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Artikel ; Online: Erworbene Form einer Chiari-1,5-Malforation bei Crouzon-Syndrom (Dysostosis craniofacialis).

Bonsignore, Razmin / Ottenhausen, Malte / Othman, Ahmed E

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

2023 Band 195, Heft 11, Seite(n) 1027–1028

Titelübersetzung	Acquired form of Chiari 1.5 malformation in Crouzon syndrome (dysostosis craniofacialis).
Mesh-Begriff(e)	Humans ; Craniofacial Dysostosis/diagnostic imaging ; Dysostoses
Sprache	Deutsch
Erscheinungsdatum	2023-06-22
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	554830-5
ISSN	1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
ISSN (online)	1438-9010
ISSN	0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
DOI	10.1055/a-2088-9633
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Erworbene Form einer Chiari-1,5-Malforation bei Crouzon-Syndrom (Dysostosis craniofacialis)

Bonsignore, Razmin / Ottenhausen, Malte / Othman, Ahmed E.

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

2023 Band 195, Heft 11, Seite(n) 1027–1028

Sprache	Deutsch
Erscheinungsdatum	2023-06-22
Verlag	Georg Thieme Verlag KG
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel
ZDB-ID	554830-5
ISSN	1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
ISSN (online)	1438-9010
ISSN	1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
DOI	10.1055/a-2088-9633
Datenquelle	Thieme Verlag

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Artikel ; Online: New organisation for follow-up and assessment of treatment efficacy in sleep apnoea.

Suarez-Giron, Monique / Bonsignore, Maria R / Montserrat, Josep M

European respiratory review : an official journal of the European Respiratory Society

2019 Band 28, Heft 153

Abstract: Obstructive sleep apnoea (OSA) is a highly prevalent disease, and there is an increased demand for OSA diagnosis and treatment. However, resources are limited compared with the growing needs for OSA diagnosis and management, and alternative strategies ... ...

Abstract	Obstructive sleep apnoea (OSA) is a highly prevalent disease, and there is an increased demand for OSA diagnosis and treatment. However, resources are limited compared with the growing needs for OSA diagnosis and management, and alternative strategies need to be developed to optimise the OSA clinical pathway. In this review, we propose a management strategy for OSA, and in general for sleep-disordered breathing, to be implemented from diagnosis to follow-up. For this purpose, the best current options seem to be: 1) networking at different levels of care, from primary physicians to specialised sleep laboratories; and 2) use of telemedicine. Telemedicine can contribute to the improved cost-effectiveness of OSA management during both the diagnostic and therapeutic phases. However, although the technology is already in place and different commercial platforms are in use, it is still unclear how to use telemedicine effectively in the sleep field. Application of telemedicine for titration of positive airway pressure treatment, follow-up to improve compliance to treatment through early identification and solution of problems, and teleconsultation all appear to be promising areas for improved OSA management.
Mesh-Begriff(e)	Delivery of Health Care, Integrated/organization & administration ; Health Services Needs and Demand/organization & administration ; Humans ; Lung/physiopathology ; Needs Assessment/organization & administration ; Patient Compliance ; Predictive Value of Tests ; Recovery of Function ; Respiration ; Respiratory Therapy ; Sleep ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/therapy ; Telemedicine/organization & administration ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2019-09-11
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0059-2019
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Taking care of life: the new Italian law on post-mortem donation for study purposes, training and scientific research.

Ciliberti, Rosagemma / Bonsignore, Alessandro / Bonzano, Chiara / Ventura, Francesco / Licata, Marta

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2021 Band 236, Seite(n) 151712

Abstract: Anatomical dissection is considered a fundamental practice in the medical curriculum. Not only does it help students to familiarize themselves with the various bodily organs and to refine their surgical practice, it also fosters an attitude of awareness ... ...

Abstract	Anatomical dissection is considered a fundamental practice in the medical curriculum. Not only does it help students to familiarize themselves with the various bodily organs and to refine their surgical practice, it also fosters an attitude of awareness and respect towards death and the values of solidarity. On 10th February 2020, the Italian Parliament passed a new law entitled "Rules on the disposition of one's own body and post-mortem tissues for study purposes, training and scientific research". Here, we outline the main ethical and legal aspects of this law and suggest initiatives to encourage body donation. Through careful analysis of the law, we intend to open a discussion on the main ethical issues and to make comparisons with the international situation. The new legislation fills serious gaps in an area of great ethical relevance; not only does it endorse fundamental ethical principles, it also provides important guidelines for strengthening body donation, such as: ensuring respect for the dignity of the deceased, providing express consent, appointing a trustee, promoting information for both doctors and the community, and banning all forms of trade in bodies or body parts. This law is certainly an important milestone on the road to overcoming the scarcity of bodies for study and research. However, it is also essential to promote a favourable attitude to body donation and to strive to overcome obstacles to this practice by supporting continuous dialogue between anatomical institutes and the community. Further studies are necessary in order to assess the impact of the new law.
Mesh-Begriff(e)	Autopsy ; Dissection ; Human Body ; Humans ; Italy ; Physicians ; Tissue and Organ Procurement
Sprache	Englisch
Erscheinungsdatum	2021-03-05
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2021.151712
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Competitive profiling of ligandable cysteines in

Schmidt, Claudia / Zollo, Michael / Bonsignore, Riccardo / Casini, Angela / Hacker, Stephan M

Chemical communications (Cambridge, England)

2022 Band 58, Heft 36, Seite(n) 5526–5529

Abstract: With the idea of exploiting metal templated C-S bond forming reactions to achieve modification of cysteines in bacterial proteins, a cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach ... ...

Abstract	With the idea of exploiting metal templated C-S bond forming reactions to achieve modification of cysteines in bacterial proteins, a cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach in
Mesh-Begriff(e)	Cysteine/chemistry ; Organogold Compounds/chemistry ; Staphylococcus aureus
Chemische Substanzen	Organogold Compounds ; Cysteine (K848JZ4886)
Sprache	Englisch
Erscheinungsdatum	2022-05-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc01259f
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Burden of hospital-acquired SARS-CoV-2 infections in Germany: occurrence and outcomes of different variants.

Bonsignore, M / Hohenstein, S / Kodde, C / Leiner, J / Schwegmann, K / Bollmann, A / Möller, R / Kuhlen, R / Nachtigall, I

The Journal of hospital infection

2022 Band 129, Seite(n) 82–88

Abstract: Background: Avoiding in-hospital transmissions has been crucial in the COVID-19 pandemic. Little is known on the extent to which hospital-acquired SARS-CoV-2 variants have caused infections in Germany.: Aim: To analyse the occurrence and the outcomes ...

Abstract	Background: Avoiding in-hospital transmissions has been crucial in the COVID-19 pandemic. Little is known on the extent to which hospital-acquired SARS-CoV-2 variants have caused infections in Germany. Aim: To analyse the occurrence and the outcomes of HAI with regard to different SARS-CoV-2 variants. Methods: Patients with SARS-CoV-2 infections hospitalized between March 1 Findings: In all, 62,875 SARS-CoV-2 patients were analysed, of whom 10.6% had HAI. HAIs represented 14.7% of SARS-CoV-2 inpatients during the Wildtype period, 3.5% during Alpha (odds ratio: 0.21; 95% confidence interval: 0.19-0.24), 8.8% during Delta (2.70; 2.35-3.09) and 10.1% during Omicron (1.10; 1.03-1.19). When age and comorbidities were accounted for, HAI had lower odds for death than community-acquired infections (0.802; 0.740-0.866). Compared to the Wildtype period, HAIs during Omicron were associated with lower odds for ICU (0.78; 0.69-0.88), ventilation (0.47; 0.39-0.56), and death (0.33; 0.28-0.40). Conclusion: Hospital-acquired SARS-CoV-2 infections occurred throughout the pandemic, affecting highly vulnerable patients. Although transmissibility increased with newer variants, the proportion of HAIs decreased, indicating improved infection prevention and/or the effect of immunization. Furthermore, the Omicron period was associated with improved outcomes. However, the burden of hospital-acquired SARS-CoV-2 infections remains high.
Mesh-Begriff(e)	Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Pandemics ; Cross Infection/epidemiology ; Germany/epidemiology ; Hospitals
Sprache	Englisch
Erscheinungsdatum	2022-08-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2022.08.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of Dexamethasone on the Pathogen Profile of Critically Ill COVID-19 Patients.

Kodde, Cathrin / Timmen, Finja / Hohenstein, Sven / Bollmann, Andreas / Bonsignore, Marzia / Kuhlen, Ralf / Nachtigall, Irit / Tasci, Selcuk

Viruses

2023 Band 15, Heft 5

Abstract: Background: Even though several therapeutic options are available, COVID-19 is still lacking a specific treatment regimen. One potential option is dexamethasone, which has been established since the early beginnings of the pandemic. The aim of this ... ...

Abstract	Background: Even though several therapeutic options are available, COVID-19 is still lacking a specific treatment regimen. One potential option is dexamethasone, which has been established since the early beginnings of the pandemic. The aim of this study was to determine its effects on the microbiological findings in critically ill COVID-19 patients. Methods: A multi-center, retrospective study was conducted, in which all the adult patients who had a laboratory-confirmed (PCR) SARS-CoV-2 infection and were treated on intensive care units in one of twenty hospitals of the German Helios network between February 2020-March 2021 were included. Two cohorts were formed: patients who received dexamethasone and those who did not, followed by two subgroups according to the application of oxygen: invasive vs. non-invasive. Results: The study population consisted of 1.776 patients, 1070 of whom received dexamethasone, and 517 (48.3%) patients with dexamethasone were mechanically ventilated, compared to 350 (49.6%) without dexamethasone. Ventilated patients with dexamethasone were more likely to have any pathogen detection than those without ( Conclusion: Our results show that the decision to treat COVID-19 patients with dexamethasone should be a matter of careful consideration as it involves risks and bacterial shifts.
Mesh-Begriff(e)	Adult ; Humans ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; Critical Illness ; COVID-19 Drug Treatment ; Dexamethasone/therapeutic use
Chemische Substanzen	Dexamethasone (7S5I7G3JQL)
Sprache	Englisch
Erscheinungsdatum	2023-04-28
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051076
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sex reassignement with or without surgery. New ethical and juridical pathways.

Ciliberti, Rosagemma / Gulino, Matteo / Baldelli, Ilaria / Bonsignore, Alessandro

Annali italiani di chirurgia

2019 Band 90, Seite(n) 95–99

Abstract: Introduction: The access to sex-reassignment surgery is based on the existence of an unequivocal dyscrasia between the morphological sex and the objective evidence that emerges from in-depth analysis of the individual's personality. In Italy, such type ... ...

Abstract	Introduction: The access to sex-reassignment surgery is based on the existence of an unequivocal dyscrasia between the morphological sex and the objective evidence that emerges from in-depth analysis of the individual's personality. In Italy, such type of surgical intervention is subject to the authorization of a judge. Material of study: Authors examine the recent Italian Constitutional judgement which has addressed the right to change legal sex status without the need for sex-reassignment surgery. Discussion: The Italian approach is in line with scientific evidence that the physical and mental well-being of an individual does not always require the surgical rectification of primary sexual features. Thus, sex reassignment surgery is not to be considered mandatory; rather, it should be aimed at ensuring the transsexual individual's stable psychological and physical good. From an ethical point of view, the Court's decision is very important, since it does not subordinate such fundamental rights as gender identity, healthcare and equality to prior, highly invasive surgery. Conclusions: The authors point out that critical issues and obstacles to the full implementation of the right to gender identity remain, in that this right is still subject to the authorization of a judge. This approach does not seem to be in line with the recent World Health Organization (WHO) decision to remove the "gender incongruity" from the list of mental and behavioural disorders (as it is in the current International Classification of Diseases-10, so far), to decrease the stigma surrounding such a condition. Key words: Gender identity, Sex reassignment, Surgery, Stigma, Transsexualism, Transgender.
Mesh-Begriff(e)	Female ; Humans ; Italy ; Male ; Sex Reassignment Procedures/ethics ; Sex Reassignment Procedures/methods ; Sex Reassignment Surgery/ethics ; Sex Reassignment Surgery/legislation & jurisprudence
Sprache	Englisch
Erscheinungsdatum	2019-06-10
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Distance follow-up by a remote medical care centre improves adherence to CPAP in patients with obstructive sleep apnoea over the short and long term.

Schisano, Matteo / Libra, Alessandro / Rizzo, Ludovica / Morana, Giorgio / Mancuso, Salvatore / Ficili, Antonella / Campagna, Davide / Vancheri, Carlo / Bonsignore, Maria R / Spicuzza, Lucia

Journal of telemedicine and telecare

2024 , Seite(n) 1357633X241238483

Abstract: Background: Adherence to continuous positive air pressure (CPAP) in patients with obstructive sleep apnoea (OSA) has remained invariably low over the last decades. Remote monitoring of the nocturnal CPAP treatment, within telemedicine (TM)-based follow- ... ...

Abstract	Background: Adherence to continuous positive air pressure (CPAP) in patients with obstructive sleep apnoea (OSA) has remained invariably low over the last decades. Remote monitoring of the nocturnal CPAP treatment, within telemedicine (TM)-based follow-up programs, in these patients has been suggested as a potential tool to improve adherence and release the workload of sleep units. The aim of this study was therefore to assess whether a follow-up program carried out by a Remote Medical Care Centre (RMCC), outside the sleep unit, improves adherence to CPAP in the short and long term in patients with OSA. Methods: In this pilot protocol, we enrolled 37 patients starting CPAP in our Sleep Centre (SC). After three months of standard care in our SC, patients initiated a six-month remote follow-up carried out by the RMCC, functioning as an intermediary between patients and SC. Monthly reports and indication for face-to-face visits were sent to the SC for six months. After this period patients returned to usual care for one year. Results were compared with those obtained in 38 patients (controls) followed with usual care over the same time range. Results: Mean nightly use of CPAP increased from 3.2 ± 2.4 h pre-RMCC to 5.2 ± 1.9 h post-RMCC ( Conclusion: A six-month follow-up through a remote facility can significantly improve adherence to CPAP in the short and long term. This pilot study provides a solid base for the design of multicentre randomized trials focusing on new models which are able to increase the long-term efficacy of TM programs.
Sprache	Englisch
Erscheinungsdatum	2024-03-27
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1340281-x
ISSN	1758-1109 ; 1357-633X
ISSN (online)	1758-1109
ISSN	1357-633X
DOI	10.1177/1357633X241238483
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Male circumcision: ritual, science and responsibility.

Ventura, Francesco / Caputo, Fiorella / Licata, Marta / Bonsignore, Alessandro / Ciliberti, Rosagemma

Annali dell'Istituto superiore di sanita

2020 Band 56, Heft 3, Seite(n) 351–358

Abstract: Introduction and objectives: In Italy, four minors have died in the last year as a result of male circumcision (MC) procedures performed for cultural and religious reasons by unqualified persons in unhygienic conditions.: Results and discussion: ... ...

Abstract	Introduction and objectives: In Italy, four minors have died in the last year as a result of male circumcision (MC) procedures performed for cultural and religious reasons by unqualified persons in unhygienic conditions. Results and discussion: After illustrating the historical and ethical outlines of the moral admissibility of MC within a comparative perspective, we examine the features of the Italian healthcare system with particular regard both to the heterogeneity of services available in the various Regions and to the risks engendered by excluding MC from the public health setting. Conclusion: In order to adequately safeguard public health, particularly that of minors, there is a pressing need for thorough discussion of whether the National Health Service should perform MC on minors free of charge or, at least, for a reduced fee. The implementation of targeted campaigns may raise awareness of the importance of proper safety measures in MC.
Mesh-Begriff(e)	Ceremonial Behavior ; Child, Preschool ; Circumcision, Male/adverse effects ; Circumcision, Male/ethics ; Circumcision, Male/history ; Circumcision, Male/legislation & jurisprudence ; Diseases in Twins ; Evidence-Based Medicine ; Health Education ; History, 19th Century ; History, 21st Century ; History, Ancient ; History, Medieval ; Humans ; Infant ; Infant, Newborn ; Italy/epidemiology ; Male ; Motivation ; Parental Consent ; Penile Diseases/prevention & control ; Public Health ; Religion and Medicine ; Social Responsibility ; Wound Infection/etiology ; Wound Infection/mortality
Sprache	Englisch
Erscheinungsdatum	2020-09-22
Erscheinungsland	Italy
Dokumenttyp	Historical Article ; Journal Article
ZDB-ID	950344-4
ISSN	2384-8553 ; 0021-2571
ISSN (online)	2384-8553
ISSN	0021-2571
DOI	10.4415/ANN_20_03_13
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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