Oxidoreductases (EC 1.-) ; flavonol synthase (EC 1.3.-)
Language	English
Publishing date	2014-11
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208907-5
ISSN	1471-9053 ; 0032-0781
ISSN (online)	1471-9053
ISSN	0032-0781
DOI	10.1093/pcp/pcu121
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Article ; Online: N-terminal pro-B-type natriuretic peptide-ratio predicts mortality after transcatheter aortic valve replacement.

Stähli, Barbara E / Gebhard, Cathérine / Saleh, Lanja / Falk, Volkmar / Landmesser, Ulf / Nietlispach, Fabian / Maisano, Francesco / Lüscher, Thomas F / Maier, Willibald / Binder, Ronald K

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2015 Volume 85, Issue 7, Page(s) 1240–1247

Abstract: Objectives: We studied the prognostic value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP)-ratio, which is independent of individual cutoff levels, in predicting mortality in patients undergoing transcatheter aortic valve replacement ( ... ...

Abstract	Objectives: We studied the prognostic value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP)-ratio, which is independent of individual cutoff levels, in predicting mortality in patients undergoing transcatheter aortic valve replacement (TAVR). Background: Elevated levels of natriuretic peptides are associated with adverse outcomes across a wide spectrum of cardiovascular diseases. However, cutoff values differ according to age, gender, and body weight. Methods: 244 TAVR patients with preprocedural NT-proBNP levels were analyzed, and the predictive value of NT-proBNP-ratio (measured NT-proBNP/maximal normal NT-proBNP values specific for age and gender) on all-cause-mortality was assessed in a multivariate model. Results: Median NT-proBNP-ratio was 4.2 [IQR 1.8-9.7]. All-cause mortality at 30 days was 3.4% in patients with less than median NT-proBNP-ratio, and 14.0% in patients with more than median NT-proBNP-ratio (P=0.02). All-cause mortality at 1 year was 8.5% in patients with less than median NT-proBNP-ratio, and 32.1% in those with more than median NT-proBNP-ratio (P=0.001). Cumulative survival declined with increasing quartiles of NT-proBNP-ratio (log rank P=0.001). All patients with a NT-proBNP-ratio below 1.5 survived at 1-year follow-up. In ROC analysis, NT-proBNP-ratio significantly predicted 30-day (AUC=0.72; P=0.002) and 1-year all-cause mortality (AUC=0.72; P<0.001). By multivariate Cox regression analysis, NT-proBNP-ratio, chronic obstructive pulmonary disease, and serum creatinine were the only independent predictors of all-cause mortality. Conclusions: Elevated NT-proBNP-ratio was associated with increased short- and long-term mortality after TAVR, and independently predicted all-cause mortality. NT-proBNP-ratio should be considered in the risk stratification of patients undergoing TAVR.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/physiopathology ; Aortic Valve Stenosis/blood ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/therapy ; Area Under Curve ; Biomarkers/blood ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/mortality ; Cause of Death ; Chi-Square Distribution ; Female ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Multivariate Analysis ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Predictive Value of Tests ; Proportional Hazards Models ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Switzerland ; Time Factors ; Treatment Outcome ; Up-Regulation
Chemical Substances	Biomarkers ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.25788
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Zs.A 1226: Show issues

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Article ; Online: Ultraviolet-B radiation modifies the quantitative and qualitative profile of flavonoids and amino acids in grape berries.

Martínez-Lüscher, J / Torres, N / Hilbert, G / Richard, T / Sánchez-Díaz, M / Delrot, S / Aguirreolea, J / Pascual, I / Gomès, E

Phytochemistry

2014 Volume 102, Page(s) 106–114

Abstract: Grapevine cv. Tempranillo fruit-bearing cuttings were exposed to supplemental ultraviolet-B (UV-B ... and flavonoid profile. The plants were exposed to two doses of UV-B biologically effective (5.98 and 9 ... A 0kJm(-2)d(-1) treatment was included as a control. UV-B did not significantly modify grape berry size ...

Abstract	Grapevine cv. Tempranillo fruit-bearing cuttings were exposed to supplemental ultraviolet-B (UV-B) radiation under controlled conditions, in order to study its effect on grape traits, ripening, amino acids and flavonoid profile. The plants were exposed to two doses of UV-B biologically effective (5.98 and 9.66kJm(-2)d(-1)), applied either from fruit set to ripeness or from the onset of veraison to ripeness. A 0kJm(-2)d(-1) treatment was included as a control. UV-B did not significantly modify grape berry size, but increased the relative mass of berry skin. Time to reach ripeness was not affected by UV-B, which may explain the lack of changes in technological maturity. The concentration of must extractable anthocyanins, colour density and skin flavonols were enhanced by UV-B, especially in plants exposed from fruit set. The quantitative and qualitative profile of grape skin flavonols were modified by UV-B radiation. Monosubstituted flavonols relative abundance increased proportionally to the accumulated UV-B doses. Furthermore, trisubstituted forms, which where predominant in non-exposed berries, were less abundant as UV-B exposure increased. Although total free amino acid content remained unaffected by the treatments, the increased levels of gamma-aminobutyric acid (GABA), as well as the decrease in threonine, isoleucine, methionine, serine and glycine, revealed a potential influence of UV-B on the GABA-mediated signalling and amino acid metabolism. UV-B had an overall positive impact on grape berry composition.
MeSH term(s)	Amino Acids/chemistry ; Flavonoids/chemistry ; Fruit/chemistry ; Ultraviolet Rays ; Vitis/chemistry
Chemical Substances	Amino Acids ; Flavonoids
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2014.03.014
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Z 8.5: Show issues

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Article ; Online: Characterization of the adaptive response of grapevine (cv. Tempranillo) to UV-B radiation under water deficit conditions.

Martínez-Lüscher, J / Morales, F / Delrot, S / Sánchez-Díaz, M / Gomès, E / Aguirreolea, J / Pascual, I

Plant science : an international journal of experimental plant biology

2014 Volume 232, Page(s) 13–22

Abstract: ... Tempranillo to UV-B radiation under water deficit conditions. Grapevine fruit-bearing cuttings were exposed ... to three levels of supplemental biologically effective UV-B radiation (0, 5.98 and 9.66kJm(-2)day(-1)) and ... under glasshouse-controlled conditions. UV-B induced a transient decrease in net photosynthesis (Anet ...

Abstract	This work aims to characterize the physiological response of grapevine (Vitis vinifera L.) cv. Tempranillo to UV-B radiation under water deficit conditions. Grapevine fruit-bearing cuttings were exposed to three levels of supplemental biologically effective UV-B radiation (0, 5.98 and 9.66kJm(-2)day(-1)) and two water regimes (well watered and water deficit), in a factorial design, from fruit-set to maturity under glasshouse-controlled conditions. UV-B induced a transient decrease in net photosynthesis (Anet), actual and maximum potential efficiency of photosystem II, particularly on well watered plants. Methanol extractable UV-B absorbing compounds (MEUVAC) concentration and superoxide dismutase activity increased with UV-B. Water deficit effected decrease in Anet and stomatal conductance, and did not change non-photochemical quenching and the de-epoxidation state of xanthophylls, dark respiration and photorespiration being alternative ways to dissipate the excess of energy. Little interactive effects between UV-B and drought were detected on photosynthesis performance, where the impact of UV-B was overshadowed by the effects of water deficit. Grape berry ripening was strongly delayed when UV-B and water deficit were applied in combination. In summary, deficit irrigation did not modify the adaptive response of grapevine to UV-B, through the accumulation of MEUVAC. However, combined treatments caused additive effects on berry ripening.
MeSH term(s)	Chlorophyll/metabolism ; Desiccation ; Lipid Peroxidation/radiation effects ; Photosynthesis/radiation effects ; Plant Stomata/radiation effects ; Superoxide Dismutase/metabolism ; Ultraviolet Rays ; Vitis/metabolism ; Vitis/physiology ; Vitis/radiation effects ; Water/metabolism
Chemical Substances	Water (059QF0KO0R) ; Chlorophyll (1406-65-1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2014-12-23
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2014.12.013
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Article ; Online: Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells.

Cornelissen, C / Brans, R / Czaja, K / Skazik, C / Marquardt, Y / Zwadlo-Klarwasser, G / Kim, A / Bickers, D R / Lüscher-Firzlaff, J / Lüscher, B / Baron, J M

The British journal of dermatology

2011 Volume 165, Issue 5, Page(s) 966–975

Abstract: ... the effects of ultraviolet (UV) B radiation and H₂O₂ on IL-31 mRNA and protein expression in skin and ...

Abstract	Background: Interleukin (IL)-31 is a novel Th2 T-cell cytokine that induces pruritus and dermatitis in transgenic mice. While enhanced mRNA expression of this cytokine is detected in skin samples of inflammatory skin diseases, the regulation of IL-31 expression is poorly understood. Objectives: To assess the effects of ultraviolet (UV) B radiation and H₂O₂ on IL-31 mRNA and protein expression in skin and different peripheral blood mononuclear cells (PBMCs). Methods: The effects of UVB radiation and H₂O₂, as a prototypic reactive oxygen species, on IL-31 mRNA and protein expression were analysed in various inflammation-related cells and murine skin tissue. RESULTSTreatment of cells with UVB radiation and H₂ O₂ strongly induced IL-31 mRNA and protein expression in human PBMCs and in the skin of SKH-1 mice. Following exposure to UVB or H₂O₂, we observed increased expression of IL-31 mRNA in T cells, monocytes, macrophages, and immature and especially mature dendritic cells. H₂O₂ treatment but not UVB radiation led to a moderate upregulation of IL-31 mRNA expression in epidermal keratinocytes and dermal fibroblasts. Pretreatment of T lymphocytes with the MAPK p38 inhibitor SB203580 or the MEK1 inhibitor U0126 reduced the stimulatory effect of H₂O₂. These experiments suggest that p38 is involved in the regulation of IL-31 expression in human skin. Conclusions: Our studies reveal that UVB and reactive oxygen species stimulate the expression of IL-31 in PBMCs and skin, especially in T cells, monocytes and monocyte-derived dendritic cells.
MeSH term(s)	Animals ; Cells, Cultured ; Dendritic Cells/radiation effects ; Fibroblasts/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Interleukins/metabolism ; Keratinocytes/metabolism ; Leukocytes, Mononuclear/radiation effects ; Mice ; Mice, Hairless ; RNA, Messenger/metabolism ; Reactive Oxygen Species/pharmacology ; Skin/metabolism ; T-Lymphocytes/radiation effects ; Ultraviolet Rays
Chemical Substances	IL31 protein, human ; Interleukins ; RNA, Messenger ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2011-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/j.1365-2133.2011.10487.x
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Article ; Online: Short- and long-term physiological responses of grapevine leaves to UV-B radiation.

Martínez-Lüscher, J / Morales, F / Delrot, S / Sánchez-Díaz, M / Gomés, E / Aguirreolea, J / Pascual, I

Plant science : an international journal of experimental plant biology

2013 Volume 213, Page(s) 114–122

Abstract: The present study aimed at evaluating the short- and long-term effects of UV-B radiation on leaves ... of supplemental biologically effective UV-B radiation (UV-BBE) under glasshouse-controlled conditions: 5.98 and 9 ... from fruit set to ripeness). A 0kJm(-2)d(-1) UV-B treatment was included as control. The main effects of UV-B ...

Abstract	The present study aimed at evaluating the short- and long-term effects of UV-B radiation on leaves of grapevine Vitis vinifera (cv. Tempranillo). Grapevine fruit-bearing cuttings were exposed to two doses of supplemental biologically effective UV-B radiation (UV-BBE) under glasshouse-controlled conditions: 5.98 and 9.66kJm(-2)d(-1). The treatments were applied either for 20d (from mid-veraison to ripeness) or 75d (from fruit set to ripeness). A 0kJm(-2)d(-1) UV-B treatment was included as control. The main effects of UV-B were observed after the short-term exposure (20d) to 9.66kJm(-2)d(-1). Significant decreases in net photosynthesis, stomatal conductance, sub-stomatal CO2 concentration, the actual photosystem II (PSII) efficiency, total soluble proteins and de-epoxidation state of the VAZ cycle were observed, whereas the activities of several antioxidant enzymes increased significantly. UV-B did not markedly affect dark respiration, photorespiration, the maximum potential PSII efficiency (Fv/Fm), non-photochemical quenching (NPQ), as well as the intrinsic PSII efficiency. However, after 75d of exposure to 5.98and 9.66kJm(-2)d(-1) UV-B most photosynthetic and biochemical variables were unaffected and there were no sign of oxidative damage in leaves. The results suggest a high long-term acclimation capacity of grapevine to high UV-B levels, associated with a high accumulation of UV-B absorbing compounds in leaves, whereas plants seemed to be tolerant to moderate doses of UV-B.
MeSH term(s)	Acclimatization/radiation effects ; Antioxidants/analysis ; Antioxidants/metabolism ; Carbon Dioxide/metabolism ; Carotenoids/analysis ; Carotenoids/metabolism ; Cell Respiration/radiation effects ; Chlorophyll/analysis ; Chlorophyll/metabolism ; Lipid Peroxidation/radiation effects ; Oxidation-Reduction/radiation effects ; Photosynthesis/radiation effects ; Photosystem II Protein Complex/radiation effects ; Plant Extracts/analysis ; Plant Extracts/isolation & purification ; Plant Leaves/physiology ; Plant Leaves/radiation effects ; Plant Proteins/analysis ; Plant Proteins/metabolism ; Plant Stomata/physiology ; Plant Stomata/radiation effects ; Plant Transpiration/radiation effects ; Time Factors ; Ultraviolet Rays ; Vitis/physiology ; Vitis/radiation effects
Chemical Substances	Antioxidants ; Photosystem II Protein Complex ; Plant Extracts ; Plant Proteins ; Chlorophyll (1406-65-1) ; Carbon Dioxide (142M471B3J) ; Carotenoids (36-88-4)
Language	English
Publishing date	2013-09-07
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2013.08.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Characterization of the adaptive response of grapevine (cv. Tempranillo) to UV-B radiation under water deficit conditions

Martínez-Lüscher, J / E. Gomès / F. Morales / I. Pascual / J. Aguirreolea / M. Sánchez-Díaz / S. Delrot

Plant science. 2015 Mar., v. 232

2015

Abstract: ... Tempranillo to UV-B radiation under water deficit conditions. Grapevine fruit-bearing cuttings were exposed ... to three levels of supplemental biologically effective UV-B radiation (0, 5.98 and 9.66kJm−2day−1) and two ... glasshouse-controlled conditions. UV-B induced a transient decrease in net photosynthesis (Anet), actual and ...

Abstract	This work aims to characterize the physiological response of grapevine (Vitis vinifera L.) cv. Tempranillo to UV-B radiation under water deficit conditions. Grapevine fruit-bearing cuttings were exposed to three levels of supplemental biologically effective UV-B radiation (0, 5.98 and 9.66kJm−2day−1) and two water regimes (well watered and water deficit), in a factorial design, from fruit-set to maturity under glasshouse-controlled conditions. UV-B induced a transient decrease in net photosynthesis (Anet), actual and maximum potential efficiency of photosystem II, particularly on well watered plants. Methanol extractable UV-B absorbing compounds (MEUVAC) concentration and superoxide dismutase activity increased with UV-B. Water deficit effected decrease in Anet and stomatal conductance, and did not change non-photochemical quenching and the de-epoxidation state of xanthophylls, dark respiration and photorespiration being alternative ways to dissipate the excess of energy. Little interactive effects between UV-B and drought were detected on photosynthesis performance, where the impact of UV-B was overshadowed by the effects of water deficit. Grape berry ripening was strongly delayed when UV-B and water deficit were applied in combination. In summary, deficit irrigation did not modify the adaptive response of grapevine to UV-B, through the accumulation of MEUVAC. However, combined treatments caused additive effects on berry ripening.
Keywords	additive effect ; deficit irrigation ; drought ; energy ; fruit set ; grapes ; methanol ; photorespiration ; photosystem II ; physiological response ; ripening ; stomatal conductance ; superoxide dismutase ; ultraviolet radiation ; Vitis vinifera ; xanthophylls
Language	English
Dates of publication	2015-03
Size	p. 13-22.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2014.12.013
Database	NAL-Catalogue (AGRICOLA)

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