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  1. Article: Catheter-based Interventions to Reduce or Modify Surgical Risk in High-Risk Adult Congenital Heart Disease Patients.

    Tan, Weiyi / Aboulhosn, Jamil

    Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual

    2022  Volume 26, Page(s) 89–97

    Abstract: The field of adult congenital heart disease has changed greatly over the past sixty years. As patients are now surviving longer into adulthood due to various improvements in surgical technique and medical technology, the demographic of patients with ... ...

    Abstract The field of adult congenital heart disease has changed greatly over the past sixty years. As patients are now surviving longer into adulthood due to various improvements in surgical technique and medical technology, the demographic of patients with congenital heart disease (CHD) has changed, such that there are now more adults with CHD than there are children with CHD. This older and more medically complex population needs more interventions to treat residual defects or sequelae of their initial surgeries, and many of these patients are now deemed high risk for surgery. When the surgical risk becomes too great, either due to patient complexity, surgical complexity, or both, then transcatheter procedures may have a role in either mitigating or avoiding the risk altogether.
    MeSH term(s) Child ; Adult ; Humans ; Heart Defects, Congenital/surgery ; Disease Progression ; Catheters
    Language English
    Publishing date 2022-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1425449-9
    ISSN 1876-4665 ; 1092-9126
    ISSN (online) 1876-4665
    ISSN 1092-9126
    DOI 10.1053/j.pcsu.2022.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 2039: Show issues Location:
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  2. Article ; Online: Autohydrolysis of Diglycine-Activated Succinic Esters Boosts Cellular Uptake.

    Guo, Jiaqi / Tan, Weiyi / He, Hongjian / Xu, Bing

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 36, Page(s) e202308022

    Abstract: Rapid cellular uptake of synthetic molecules remains a challenge, and the motif frequently employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the desired drugs due to their slow ester hydrolysis and low cell entry. Here ... ...

    Abstract Rapid cellular uptake of synthetic molecules remains a challenge, and the motif frequently employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the desired drugs due to their slow ester hydrolysis and low cell entry. Here we show that succinic ester-containing diglycine drastically boosts the cellular uptake of supramolecular assemblies or prodrugs. Specifically, autohydrolysis of the diglycine-activated succinic esters turns the nanofibers of the conjugates of succinic ester and self-assembling motif into nanoparticles for fast cellular uptake. The autohydrolysis of diglycine-activated succinic esters and drug conjugates also restores the efficacy of the drugs. 2D nuclear magnetic resonance (NMR) suggests that a "U-turn" of diglycine favors intramolecular hydrolysis of diglycine-activated succinic esters to promote autohydrolysis. As an example of rapid autohydrolysis of diglycine-activated succinic esters for instant cellular uptake, this work illustrates a nonenzymatic bond cleavage approach to develop effective therapeutics for intracellular targeting.
    MeSH term(s) Prodrugs/pharmacology ; Prodrugs/chemistry ; Esters/chemistry ; Glycylglycine ; Biological Transport ; Hydrolysis
    Chemical Substances Prodrugs ; Esters ; Glycylglycine (10525P22U0)
    Language English
    Publishing date 2023-07-31
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202308022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Synthesis and bioactivity of pyrrole-conjugated phosphopeptides.

    Zhang, Qiuxin / Tan, Weiyi / Xu, Bing

    Beilstein journal of organic chemistry

    2022  Volume 18, Page(s) 159–166

    Abstract: Here we report the synthesis and effect on the cell viability of pyrrole-conjugated phosphopeptides. Encouraged by the selective inhibition of cancer cells by a naphthyl-capped phosphopeptide (Nap- ... ...

    Abstract Here we report the synthesis and effect on the cell viability of pyrrole-conjugated phosphopeptides. Encouraged by the selective inhibition of cancer cells by a naphthyl-capped phosphopeptide (Nap-ff
    Language English
    Publishing date 2022-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.18.17
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  4. Article ; Online: Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons.

    Qiao, Yuchen / Wu, Grace / Liu, Zhiyu / He, Hongjian / Tan, Weiyi / Xu, Bing

    Biomacromolecules

    2024  Volume 25, Issue 2, Page(s) 1310–1318

    Abstract: Although the formation of peptide assemblies catalyzed by alkaline phosphatase (ALP) has received increasing attention in inhibiting cancer cells, the detailed enzyme kinetics of the dephosphorylation of the corresponding phosphopeptide assemblies have ... ...

    Abstract Although the formation of peptide assemblies catalyzed by alkaline phosphatase (ALP) has received increasing attention in inhibiting cancer cells, the detailed enzyme kinetics of the dephosphorylation of the corresponding phosphopeptide assemblies have yet to be determined. We recently discovered that assemblies from a phosphopentapeptide can form intracellular nanoribbons that kill induced pluripotent stem cells or osteosarcoma cells, but the kinetics of enzymatic dephosphorylation remain unknown. Thus, we chose to examine the enzyme kinetics of the dephosphorylation of the phosphopentapeptide [NBD-LLLLpY (
    MeSH term(s) Phosphopeptides ; Alkaline Phosphatase/metabolism ; Nanotubes, Carbon ; Kinetics
    Chemical Substances Phosphopeptides ; Alkaline Phosphatase (EC 3.1.3.1) ; Nanotubes, Carbon
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01288
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  5. Article: [Renaissance of prepectoral implant-based breast reconstruction: theoretical basis and research status].

    Lin, Weiyi / Chen, Jie / Tan, Qiuwen

    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

    2023  Volume 37, Issue 2, Page(s) 233–239

    Abstract: Objective: To overview the theoretical basis and research status of prepectoral implant-based breast reconstruction.: Methods: The domestic and foreign researches on the application of prepectoral implant-based breast reconstruction in breast ... ...

    Abstract Objective: To overview the theoretical basis and research status of prepectoral implant-based breast reconstruction.
    Methods: The domestic and foreign researches on the application of prepectoral implant-based breast reconstruction in breast reconstruction were retrospectively analyzed. The theoretical basis, clinical advantages, and limitations of this technique were summarized and the future development trend in this field was discussed.
    Results: The recent advances in breast cancer oncology, the development of materials and the concept of oncology reconstruction have provided a theoretical basis for prepectoral implant-based breast reconstruction. The selection of patients and the experience of surgeons are crucial for postoperative outcomes. Ideal thickness and blood flow of flaps are the most important considerations for the selection of prepectoral implant-based breast reconstruction. However, its long-term reconstruction outcomes and clinical benefits and risks in Asian populations still need to be confirmed by more studies.
    Conclusion: Prepectoral implant-based breast reconstruction has a broad application prospect in breast reconstruction following mastectomy. However, the evidence is limited at present. Randomized study with long-term follow-up is urgently in need to provide sufficient evidence to evaluate the safety and reliability of prepectoral implant-based breast reconstruction.
    MeSH term(s) Humans ; Female ; Mastectomy/methods ; Breast Neoplasms/surgery ; Breast Implants ; Breast Implantation/methods ; Retrospective Studies ; Reproducibility of Results ; Mammaplasty/methods ; Acellular Dermis
    Language Chinese
    Publishing date 2023-02-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1420212-8
    ISSN 1002-1892
    ISSN 1002-1892
    DOI 10.7507/1002-1892.202210100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4866: Show issues Location:
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  6. Article ; Online: Small peptides: novel targets for modulating plant-rhizosphere microbe interactions.

    Tan, Weiyi / Nian, Hai / Tran, Lam-Son Phan / Jin, Jing / Lian, Tengxiang

    Trends in microbiology

    2024  

    Abstract: The crucial role of rhizosphere microbes in plant growth and their resilience to environmental stresses underscores the intricate communication between microbes and plants. Plants are equipped with a diverse set of signaling molecules that facilitate ... ...

    Abstract The crucial role of rhizosphere microbes in plant growth and their resilience to environmental stresses underscores the intricate communication between microbes and plants. Plants are equipped with a diverse set of signaling molecules that facilitate communication across different biological kingdoms, although our comprehension of these mechanisms is still evolving. Small peptides produced by plants (SPPs) and microbes (SPMs) play a pivotal role in intracellular signaling and are essential in orchestrating various plant development stages. In this review, we posit that SPPs and SPMs serve as crucial signaling agents for the bidirectional cross-kingdom communication between plants and rhizosphere microbes. We explore several potential mechanistic pathways through which this communication occurs. Additionally, we propose that leveraging small peptides, inspired by plant-rhizosphere microbe interactions, represents an innovative approach in the field of holobiont engineering.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2024.03.011
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  7. Article ; Online: Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells.

    Zhang, Qiuxin / Tan, Weiyi / Liu, Zhiyu / Zhang, Yichi / Wei, Wei-Shao / Fraden, Seth / Xu, Bing

    Journal of the American Chemical Society

    2024  

    Abstract: Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these membranes for cancer inhibition. Here we report the first case of unnatural peptide ( ...

    Abstract Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these membranes for cancer inhibition. Here we report the first case of unnatural peptide (
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c03101
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  8. Article ; Online: Managing Myocardial Bridge and Right Ventricular Outflow Tract Obstruction in an Adolescent With Hypertrophic Cardiomyopathy.

    Joseph, Alysha / Hernandez, Nathanya Baez / Davies, Ryan / Tan, Weiyi

    World journal for pediatric & congenital heart surgery

    2023  Volume 14, Issue 4, Page(s) 530–532

    Abstract: We report a case of symptomatic myocardial bridge in an adolescent with dynamic right ventricular outflow tract obstruction and history of congenital pulmonary valve stenosis as well as hypertrophic cardiomyopathy. Definitive treatment was surgical ... ...

    Abstract We report a case of symptomatic myocardial bridge in an adolescent with dynamic right ventricular outflow tract obstruction and history of congenital pulmonary valve stenosis as well as hypertrophic cardiomyopathy. Definitive treatment was surgical infundibular myectomy and coronary unroofing, resulting in improvement in right ventricular outflow tract gradient and ischemic symptoms.
    MeSH term(s) Humans ; Adolescent ; Ventricular Outflow Obstruction, Right ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/etiology ; Ventricular Outflow Obstruction/surgery ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/surgery ; Myocardium ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351231166661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Response to the letter, "The cardiovascular burden of congenital heart disease - not only in times of COVID-19".

    Tan, Weiyi / Aboulhosn, Jamil

    International journal of cardiology

    2020  Volume 318, Page(s) 52

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Heart Diseases ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.05.081
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  10. Article: Novel oxicam nonsteroidal compound XK01 attenuates inflammation by suppressing the NF-κB and MAPK pathway in RAW264.7 macrophages.

    Wang, Jixiang / Tan, Jiawang / Hu, Qianmei / Mao, Siyu / Chen, Hongting / Luo, Weiyi / Feng, Xing

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24004

    Abstract: Traditional non-steroidal anti-inflammatory drugs (NSAIDs) show serious adverse effects during clinical use, which limits their usage. Oxicams (e.g., piroxicam, meloxicam) are widely used as NSAIDs. However, selectivity to cyclooxygenase (COX) 2 may ... ...

    Abstract Traditional non-steroidal anti-inflammatory drugs (NSAIDs) show serious adverse effects during clinical use, which limits their usage. Oxicams (e.g., piroxicam, meloxicam) are widely used as NSAIDs. However, selectivity to cyclooxygenase (COX) 2 may cause cardiovascular problems considering the long-term use of the drugs. Therefore, it is important to develop new non-steroidal compounds as anti-inflammatory drugs. In the present study, we evaluated the anti-inflammatory activity of a newly developed nonsteroidal drug XK01. Our data showed that XK01 reduced the contents of nitric oxide (NO) and reactive oxygen species (ROS)and inhibited the transcription levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 macrophages. XK01 showed no significant inhibitory effect on COX-1, but inhibited the expression of COX-2. At molecular level, XK01 prevented the translocation of p65 protein from the cytoplasm to the nucleus and inhibited the phosphorylation of p65, IκB, and MAPKs proteins. And high concentration of XK01 also inhibited the phosphorylation of JNK, p38 and ERK, showing stronger effect than that of meloxicam. In addition, the anti-inflammatory activity of XK01 was further validated in Xylene-induced mouse ear swelling model. Thus, this study verified that XK01 inhibits the expression of inflammatory mediators and COX-2, and exhibits potential anti-inflammatory effects via suppressing the NF-κB and MAPK pathway.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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