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  1. Article ; Online: Maternal intake of N-nitroso compounds from cured meat and the risk of pediatric brain tumors: a review.

    Huncharek, Michael

    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

    2011  Volume 29, Issue 3, Page(s) 245–253

    Abstract: Experimental investigations conducted over the last several decades suggest that transplacental exposure of offspring to certain N-nitroso compounds (NOCs) results in the development of brain tumors in laboratory animals. Dietary cured meats are a ... ...

    Abstract Experimental investigations conducted over the last several decades suggest that transplacental exposure of offspring to certain N-nitroso compounds (NOCs) results in the development of brain tumors in laboratory animals. Dietary cured meats are a recognized source of such exposures in humans, which raises the possibility that maternal consumption of cured meat products during pregnancy could increase the risk of childhood brain tumors. This hypothesis was first suggested by an observational study conducted by Preston-Martin et al. in 1982 supporting such a role in human disease. Since that time, additional epidemiological analyses have been performed addressing this hypothesis although results are inconsistent across studies. Due to the possible impact of bias and confounding in the available observational studies, the relatively weak effect seen in some observational analyses is of questionable validity. Nonetheless, since the association of transplacental NOC exposure and brain tumor risk is biologically plausible, the suspected association cannot be unequivocally dismissed. This paper reviews the current epidemiological evidence dealing with the maternal cured meat intake/childhood brain tumor association and suggests further avenues for research.
    MeSH term(s) Brain Neoplasms/chemically induced ; Female ; Fetus/drug effects ; Food Handling ; Humans ; Meat ; Nitroso Compounds/toxicity ; Pregnancy ; Risk
    Chemical Substances Nitroso Compounds
    Language English
    Publishing date 2011-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441790-2
    ISSN 2162-6537 ; 0731-8898 ; 0146-4779
    ISSN (online) 2162-6537
    ISSN 0731-8898 ; 0146-4779
    DOI 10.1615/jenvironpatholtoxicoloncol.v29.i3.70
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1472: Show issues Location:
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  2. Article: Non-asbestos related diffuse malignant mesothelioma.

    Huncharek, Michael

    Tumori

    2002  Volume 88, Issue 1, Page(s) 1–9

    Abstract: Aims: The association between asbestos exposure and the development of malignant mesothelioma is well known. Nonetheless, a proportion of patients suffering from this disease do not appear to have documented exposure to asbestos fibers from any known ... ...

    Abstract Aims: The association between asbestos exposure and the development of malignant mesothelioma is well known. Nonetheless, a proportion of patients suffering from this disease do not appear to have documented exposure to asbestos fibers from any known source. Available information suggests that a true "background" incidence of this disease exits raising the possibility that other factors contribute to its etiology. This paper will review existing data related to non-asbestos related mesothelioma and suggest avenues for further research.
    Methods and study design: A comprehensive electronic MEDLARS search of the literature pertinent to non-asbestos related malignant mesothelioma was performed including the years 1996-2001. Hand searches were also carried out to supplement electronically derived information and literature pre-dating 1996. The resulting references were stratified into the following categories and reviewed; (1) radiation associated mesothelioma, (2) familial mesothelioma, (3) dietary factors, (4) childhood mesothelioma and (5) the role or SV40.
    Result: Available information suggests that genetic factors may play a larger role in the etiology of this disease than currently appreciated. The interplay of genes and environment require further elucidation in the pathogenesis of mesothelioma. The role of diet is poorly understood with few studies directly addressing this issue. Whether other environmental or infectious agents are involved in mesothelioma development remains speculative.
    Conclusion: The biology of mesothelioma is an enigma. Although this disease appears to occur in the absence of asbestos exposure, the genetic and biological differences between asbestos related and non-asbestos related tumors is unclear. Additional epidemiological and laboratory studies are needed to provide a better understanding of the relationship between environmental and non-environmental causes of mesothelioma.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Diet/adverse effects ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Mesothelioma/etiology ; Mesothelioma/pathology ; Middle Aged ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Radiation-Induced/pathology ; Pleural Neoplasms/etiology ; Pleural Neoplasms/pathology ; Polyomavirus Infections/complications ; Simian virus 40/pathogenicity ; Tumor Virus Infections/complications
    Language English
    Publishing date 2002-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.43: Show issues Location:
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  3. Article ; Online: Perineal talc use and ovarian cancer risk: a case study of scientific standards in environmental epidemiology.

    Huncharek, Michael / Muscat, Joshua

    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

    2011  Volume 20, Issue 6, Page(s) 501–507

    Abstract: A number of observational studies (largely case-control) conducted over the last two decades suggest an association between use of talc powders on the female perineum and increased risk of ovarian cancer. A subset of these reports shows a roughly 30-60% ... ...

    Abstract A number of observational studies (largely case-control) conducted over the last two decades suggest an association between use of talc powders on the female perineum and increased risk of ovarian cancer. A subset of these reports shows a roughly 30-60% increased risk of ovarian cancer associated with perineal talc exposure. A number of researchers partly base their conclusions of an association on the '…chemical relationship between talc and asbestos', the latter substance being a known human carcinogen. Although separating causal from noncausal explanations for an observed statistical association is a difficult process, there currently exist commonly accepted guidelines by which such inferences can be made. These scientific approaches include consideration of the strength of the association, the consistency of the finding across studies, and existence of a biological explanation of the observed phenomenon, among others. When applied to the context of a proposed talc/ovarian cancer association, we conclude that the weak statistical associations observed in a number of epidemiological studies do not support a causal association.
    MeSH term(s) Case-Control Studies ; Environmental Exposure/adverse effects ; Female ; Humans ; Ovarian Neoplasms/chemically induced ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Perineum ; Talc/adverse effects
    Chemical Substances Talc (14807-96-6)
    Language English
    Publishing date 2011-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1137033-6
    ISSN 1473-5709 ; 0959-8278
    ISSN (online) 1473-5709
    ISSN 0959-8278
    DOI 10.1097/CEJ.0b013e3283476242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3621: Show issues Location:
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  4. Article: Meta-analytic re-evaluation of misonidazole in the treatment of high grade astrocytoma.

    Huncharek, M

    Anticancer research

    1998  Volume 18, Issue 3B, Page(s) 1935–1939

    Abstract: Background: The clinical effects of the radiation sensitizer, misonidazole, in the treatment of high grade astrocytoma are equivocal based on available clinical trial data. A meta-analysis was performed in order to evaluate the impact of this compound ... ...

    Abstract Background: The clinical effects of the radiation sensitizer, misonidazole, in the treatment of high grade astrocytoma are equivocal based on available clinical trial data. A meta-analysis was performed in order to evaluate the impact of this compound on treatment outcome for this disease.
    Methods: One year survival data derived from over 1,700 patients enrolled in 9 randomized clinical trials were analyzed using the meta-analytic techniques previously described by Peto et al. This analysis compared the proportion of patients surviving one year treated with misonidazole sensitized radiation therapy (+/- chemotherapy) versus radiation alone (+/- chemotherapy).
    Results: A summary odds ratio was calculated following a statistical analysis showing a lack of heterogeneity among the included studies in terms of their estimate of effect. The calculated Peto odds ratio was 0.92 with a 95% confidence interval of 0.77-1.09. These data indicate that misonidazole treatment is associated with an approximately 8% improved 1 year survival compared with non-misonidazole treatment arms. This odds ratio increased to 0.87 when only those trials using "conventional" radiation therapy schedules were analyzed.
    Conclusion: This analysis suggests that misonidazole may contribute to improved 1 year survival in patients with high grade astrocytoma and that the magnitude of this improvement may be comparable to that seen with the use of chemotherapy in this patient group.
    MeSH term(s) Astrocytoma/drug therapy ; Astrocytoma/mortality ; Astrocytoma/radiotherapy ; Brain Neoplasms/drug therapy ; Brain Neoplasms/mortality ; Brain Neoplasms/radiotherapy ; Humans ; Misonidazole/therapeutic use ; Radiation-Sensitizing Agents/therapeutic use ; Survival Analysis ; Treatment Outcome
    Chemical Substances Radiation-Sensitizing Agents ; Misonidazole (8FE7LTN8XE)
    Language English
    Publishing date 1998-05
    Publishing country Greece
    Document type Comparative Study ; Journal Article ; Meta-Analysis
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Show issues Location:
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  5. Article: In regard to Glatstein: Scientific physicians and evidence-based medicine. IJROBP 2001;49:619-21.

    Huncharek, M S

    International journal of radiation oncology, biology, physics

    2001  Volume 50, Issue 5, Page(s) 1374–1375

    MeSH term(s) Attitude of Health Personnel ; Education, Medical ; Epidemiology/education ; Evidence-Based Medicine ; Humans ; Meta-Analysis as Topic ; Physicians/psychology
    Language English
    Publishing date 2001-08-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/s0360-3016(01)01632-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1218: Show issues Location:
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  6. Article: Genetic factors in the aetiology of malignant mesothelioma.

    Huncharek, M

    European journal of cancer (Oxford, England : 1990)

    1995  Volume 31A, Issue 11, Page(s) 1741–1747

    MeSH term(s) Chromosome Aberrations ; Family Health ; Genes, Tumor Suppressor ; Humans ; Mesothelioma/genetics ; Neoplastic Syndromes, Hereditary/genetics ; Oncogenes ; Ploidies
    Language English
    Publishing date 1995-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0959-8049 ; 0277-5379 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0959-8049 ; 0277-5379 ; 0964-1947
    DOI 10.1016/0959-8049(95)00365-p
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  7. Article: Types of asbestos fibers and disease-causing potential.

    Huncharek, M

    American family physician

    1994  Volume 50, Issue 2, Page(s) 306–8; author reply 308, 310

    MeSH term(s) Animals ; Asbestos, Amphibole/adverse effects ; Environmental Exposure ; Humans ; Mesothelioma/etiology ; Particle Size
    Chemical Substances Asbestos, Amphibole
    Language English
    Publishing date 1994-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 412694-4
    ISSN 0002-838X ; 0572-3612
    ISSN 0002-838X ; 0572-3612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 848: Show issues Location:
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  8. Article: Miliary mesothelioma.

    Huncharek, M

    Chest

    1994  Volume 106, Issue 2, Page(s) 605–606

    Abstract: Metastases in pleural mesothelioma usually occur late in the disease process. Diffuse involvement of the lung parenchyma is rare. A patient with miliary pulmonary parenchymal involvement with malignant mesothelioma is described. To our knowledge, this ... ...

    Abstract Metastases in pleural mesothelioma usually occur late in the disease process. Diffuse involvement of the lung parenchyma is rare. A patient with miliary pulmonary parenchymal involvement with malignant mesothelioma is described. To our knowledge, this represents the first such case reported.
    MeSH term(s) Biopsy ; Diagnosis, Differential ; Female ; Humans ; Mesothelioma/diagnostic imaging ; Mesothelioma/pathology ; Middle Aged ; Pleural Neoplasms/diagnostic imaging ; Pleural Neoplasms/pathology ; Radiography ; Tuberculosis, Miliary/diagnostic imaging
    Language English
    Publishing date 1994-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.106.2.605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  9. Article: Long-term survival associated with metastatic small cell carcinoma of the esophagus treated by chemotherapy, autologous bone marrow transplantation, and adjuvant radiation therapy.

    Huncharek, M

    Cancer

    1994  Volume 74, Issue 1, Page(s) 217

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow Transplantation ; Brachytherapy ; Carcinoma, Small Cell/therapy ; Combined Modality Therapy ; Esophageal Neoplasms/therapy ; Female ; Humans ; Middle Aged ; Transplantation, Autologous
    Language English
    Publishing date 1994-07-01
    Publishing country United States
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(19940701)74:1<217::aid-cncr2820740133>3.0.co;2-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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  10. Article: Pleural mesothelioma in a cigarette filter factory worker.

    Huncharek, M

    Scandinavian journal of work, environment & health

    1994  Volume 20, Issue 2, Page(s) 146–147

    Abstract: The incidence of pleural mesothelioma is increasing. Over the past two decades many new occupational and nonoccupational risk groups have been identified. This paper reports a case of pleural mesothelioma in an office worker employed in a cigarette ... ...

    Abstract The incidence of pleural mesothelioma is increasing. Over the past two decades many new occupational and nonoccupational risk groups have been identified. This paper reports a case of pleural mesothelioma in an office worker employed in a cigarette filter factory. Both secondary occupational and domestic asbestos exposure may have occurred. Only one prior report describes the potential asbestos health risks of this occupational group.
    MeSH term(s) Asbestos/adverse effects ; Fatal Outcome ; Female ; Humans ; Industry ; Mesothelioma/chemically induced ; Mesothelioma/diagnostic imaging ; Middle Aged ; Occupational Diseases/chemically induced ; Occupational Diseases/diagnostic imaging ; Occupational Exposure ; Plants, Toxic ; Pleural Neoplasms/chemically induced ; Pleural Neoplasms/diagnostic imaging ; Radiography ; Nicotiana
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 1994-04
    Publishing country Finland
    Document type Case Reports ; Journal Article
    ZDB-ID 191563-0
    ISSN 1795-990X ; 0355-3140
    ISSN (online) 1795-990X
    ISSN 0355-3140
    DOI 10.5271/sjweh.1418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1153: Show issues Location:
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