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Article ; Online: The reciprocal associations between caregiver burden, and mental health in primary caregivers of cancer patients: A longitudinal study: Family functioning, caregiver burden, and mental health Wenjun Yu et al.

Yu, Wenjun / Chen, Jia / Sun, Shiyan / Liu, Peiwen / Ouyang, Longqiang / Hu, Jize

2021 Volume 30, Issue 6, Page(s) 892–900

Abstract: Objective: The vital role played by primary caregivers in caring for cancer patients is well-recognized, but the caregiver burden and impact on family functioning to caregivers' mental health is poorly understood. This study examined the prospective and ...

Abstract	Objective: The vital role played by primary caregivers in caring for cancer patients is well-recognized, but the caregiver burden and impact on family functioning to caregivers' mental health is poorly understood. This study examined the prospective and reciprocal relationships between family functioning, caregiver burden, and mental health. We aimed to determine whether inferior family functioning and heavy caregiver burden act as risk factors for mental health, as consequences of mental health, or both. Methods: Participants were 187 primary caregivers of cancer patients. They completed questionnaires with standardized measures assessing family functioning, caregiver burden, and mental health. A quantitative longitudinal design and a cross-lag model were used to test the reciprocal relationships between variables at three time points with 6-month intervals during the first year of early-stage cancer diagnosis and treatment. Results: Family functioning did not predict participants' future mental health, but their mental health state predicted future caregiver burden and family functioning. Caregiver burden also predicted participants' future mental health. There was a dynamic reciprocal relationship between caregiver burden and mental health over time. Conclusions: The findings of this study emphasize the adverse effects of caregiver burden and may contribute to shedding light on the distinct mechanisms that underlie the relationships between caregiver burden, family functioning, and mental health. Our findings indicate the necessity of developing interventions to reduce the burden of caregiving and to facilitate family functioning. They will provide direction for family-centered nursing to meet primary caregivers' mental health needs in the care of cancer patients.
MeSH term(s)	Caregiver Burden ; Caregivers ; Cross-Sectional Studies ; Family ; Humans ; Longitudinal Studies ; Mental Health ; Neoplasms/therapy ; Prospective Studies
Language	English
Publishing date	2021-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.5667
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Article ; Online: Application of PET Imaging in the Brain Regions of the Emotional Control Loop in Patients with Generalized Anxiety Disorder.

Li, Jing / Ouyang, Wenjun

Journal of healthcare engineering

2021 Volume 2021, Page(s) 4505227

Abstract: Objective: This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose (: Methods: The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, : Results: ...

Abstract	Objective: This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose ( Methods: The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, Results: Compared with the healthy control group, the peak uptake of the bilateral prefrontal cortex and the average uptake rate before the peak in GAD patients were significantly reduced ( Conclusion: There are
MeSH term(s)	Anxiety Disorders/diagnostic imaging ; Brain/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/4505227
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Article ; Online: The Application of the Big Data Medical Imaging System in Improving the Medical and Health Examination.

Zhou, Xiaojuan / Ouyang, Wenjun

Journal of healthcare engineering

2021 Volume 2021, Page(s) 8251702

Abstract: To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases ...

Abstract	To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases examined by the tertiary diagnostic system of big data medical imaging will be set as the observation group. Clinical cases not involved in the tertiary diagnostic system of big data medical imaging were set as the control group. The qualified rate, film positive rate, and film diagnosis accuracy between the two groups are compared, and X-ray perspective, X-ray examination, and CT multiple medical imaging examinations are used in two groups. The experimental results showed that the pass rate was 86.57%, positive rate was 72.32%, and diagnosis rate was 80.17%. Pass rate, positive rate, and diagnostic accuracy were higher than the control group (
MeSH term(s)	Big Data ; Humans ; Radiography ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/8251702
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Article ; Online: Multi-criteria assessment and triple-objective optimization of a bio-anode microfluidic microbial fuel cell.

Ouyang, Tiancheng / Liu, Wenjun / Shi, Xiaomin / Li, Yinxuan / Hu, Xiaoyi

Bioresource technology

2023 Volume 382, Page(s) 129193

Abstract: Microfluidic microbial fuel cell has lower costs and greater potential than typical microbial fuel cell due to the elimination of proton exchange membrane. However, the development has mostly relied on experiments, and there has been little research on ... ...

Abstract	Microfluidic microbial fuel cell has lower costs and greater potential than typical microbial fuel cell due to the elimination of proton exchange membrane. However, the development has mostly relied on experiments, and there has been little research on numerical simulations. Based on experimental validation, a reliable and universal model for microfluidic microbial fuel cell without quantifying the biomass concentration is proposed. Subsequently, the primary work is to study the output performance and energy efficiency of the microfluidic microbial fuel cell under different operating conditions and to comprehensively optimize the cell performance by employing the multi-objective particle swarm algorithm. Compared the optimal case with the base case, the increase ratios of maximum current density, power density, fuel utilization and exergy efficiency are 40.96%, 20.87%, 61.58% and 32.19%, respectively. On the basis of improving energy efficiency, the maximum power density and current density can reach 1.193 W/m
MeSH term(s)	Bioelectric Energy Sources ; Microfluidics ; Electricity ; Electrodes ; Biomass
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129193
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Article: Antibacterial activity and mechanism of flavonoids from

Zhou, Huan / Chen, Lingli / Ouyang, Kehui / Zhang, Qingfeng / Wang, Wenjun

Frontiers in microbiology

2023 Volume 13, Page(s) 1103476

Abstract: Introduction: Chimonanthus salicifolius: Method: Maximum diameter of inhibition zone (DIZ), maximum diameter of inhibition zone (DIZ), the lowest minimum inhibition concentration (MIC), and the lowest minimum bactericide concentration (MBC) were used ...

Abstract	Introduction: Chimonanthus salicifolius Method: Maximum diameter of inhibition zone (DIZ), maximum diameter of inhibition zone (DIZ), the lowest minimum inhibition concentration (MIC), and the lowest minimum bactericide concentration (MBC) were used to detect the antibacterial activity. Meanwhile, related enzyme activities, the transcriptome analysis and quantitative RT-PCR were used to investigate the antibacterial activity mechanisms. Results: The results showed that FCS (with a purity of 84.2 ± 2.0%) has potential effects on tested strains with the maximum diameter of inhibition zone (DIZ) was 15.93 ± 2.63 mm, the lowest minimum inhibition concentration (MIC) was 1.56 mg/ml and the lowest minimum bactericide concentration (MBC) was 6.25 mg/ml. In addition, the bacterial growth curve test, release of extracellular alkaline phosphatase (AKP), loss of intracellular components, DNA damage and transmission electron microscope (TEM) suggested that FCS could destroy the cell wall and membrane, cause the loss of intracellular substance, cause DNA damage and even lead to cell death. Moreover, the antibacterial mechanism of FCS against Discussion: Overall, our research provides theoretical guidance for the application of FCS, which is expected to be potentially used as a natural antimicrobial agent in food safety.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1103476
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Article ; Online: The Application of the Big Data Medical Imaging System in Improving the Medical and Health Examination

Xiaojuan Zhou / Wenjun Ouyang

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract	To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases examined by the tertiary diagnostic system of big data medical imaging will be set as the observation group. Clinical cases not involved in the tertiary diagnostic system of big data medical imaging were set as the control group. The qualified rate, film positive rate, and film diagnosis accuracy between the two groups are compared, and X-ray perspective, X-ray examination, and CT multiple medical imaging examinations are used in two groups. The experimental results showed that the pass rate was 86.57%, positive rate was 72.32%, and diagnosis rate was 80.17%. Pass rate, positive rate, and diagnostic accuracy were higher than the control group (P<0.05). X-line film is the most cost effective. CT examination has a high diagnostic sensitivity and can achieve a clear diagnosis of the benign and malignant diseases. The three-level diagnosis system of medical imaging has significantly improved and improved the technical level in the medical and health examination, which has good practical value.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of PET Imaging in the Brain Regions of the Emotional Control Loop in Patients with Generalized Anxiety Disorder

Jing Li / Wenjun Ouyang

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract: Objective. This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose (18F-FDG) in the multibrain areas of the emotional control loop in patients with generalized anxiety disorder (GAD) and investigate the brain of GAD ... ...

Abstract	Objective. This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose (18F-FDG) in the multibrain areas of the emotional control loop in patients with generalized anxiety disorder (GAD) and investigate the brain of GAD patient’s functional abnormality mechanism. Methods. The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, 18F-FDG whole-brain uptake and metabolism data were collected. Image fusion and semiquantitative analysis were used to measure emotional control loops. The maximum standard uptake value (SUVmax) and dynamic uptake and metabolic changes of 11 time points in the brain area at 150 min were measured. Results. Compared with the healthy control group, the peak uptake of the bilateral prefrontal cortex and the average uptake rate before the peak in GAD patients were significantly reduced (P<0.05), and the average metabolic rate after the peak was significantly increased (P<0.05). The peak uptake of the left striatum and the left hippocampus, the average uptake rate before the peak, and the average metabolic rate after the peak were all significantly reduced (P<0.05); There were no obvious changes in the three indexes of the right striatum and the right hippocampus. Conclusion. There are 18F-FDG uptake and metabolic disorders in multiple brain areas of the affective control loop of GAD patients. The abnormal peak and rate of uptake may be related to the pathogenesis of GAD.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chimonanthus nitens Oliv

Zhang, Yang / Tang, Yantian / Cai, Lei / He, Jing / Chen, Lingli / Ouyang, Kehui / Wang, Wenjun

Oxidative medicine and cellular longevity

2023 Volume 2023, Page(s) 6208680

Abstract: To investigate the immunomodulatory activities ... ...

Abstract	To investigate the immunomodulatory activities of
MeSH term(s)	Gastrointestinal Microbiome ; Cytokines/metabolism ; Immunoglobulin A, Secretory/pharmacology ; Immunosuppressive Agents/pharmacology ; Polysaccharides/pharmacology
Chemical Substances	Cytokines ; Immunoglobulin A, Secretory ; Immunosuppressive Agents ; Polysaccharides
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2023/6208680
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Article ; Online: Lignin removal improves xylooligosaccharides production from poplar by acetic acid hydrolysis.

Ying, Wenjun / Ouyang, Jia / Lian, Zhina / Xu, Yong / Zhang, Junhua

Bioresource technology

2022 Volume 354, Page(s) 127190

Abstract: Organic acid hydrolysis is a potential method for xylooligosaccharides (XOS) production from lignocelluloses. However, the effect of lignin content on XOS production using organic acid hydrolysis remains unclear. In this work, the effect of ... ...

Abstract	Organic acid hydrolysis is a potential method for xylooligosaccharides (XOS) production from lignocelluloses. However, the effect of lignin content on XOS production using organic acid hydrolysis remains unclear. In this work, the effect of delignification on XOS production from poplar by acetic acid (AC) hydrolysis was investigated. Hydrogen peroxide-acetic acid (HPAC) pretreatment catalyzed by 0-200 mM H
MeSH term(s)	Acetic Acid ; Glucuronates ; Hydrogen Peroxide ; Hydrolysis ; Lignin ; Oligosaccharides ; Populus ; Xylans
Chemical Substances	Glucuronates ; Oligosaccharides ; Xylans ; xylooligosaccharide ; Lignin (9005-53-2) ; Hydrogen Peroxide (BBX060AN9V) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.127190
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Article ; Online: Immune characteristics and clinical significance of peripheral blood lymphocytes in breast cancer.

Gao, Hongyu / Ouyang, Dengjie / Guan, Xinyu / Xu, Jiachi / Chen, Qitong / Zeng, Liyun / Pang, Jian / Zou, Qiongyan / Qian, Ke / Yi, Wenjun

BMC cancer

2024 Volume 24, Issue 1, Page(s) 50

Abstract: Background: In the context of breast cancer (BC), the correlation between lymphocytes and clinical outcomes, along with treatment response, has garnered attention. Despite this, few investigations have delved into the interplay among distinct peripheral ...

Abstract	Background: In the context of breast cancer (BC), the correlation between lymphocytes and clinical outcomes, along with treatment response, has garnered attention. Despite this, few investigations have delved into the interplay among distinct peripheral blood lymphocyte (PBL) types, immune attributes, and their clinical implications within the BC landscape. Methods: The primary objective of this study was to scrutinize the baseline status of PBL subsets in patients with primary BC, track their dynamic changes throughout treatment, and ascertain their interrelation with prognosis. Flow cytometry was employed to analyse PBLs from a cohort of 74 BC patients. Results: Our analysis revealed that baseline levels of Treg and PD-L1 + T cells were lower in BC patients compared to the reference values. Notably, a disparity in baseline PD-L1 + T cell levels surfaced between patients who underwent adjuvant therapy and those subjected to neoadjuvant therapy (NAT). Furthermore, a meticulous evaluation of PBL subsets before and after treatment underscored discernible alterations in 324 + T cells and CD19 + CD32 + B cells over the course of therapy. Strikingly, heightened CD4 + T cell levels at baseline were linked to enhanced event-free survival (EFS) (p = 0.02) and a robust response to chemotherapy. Conclusions: These results indicate that PBLs may serve as a significant marker to assess the immune status of BC patients, and therapy has the potential to modify patient immune profiles. In addition, peripheral blood CD4 + T cell levels may serve as promising biomarkers for diagnosis and prognosis in future studies of BC.
MeSH term(s)	Humans ; Female ; B7-H1 Antigen ; Breast Neoplasms/therapy ; Clinical Relevance ; B-Lymphocytes ; CD4-Positive T-Lymphocytes
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11815-8
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