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  1. Book ; Thesis: Assessing human iPSC-derived iMicroglia as a promising model in neurosteroid research

    Habiballa, Moataz / Rune, Gabriele M. / Krasemann, Susanne

    2023  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Moataz Habiballa ; Prüfungsausschuss, der/die Vorsitzende: Prof. Dr. Gabriele Rune, Prüfungsausschuss, zweite/r Gutachter/in: PD Dr. Susanne Krasemann
    Language English
    Size 135 Blätter, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2023
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache ; Literature: Blatt 110-128 ; Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg
    HBZ-ID HT030621289
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1506 order for loan Magazin

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  2. Article ; Online: Four-wheel-drive immune protection.

    Heinrich, Fabian / Krasemann, Susanne

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 337

    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01180-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe.

    Krasemann, Susanne / Glatzel, Markus / Pless, Ole

    Stem cell reports

    2022  Volume 17, Issue 5, Page(s) 1014–1015

    MeSH term(s) Brain ; COVID-19 ; Endothelial Cells ; Humans ; Interferon Type I ; SARS-CoV-2
    Chemical Substances Interferon Type I
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Using autopsies to dissect COVID-19 pathogenesis.

    Heinrich, Fabian / Mertz, Kirsten D / Glatzel, Markus / Beer, Martin / Krasemann, Susanne

    Nature microbiology

    2023  Volume 8, Issue 11, Page(s) 1986–1994

    Abstract: The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since ... ...

    Abstract The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since then, autopsies of patients have substantially contributed to our understanding of the pathogenesis of COVID-19 and associated major organ complications. Here we summarize how autopsies have complemented experimental studies, mainly in animal models, and how they have facilitated critical knowledge of COVID-19 to improve daily clinical practice and develop therapeutic interventions. Employing advanced histopathologic and molecular genetic methods in post-mortem tissues, the COVID-19 pandemic has highlighted the importance of autopsies for virology research and clinical practice in current and emerging infectious diseases.
    MeSH term(s) Animals ; Humans ; COVID-19 ; SARS-CoV-2 ; Autopsy ; Pandemics ; Models, Animal
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01488-7
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  5. Article: [No title information]

    Krasemann, Susann

    Pflege

    2017  Volume 30, Issue 5, Page(s) 307–309

    Title translation Rahmenbedingungen und Strukturen für einen fruchtbaren Austausch zwischen Wissenschaft und Praxis schaffen.
    Language German
    Publishing date 2017-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 645005-2
    ISSN 1664-283X ; 1012-5302
    ISSN (online) 1664-283X
    ISSN 1012-5302
    DOI 10.1024/1012-5302/a000581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2399: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease.

    Sepulveda-Falla, Diego / Vélez, Jorge I / Acosta-Baena, Natalia / Baena, Ana / Moreno, Sonia / Krasemann, Susanne / Lopera, Francisco / Mastronardi, Claudio A / Arcos-Burgos, Mauricio

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 4, Page(s) 2873–2885

    Abstract: Introduction: Rate of cognitive decline (RCD) in Alzheimer's disease (AD) determines the degree of impairment for patients and of burden for caretakers. We studied the association of RCD with genetic variants in AD.: Methods: RCD was evaluated in 62 ... ...

    Abstract Introduction: Rate of cognitive decline (RCD) in Alzheimer's disease (AD) determines the degree of impairment for patients and of burden for caretakers. We studied the association of RCD with genetic variants in AD.
    Methods: RCD was evaluated in 62 familial AD (FAD) and 53 sporadic AD (SAD) cases, and analyzed by whole-exome sequencing for association with common exonic functional variants. Findings were validated in post mortem brain tissue.
    Results: One hundred seventy-two gene variants in FAD, and 227 gene variants in SAD associated with RCD. In FAD, performance decline of the immediate recall of the Rey-Osterrieth figure test associated with 122 genetic variants. Olfactory receptor OR51B6 showed the highest number of associated variants. Its expression was detected in temporal cortex neurons.
    Discussion: Impaired olfactory function has been associated with cognitive impairment in AD. Genetic variants in these or other genes could help to identify risk of faster memory decline in FAD and SAD patients.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Brain/metabolism ; Neurons/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Mutation/genetics
    Chemical Substances Presenilin-1 ; PSEN1 protein, human
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

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  7. Article ; Online: Using autopsies to dissect COVID-19 pathogenesis

    Heinrich, Fabian / Mertz, Kirsten D. / Glatzel, Markus / Beer, Martin / Krasemann, Susanne

    2023  

    Abstract: The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since ... ...

    Abstract The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since then, autopsies of patients have substantially contributed to our understanding of the pathogenesis of COVID-19 and associated major organ complications. Here we summarize how autopsies have complemented experimental studies, mainly in animal models, and how they have facilitated critical knowledge of COVID-19 to improve daily clinical practice and develop therapeutic interventions. Employing advanced histopathologic and molecular genetic methods in post-mortem tissues, the COVID-19 pandemic has highlighted the importance of autopsies for virology research and clinical practice in current and emerging infectious diseases.
    Keywords article ; Text ; ddc:570
    Language English
    Publishing date 2023-10-05
    Publisher Springer Science and Business Media LLC
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Loss of Homeostatic Microglia Signature in Prion Diseases.

    Wang, Yue / Hartmann, Kristin / Thies, Edda / Mohammadi, Behnam / Altmeppen, Hermann / Sepulveda-Falla, Diego / Glatzel, Markus / Krasemann, Susanne

    Cells

    2022  Volume 11, Issue 19

    Abstract: Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein ( ... ...

    Abstract Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein (PrP
    MeSH term(s) Animals ; Homeostasis ; Humans ; Mice ; Microglia/metabolism ; Neurodegenerative Diseases/metabolism ; Prion Diseases/metabolism ; Prion Proteins/metabolism ; Prions/metabolism ; Protein Isoforms/metabolism
    Chemical Substances Prion Proteins ; Prions ; Protein Isoforms
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11192948
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  9. Article: Reactive Astrocytes Contribute to Alzheimer's Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay.

    Wasilewski, David / Villalba-Moreno, Nelson David / Stange, Inke / Glatzel, Markus / Sepulveda-Falla, Diego / Krasemann, Susanne

    Frontiers in cellular neuroscience

    2022  Volume 15, Page(s) 739411

    Abstract: Pathological hallmarks of Alzheimer's disease (AD) include deposition and accumulation of amyloid- β (Aβ), neurofibrillary tangle formation, and neuronal loss. Pathogenesis of presymptomatic disease stages remains elusive, although studies suggest that ... ...

    Abstract Pathological hallmarks of Alzheimer's disease (AD) include deposition and accumulation of amyloid- β (Aβ), neurofibrillary tangle formation, and neuronal loss. Pathogenesis of presymptomatic disease stages remains elusive, although studies suggest that the early structural and functional alterations likely occur at neuronal dendritic spines. Presymptomatic alterations may also affect different CNS cell types. However, specific contributions of these cell types as cause or consequence of pathology are difficult to study
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.739411
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  10. Article: APOE3

    Perez-Corredor, Paula / Vanderleest, Timothy E / Vacano, Guido N / Sanchez, Justin S / Villalba-Moreno, Nelson D / Marino, Claudia / Krasemann, Susanne / Mendivil-Perez, Miguel A / Aguillón, David / Jiménez-Del-Río, Marlene / Baena, Ana / Sepulveda-Falla, Diego / Lopera, Francisco / Quiroz, Yakeel T / Arboleda-Velasquez, Joseph F / Mazzarino, Randall C

    Frontiers in molecular neuroscience

    2024  Volume 17, Page(s) 1373568

    Abstract: A patient with ... ...

    Abstract A patient with the
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1373568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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