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Article ; Online: Late-onset 5,10-methylenetetrahydrofolate reductase deficiency with subacute disturbance of consciousness.

Miura, Maki / Nishijima, Haruo / Suzuki, Chieko / Tomiyama, Masahiko

Pediatrics international : official journal of the Japan Pediatric Society

2024 Volume 66, Issue 1, Page(s) e15720

MeSH term(s)	Humans ; Consciousness ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Homocystinuria ; Muscle Spasticity ; Psychotic Disorders
Chemical Substances	Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	English
Publishing date	2024-01-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15720
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Zs.A 848: Show issues

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Article ; Online: An extensive ion-pair/hydrogen-bond network contributes to the thermostability of the MutL ATPase domain from Aquifex aeolicus.

Shibuya, Ayaka / Yokote, Maki / Suzuki, Atsushi / Fukui, Kenji / Yano, Takato

FEMS microbiology letters

2024 Volume 371

Abstract: Proteins from hyperthermophiles often contain a large number of ionic interactions. Close examination of the previously determined crystal structure of the ATPase domain of MutL from a hyperthermophile, Aquifex aeolicus, revealed that the domain contains ...

Abstract	Proteins from hyperthermophiles often contain a large number of ionic interactions. Close examination of the previously determined crystal structure of the ATPase domain of MutL from a hyperthermophile, Aquifex aeolicus, revealed that the domain contains a continuous ion-pair/hydrogen-bond network consisting of 11 charged amino acid residues on a β-sheet. Mutations were introduced to disrupt the network, showing that the more extensively the network was disrupted, the greater the thermostability of the protein was decreased. Based on urea denaturation analysis, a thermodynamic parameter, energy for the conformational stability, was evaluated, which indicated that amino acid residues in the network contributed additively to the protein stability. A continuous network rather than a cluster of isolated interactions would pay less entropic penalty upon fixing the side chains to make the same number of ion pairs/hydrogen bonds, which might contribute more favorably to the structural formation of thermostable proteins.
MeSH term(s)	Protein Folding ; Hydrogen Bonding ; Bacteria/genetics ; Ions ; Adenosine Triphosphatases/genetics ; Amino Acids ; Aquifex
Chemical Substances	Ions ; Adenosine Triphosphatases (EC 3.6.1.-) ; Amino Acids
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1093/femsle/fnae020
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Zs.A 1372: Show issues

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Article ; Online: Age estimation using postmortem computed tomography-based Hounsfield unit values of the palate and mandibular condyle and the Eichner classification.

Suzuki, Shoken / Ohtani, Maki / Matsuo, Yuhei / Fukuda, Masayuki / Mimasaka, Sohtaro

Legal medicine (Tokyo, Japan)

2024 Volume 69, Page(s) 102446

Abstract: Age estimation is important in forensic investigations of unidentified human remains. This study assessed the correlation between age and Hounsfield unit (HU) values of the palate and mandibular condyle based on postmortem computed tomography (CT) and ... ...

Abstract	Age estimation is important in forensic investigations of unidentified human remains. This study assessed the correlation between age and Hounsfield unit (HU) values of the palate and mandibular condyle based on postmortem computed tomography (CT) and analyzed the influence of occlusal support in developing an age estimation method for Japanese individuals, including older adults. The sample consisted of a training dataset (357 cadavers) and a validation dataset (300 cadavers) that underwent postmortem CT. Three measurements were selected: the respective HU values of the palate and mandibular condyle and the Eichner classification. The correlation coefficients between age and HU values were also evaluated. Multiple stepwise regression analysis was performed to evaluate the significance of four parameters (sex, respective HU values of the palate and mandibular condyle, and the Eichner classification) for age estimation and to determine the best age estimation formula. In the validation tests, inaccuracy and bias were calculated for the groups aged ≥65 or <65 years. Significant correlations between age and HU values of the palate and mandibular condyle were observed, regardless of sex. In multiple stepwise regression analysis, all variables except sex were significantly correlated with age. The age estimation formula from the regression analysis was useful, and the validation test exhibited high accuracy, especially in older adults. The HU values of the palate and mandibular condyle and the Eichner classification are useful for age estimation in Japanese individuals.
Language	English
Publishing date	2024-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2024.102446
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Zs.A 5250: Show issues

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Article: Genetic variants of G-protein coupled receptors associated with pubertal disorders.

Suzuki, Erina / Miyado, Mami / Kuroki, Yoko / Fukami, Maki

Reproductive medicine and biology

2023 Volume 22, Issue 1, Page(s) e12515

Abstract: Background: The human hypothalamic-pituitary-gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G-protein coupled receptors (GPCRs) encoded by : Methods: Previous studies have identified several rare variants ...

Abstract	Background: The human hypothalamic-pituitary-gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G-protein coupled receptors (GPCRs) encoded by Methods: Previous studies have identified several rare variants of the six GPCR genes in patients with pubertal disorders. In vitro assays and animal studies have provided information on the function of wild-type and variant GPCRs. Main findings: Of the six GPCRs, those encoded by Conclusion: The six GPCRs in the HPG axis govern pubertal development through fine-tuning of hormone secretion. Rare sequence variants in these genes jointly account for a certain percentage of genetic causes of pubertal disorders. Still, much remains to be clarified about the molecular network involving the six GPCRs.
Language	English
Publishing date	2023-04-27
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2185775-1
ISSN	1447-0578 ; 1445-5781
ISSN (online)	1447-0578
ISSN	1445-5781
DOI	10.1002/rmb2.12515
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Article ; Online: Usefulness of an online system to support daily life activities of outpatients with young-onset dementia: a case report.

Nagata, Yuma / Hotta, Maki / Satake, Yuto / Ishimaru, Daiki / Suzuki, Maki / Ikeda, Manabu

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

2022 Volume 22, Issue 6, Page(s) 890–894

MeSH term(s)	Humans ; Outpatients ; Activities of Daily Living ; Dementia ; Online Systems
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Case Reports
ZDB-ID	2213105-X
ISSN	1479-8301 ; 1346-3500
ISSN (online)	1479-8301
ISSN	1346-3500
DOI	10.1111/psyg.12896
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Zs.A 6210: Show issues

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Article ; Online: Quantifying the direct and indirect effects of sika deer (Cervus nippon) on the prevalence of infection with Rickettsia in questing Haemaphysalis megaspinosa: A field experimental study.

Matsuyama, Hiroyuki / Doi, Kandai / Agetsuma, Naoki / Suzuki, Maki

Ticks and tick-borne diseases

2023 Volume 14, Issue 5, Page(s) 102201

Abstract: Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of ... ...

Abstract	Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of Rickettsia infection in questing H. megaspinosa. As sika deer decrease vegetation cover and height and thereby indirectly cause changes in the abundance of other hosts, including reservoirs of Rickettsia, the prevalence of Rickettsia infection in questing ticks can also change. We investigated these possible effects of deer on the prevalence of infection with Rickettsia in questing ticks in a field experiment in which deer density was manipulated at three fenced sites: a deer enclosure (Deer-enclosed site); a deer enclosure where deer had been present until 2015 and only indirect effects remained (Indirect effect site); and a deer exclosure in place since 2004 (Deer-exclosed site). Density of questing nymphs and the prevalence of infection with Rickettsia sp. 1 in questing nymphs at each site were compared from 2018 to 2020. The nymph density at the Deer-exclosed site did not significantly differ from that at the Indirect effect site, suggesting that the deer herbivory did not affect the nymph density by reducing vegetation and increasing the abundance of other host mammals. However, the prevalence of infection with Rickettsia sp. 1 in questing nymphs was higher at the Deer-exclosed site than at the Deer-enclosed site, possibly because ticks utilized alternative hosts when deer were absent. The difference in Rickettsia sp. 1 prevalence between the Indirect effect and Deer-exclosed sites was comparable to that between the Indirect effect and Deer-enclosed sites, indicating that the indirect effects of deer were as strong as the direct effects. Examining the indirect effects of ecosystem engineers in the study of tick-borne diseases may be more important than previously recognized.
MeSH term(s)	Animals ; Rickettsia ; Ecosystem ; Prevalence ; Deer/microbiology ; Ixodidae ; Ticks ; Rickettsia Infections/epidemiology ; Nymph ; Ixodes/microbiology
Language	English
Publishing date	2023-05-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2023.102201
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Article: The Role of Silica Nanoparticles in Promoting the Germination of Tomato (

Sembada, Anca Awal / Maki, Shinya / Faizal, Ahmad / Fukuhara, Toshiyuki / Suzuki, Takeshi / Lenggoro, I Wuled

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 14

Abstract: The addition of nanoparticles has been reported to be an effective strategy for enhancing seed germination, but the underlying mechanisms whereby this occurs are unclear. In the present study, we added silica nanoparticles (SiNPs) to an aqueous growth ... ...

Abstract	The addition of nanoparticles has been reported to be an effective strategy for enhancing seed germination, but the underlying mechanisms whereby this occurs are unclear. In the present study, we added silica nanoparticles (SiNPs) to an aqueous growth medium in which tomato seeds were germinated. We examined the effects of SiNPs on growth and possible mechanisms of action. SiNPs had a diameter of 10-17 nm and 110-120 nm. SiNPs shortened the mean germination time from 5.24 ± 0.29 days to 4.64 ± 0.29 days. Seedling vigor, measured by criteria including length and weight, was also improved compared to the control condition. The presence of SiNPs in the seedlings was assessed using an X-ray fluorescence spectrometer. The nanoparticles may have promoted germination by enhancing water imbibition by the seeds or altering the external microenvironment. Scanning electron microscopy revealed changes in the seed coat during germination, many of which were only observed in the presence of nanoparticles. Soil bacteria affect germination; specifically,
Language	English
Publishing date	2023-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13142110
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Article ; Online: Influence of alpine vegetation on water storage and discharge functions in an alpine headwater of Northern Japan Alps

Mayu Fujino / Koichi Sakakibara / Maki Tsujimura / Keisuke Suzuki

Journal of Hydrology X, Vol 18, Iss , Pp 100146- (2023)

1480

Abstract: As mountainous areas provide abundant water resources to lower elevations, and alpine zones are major recharge areas for water resources, it is important to understand water storage and discharge processes in these zones. Regarding water storage, ... ...

Abstract	As mountainous areas provide abundant water resources to lower elevations, and alpine zones are major recharge areas for water resources, it is important to understand water storage and discharge processes in these zones. Regarding water storage, sedimentary structures (e.g., talus and moraines) in alpine zones function as aquifers. However, the functions of vegetation, thought to contribute to water recharge and storage in forested watersheds, have rarely been investigated. Accordingly, we evaluated the influence of alpine vegetation on water storage processes in alpine zones. Two intensive field surveys were conducted on August 17 and October 5, 2019, in the alpine headwaters of Mt. Norikura in the Northern Japan Alps. Chemical analyses were conducted of rainwater, snowmelt water, and runoff water from bare and vegetated catchments. From the results, a two-component separation was conducted to calculate the contributions of precipitation and groundwater components to runoff water. Our results implied that runoff water from vegetated catchments was in contact with the regolith for longer, with the contribution of groundwater being higher in this runoff water. Moreover, the groundwater component contribution tended to increase as the ratio of vegetation area to bare area in each catchment increased, suggesting a higher water storage function for vegetated areas. In other words, the subsurface water flow should be slower in vegetated areas due to the presence of vegetated soils compared to bare areas where coarse-grained sediments are dominant. Accordingly, the alpine vegetated area has a higher water storage function than the alpine bare area.
Keywords	Alpine zone ; Land cover ; Alpine vegetation ; Water storage function ; Component separation ; Environmental engineering ; TA170-171 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Elucidation of pericholangitis and periductal fibrosis in cholestatic liver diseases via extracellular vesicles released by polarized biliary epithelial cells.

Maki, Keita / Katsumi, Tomohiro / Hanatani, Takumi / Uchiyama, Fumi / Suzuki, Fumiya / Hoshikawa, Kyoko / Haga, Hiroaki / Saito, Takafumi / Ueno, Yoshiyuki

American journal of physiology. Cell physiology

2024 Volume 326, Issue 4, Page(s) C1094–C1105

Abstract: Cholestatic liver diseases causes inflammation and fibrosis around bile ducts. However, the pathological mechanism has not been elucidated. Extracellular vesicles (EVs) are released from both the basolateral and apical sides of polarized biliary ... ...

Abstract	Cholestatic liver diseases causes inflammation and fibrosis around bile ducts. However, the pathological mechanism has not been elucidated. Extracellular vesicles (EVs) are released from both the basolateral and apical sides of polarized biliary epithelial cells. We aimed to investigate the possibility that EVs released from the basolateral sides of biliary epithelial cells by bile acid stimulation induce inflammatory cells and fibrosis around bile ducts, and they may be involved in the pathogenesis of cholestatic liver disease. Human biliary epithelial cells (H69) were grown on cell culture inserts and stimulated with chenodeoxycholic acid + IFN-γ. Human THP-1-derived M1-macrophages, LX-2 cells, and KMST-6 cells were treated with the extracted basolateral EVs, and inflammatory cytokines and fibrosis markers were detected by RT-PCR. Highly expressed proteins from stimulated EVs were identified, and M1-macrophages, LX-2, KMST-6 were treated with these recombinant proteins. Stimulated EVs increased the expression of TNF, IL-1β, and IL-6 in M1-macrophages, TGF-β in LX-2 and KMST-6 compared with the corresponding expression levels in unstimulated EVs. Nucleophosmin, nucleolin, and midkine levels were increased in EVs from stimulated cells compared with protein expression in EVs from unstimulated cells. Leukocyte cell-derived chemotaxin-2 (LECT2) is highly expressed only in EVs from stimulated cells. Stimulation of M1-macrophages with recombinant nucleophosmin, nucleolin, and midkine significantly increased the expression of inflammatory cytokines. Stimulation of LX-2 and KMST-6 with recombinant LECT2 significantly increased the expression of fibrotic markers. These results suggest that basolateral EVs are related to the development of pericholangitis and periductal fibrosis in cholestatic liver diseases.
MeSH term(s)	Humans ; Midkine/metabolism ; Nucleophosmin ; Epithelial Cells/metabolism ; Cytokines/metabolism ; Inflammation/metabolism ; Liver Diseases/metabolism ; Bile Acids and Salts/metabolism ; Fibrosis ; Extracellular Vesicles/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism
Chemical Substances	Midkine (137497-38-2) ; Nucleophosmin (117896-08-9) ; Cytokines ; Bile Acids and Salts ; LECT2 protein, human ; Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00655.2023
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Uc I Zs.89: Show issues

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Article ; Online: Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders.

Suzuki, Yuichi / Itagaki, Shuntaro / Nodera, Maki / Suyama, Kazuhide / Yabe, Hirooki / Hosoya, Mitsuaki

Fukushima journal of medical science

2024

Abstract: Background: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.: Methods: We prospectively assessed the physical ... ...

Abstract	Background: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration. Methods: We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks. Lipid metabolism was assessed based on triglyceride (TG), total cholesterol (TC), and free carnitine (FC) levels, as well as acylcarnitine/free carnitine (AC/FC) ratio. Results: A total of 18 patients were included. Of these, 12 and 6 received an oral diet (OD group) and total parenteral nutrition (TPN group), respectively. The mean body mass indexes at hospital admission were 12.8 kg/m Conclusions: Fat-free glucose-based nutrition promoted lipid metabolism over a 2-week period after the start of refeeding, suggesting that balanced energy and lipid intake are essential, even in TPN.
Language	English
Publishing date	2024-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	958255-1
ISSN	2185-4610 ; 0016-2590
ISSN (online)	2185-4610
ISSN	0016-2590
DOI	10.5387/fms.2023_02
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