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  1. Book ; Conference proceedings: Methods in protein sequence analysis

    Imahori, Kazutomo

    [proceedings of the Ninth International Conference on Methods in Protein Sequence Analysis, held September 20 - 24, 1992, in Otsu, Japan]

    1993  

    Event/congress International Conference on Methods in Protein Sequence Analysis (9, 1992, Ōtsu)
    Author's details ed. by Kazutomo Imahori
    Keywords Proteins / analysis / congresses ; Amino Acid Sequence / congresses ; Proteine ; Aminosäurensequenz ; Sequenzanalyse
    Subject Chemische Analyse ; Sequenzierung ; Backbone ; AS-Sequenz ; Primärstruktur ; Eiweiss ; Protein
    Language English
    Size XVI, 310 S. : Ill., graph. Darst.
    Publisher Plenum Press
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006135370
    ISBN 0-306-44488-7 ; 978-0-306-44488-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 828 order for loan Magazin

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  2. Article ; Online: Thiol Protease Inhibitor, E-64-d, Prevents Spindle Formation during Mouse Oocyte Maturation

    Hashimoto, Naohiro / Iwashita, Shintaro / Shoji-Kasai, Yoko / Kishimoto, Takeo / Imahori, Kazutomo

    Development, growth & differentiation

    2023  Volume 32, Issue 2, Page(s) 197–203

    Abstract: E-64-d, a membrane permeant derivative of E-64, the thiol protease inhibitor, was found to prevent meiotic maturation of mouse oocytes in a dose dependent manner. When immature mouse oocytes were incubated with E-64-d for up to 14 hr, first polar body ... ...

    Abstract E-64-d, a membrane permeant derivative of E-64, the thiol protease inhibitor, was found to prevent meiotic maturation of mouse oocytes in a dose dependent manner. When immature mouse oocytes were incubated with E-64-d for up to 14 hr, first polar body emission was blocked to 36% at 200 μg/ml and 6% at 400 μg/ml, but germinal vesicle breakdown occurred normally. Cytological analysis revealed that meiotic spindles were not formed, while chromosome condensation occurred. Thus, E-64-d prevents oocytes from progressing to the first meiotic metaphase. When exposed to E-64-d after 8 hr of incubation without E-64-d, one-fourth of oocytes completed the first meiotic division but never progressed to the second metaphase. In three-fourth of the oocytes inhibited to emit the first polar body, spindles disappeared after incubation with E-64-d. The results suggest that E-64-d promotes disassembly of meiotic spindles resulting in inhibition of meiotic maturation. We propose that thiol protease is involved in spindle formation in mouse meiotic maturation.
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1990.00197.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Conference proceedings: Polyamines: basic and clinical aspects

    Imahori, Kazutomo

    proc. of a satellite symposium of the 3rd International Congress on Cell Biology, Gifu, Japan, 22 - 24 August 1984

    1985  

    Event/congress International Congress on Cell Biology (3, 1984, Tokio)
    Author's details ed. by Kazutomo Imahori
    Keywords Polyamines / metabolism / congresses ; Polyamine ; Physiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion
    Size XV, 528 S. : Ill., graph. Darst.
    Publisher VNU Science Pr
    Publishing place Utrecht
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT002526287
    ISBN 90-6764-042-5 ; 978-90-6764-042-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 1682 order for loan Magazin

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  4. Article ; Online: The biochemical study on the etiology of Alzheimer's disease.

    Imahori, Kazutomo

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2010  Volume 86, Issue 1, Page(s) 54–61

    Abstract: Alzheimer's disease has been characterized by senile plaque and neurofibrillary tangle in the brain. However, their relation to etiology of this disease has been left unclear. Recently it has been clarified that neurofibrillary tangle consists of highly ... ...

    Abstract Alzheimer's disease has been characterized by senile plaque and neurofibrillary tangle in the brain. However, their relation to etiology of this disease has been left unclear. Recently it has been clarified that neurofibrillary tangle consists of highly phosphorylated tau protein. Then we have started to identify the enzyme(s) responsible for this phosphorylation and obtained tau protein kinase I and II. Tau protein kinase I phosphorylated not only tau protein but also pyruvate dehydrogenase, phosphorylation of which caused inactivation of this enzyme and finally led the cell to death. Then we have proved that TPKI is upregulated in AD brain but not in control brain. Upregulation of TPKI was induced by treating the neuronal cells with Abeta protein. Finally we have identified oligomeric aggregation of Abeta protein named Amylospheroid is highly potent to degenerate neuronal cells both in vitro and in vivo systems.
    MeSH term(s) Acetylcholine/biosynthesis ; Alzheimer Disease/enzymology ; Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/enzymology ; Brain/metabolism ; Cyclin-Dependent Kinase 5/biosynthesis ; Cyclin-Dependent Kinase 5/metabolism ; Glycogen Synthase Kinase 3/biosynthesis ; Glycogen Synthase Kinase 3/metabolism ; Humans
    Chemical Substances Amyloid beta-Peptides ; Cyclin-Dependent Kinase 5 (EC 2.7.11.1) ; tau protein kinase II (EC 2.7.11.22) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; tau-protein kinase (EC 2.7.11.26) ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2010-01-07
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.86.54
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/60 b: Show issues
    Z PRO 15: Show issues

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  5. Book ; Conference proceedings: Methods in protein sequence analysis

    Imahori, Kazutomo

    [proceedings of the Ninth International Conference, held September 20 - 24, 1992, in Otsu, Japan]

    1993  

    Institution International Conference on Methods in Protein Sequence Analysis
    Event/congress International Conference on Methods in Protein sequence Analysis (9, 1992.09.20-24, Otsu)
    Author's details edited by Kazutomo Imahori and Fumio Sakiyama
    Language English
    Size XVI, 310 S, ill
    Document type Book ; Conference proceedings
    Note Includes bibliographical references and index ; Proceedings of the Ninth International Conference on Methods in Protein Sequence Analysis, held September 20-24, 1992, in Otsu, Japan"--T.p. verso
    ISBN 0306444887 ; 9780306444883
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Conference proceedings: Methods in protein sequence analysis

    Imahori, Kazutomo / Sakiyama, Fumio

    (The Language of science)

    1993  

    Event/congress International Conference on Methods in Protein Sequence Analysis (9th, 1992, OtsuJapan)
    Author's details edited by Kazutomo Imahori and Fumio Sakiyama
    Series title The Language of science
    Keywords Amino acid sequence/Congresses.
    Language English
    Size xvi, 310 p. :, ill. ;, 26 cm.
    Publisher Plenum Press
    Publishing place New York
    Document type Book ; Conference proceedings
    Note "Proceedings of the Ninth International Conference on Methods in Protein Sequence Analysis, held September 20-24, 1992, in Otsu, Japan"--T.p. verso.
    ISBN 0306444887 ; 9780306444883
    Database NAL-Catalogue (AGRICOLA)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  7. Book ; Conference proceedings: Methods in protein sequence analysis

    Imahori, Kazutomo / Sakiyama, Fumio

    (Language of science)

    1993  

    Event/congress International Conference on Methods in Protein Sequence Analysis (9th, 1992, OtsuJapan)
    Author's details edited by Kazutomo Imahori and Fumio Sakiyama
    Series title Language of science
    MeSH term(s) Amino Acid Sequence
    Language English
    Size xvi, 310 p. :, ill.
    Publisher Plenum Press
    Publishing place New York
    Document type Book ; Conference proceedings
    Note "Proceedings of the Ninth International Conference on Methods in Protein Sequence Analysis, held September 20-24, 1992, in Otsu, Japan"--T.p. verso.
    ISBN 9780306444883 ; 0306444887
    Database Catalogue of the US National Library of Medicine (NLM)

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    Inter-library loan at ZB MED

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  8. Book ; Conference proceedings: Polyamines

    Imahori, Kazutomo

    basic and clinical aspects : proceedings of a satellite symposium of the 3rd International Congress on Cell Biology, Gifu, Japan, 22-24 August 1984

    1985  

    Event/congress International Symposium on Polyamines (1984, Gifu-kenJapan) ; International Congress on Cell Biology (3rd, 1984, TokyoJapan)
    Author's details edited by Kazutomo Imahori ... [et al.]
    Keywords Polyamines/Congresses.
    Language English
    Size xv, 528 p. :, ill. ;, 24 cm.
    Publisher VNU Science Press
    Publishing place Utrecht, the Netherlands
    Document type Book ; Conference proceedings
    Note Based on proceedings of the International Symposium on Polyamines, 22-24 August 1984, Gifu, Japan.
    ISBN 9067640425 ; 9789067640428
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Conference proceedings: Polyamines

    Imahori, Kazutomo

    basic and clinical aspects : proceedings of a satellite symposium of the 3rd International Congress on Cell Biology, Gifu, Japan, 22-24 August 1984

    1985  

    Event/congress International Symposium on Polyamines (1984, Gifu-kenJapan) ; International Congress on Cell Biology (3rd, 1984, TokyoJapan)
    Author's details edited by Kazutomo Imahori ... [et al.]
    MeSH term(s) Polyamines
    Language English
    Size xv, 528 p. :, ill.
    Publisher VNU Science Press
    Publishing place Utrecht, the Netherlands
    Document type Book ; Conference proceedings
    Note Based on proceedings of the International Symposium on Polyamines, 22-24 August 1984, Gifu, Japan.
    ISBN 9789067640428 ; 9067640425
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Seitai kōbunshi gairon

    Imahori, Kazutomo

    1978  

    Title translation Outline of biopolymers.
    Author's details Imahori Kazutomo, cho
    MeSH term(s) Macromolecular Substances
    Language Japanese
    Size vi, 245 p. :, ill.
    Publisher Baifūkan
    Publishing place Tōkyō
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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