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Article ; Online: Piers-Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol.

Cocco, Emanuele / Iapadre, Debora / Brusa, Alessandro / Allegrini, Pietro / Thomas, Stephen P / Pesciaioli, Fabio / Carlone, Armando

RSC advances

2024 Volume 14, Issue 4, Page(s) 2741–2744

Abstract: A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (-)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers-Rubinsztajn reaction was key to enable a mild ... ...

Abstract	A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (-)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers-Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield.
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra08392f
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Article ; Online: Effects of Hydroxyapatite-Containing Toothpastes on Some Caries-Related Variables: A Randomised Clinical Trial.

Campus, Guglielmo / Cocco, Fabio / Wierichs, Richard Johannes / Wolf, Thomas Gerhard / Salerno, Claudia / Arghittu, Antonella / Dettori, Marco / Cagetti, Maria Grazia

International dental journal

2024

Abstract: Objectives: This randomised clinical trial was designed and carried out with the aim to evaluate the capacity of fluoride-substituted hydroxyapatite (HAF) toothpaste to modulate oral microflora composition and biofilm acidogenicity in schoolchildren.: ...

Abstract	Objectives: This randomised clinical trial was designed and carried out with the aim to evaluate the capacity of fluoride-substituted hydroxyapatite (HAF) toothpaste to modulate oral microflora composition and biofilm acidogenicity in schoolchildren. Methods: In all, 610 children (4 to 5 and 6 to 7 years) were enrolled. Four toothpastes were randomly administered during 24 months: 2 contained fluoride-substituted hydroxyapatite (HAF Results: During the trial, the minimum pH value increased statistically significantly in all groups; in HAF Conclusions: The trial provides robust but still inconclusive evidence on the efficacy of HAF toothpastes compared to traditional fluoridated toothpastes to reduce caries risk factors and to prevent caries lesions.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	218262-2
ISSN	1875-595X ; 0020-6539
ISSN (online)	1875-595X
ISSN	0020-6539
DOI	10.1016/j.identj.2024.01.028
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Zs.A 205: Show issues

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Article ; Online: "Daddy wrist": A high-resolution ultrasound diagnosis of de Quervain tenosynovitis.

Corvino, Antonio / Lonardo, Valeria / Corvino, Fabio / Tafuri, Domenico / Pizzi, Andrea Delli / Cocco, Giulio

Journal of clinical ultrasound : JCU

2023 Volume 51, Issue 5, Page(s) 845–847

Abstract: De Quervain's tenosynovitis involves the first of the six dorsal compartments of the wrist, which contains the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) tendons. It seems to be associated with female sex (F:M = 10:1), middle age ( ... ...

Abstract	De Quervain's tenosynovitis involves the first of the six dorsal compartments of the wrist, which contains the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) tendons. It seems to be associated with female sex (F:M = 10:1), middle age (30-50 years) and activities involving repetitive hand and wrist motions such as typing, piano playing or repetitively lifting children head, such as in postpartum females (hence the term "baby wrist" or "mommy wrist"). Aim of this paper was to illustrate high-resolution ultrasound (US) features of the DQD by describing a well-documented case that occurred in a "new dad" taking care of his babe. Hence, firstly in literature we could refer to this condition with the term of "daddy wrist".
MeSH term(s)	Middle Aged ; Child ; Humans ; Female ; Adult ; Wrist/diagnostic imaging ; Tenosynovitis/diagnostic imaging ; Wrist Joint/diagnostic imaging ; Tendons/diagnostic imaging ; Forearm
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23440
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Zs.A 1186: Show issues

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Article ; Online: Complications Subsequent to Urinary Tract Stent Placement: An Overview Focusing on the Imaging of Cancer Patients.

Corvino, Antonio / Basile, Luigi / Cocco, Giulio / Delli Pizzi, Andrea / Tafuri, Domenico / Corvino, Fabio / Catalano, Orlando

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: Ureteral involvement by a tumor is common, and both partial and complete obstructions can result in symptoms that are distressing and debilitating, especially in cancer patients for whom the resection of the primary tumor is not considered an option. ... ...

Abstract	Ureteral involvement by a tumor is common, and both partial and complete obstructions can result in symptoms that are distressing and debilitating, especially in cancer patients for whom the resection of the primary tumor is not considered an option. Maintaining ureteric patency in these patients is a challenge. In addition, in cases where a patient has undergone nephroureterectomy due to primary transitional cell cancer, it becomes necessary to decompress the urinary tract to preserve the contralateral kidney from irreversible damage. This is possibly due to ureteral stenting, both retrograde and anterograde, and percutaneous nephrostomy (PCN). Since imaging plays an important role in the routine monitoring of stents, their more and more increasing use requires radiologists to be familiar with these devices, their correct position, their potential complications, and their consequences. The aim of this review is to offer a comprehensive review of the imaging features of some urinary stents and to show the complications encountered in cancer patients as a direct consequence of an invasive diagnostic or therapeutic procedure. Specifically, we focus on ureteral stents and PCN.
MeSH term(s)	Humans ; Ureteral Obstruction/diagnostic imaging ; Ureteral Obstruction/etiology ; Ureteral Obstruction/surgery ; Nephrostomy, Percutaneous/adverse effects ; Nephrostomy, Percutaneous/methods ; Ureter/diagnostic imaging ; Ureter/surgery ; Urinary Bladder Neoplasms ; Stents/adverse effects ; Retrospective Studies
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020338
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Zs.A 6270: Show issues

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Article ; Online: Ultrasound diagnosis of a pseudoaneurysm of the internal right mammary artery.

Boccatonda, Andrea / Balletta, Marco / D'Ardes, Damiano / Cocco, Giulio / Piscaglia, Fabio / Serra, Carla / Vicari, Susanna / Schiavone, Cosima

Journal of ultrasound

2024

Abstract: One of the principles of managing trauma patients is that of their continuous re-evaluation over the hours and days. Even if the execution of the computed tomography method is classically recommended, especially in the most serious cases and in ... ...

Abstract	One of the principles of managing trauma patients is that of their continuous re-evaluation over the hours and days. Even if the execution of the computed tomography method is classically recommended, especially in the most serious cases and in polytraumas with major dynamics, the clinician can use or request an ultrasound examination, especially in subsequent re-evaluations. Here we report a clinical case demonstrating how an ultrasound re-evaluation after the acute event can lead to a correct diagnosis of a rare complication of thoracic trauma. The findings were suggestive for a pseudoaneurysm of the internal right mammary artery. Subsequently, an ultrasound-guided injection of thrombin was carried out until complete interruption of the flow within the formation. At subsequent follow-up, no arterial or venous blush was highlighted.
Language	English
Publishing date	2024-04-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-024-00889-6
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Article ; Online: Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes.

Cocco, Claudia / Morandi, Fabio / Airoldi, Irma

Cells

2021 Volume 10, Issue 4

Abstract: The tumor microenvironment (TME) represents a complex network between tumor cells and a variety of components including immune, stromal and vascular endothelial cells as well as the extracellular matrix. A wide panel of signals and interactions here take ...

Abstract	The tumor microenvironment (TME) represents a complex network between tumor cells and a variety of components including immune, stromal and vascular endothelial cells as well as the extracellular matrix. A wide panel of signals and interactions here take place, resulting in a bi-directional modulation of cellular functions. Many stimuli, on one hand, induce tumor growth and the spread of metastatic cells and, on the other hand, contribute to the establishment of an immunosuppressive environment. The latter feature is achieved by soothing immune effector cells, mainly cytotoxic T lymphocytes and B and NK cells, and/or through expansion of regulatory cell populations, including regulatory T and B cells, tumor-associated macrophages and myeloid-derived suppressor cells. In this context, immune checkpoints (IC) are key players in the control of T cell activation and anti-cancer activities, leading to the inhibition of tumor cell lysis and of pro-inflammatory cytokine production. Thus, these pathways represent promising targets for the development of effective and innovative therapies both in adults and children. Here, we address the role of different cell populations homing the TME and of well-known and recently characterized IC in the context of pediatric solid tumors. We also discuss preclinical and clinical data available using IC inhibitors alone, in combination with each other or administered with standard therapies.
MeSH term(s)	Child ; Humans ; Immune Checkpoint Proteins/metabolism ; Immunotherapy ; Models, Biological ; Molecular Targeted Therapy ; Neoplasms/metabolism ; Tumor Microenvironment/immunology
Chemical Substances	Immune Checkpoint Proteins
Language	English
Publishing date	2021-04-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10040927
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Article ; Online: Pediatric Gastric Volvulus: Is Laparoscopic Hill-Snow-Modified Gastropexy the Effective Long-Term Minimally Invasive Solution?

Chiarenza, Salvatore Fabio / Zolpi, Elisa / Costa, Lorenzo / Cocco, Paolo / Conighi, Maria Luisa / Bleve, Cosimo

Journal of laparoendoscopic & advanced surgical techniques. Part A

2022 Volume 32, Issue 8, Page(s) 913–919

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Abdominal Pain/surgery ; Child ; Female ; Gastropexy/adverse effects ; Hernia, Hiatal/surgery ; Humans ; Infant ; Infant, Newborn ; Laparoscopy/adverse effects ; Male ; Stomach Volvulus/surgery ; Vomiting/etiology
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0836
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Zs.A 3246: Show issues

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Article: Use of High-Frequency Transducers in Breast Sonography.

Corvino, Antonio / Varelli, Carlo / Catalano, Fabio / Cocco, Giulio / Delli Pizzi, Andrea / Boccatonda, Andrea / Corvino, Fabio / Basile, Luigi / Catalano, Orlando

Journal of personalized medicine

2022 Volume 12, Issue 12

Abstract: Sonography companies have recently developed high-frequency transducers (20-30 MHz) to image the skin and small joints. In this pictorial review, we present a number of settings where these probes can be usefully employed to scan the breast. These ... ...

Abstract	Sonography companies have recently developed high-frequency transducers (20-30 MHz) to image the skin and small joints. In this pictorial review, we present a number of settings where these probes can be usefully employed to scan the breast. These include skin abnormalities of the breast and axilla; nipple-areolar complex abnormalities; superficial breast parenchyma abnormalities; breast parenchyma abnormalities in subjects with implants; very small female breasts; peripheral areas in breasts of any size; pre-puberal breasts; male breasts; post-mastectomy chest wall; and intraoperative breast sonography. Comparatively, side-by-side images obtained with conventional breast frequencies and high frequencies are shown.
Language	English
Publishing date	2022-11-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12121960
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Article ; Online: A multidisciplinary approach to optimizing the mechanical characterization and dismantling of nuclear-grade graphite

Riccardo Chebac / Fabio Vanoni / Alessandro Porta / Fabrizio Campi / Alessandro Cocco / Silvia Barella / Andrea Gruttadauria

Carbon Trends, Vol 10, Iss , Pp 100253- (2023)

2023

Abstract: The large variability of the physical properties related to different types of nuclear-grade graphite makes its characterization for the decommissioning of nuclear power plants extremely problematic and time consuming. To facilitate this process, ... ...

Abstract	The large variability of the physical properties related to different types of nuclear-grade graphite makes its characterization for the decommissioning of nuclear power plants extremely problematic and time consuming. To facilitate this process, standardized procedures must be implemented taking into account the complexity of handling irradiated graphite. To this goal, the following study will present the mechanical tests chosen for a clear and easy characterization process. Virgin Atcheson Graphite Ordinary Temperature (AGOT), used as moderator and reflector in the L-54 M research reactor, has been used as a first attempt. Two standard mechanical tests are performed: uni-axial compression and four-point bending. Mechanical anisotropy of graphite was studied and verified, showing roughly a 30% difference between the machining directions parallel and perpendicular to the extrusion direction. A modified three-point bending test has been proposed, which may be used as a four-point bending substitute in case samples with non-standard geometries are needed. A correlation has been presented between the compressive, tensile strength and Young's modulus properties of graphite with Vickers microhardness with R2 respectively of 0.58, 0.53, and 0.91. Non-linear structural simulations of the tests have then been developed as supporting tools for retrieving additional mechanical information, such as Young's modulus. Finally, stress-strain curves have been used as input to develop a finite element method (FEM) which drastically improves the predictive capabilities by reducing the error from 102.2% to 27.6% for AGOT compressive strength, and from 16% to 0% AGOT tensile strength, when compared to in-built graphite models. The potential capabilities of this model to simulate potential graphite handling scenarios in the decommissioning process of nuclear power plants has been demonstrated.
Keywords	Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Interventional Ultrasound in Dermatology: A Pictorial Overview Focusing on Cutaneous Melanoma Patients.

Corvino, Antonio / Catalano, Fabio / Cipolletta Campanile, Anna / Cocco, Giulio / Delli Pizzi, Andrea / Corvino, Fabio / Varelli, Carlo / Catalano, Orlando

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2022 Volume 41, Issue 12, Page(s) 3137–3144

Abstract: Cutaneous melanoma incidence is increasing worldwide, representing an aggressive tumor when evolving to the metastatic phase. High-resolution ultrasound (US) is playing a growing role in the assessment of newly diagnosed melanoma cases, in the ... ...

Abstract	Cutaneous melanoma incidence is increasing worldwide, representing an aggressive tumor when evolving to the metastatic phase. High-resolution ultrasound (US) is playing a growing role in the assessment of newly diagnosed melanoma cases, in the locoregional staging prior to the sentinel lymph-node biopsy procedure, and in the melanoma patient follow-up. Additionally, US may guide a number of percutaneous procedures in the melanoma patients, encompassing diagnostic and therapeutic modalities. These include fine needle cytology, core biopsy, placement of presurgical guidewires, aspiration of lymphoceles and seromas, and electrochemotherapy.
MeSH term(s)	Humans ; Dermatology ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Melanoma/diagnostic imaging ; Melanoma/secondary ; Neoplasm Staging ; Sentinel Lymph Node Biopsy/methods ; Skin Neoplasms/pathology ; Ultrasonography, Interventional/methods ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Case Reports ; Review
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.16073
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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