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Article ; Online: Linking ecosystems to public health based on combination of social and ecological systems.

Khosravi Mashizi, Azam / Sharafatmandrad, Mohsen

2024 Volume 14, Issue 1, Page(s) 9911

Abstract: Promotion of public health is one of the most important benefits of ecosystems. Nevertheless, the relationship between ecosystems and social health' needs is not well understood. Therefore, a study was done to investigate the potential of natural ( ... ...

Abstract	Promotion of public health is one of the most important benefits of ecosystems. Nevertheless, the relationship between ecosystems and social health' needs is not well understood. Therefore, a study was done to investigate the potential of natural (forests and rangelands) and artificial (urban parks and gardens) ecosystems in ensuring the five dimensions of public health (i.e. physical, mental, spiritual, social and environmental) in the social systems (urban and rural societies). Therefore, 47 health indicators were used in order to relate different ecosystems and social' needs to five dimensions of public health through questionnaire. The results indicated that natural ecosystems had the greatest potential in providing mental, spiritual and environmental health due to ecological characteristics of wilderness and aesthetic. The artificial ecosystems had the greatest potential in providing physical and social health due to their easy access. However, there was a match between social health' needs and ecosystem potential in the rural areas. The study highlighted the need for promotion of ecological indicators related to mental health in urban areas by enhancing silence and aesthetic in artificial ecosystems. Presented framework can provide comprehensive information on the weaknesses and strengths of different ecosystems to promote public health based on social needs and fixing the weaknesses of artificial ecosystems in urban areas.
MeSH term(s)	Ecosystem ; Public Health ; Humans ; Surveys and Questionnaires ; Mental Health
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60814-z
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Article ; Online: Antibiotic resistance and genomic characterization of Mycobacterium abscessus complex isolates from patients with pulmonary tuberculosis in Iran: A multi-center study (2010-2021).

Hashemzadeh, Mohammad / Asareh Zadegan Dezfuli, Aram / Khosravi, AzarDokht / Ahmad Khosravi, Nazanin / Saki, Morteza

Acta microbiologica et immunologica Hungarica

2024 Volume 71, Issue 1, Page(s) 82–88

Abstract: One hundred and eighteen sputum specimens suspected of Mycobacterium abscessus infection were collected. Species level identification of M. abscessus was performed by rpoB sequencing. Clonality analysis was done by multilocus sequence typing (MLST) for M. ...

Abstract	One hundred and eighteen sputum specimens suspected of Mycobacterium abscessus infection were collected. Species level identification of M. abscessus was performed by rpoB sequencing. Clonality analysis was done by multilocus sequence typing (MLST) for M. abscessus. Antibiotic susceptibility testing was performed for clarithromycin, amikacin, ciprofloxacin and moxifloxacin. Altogether 128 isolates were obtained and were subjected to rpoB gene sequencing for definite identification. Among them 59 were identified as M. abscessus, and these included 22 (37.28%) isolates of M. abscessus subsp. abscessus, 22 (37.28%) isolates of M. abscessus subsp. massiliense, and 15 (25.42%) isolates of M. abscessus subsp. bolletii. All 59 M. abscessus complex isolates were analyzed by MLST in this study. Certain sequence types (STs) were identified among the 59 isolates and were specific for each subspecies. Two STs (ST40 and ST33) were specific to M. abscessus subsp. abscessus, one ST (ST20) was specific to M. abscessus subsp. bolletii, and one ST (ST15) was specific to M. abscessus subsp. massiliense. In antibiotic resistance, clarithromycin susceptibility testing of 22 M. abscessus subsp. abscessus strains detected 15 (68.18%) resistant strains, while among 22 M. abscessus subsp. massiliense strains 5 (22.72%) exhibited resistance, and among 15 M. abscessus subsp. bolletii 8 (53.33%) were resistant. Our study revealed a significant level of antibiotic resistance in isolates of the M. abscessus complex.
MeSH term(s)	Humans ; Mycobacterium abscessus/genetics ; Clarithromycin/pharmacology ; Multilocus Sequence Typing ; Iran/epidemiology ; Tuberculosis, Pulmonary/epidemiology ; Genomics ; Drug Resistance, Microbial ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Clarithromycin (H1250JIK0A) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-29
Publishing country	Hungary
Document type	Multicenter Study ; Journal Article
ZDB-ID	918256-1
ISSN	1588-2640 ; 1217-8950
ISSN (online)	1588-2640
ISSN	1217-8950
DOI	10.1556/030.2024.02169
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Article ; Online: Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis.

Khosravi, Marten A / Seifert, Roland

Naunyn-Schmiedeberg's archives of pharmacology

2023

Abstract: Curcumin is an ingredient of the root Curcuma longa, which is responsible for the characteristic yellow color of curcuma. Curcumin is said to have the potential ability to fight malignant diseases and to have an anti-inflammatory effect. In addition, it ... ...

Abstract	Curcumin is an ingredient of the root Curcuma longa, which is responsible for the characteristic yellow color of curcuma. Curcumin is said to have the potential ability to fight malignant diseases and to have an anti-inflammatory effect. In addition, it is used as a dietary supplement. However, one problem with the use of curcumin is its extremely low bioavailability. The aim of this study is to systematically review and critically analyze clinical studies related to the pharmacokinetics (or bioavailability) and to the use of curcumin in the treatment of malignant diseases. The platforms clinicaltrials.gov and PubMed served as the database for the literature research. A total of 293 available studies on curcumin were filtered according to their focus (bioavailability, therapy of malignant diseases) and other criteria (study results, main substance, topic reference, existing disease/other research purpose, reference to malignant diseases). The studies were further analyzed regarding their outcome measures, their design (number of participants, randomization, placebo group, masking, ethical standards, sponsor, primary outcome measures, secondary outcome measures, study bias) and their findings. The analysis failed to convincingly demonstrate that curcumin has a significant, positive effect on the therapy of malignant diseases. Regarding the increase in bioavailability, positive results have been obtained, which are in proximity to the pharmaceutical industry. Independent studies could not achieve increased bioavailability of curcumin. The available reviews in the literature also do not provide convincing evidence for the efficacy of curcumin. Thus, at the time being, the use of curcumin in malignant diseases is not justified scientifically.
Language	English
Publishing date	2023-11-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02825-7
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Article ; Online: [No title information]

Pourghadiri, Amir / Khosravi-Hafshejani, Touraj / Hong, H Chih-Ho

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2024 Volume 196, Issue 2, Page(s) E61–E62

Title translation	Érythème polymorphe majeur associé à une infection au SRAS-CoV-2 chez un patient à la peau foncée.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Erythema Multiforme
Language	French
Publishing date	2024-01-21
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.230926-f
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Article ; Online: Exosomes from SHED-MSC regulate polarization and stress oxidative indexes in THP-1 derived M1 macrophages.

Fallah, Ali / Hosseinzadeh Colagar, Abasalt / Khosravi, Ayyoob / Saeidi, Mohsen

Archives of biochemistry and biophysics

2024 Volume 755, Page(s) 109987

Abstract: Objective: The inhibition of M1 macrophages may be interesting for targeted therapy with mesenchymal stem cell-derived Exosomes (MSC-EXOs). This study aimed to investigate the stem cells of human exfoliated deciduous teeth-derived EXOs (SHED-MSC-EXOs) ... ...

Abstract	Objective: The inhibition of M1 macrophages may be interesting for targeted therapy with mesenchymal stem cell-derived Exosomes (MSC-EXOs). This study aimed to investigate the stem cells of human exfoliated deciduous teeth-derived EXOs (SHED-MSC-EXOs) effect on regulating the pro- and anti-oxidant indexes and inhibiting M1 macrophage polarization. Besides, an in-silico analysis of SHED-MSC-EXO miRNAs as the highest frequency of small RNAs in the exosomes was performed to discover the possible mechanism. Methods: The flow cytometry analysis of CD80 and CD86 as M1-specific markers confirmed the polarization of macrophages derived from THP-1 cells. After exosome isolation, characterization, and internalization, THP-1-derived M1 macrophages were treated with SHED-MSC-EXOs. M1-specific markers and pro- and anti-oxidant indexes were evaluated. For in-silico analysis of SHED-MSC-EXOs miRNAs, initial miRNA array data of SHED-EXOs is collected from GEO, and the interaction of the miRNAs in M1 macrophage polarization (M1P), mitochondrial oxidative stress (MOS) and LPS-induced oxidative stress (LOS) were analyzed by miRWalk 3.0 server. Outcomes were filtered by 75th percentile signal intensity, score cut-off ≥0.95, minimum free energy (MEF)≤ -20 kcal/mol, and seed = 1. Results: It shows a decrease in the expression of CD80 and CD81, a reduction in pro-oxidant indicators, and an increase in the anti-oxidant indexes (P < 0.05). Computational analysis showed that eight microRNAs of SHED-MSC-EXO miRNAs can bind to and interfere with the expression of candidate genes in the M1P, MOS, and LOS pathways simultaneously. Conclusion: SHED-MSCs-EXOs can be utilized to treat conditions related to M1 macrophage-induced diseases (M1IDs) due to their unique physical properties and ability to penetrate target cells easily.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2024.109987
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Article ; Online: Desired Care for Perinatal Bereavement: Meeting the Needs of Mothers After Discharge From the Hospital-a Qualitative Study.

Atashsokhan, Giti / Farjamfar, Maryam / Khosravi, Ahmad / Taher, Mahboobe / Keramat, Afsaneh

Inquiry : a journal of medical care organization, provision and financing

2024 Volume 61, Page(s) 469580231223763

Abstract: This study aimed to investigate the understanding and experiences of mothers who have suffered perinatal loss regarding their needs after being discharged from the hospital. Data were collected through semi-structured face-to-face and telephone ... ...

Abstract	This study aimed to investigate the understanding and experiences of mothers who have suffered perinatal loss regarding their needs after being discharged from the hospital. Data were collected through semi-structured face-to-face and telephone interviews using purposive sampling with maximum diversity. The sample included 15 mothers and 6 midwives who had experienced fetal loss and perinatal bereavement. The interviews were audio-recorded and transcribed verbatim. Conventional content analysis was used to analyze the data. Sampling was conducted from July 2022 to March 2023, continuing until data saturation was reached. The study identified 2 main categories of needs for mothers who have experienced perinatal loss: continuous healthcare (including the Comprehensive Mother Tracking System, provision of psychological welfare, and educational needs) and provision of a support network, including "spouse and family support" and "peer and colleague support." The primary theme of this study was "Deliberating Care for Grieving Mothers." The study results indicate that mothers who experience perinatal loss require continuity of care after being discharged. Psychological screening and counseling support are essential for both parents. Considering the significant impact of spousal, familial, and community support on an individual's life, it is crucial to prepare the community to comprehend and embrace grieving parents.
MeSH term(s)	Pregnancy ; Female ; Humans ; Mothers/psychology ; Patient Discharge ; Bereavement ; Grief ; Qualitative Research ; Hospitals
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	42153-4
ISSN	1945-7243 ; 0046-9580
ISSN (online)	1945-7243
ISSN	0046-9580
DOI	10.1177/00469580231223763
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Article: Impact of umbelliprenin-containing niosome nanoparticles on

Dastaviz, Farzad / Vahidi, Akram / Khosravi, Teymoor / Khosravi, Ayyoob / Sheikh Arabi, Mehdi / Bagheri, Abouzar / Rashidi, Mohsen / Oladnabi, Morteza

International journal of ophthalmology

2024 Volume 17, Issue 1, Page(s) 7–15

Abstract: Aim: To investigate the impact of niosome nanoparticles carrying umbelliprenin (UMB), an anti-angiogenic and anti-inflammatory plant compound, on the expression of vascular endothelial growth factor (: Methods: UMB-containing niosomes were created, ... ...

Abstract	Aim: To investigate the impact of niosome nanoparticles carrying umbelliprenin (UMB), an anti-angiogenic and anti-inflammatory plant compound, on the expression of vascular endothelial growth factor ( Methods: UMB-containing niosomes were created, optimized, and characterized. RPE-like cells were treated with free UMB and UMB-containing niosomes. The IC Results: Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in Conclusion: Both free UMB and niosome-encapsulated UMB inhibits
Language	English
Publishing date	2024-01-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2024.01.02
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Article: STAIR Plus Narrative Therapy-Adolescent Version (SNT-A) in An 11-Year-Old Girl With PTSD and Suicidal Behaviors Following Rape/Sexual Assault: A Case Report.

Khosravi, Mohsen / Adibi, Amir

Journal of child & adolescent trauma

2022 Volume 15, Issue 3, Page(s) 943–948

Abstract: Rape/sexual assault can profoundly affect the physical, mental, and social well-being of victims. Post-traumatic stress disorder (PTSD) and suicide in rape/sexual assault survivors are significantly more frequent than the national prevalence of the ... ...

Abstract	Rape/sexual assault can profoundly affect the physical, mental, and social well-being of victims. Post-traumatic stress disorder (PTSD) and suicide in rape/sexual assault survivors are significantly more frequent than the national prevalence of the condition, indicating that existing treatments require improvement. In this case report, we presented an 11-year-old Iranian girl with PTSD and suicidal behaviors following rape/sexual assault. We specifically focused on the process of helping the victim to develop effective coping skills and overcome the trauma through 16 weekly sessions of Skill Training in Affective and Interpersonal Regulation (STAIR) plus Narrative Therapy-Adolescent Version (SNT-A). During this therapeutic approach, the patient regained emotional control over the traumatic experience and made sense of the experience. Our findings revealed that SNT-A might be an effective intervention to reduce suicidal ideation among adolescent victims of rape/sexual assault. Nonetheless, further investigations in this field need to be carried out through randomized controlled trials.
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2502136-9
ISSN	1936-153X ; 1936-1521
ISSN (online)	1936-153X
ISSN	1936-1521
DOI	10.1007/s40653-021-00430-5
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Article ; Online: A new real-time analog circuit of Ca

Khosravi, Ali / Karimi, Gholamreza

Journal of theoretical biology

2022 Volume 547, Page(s) 111164

Abstract: Different biological models are used to study physical behaviors in neural networks. So far, various models of neural network components such as neurons, synapses, and astrocytes have been proposed. An astrocyte is one of the crucial parts introduced in ... ...

Abstract	Different biological models are used to study physical behaviors in neural networks. So far, various models of neural network components such as neurons, synapses, and astrocytes have been proposed. An astrocyte is one of the crucial parts introduced in multiple models. A model of astrocytes used as a good reference in various papers is the Li-Rinzel calcium model. This paper presents a real-time analog circuit of the Li-Rinzel calcium model based on common-mode (CM) in 180 nm CMOS technology. To the best of our knowledge, this work is the first report to introduce a real-time analog circuit of Li-Rinzel model in an integrated standard CMOS technology. The careful design of equations and low power consumption are essential features of this circuit. The real-time behavior is also crucial compared with the accelerated time circuits presented so far.
MeSH term(s)	Astrocytes ; Calcium ; Models, Neurological ; Neurons/physiology ; Synapses/physiology
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2022.111164
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Article: Graph Convolutional Network for predicting secondary structure of RNA.

Busaranuvong, Palawat / Ammartayakun, Aukkawut / Korkin, Dmitry / Khosravi-Far, Roya

Research square

2024

Abstract: The prediction of RNA secondary structures is essential for understanding its underlying principles and applications in diverse fields, including molecular diagnostics and RNA-based therapeutic strategies. However, the complexity of the search space ... ...

Abstract	The prediction of RNA secondary structures is essential for understanding its underlying principles and applications in diverse fields, including molecular diagnostics and RNA-based therapeutic strategies. However, the complexity of the search space presents a challenge. This work proposes a Graph Convolutional Network (GCNfold) for predicting the RNA secondary structure. GCNfold considers an RNA sequence as graph-structured data and predicts posterior base-pairing probabilities given the prior base-pairing probabilities, calculated using McCaskill's partition function. The performance of GCNfold surpasses that of the state-of-the-art folding algorithms, as we have incorporated minimum free energy information into the richly parameterized network, enhancing its robustness in predicting non-homologous RNA secondary structures. A Symmetric Argmax Post-processing algorithm ensures that GCNfold formulates valid structures. To validate our algorithm, we applied it to the SARS-CoV-2 E gene and determined the secondary structure of the E-gene across the
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3798842/v1
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