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  1. Book: Notch signaling

    Kopan, Raphael

    (Current topics in developmental biology ; 92)

    2010  

    Author's details ed. by Raphael Kopan
    Series title Current topics in developmental biology ; 92
    Collection
    Keywords Signaltransduktion ; Gen notch
    Subject Signalübertragung ; Signalvermittlung ; Notch ; Notch-Rezeptor ; Notch-Signalweg
    Language English
    Size XVI, 530 S., [12] Bl. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016579017
    ISBN 978-0-12-380914-8 ; 0-12-380914-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
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  2. Article ; Online: The Unaimed Arrow Never Misses.

    Kopan, Raphael

    Current topics in developmental biology

    2016  Volume 116, Page(s) 547–550

    Abstract: In this assay, Raphael Kopan argues that focused emphasis on disease and translation stifles ...

    Abstract In this assay, Raphael Kopan argues that focused emphasis on disease and translation stifles innovation, and outline the reasons why, in my opinion, developmental biologists are more likely to produce new and important discoveries than their more "focused" colleagues.
    MeSH term(s) Animals ; Biomedical Research ; Developmental Biology ; Diffusion of Innovation ; Humans ; Preventive Medicine
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2015.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Regulation of nephron progenitor cell lifespan and nephron endowment.

    Perl, Alison J / Schuh, Meredith P / Kopan, Raphael

    Nature reviews. Nephrology

    2022  Volume 18, Issue 11, Page(s) 683–695

    Abstract: Low nephron number - resulting, for example, from prematurity or developmental anomalies - is a risk factor for the development of hypertension, chronic kidney disease and kidney failure. Considerable interest therefore exists in the mechanisms that ... ...

    Abstract Low nephron number - resulting, for example, from prematurity or developmental anomalies - is a risk factor for the development of hypertension, chronic kidney disease and kidney failure. Considerable interest therefore exists in the mechanisms that regulate nephron endowment and contribute to the premature cessation of nephrogenesis following preterm birth. The cessation of nephrogenesis in utero or shortly after birth is synchronized across multiple niches in all mammals, and is coupled with the exhaustion of nephron progenitor cells. Consequently, no nephrons are formed after the cessation of developmental nephrogenesis, and lifelong renal function therefore depends on the complement of nephrons generated during gestation. In humans, a tenfold variation in nephron endowment between individuals contributes to differences in susceptibility to kidney disease; however, the mechanisms underlying this variation are not yet clear. Salient advances in our understanding of environmental inputs, and of intrinsic molecular mechanisms that contribute to the regulation of cessation timing or nephron progenitor cell exhaustion, have the potential to inform interventions to enhance nephron endowment and improve lifelong kidney health for susceptible individuals.
    MeSH term(s) Animals ; Female ; Infant, Newborn ; Humans ; Longevity ; Premature Birth ; Kidney ; Stem Cells ; Renal Insufficiency, Chronic ; Mammals ; Financial Management
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00620-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer-Promoter Interactions in the Transgene.

    Perl, Alison J / Liu, Han / Hass, Matthew / Adhikari, Nirpesh / Chaturvedi, Praneet / Hu, Yueh-Chiang / Jiang, Rulang / Liu, Yaping / Kopan, Raphael

    Journal of the American Society of Nephrology : JASN

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Characterizing post-branching nephrogenesis in the neonatal rabbit.

    Schuh, Meredith P / Yarlagadda, Sunitha / Alkhudairy, Lyan / Preusse, Kristina / Kopan, Raphael

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19234

    Abstract: Human nephrogenesis ends prior to birth in term infants (34-36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. Preterm infants, however, ... ...

    Abstract Human nephrogenesis ends prior to birth in term infants (34-36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. Preterm infants, however, must execute PBN postnatally. Extreme prematurity is associated with low nephron counts. Identifying additional model(s) that undergo PBN postnatally will help support postnatal PBN in preterm infants. The rabbit exhibits longer postnatal nephrogenesis than the mouse but whether it forms nephrons through PBN has not been determined. We performed morphologic and immunohistological assessments of rabbit nephrogenesis from birth (post-conceptual day 31 or 32) to PC49 using H&E and antibodies against SIX1, SIX2, WT1, ZO-1, and JAG1 in the postnatal period. We performed 3D rendering of the nephrogenic niche to assess for PBN, and supplemented the staining with RNAScope to map the expression of Six1, Six2 (nephron progenitors, NPC), and Ret (ureteric bud tip) transcripts to determine the nephrogenic niche postnatal lifespan. Unlike the mouse, rabbit SIX2 disappeared from NPC before SIX1, resembling the human niche. Active nephrogenesis as defined by the presence of SIX1 + naïve NPC/tip population persisted only until PC35-36 (3-5 postnatal days). 3D morphologic assessments of the cortical nephrons identified an elongated tubule with attached glomeruli extending below the UB tip, consistent with PBN arcades, but not with lateral branch nephrogenesis. We conclude that the rabbit shows morphologic and molecular evidence of PBN arcades continuing postnatally for a shorter period than previously thought. The rabbit is the first non-primate expressing SIX1 in the progenitor population. Our findings suggest that studies of arcading in postnatal nephrogenic niche should be performed within the first 5 days of life in the rabbit.
    MeSH term(s) Infant, Newborn ; Rabbits ; Animals ; Mice ; Humans ; Pregnancy ; Female ; Infant, Premature ; Kidney/metabolism ; Nephrons/metabolism ; Kidney Glomerulus/pathology ; Organogenesis ; Homeodomain Proteins/metabolism
    Chemical Substances SIX1 protein, human ; Homeodomain Proteins
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46624-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Notch signaling.

    Kopan, Raphael

    Cold Spring Harbor perspectives in biology

    2012  Volume 4, Issue 10

    MeSH term(s) Cell Death ; Cell Differentiation ; Cell Proliferation ; Models, Biological ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Receptors, Notch/physiology ; Signal Transduction
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2012-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a011213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The unique function of Runx1 in skeletal muscle differentiation and regeneration is mediated by an ETS interaction domain.

    Yu, Meng / Thorner, Konrad / Parameswaran, Sreeja / Wei, Wei / Yu, Chuyue / Lin, Xinhua / Kopan, Raphael / Hass, Matthew R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The conserved Runt-related (RUNX) transcription factor family are well-known master regulators of developmental and regenerative processes. ...

    Abstract The conserved Runt-related (RUNX) transcription factor family are well-known master regulators of developmental and regenerative processes.
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.21.568117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterizing post-branching nephrogenesis in the neonatal rabbit

    Meredith P. Schuh / Sunitha Yarlagadda / Lyan Alkhudairy / Kristina Preusse / Raphael Kopan

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Human nephrogenesis ends prior to birth in term infants (34–36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. Preterm infants, ... ...

    Abstract Abstract Human nephrogenesis ends prior to birth in term infants (34–36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. Preterm infants, however, must execute PBN postnatally. Extreme prematurity is associated with low nephron counts. Identifying additional model(s) that undergo PBN postnatally will help support postnatal PBN in preterm infants. The rabbit exhibits longer postnatal nephrogenesis than the mouse but whether it forms nephrons through PBN has not been determined. We performed morphologic and immunohistological assessments of rabbit nephrogenesis from birth (post-conceptual day 31 or 32) to PC49 using H&E and antibodies against SIX1, SIX2, WT1, ZO-1, and JAG1 in the postnatal period. We performed 3D rendering of the nephrogenic niche to assess for PBN, and supplemented the staining with RNAScope to map the expression of Six1, Six2 (nephron progenitors, NPC), and Ret (ureteric bud tip) transcripts to determine the nephrogenic niche postnatal lifespan. Unlike the mouse, rabbit SIX2 disappeared from NPC before SIX1, resembling the human niche. Active nephrogenesis as defined by the presence of SIX1 + naïve NPC/tip population persisted only until PC35–36 (3–5 postnatal days). 3D morphologic assessments of the cortical nephrons identified an elongated tubule with attached glomeruli extending below the UB tip, consistent with PBN arcades, but not with lateral branch nephrogenesis. We conclude that the rabbit shows morphologic and molecular evidence of PBN arcades continuing postnatally for a shorter period than previously thought. The rabbit is the first non-primate expressing SIX1 in the progenitor population. Our findings suggest that studies of arcading in postnatal nephrogenic niche should be performed within the first 5 days of life in the rabbit.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Reduced nephron endowment in the common

    Perl, Alison J / Liu, Han / Hass, Matthew / Adhikari, Nirpesh / Chaturvedi, Praneet / Hu, Yueh-Chiang / Jiang, Rulang / Liu, Yaping / Kopan, Raphael

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Lifelong kidney function relies on the complement of nephrons generated during mammalian development from a mesenchymal nephron progenitor cell (NPC) population. Low nephron endowment confers increased susceptibility to chronic kidney disease. We asked ... ...

    Abstract Lifelong kidney function relies on the complement of nephrons generated during mammalian development from a mesenchymal nephron progenitor cell (NPC) population. Low nephron endowment confers increased susceptibility to chronic kidney disease. We asked whether reduced nephron numbers in the popular
    Significance: Using high-resolution chromatin conformation and accessibility datasets we mapped the integration site of two popular transgenes used in studies of nephron progenitor cells and kidney development. Aberrant enhancer-promoter interactions drive ectopic expression of
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.06.561202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis.

    Duvall, Kathryn / Crist, Lauren / Perl, Alison J / Pode Shakked, Naomi / Chaturvedi, Praneet / Kopan, Raphael

    Development (Cambridge, England)

    2022  Volume 149, Issue 10

    Abstract: Notch signaling promotes maturation of nephron epithelia, but its proposed contribution to nephron segmentation into proximal and distal domains has been called into doubt. We leveraged single cell and bulk RNA-seq, quantitative immunofluorescent lineage/ ...

    Abstract Notch signaling promotes maturation of nephron epithelia, but its proposed contribution to nephron segmentation into proximal and distal domains has been called into doubt. We leveraged single cell and bulk RNA-seq, quantitative immunofluorescent lineage/fate tracing, and genetically modified human induced pluripotent stem cells (iPSCs) to revisit this question in developing mouse kidneys and human kidney organoids. We confirmed that Notch signaling is needed for maturation of all nephron lineages, and thus mature lineage markers fail to detect a fate bias. By contrast, early markers identified a distal fate bias in cells lacking Notch2, and a concomitant increase in early proximal and podocyte fates in cells expressing hyperactive Notch1 was observed. Orthogonal support for a conserved role for Notch signaling in the distal/proximal axis segmentation is provided by the demonstration that nicastrin (NCSTN)-deficient human iPSC-derived organoids differentiate into TFA2B+ distal tubule and CDH1+ connecting segment progenitors, but not into HNF4A+ or LTL+ proximal progenitors.
    MeSH term(s) Animals ; Cell Differentiation ; Gene Expression Regulation, Developmental ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Kidney/metabolism ; Mice ; Nephrons/metabolism ; Organogenesis/genetics ; Receptors, Notch/genetics ; Receptors, Notch/metabolism
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.200446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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