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Article ; Online: The SKIN-Q: An Innovative Patient-Reported Outcome Measure for Evaluating Minimally Invasive Skin Treatments for the Face and Body.

Klassen, Anne F / Pusic, Andrea L / Kaur, Manraj / Mansouri, Jasmine / Tsangaris, Elena / Dayan, Steven / Klok, Jennifer / Armstrong, Katie / Santosa, Katherine / Rae, Charlene / Poulsen, Lotte / Cano, Stefan J

Facial plastic surgery & aesthetic medicine

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	3006458-2
ISSN	2689-3622 ; 2689-3614
ISSN (online)	2689-3622
ISSN	2689-3614
DOI	10.1089/fpsam.2023.0204
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Article ; Online: "I Want to Look Natural": Development and Validation of the FACE-Q Aesthetics Natural Module.

Klassen, Anne F / Cano, Stefan / Mansouri, Jasmine / Poulsen, Lotte / Rae, Charlene / Kaur, Manraj / Dayan, Steven / Tsangaris, Elena / Armstrong, Kathleen / Klok, Jennifer / Santosa, Katherine / Pusic, Andrea

Aesthetic surgery journal

2024

Abstract: Background: The concept of natural after a facial aesthetic treatment represents an under-studied area. We added scales to FACE-Q Aesthetics to provide a means to measure this concept from the patient's perspective.: Objectives: To develop and ... ...

Abstract	Background: The concept of natural after a facial aesthetic treatment represents an under-studied area. We added scales to FACE-Q Aesthetics to provide a means to measure this concept from the patient's perspective. Objectives: To develop and validate FACE-Q natural scales. Methods: Concept elicitation interviews with people having minimally invasive treatments were conducted to explore the natural concept and develop scales. Patient and expert input was used to refine scale content. An online sample (i.e., Prolific) of people who had a facial aesthetic treatment to examine psychometric properties using Rasch Measurement Theory analysis. A test-retest reliability study was performed, and construct validity examined. Results: Interviews with 26 people were conducted. Three scales were developed and refined with input from 12 experts, 11 patients, and 184 online survey participants. Data from 1358 online participants provided evidence of scale reliability and validity. Reliability was high with Person Separation Index, Cronbach alpha and intraclass correlation coefficients values without extremes >0.82. Tests of construct validity confirmed that the scales functioned as hypothesized. Higher scores on the Expectations scale were associated with wanting a more natural look and movement after treatment. In addition, higher scores on the Natural Appearance and Natural Outcome scales correlated with better scores on other FACE-Q Aesthetics scales, and were associated with the face looking and feeling natural. Conclusions: Many people seeking facial aesthetic treatments want to look natural. These new FACE-Q Aesthetics scales provide a means to measure the concept of 'natural' from the patient's perspective.
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad374
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Article: Extending the Range of Measurement for Minimally Invasive Treatments by Adding New Concepts to FACE-Q Aesthetics Scales.

Klassen, Anne F / Pusic, Andrea L / Kaur, Manraj / Rae, Charlene / Poulsen, Lotte / Mansouri, Jasmine / Tsangaris, Elena / Dayan, Steven / Klok, Jennifer / Armstrong, Kathleen / Santosa, Katherine / Cano, Stefan

Plastic and reconstructive surgery. Global open

2024 Volume 12, Issue 4, Page(s) e5736

Abstract: Background: The Satisfaction with Face Overall and Psychological Function scales are the most frequently used FACE-Q Aesthetics module scales. This study aimed to extend their range of measurement by adding and testing new concepts. We aimed to create ... ...

Abstract	Background: The Satisfaction with Face Overall and Psychological Function scales are the most frequently used FACE-Q Aesthetics module scales. This study aimed to extend their range of measurement by adding and testing new concepts. We aimed to create FACE-Q Aesthetics item libraries. Methods: In-depth concept elicitation interviews were conducted. Concepts were formed into items and refined through multiple rounds of patient and expert input. The items were tested with people living in the United States, Canada, and the United Kingdom who had minimally invasive facial aesthetic treatments. Participants were recruited through an online platform (ie, Prolific). Psychometric properties were examined using Rasch measurement theory analysis, test-retest reliability, and construct validity. Results: We conducted 26 interviews. New concepts were developed into items and refined with input from 12 experts, 11 clinic patients, and 184 Prolific participants. A sample of 1369 Prolific participants completed 52 appearance and 22 psychological items. After removing 10 and 2 items respectively, the psychometric tests provided evidence of reliability with the person separation index, Cronbach alpha, and test-retest reliability values without extremes of 0.88 or more. For validity, lower scores were associated with looking older than one's age, being more bothered by facial skin laxity, treatment wearing off, and having deeper lines on Merz Assessment scales. Short-form scales formed from the 42 appearance items provide examples of item library application. Conclusions: This study provides an innovative means to customize scales to measure appearance and psychological function that maximizes content validity and minimizes respondent burden in the context of minimally invasive treatments.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000005736
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Article: Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics.

Taylor Sundby, R / Szymanski, Jeffrey J / Pan, Alexander / Jones, Paul A / Mahmood, Sana Z / Reid, Olivia H / Srihari, Divya / Armstrong, Amy E / Chamberlain, Stacey / Burgic, Sanita / Weekley, Kara / Murray, Béga / Patel, Sneh / Qaium, Faridi / Lucas, Andrea N / Fagan, Margaret / Dufek, Anne / Meyer, Christian F / Collins, Natalie B /

Pratilas, Christine A / Dombi, Eva / Gross, Andrea M / Kim, AeRang / Chrisinger, John S A / Dehner, Carina A / Widemann, Brigitte C / Hirbe, Angela C / Chaudhuri, Aadel A / Shern, Jack F

medRxiv : the preprint server for health sciences

2024

Abstract: Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes ...

Abstract	Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes non-malignant, pre-malignant and malignant forms of NF1 PNST. Using plasma samples from a novel cohort of 101 NF1 patients and 21 healthy controls, we validated that our previous cfDNA copy number alteration (CNA)-based approach identifies malignant peripheral nerve sheath tumor (MPNST) but cannot distinguish among benign and premalignant states. We therefore investigated the ability of fragment-based cfDNA features to differentiate NF1-associated tumors including binned genome-wide fragment length ratios, end motif analysis, and non-negative matrix factorization deconvolution of fragment lengths. Fragmentomic methods were able to differentiate pre-malignant states including atypical neurofibromas (AN). Fragmentomics also adjudicated AN cases suspicious for MPNST, correctly diagnosing samples noninvasively, which could have informed clinical management. Overall, this study pioneers the early detection of malignant and premalignant peripheral nerve sheath tumors in NF1 patients using plasma cfDNA fragmentomics. In addition to screening applications, this novel approach distinguishes atypical neurofibromas from benign plexiform neurofibromas and malignant peripheral nerve sheath tumors, enabling more precise clinical diagnosis and management.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.18.24301053
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Article ; Online: Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease.

Evangelisti, Stefania / Boessenkool, Sirius / Pflanz, Chris Patrick / Basting, Romina / Betts, Jill F / Jenkinson, Mark / Clare, Stuart / Muhammed, Kinan / LeHeron, Campbell / Armstrong, Richard / Klein, Johannes C / Husain, Masud / Nemeth, Andrea H / Hu, Michele T / Douaud, Gwenaëlle

Brain communications

2023 Volume 5, Issue 6, Page(s) fcad282

Abstract: Huntington's and Parkinson's disease are two movement disorders representing mainly opposite states of the basal ganglia inhibitory function. Despite being an integral part of the cortico-subcortico-cortical circuitry, the subthalamic nucleus function ... ...

Abstract	Huntington's and Parkinson's disease are two movement disorders representing mainly opposite states of the basal ganglia inhibitory function. Despite being an integral part of the cortico-subcortico-cortical circuitry, the subthalamic nucleus function has been studied at the level of detail required to isolate its signal only through invasive studies in Huntington's and Parkinson's disease. Here, we tested whether the subthalamic nucleus exhibited opposite functional signatures in early Huntington's and Parkinson's disease. We included both movement disorders in the same whole-brain imaging study, and leveraged ultra-high-field 7T MRI to achieve the very fine resolution needed to investigate the smallest of the basal ganglia nuclei. Eleven of the 12 Huntington's disease carriers were recruited at a premanifest stage, while 16 of the 18 Parkinson's disease patients only exhibited unilateral motor symptoms (15 were at Stage I of Hoehn and Yahr off medication). Our group comparison interaction analyses, including 24 healthy controls, revealed a differential effect of Huntington's and Parkinson's disease on the functional connectivity at rest of the subthalamic nucleus within the sensorimotor network, i.e. an opposite effect compared with their respective age-matched healthy control groups. This differential impact in the subthalamic nucleus included an area precisely corresponding to the deep brain stimulation 'sweet spot'-the area with maximum overall efficacy-in Parkinson's disease. Importantly, the severity of deviation away from controls' resting-state values in the subthalamic nucleus was associated with the severity of motor and cognitive symptoms in both diseases, despite functional connectivity going in
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcad282
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Article ; Online: Hemodynamic effects of portable non-invasive ventilation in healthy men.

Chynkiamis, Nikolaos / Armstrong, Matthew / Manifield, James / Hume, Emily / Reilly, Caroline / Aliverti, Andrea / O'Doherty, Alasdair F / Vogiatzis, Ioannis

Respiratory physiology & neurobiology

2019 Volume 268, Page(s) 103248

Abstract: VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 ... ...

Abstract	VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH
MeSH term(s)	Adolescent ; Adult ; Blood Pressure/physiology ; Hemodynamics/physiology ; Humans ; Male ; Noninvasive Ventilation/adverse effects ; Noninvasive Ventilation/instrumentation ; Respiratory Muscles/physiology ; Respiratory Physiological Phenomena ; Young Adult
Language	English
Publishing date	2019-07-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2019.06.005
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Article ; Online: Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(I) and Tc(I) carborane complexes.

Armstrong, Andrea F / Valliant, John F

Dalton transactions (Cambridge, England : 2003)

2010 Volume 39, Issue 35, Page(s) 8128–8131

Abstract: Carboranes form stable complexes with the [M(CO)(3)](+) (M = (99m)Tc, Re) core and are viable ligands for the development of targeted radiopharmaceuticals. (99m)Tc-carborane complexes were found to exhibit substantially different 1,2-->1,7 cage ... ...

Abstract	Carboranes form stable complexes with the [M(CO)(3)](+) (M = (99m)Tc, Re) core and are viable ligands for the development of targeted radiopharmaceuticals. (99m)Tc-carborane complexes were found to exhibit substantially different 1,2-->1,7 cage isomerisation behaviour than their Re counterparts, challenging the validity of the routine use of rhenium as a surrogate for the development of technetium-99m based molecular imaging agents.
MeSH term(s)	Boranes/chemistry ; Coordination Complexes/chemistry ; Isomerism ; Isotope Labeling ; Radiopharmaceuticals/chemistry ; Rhenium/chemistry ; Technetium/chemistry ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Boranes ; Coordination Complexes ; Radiopharmaceuticals ; Rhenium (7440-15-5) ; Technetium (7440-26-8)
Language	English
Publishing date	2010-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c0dt00490a
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Article ; Online: Development of a (170)Tm source for mercury monitoring studies in humans using XRF.

Timmaraju, K Phanisree / Fajurally, Bibi Najah / Armstrong, Andrea F / Chettle, David R

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2016 Volume 110, Page(s) 70–73

Abstract: The goals of the present study were to develop a (170)Tm radioisotope and generate a K XRF spectrum of mercury. Thulium foil and thulium oxide powder were both tested for impurities and the latter was found to be a better prospect for further studies. ... ...

Abstract	The goals of the present study were to develop a (170)Tm radioisotope and generate a K XRF spectrum of mercury. Thulium foil and thulium oxide powder were both tested for impurities and the latter was found to be a better prospect for further studies. The (170)Tm radioisotope was developed from thulium oxide powder following the method of disolution and absorption. A suitable source holder and collimator were also designed based on Monte Carlo simulations. Using the radioisotope thus developed, a mercury XRF spectrum was successfully generated.
MeSH term(s)	Environmental Monitoring/methods ; Humans ; Mercury/analysis ; Mercury/toxicity ; Occupational Exposure/analysis ; Phantoms, Imaging ; Radioisotopes ; Spectrometry, X-Ray Emission/methods ; Thulium
Chemical Substances	Radioisotopes ; Thulium (8RKC5ATI4P) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2015.12.066
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Article ; Online: MEN1 mutations mediate clinical resistance to menin inhibition.

Perner, Florian / Stein, Eytan M / Wenge, Daniela V / Singh, Sukrit / Kim, Jeonghyeon / Apazidis, Athina / Rahnamoun, Homa / Anand, Disha / Marinaccio, Christian / Hatton, Charlie / Wen, Yanhe / Stone, Richard M / Schaller, David / Mowla, Shoron / Xiao, Wenbin / Gamlen, Holly A / Stonestrom, Aaron J / Persaud, Sonali / Ener, Elizabeth /

Cutler, Jevon A / Doench, John G / McGeehan, Gerard M / Volkamer, Andrea / Chodera, John D / Nowak, Radosław P / Fischer, Eric S / Levine, Ross L / Armstrong, Scott A / Cai, Sheng F

Nature

2023 Volume 615, Issue 7954, Page(s) 913–919

Abstract: Chromatin-binding proteins are critical regulators of cell state in ... ...

Abstract	Chromatin-binding proteins are critical regulators of cell state in haematopoiesis
MeSH term(s)	Animals ; Humans ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Binding Sites/drug effects ; Binding Sites/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Drug Resistance, Neoplasm/genetics ; Leukemia/drug therapy ; Leukemia/genetics ; Leukemia/metabolism ; Mutation ; Protein Binding/drug effects ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism
Chemical Substances	Antineoplastic Agents ; Chromatin ; KMT2A protein, human ; MEN1 protein, human ; NPM1 protein, human ; Proto-Oncogene Proteins
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05755-9
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Article ; Online: Hysterektomiekorrigierte Inzidenz und Mortalität von Gebärmutterhalskrebs in Deutschland

Sackmann, Andrea / Riemann, Jürgen F. / Maulbecker-Armstrong, Catharina / Burkhardt, Ernst-Alfred

GMS Medizinische Informatik, Biometrie und Epidemiologie, Vol 14, Iss 1, p Doc

2018 Volume 03

Abstract: Incidence and mortality rates of cervical cancer (C53 by ICD-10) have to be corrected significantly upwards after excluding the women from the reference population whose uterus was removed surgically. The current study is based on the German Health ... ...

Abstract	Incidence and mortality rates of cervical cancer (C53 by ICD-10) have to be corrected significantly upwards after excluding the women from the reference population whose uterus was removed surgically. The current study is based on the German Health Interview and Examination Survey for Adults (DEGS1) according to which the prevalence of hysterectomy in Germany in 2011 among women aged over 18 years was 17.4%. As per age pattern of this prevalence the incidence and mortality rates of cervical cancer are corrected. Maximal corrections can be found for women of 70–79 years. In this age group the incidence rate is corrected from 13.6 to 22.5 by 65.4%, the mortality rate from 7.5 to 12.4 by 65.3%.
Keywords	prevalence of hysterectomy ; cervical cancer ; Germany ; correction of incidence rate ; correction of mortality rate ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Infectious and parasitic diseases ; RC109-216
Language	German
Publishing date	2018-02-01T00:00:00Z
Publisher	German Medical Science GMS Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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