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  1. Book ; Online: Personalized Medicine in the Field of Inflammatory Skin Disorders

    Tampa, Mircea / Neagu, Monica / Caruntu, Constantin / Georgescu, Simona Roxana

    2022  

    Keywords Medicine ; sea-buckthorn seed oil ; long-chain fatty acids ; skin dysplastic keratinocytes ; UVA ; CD36 ; SR-B2 ; atopic dermatitis ; eczema ; JAK inhibitors ; systematic review ; meta-analysis ; evidence-based medicine ; immune-mediated skin diseases ; target therapy ; skin conditions and systemic inflammatory diseases ; systemic sclerosis ; biomarker ; calumenin ; S100A6 ; cytohesin 2 ; cannabinoids ; inflammation ; gut-lung-skin barrier ; signaling pathways ; inflammatory biomarkers ; psoriasis vulgaris ; prevalence ; comorbidities ; risk factors ; systemic lupus erythematous ; lupus nephritis ; lipid peroxidation ; DNA oxidation ; oxidized proteins ; carbohydrate oxidation ; antioxidative stress strategies ; biomarkers ; IgY ; psoriatic dermatitis ; imiquimod ; C57 BL/6 mice ; alginate ; biomaterial ; dressing ; fibers ; hydrogel ; nanofibers ; commercially available ; wound care ; wound healing ; cutaneous melanoma ; epigenetic regulation ; drug resistance ; therapeutic targets ; epigenetic therapy ; immune response ; Sutton nevi ; halo nevi ; skin tumor ; psoriasis ; proteome analysis ; estrogen ; menopause ; cSCC ; AK ; sialylation ; sialyltransferase ; sialidase ; COVID-19 ; pyoderma gangrenosum ; immunosuppression ; cyclosporine ; corticosteroids ; autoinflammatory disease ; androgenic alopecia ; clinical trial ; hair density ; platelet-rich plasma ; n/a
    Language 0|e
    Size 1 electronic resource (262 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021608745
    ISBN 9783036535739 ; 303653573X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Metabolic Traits in Cutaneous Melanoma.

    Neagu, Monica

    Frontiers in oncology

    2020  Volume 10, Page(s) 851

    Abstract: Tumor microenvironment is a network of complex cellular and molecular systems where cells will gain specific phenotypes and specific functions that would drive tumorigenesis. In skin cancers, tumor microenvironment is characterized by tumor infiltrating ... ...

    Abstract Tumor microenvironment is a network of complex cellular and molecular systems where cells will gain specific phenotypes and specific functions that would drive tumorigenesis. In skin cancers, tumor microenvironment is characterized by tumor infiltrating immune cells that sustain immune suppression, mainly lymphocytes. Melanoma cellular heterogeneity can be described on genetic, proteomic, transcriptomic and metabolomic levels. Melanoma cells display a metabolic reprogramming triggered by both genetic alterations and adaptation to a microenvironment that lacks nutrients and oxygen supply. Tumor cells present clear metabolic adaptations and identifying deregulated glycolysis pathway could offer new therapy targets. Moreover, the immune cells (T lymphocytes, macrophages, NK cells, neutrophils and so on) that infiltrate melanoma tumors have metabolic particularities that, upon interaction within tumor microenvironment, would favor tumorigenesis. Analyzing both tumor cell metabolism and the metabolic outline of immune cells can offer innovative insights in new therapy targets and cancer therapeutical approaches. In addition to already approved immune- and targeted therapy in melanoma, approaching metabolic check-points could improve therapy efficacy and hinder resistance to therapy.
    Language English
    Publishing date 2020-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The bumpy road to achieve herd immunity in COVID-19.

    Neagu, Monica

    Journal of immunoassay & immunochemistry

    2020  Volume 41, Issue 6, Page(s) 928–945

    Abstract: Herd immunity is a form of indirect protection that is offered to the community when a large proportion of individuals contained in the community are immune to a certain infection. This immunity can be due to vaccination or to the recovery post-disease. ... ...

    Abstract Herd immunity is a form of indirect protection that is offered to the community when a large proportion of individuals contained in the community are immune to a certain infection. This immunity can be due to vaccination or to the recovery post-disease. Effective herd immunity in SARS-CoV-2 infection has several hurdles upon achievement. Herd immunity cannot be obtained concomitantly in many geographical areas because the areas have different population density and the societal measures to contain the spreading are different. A proportion of 50-66% of the population needs to be immunized naturally or artificially in this SARS-Cov2 pandemic and this percentage is not easily achievable. The duration of herd immunity is another issue while information on the long-term immune response against SARS-CoV2 is yet scarce. Epitope stability, another issue to be solved when achieving herd immunity, is important. Mutation in the viral structure will call upon other sets of neutralizing antibodies and hence for other herd immunity type installment. The societal tactics to achieve the much-needed herd immunity should be developed keeping in mind the welfare of the population. Without being exhaustive, throughout our paper we will elaborate on each of the hurdles encountered in developing herd immunity to SARS-Cov2 infection.
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; Epitopes/chemistry ; Female ; Geography ; Humans ; Immunity, Herd ; Immunization, Passive ; Male ; Models, Theoretical ; Mutation ; Pandemics/prevention & control ; RNA, Viral ; T-Lymphocytes/immunology ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2020.1833919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Moving Forward in Nano-Immune Interactions.

    Bardi, Giuseppe / Neagu, Monica

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: This is the second Special Issue on the topic "Immune Responses to Nanomaterials for Biomedical Applications" [ ... ]. ...

    Abstract This is the second Special Issue on the topic "Immune Responses to Nanomaterials for Biomedical Applications" [...].
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12122033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hydrogel Extrusion Speed Measurements for the Optimization of Bioprinting Parameters.

    Arjoca, Stelian / Bojin, Florina / Neagu, Monica / Păunescu, Andreea / Neagu, Adrian / Păunescu, Virgil

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 2

    Abstract: Three-dimensional (3D) bioprinting is the use of computer-controlled transfer processes for assembling bioinks (cell clusters or materials loaded with cells) into structures of prescribed 3D organization. The correct bioprinting parameters ensure a fast ... ...

    Abstract Three-dimensional (3D) bioprinting is the use of computer-controlled transfer processes for assembling bioinks (cell clusters or materials loaded with cells) into structures of prescribed 3D organization. The correct bioprinting parameters ensure a fast and accurate bioink deposition without exposing the cells to harsh conditions. This study seeks to optimize pneumatic extrusion-based bioprinting based on hydrogel flow rate and extrusion speed measurements. We measured the rate of the hydrogel flow through a cylindrical nozzle and used non-Newtonian hydrodynamics to fit the results. From the videos of free-hanging hydrogel strands delivered from a stationary print head, we inferred the extrusion speed, defined as the speed of advancement of newly formed strands. Then, we relied on volume conservation to evaluate the extrudate swell ratio. The theoretical analysis enabled us to compute the extrusion speed for pressures not tested experimentally as well as the printing speed needed to deposit hydrogel filaments of a given diameter. Finally, the proposed methodology was tested experimentally by analyzing the morphology of triple-layered square-grid hydrogel constructs printed at various applied pressures while the printing speeds matched the corresponding extrusion speeds. Taken together, the results of this study suggest that preliminary measurements and theoretical analyses can simplify the search for the optimal bioprinting parameters.
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10020103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Nanomaterials for the diagnosis and therapy of viral infections.

    Bardi, Giuseppe / Zipeto, Donato / Neagu, Monica / Nikitovic, Dragana

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1192393

    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1192393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Looking into the Skin in Health and Disease: From Microscopy Imaging Techniques to Molecular Analysis.

    Caruntu, Constantin / Ilie, Mihaela Adriana / Neagu, Monica

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: The skin is a complex organ that includes a wide variety of tissue types with different embryological origins [ ... ]. ...

    Abstract The skin is a complex organ that includes a wide variety of tissue types with different embryological origins [...].
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The bumpy road to achieve herd immunity in COVID-19

    Neagu, Monica

    Journal of Immunoassay and Immunochemistry

    2020  , Page(s) 1–18

    Keywords Immunology ; Immunology and Allergy ; Clinical Biochemistry ; Medical Laboratory Technology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2050610-7
    ISSN 1532-1819
    ISSN 1532-1819
    DOI 10.1080/15321819.2020.1833919
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Mathematical and computational models in spheroid-based biofabrication.

    Arjoca, Stelian / Robu, Andreea / Neagu, Monica / Neagu, Adrian

    Acta biomaterialia

    2022  Volume 165, Page(s) 125–139

    Abstract: Ubiquitous in embryonic development, tissue fusion is of interest to tissue engineers who use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular constructs. This review presents mathematical models and computer ... ...

    Abstract Ubiquitous in embryonic development, tissue fusion is of interest to tissue engineers who use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular constructs. This review presents mathematical models and computer simulations of the fusion of tissue spheroids. The motivation of this study stems from the need to predict the post-printing evolution of 3D bioprinted constructs. First, we provide a brief overview of differential adhesion, the main morphogenetic mechanism involved in post-printing structure formation. It will be shown that clusters of cohesive cells behave as an incompressible viscous fluid on the time scale of hours. The discussion turns then to mathematical models based on the continuum hydrodynamics of highly viscous liquids and on statistical mechanics. Next, we analyze the validity and practical use of computational models of multicellular self-assembly in live constructs created by tissue spheroid bioprinting. Finally, we discuss the perspectives of the field as machine learning starts to reshape experimental design, and modular robotic workstations tend to alleviate the burden of repetitive tasks in biofabrication. STATEMENT OF SIGNIFICANCE: Bioprinted constructs are living systems, which evolve via morphogenetic mechanisms known from developmental biology. This review presents mathematical and computational tools devised for modeling post-printing structure formation. They help achieving a desirable outcome without expensive optimization experiments. While previous reviews mainly focused on assumptions, technical details, strengths, and limitations of computational models of multicellular self-assembly, this article discusses their validity and practical use in biofabrication. It also presents an overview of mathematical models that proved to be useful in the evaluation of experimental data on tissue spheroid fusion, and in the calibration of computational models. Finally, the perspectives of the field are discussed in the advent of robotic biofabrication platforms and bioprinting process optimization by machine learning.
    MeSH term(s) Tissue Engineering/methods ; Models, Theoretical ; Computer Simulation ; Organoids ; Bioprinting/methods ; Printing, Three-Dimensional ; Tissue Scaffolds/chemistry
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.07.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Correction to: Signal Transduction in Immune Cells and Protein Kinases.

    Neagu, Monica / Constantin, Carolina

    Advances in experimental medicine and biology

    2021  Volume 1275, Page(s) C1

    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-49844-3_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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