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Article: [：Q].

Wei, Su-Jung / Chang, Hsiao-Yun / Chen, Shu-Ming / Yeh, Shu-Hui / Yang, Li-Hui

Hu li za zhi The journal of nursing

2019 Volume 66, Issue 6, Page(s) 33–42

Abstract: ... used Q-sort to collect data. A 56-item "Nurse Practitioner Role Capacity Questionnaire" was used ...

Abstract	Background: The gap between the expectation and the development of role competency is a dilemma that nurse practitioners (NPs) face in clinical settings. Purpose: This study was designed to explore the perceived importance and actual practice of the role competencies of NPs and to compare the differences between the ideal and practical domains as well as related factors. Methods: This cross-sectional design study used Q-sort to collect data. A 56-item "Nurse Practitioner Role Capacity Questionnaire" was used as the research tool. Two questionnaires: Perceptions of Important Role Competencies and Actual Execution of Role Competencies were distributed to NPs twice, at times that were 2 weeks apart. A total of 40 participants were recruited, including 21(52.5%) internal medicine NPs and 19 (47.5%) surgical medicine NPs. Results: The significant differences that were identified in this study between the perceived importance and actual practice of role competencies were, by domain: medical assistance (t = -5.62, p < .001), clinical research (t = 4.14, p < .001), professional consultation (t = 2.29, p = .027), and direct care (t = 2.21, p = .033). The correlative factors for these differences were: education level (t = -2.17, p = .036) and membership in the Nurse Practitioner Association (t = -2.36, p = .017). NPs with higher levels of education and with membership in the Nurse Practitioner Association earned higher scores for self-expectation in important clinical competency. Conclusions: NPs face discrepancies in their role expectations, in important part due to their role as providers of medical assistance in clinical practical settings. NPs need to learn and demonstrate the roles and functions of advanced nursing practice to enhance nursing professionalism profoundly.
MeSH term(s)	Clinical Competence ; Cross-Sectional Studies ; Humans ; Nurse Practitioners/psychology ; Nurse's Role/psychology ; Q-Sort ; Surveys and Questionnaires
Language	Chinese
Publishing date	2019-12-04
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ISSN	0047-262X
ISSN	0047-262X
DOI	10.6224/JN.201912_66(6).06
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Q-YOLOP

Chang, Chi-Chih / Lin, Wei-Cheng / Wang, Pei-Shuo / Yu, Sheng-Feng / Lu, Yu-Chen / Lin, Kuan-Cheng / Wu, Kai-Chiang

Quantization-aware You Only Look Once for Panoptic Driving Perception

2023

Abstract: In this work, we present an efficient and quantization-aware panoptic driving perception model (Q ...

Abstract	In this work, we present an efficient and quantization-aware panoptic driving perception model (Q- YOLOP) for object detection, drivable area segmentation, and lane line segmentation, in the context of autonomous driving. Our model employs the Efficient Layer Aggregation Network (ELAN) as its backbone and task-specific heads for each task. We employ a four-stage training process that includes pretraining on the BDD100K dataset, finetuning on both the BDD100K and iVS datasets, and quantization-aware training (QAT) on BDD100K. During the training process, we use powerful data augmentation techniques, such as random perspective and mosaic, and train the model on a combination of the BDD100K and iVS datasets. Both strategies enhance the model's generalization capabilities. The proposed model achieves state-of-the-art performance with an mAP@0.5 of 0.622 for object detection and an mIoU of 0.612 for segmentation, while maintaining low computational and memory requirements.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
Subject code	004
Publishing date	2023-07-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: An Exploration of Pediatricians' Professional Identities: A Q-Methodology Study.

Tiao, Mao-Meng / Chang, Yu-Che / Ou, Liang-Shiou / Hung, Chi-Fa / Khwepeya, Madalitso

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 2

Abstract: ... pediatricians' professional identities. A Q-methodology was used to identify the similarities and differences ... to analyze the Q-sorts to load the viewpoints and formulate the viewpoint arrays. Additional qualitative data ...

Abstract	Professional identities may influence a wide range of attitudes, ethical standards, professional commitments and patient safety. This study aimed to explore the important elements that comprise pediatricians' professional identities. A Q-methodology was used to identify the similarities and differences in professional identity. Forty pediatricians were recruited from two tertiary referral hospitals in Taiwan. A list of statements was developed by five attending physicians and three residents. R software was used to analyze the Q-sorts to load the viewpoints and formulate the viewpoint arrays. Additional qualitative data-one-to-one personal interviews-were analyzed. Twenty-eight of forty pediatricians, 11 males and 17 females, with an average age of 39.9 (27-62) years, were associated with four viewpoints. We labeled the four viewpoints identified for professional identity as (1) professional recognition, (2) patient communication, (3) empathy and (4) insight. The professional recognition viewpoint comprised of youngest participants-28-36 years-with the majority as residents (77.8%), while the empathy viewpoint comprised the oldest participants-38-62 years-with all as attending physicians. All participants in the empathy and insight viewpoints were married. This study found professional identity to be a multifaceted concept for pediatricians, especially in the areas of professional recognition, patient communication, empathy and insight into patient care.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12020144
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Article ; Online: Antrodia camphorata and coenzyme Q

Yang, Hsin-Ling / Chang, Yao-Hsien / Pandey, Sudhir / Bhat, Asif Ali / Vadivalagan, Chithravel / Lin, Kai-Yuan / Hseu, You-Cheng

Environmental toxicology

2023 Volume 38, Issue 7, Page(s) 1548–1564

Abstract: Antrodia camphorata (AC) and Coenzyme Q ...

Abstract	Antrodia camphorata (AC) and Coenzyme Q
MeSH term(s)	Humans ; Animals ; Mice ; beta Catenin/metabolism ; Ubiquinone/pharmacology ; Vimentin/metabolism ; Epithelial-Mesenchymal Transition ; Glioblastoma/drug therapy ; Neoplasm Invasiveness/pathology ; Cadherins/genetics ; Cell Line, Tumor ; Hypoxia-Inducible Factor 1, alpha Subunit ; Cell Movement
Chemical Substances	beta Catenin ; Ubiquinone (1339-63-5) ; Vimentin ; Cadherins ; quinone (3T006GV98U) ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23785
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Article ; Online: Levels of Coenzyme Q

Yen, Hsiu-Chuan / Chen, Bing-Shian / Yang, Si-Ling / Wu, Shin-Yu / Chang, Chun-Wei / Wei, Kuo-Chen / Hsu, Jee-Ching / Hsu, Yung-Hsing / Yen, Tzung-Hai / Lin, Chih-Lung

Biomolecules

2022 Volume 12, Issue 2

Abstract: ... investigated coenzyme Q ...

Abstract	In a previous study, we reported the alterations of primary antioxidant enzymes and decreased citrate synthase (CS) activities in different grades of human astrocytoma tissues. Here, we further investigated coenzyme Q
MeSH term(s)	Astrocytoma/metabolism ; DNA, Mitochondrial/metabolism ; Humans ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Ubiquinone
Chemical Substances	DNA, Mitochondrial ; Mitochondrial Proteins ; Ubiquinone (1339-63-5)
Language	English
Publishing date	2022-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12020336
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Article: Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS.

Tong, Qingheng / Chang, Yueyue / Shang, Guanxiong / Yin, Jiu / Zhou, Xiaoqi / Wang, Suwei / Yan, Xiaofeng / Zhang, Fangfang / Wang, Suqin / Yao, Weifeng

Frontiers in pharmacology

2024 Volume 15, Page(s) 1363678

Abstract: ... time-of-flight mass spectrometry (UPLC-Q/TOF-MS). Meanwhile, a semi-quantitative approach was used ...

Abstract	Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting the health of people. Therefore, it is essential to explore effective drugs for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), a prescription modified from the classical formula Didang Decoction, has been used in the clinical treatment of DN. However, the chemical basis underlying the therapeutic effects of ZJTSD in treating DN remains unknown. In this study, compounds of ZJTSD and serum after oral administration in rats were identified and analyzed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS). Meanwhile, a semi-quantitative approach was used to analyze the dynamic changes in the compounds of ZJTSD
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1363678
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Article ; Online: Author Correction: Q-RAI data-independent acquisition for lipidomic quantitative profiling.

Chang, Jing Kai / Teo, Guoshou / Pewzner-Jung, Yael / Cuthbertson, Daniel J / Futerman, Anthony H / Wenk, Markus R / Choi, Hyungwon / Torta, Federico

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4908

Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55396-9
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Article: Coenzyme Q

Chou, Wei-Ling / Lee, Tzong-Huei / Huang, Tse-Hung / Wang, Pei-Wen / Chen, Ya-Ping / Chen, Chin-Chang / Chang, Zi-Yu / Fang, Jia-You / Yang, Shih-Chun

Frontiers in pharmacology

2019 Volume 10, Page(s) 1445

Abstract: Atopic dermatitis (AD) is an inflammatory skin disease that is usually accompanied ... ...

Abstract	Atopic dermatitis (AD) is an inflammatory skin disease that is usually accompanied by
Language	English
Publishing date	2019-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.01445
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Article ; Online: Rapid identification of chemical constituents and dynamic metabolic profile of Shenqi-Tiaoshen formula in rat plasma based on UPLC-Q-TOF/MS

Rong, Xuewen / Wu, Huan / Huang, Ruotong / Chen, Chang / Fu, Xiaojie / Yang, Mo / Zhou, An / Yang, Qinjun / Li, Zegeng

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115981

Abstract: ... liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was established ...

Abstract	Shenqi-Tiaoshen formula (SQTSF) is a traditional Chinese medicine (TCM) prescription that has been employed in the treatment of chronic obstructive pulmonary disease (COPD). Clinical practice has demonstrated that SQTSF is an effective prescription for stable COPD. However, owing to the complexity of TCM prescription, there is a lack of in-depth understanding of the chemical components of SQTSF and its in vivo metabolism studies. In this study, a comprehensive analytical strategy based on ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was established to identify the chemical components, the absorbed components, and the metabolites of SQTSF given by gavage in rats, and analyze their dynamic changes. As a result, 86 chemical components of SQTSF were characterized, which were mainly categorized into flavonoids, saponins, organic acids, terpenoids, etc. Among them, 13 compounds were confirmed unambiguously by reference standards. Furthermore, 20 prototype components and 46 metabolites were detected in rat plasma at different time points. It was found that one prototype component and thirteen metabolites could be detected during the entire 24 h, indicating that these compounds were slowly eliminated and thus accumulated in vivo over a prolonged duration. Interestingly, the phenomenon that three prototype components and fourteen metabolites reappeared after a period of disappearance from the plasma was found. It was also observed that different prototype components may generate the same metabolite. The metabolic processes of SQTSF in rats mainly included oxidation, reduction, hydration, demethylation, deglycosylation, methylation, acetylation, glucuronidation, glutathionylation, and associated combination reactions. Overall, the present study identified the chemical components of SQTSF and their dynamic metabolic profile in rat plasma, which provided a systematic and applicable strategy for screening and characterization of the prototype components and metabolites of TCM compound preparations.
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Metabolome ; Drugs, Chinese Herbal/chemistry ; Pulmonary Disease, Chronic Obstructive
Chemical Substances	shenqi ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115981
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Article ; Online: RabbitFX: Efficient Framework for FASTA/Q File Parsing on Modern Multi-Core Platforms.

Zhang, Hao / Song, Honglei / Xu, Xiaoming / Chang, Qixin / Wang, Mingkai / Wei, Yanjie / Yin, Zekun / Schmidt, Bertil / Liu, Weiguo

IEEE/ACM transactions on computational biology and bioinformatics

2023 Volume 20, Issue 3, Page(s) 2341–2348

Abstract: The continuous growth of generated sequencing data leads to the development of a variety of associated bioinformatics tools. However, many of them are not able to fully exploit the resources of modern multi-core systems since they are bottlenecked by ... ...

Abstract	The continuous growth of generated sequencing data leads to the development of a variety of associated bioinformatics tools. However, many of them are not able to fully exploit the resources of modern multi-core systems since they are bottlenecked by parsing files leading to slow execution times. This motivates the design of an efficient method for parsing sequencing data that can exploit the power of modern hardware, especially for modern CPUs with fast storage devices. We have developed RabbitFX, a fast, efficient, and easy-to-use framework for processing biological sequencing data on modern multi-core platforms. It can efficiently read FASTA and FASTQ files by combining a lightweight parsing method by means of an optimized formatting implementation. Furthermore, we provide user-friendly and modularized C++ APIs that can be easily integrated into applications in order to increase their file parsing speed. As proof-of-concept, we have integrated RabbitFX into three I/O-intensive applications: fastp, Ktrim, and Mash. Our evaluation shows that the inclusion of RabbitFX leads to speedups of at least 11.6 (6.6), 2.4 (2.4), and 3.7 (3.2) compared to the original versions on plain (gzip-compressed) files, respectively. These case studies demonstrate that RabbitFX can be easily integrated into a variety of NGS analysis tools to significantly reduce associated runtimes. It is open source software available at https://github.com/RabbitBio/RabbitFX.
MeSH term(s)	Software ; Computational Biology ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2022.3219114
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