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Article ; Online: The case for compulsory licensing during COVID-19.

Wong, Hilary

2020 Volume 10, Issue 1, Page(s) 10358

MeSH term(s)	COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Developing Countries ; Drug Industry/legislation & jurisprudence ; Drugs, Generic/economics ; Drugs, Generic/supply & distribution ; Health Services Accessibility/economics ; Humans ; Licensure/legislation & jurisprudence ; Pandemics ; Patents as Topic/legislation & jurisprudence ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology
Chemical Substances	Drugs, Generic
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2978
ISSN (online)	2047-2986
ISSN	2047-2978
DOI	10.7189/jogh.10.010358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Socioemotional and Psychological Outcomes of Hypoxic-Ischemic Encephalopathy: A Systematic Review.

Kromm, Grace H / Patankar, Hilary / Nagalotimath, Shubang / Wong, Hilary / Austin, Topun

Pediatrics

2024 Volume 153, Issue 4

Abstract: Background and objectives: Therapeutic hypothermia has reduced the risk of death or major disability following perinatal hypoxic-ischemic encephalopathy (HIE); however, many children who experience perinatal HIE still go on to develop personal and ... ...

Abstract	Background and objectives: Therapeutic hypothermia has reduced the risk of death or major disability following perinatal hypoxic-ischemic encephalopathy (HIE); however, many children who experience perinatal HIE still go on to develop personal and behavioral challenges, which can be difficult for caregivers and a public health burden for society. Our objective with this review is to systematically identify and synthesize studies that evaluate associations between perinatal HIE and socioemotional or psychological outcomes. Methods: We screened all search-returned journal articles from Cochrane Library, Embase, Medline, PsycINFO, Scopus, and Web of Science from data inception through February 1, 2023. Keywords related to HIE (eg, neonatal encephalopathy, neonatal brain injury) and outcomes (eg, social, emotion, behav* problem, psycholog, psychiatr) were searched with a predefined search string. We included all observational human studies reporting socioemotional or psychological sequelae of term HIE. Study data were recorded on standardized sheets, and the Newcastle-Ottawa Scale was adapted to assess study quality. Results: We included 43 studies documenting 3244 HIE participants and 2132 comparison participants. We found statistically significant associations between HIE and social and emotional, behavioral, and psychological and psychiatric deficits throughout infancy, childhood, and adolescence (19 studies). The authors of the included studies also report nonsignificant findings (11 studies) and outcomes without statistical comparison (25 studies). Conclusions: Perinatal HIE may be a risk factor for a range of socioemotional and psychological challenges in the short- and long-term. Routine screening, early intervention, and follow-up support may be particularly beneficial to this population.
MeSH term(s)	Infant, Newborn ; Child ; Humans ; Hypoxia-Ischemia, Brain/therapy ; Hypoxia-Ischemia, Brain/complications ; Hypothermia, Induced ; Brain Injuries ; Emotions ; Disease Progression
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-063399
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Article: The case for compulsory licensing during COVID-19

Wong, Hilary

J Glob Health

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #621275
Database	COVID19

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Article ; Online: Association between maternal hemoglobin concentration and educational attainment in mid-childhood in a high-resource obstetric setting: a prospective cohort study.

Olga, Laurentya / Sovio, Ulla / Wong, Hilary / Smith, Gordon Cs / Aiken, Catherine E

American journal of obstetrics & gynecology MFM

2024 , Page(s) 101357

Abstract: Background: Although maternal Hb levels during pregnancy are commonly associated with perinatal outcomes, their link to childhood neurodevelopment remains uncertain.: Objective: This study aimed to examine the associations between maternal hemoglobin ...

Abstract	Background: Although maternal Hb levels during pregnancy are commonly associated with perinatal outcomes, their link to childhood neurodevelopment remains uncertain. Objective: This study aimed to examine the associations between maternal hemoglobin (Hb) in early and late pregnancy with offspring mid-childhood educational attainment in a high-resource obstetric setting. Study design: Pregnancy data from a prospective birth cohort (Pregnancy Outcome Prediction Study, Cambridge, UK, 2008-2012, N=3285) were linked to mid-childhood educational outcomes (Department for Education, UK). Regression models adjusted for maternal, child, and socioeconomic factors were used to determine associations between maternal Hb, pregnancy complications, and offspring educational outcomes (ages 5-7). Results: No association was observed between maternal Hb at 12 weeks and the likelihood of either adverse pregnancy outcomes or children meeting expected educational standards between ages 5-7. Higher maternal Hb at 28 weeks was associated with an increased risk of small-for-gestational age infants (aOR1.26, 95%CI 1.11-1.59; p=0.002) and preterm birth (aOR1.38, 95%CI 1.11-1.81; p=0.005). There were no adverse birth outcomes associated with anemia. However children of mothers who were anaemic at 28 weeks had ∼40% increased risk of not attaining expected educational standards at age 5 (aOR1.42, 95%CI 1.03-1.95; p=0.03). There was no association between maternal anemia at 28 weeks and educational performance at ages 6-7. No associations were found between high maternal Hb concentrations (top decile) or change Hb concentrations between 12-28 weeks and childhood educational attainment. Conclusions: Maternal anemia at 28 weeks of pregnancy is associated with reduced educational attainment aged 5, but not at older ages (6-7 years). A proactive approach to increasing maternal hemoglobin in high-resource settings is unlikely to impact on long-term childhood educational attainment.
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2024.101357
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Article ; Online: Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data linkage study.

Olga, Laurentya / Sovio, Ulla / Wong, Hilary / Smith, Gordon / Aiken, Catherine

PLoS medicine

2023 Volume 20, Issue 4, Page(s) e1004225

Abstract: Background: Fetal growth restriction (FGR) is associated with a suboptimal intrauterine environment, which may adversely impact fetal neurodevelopment. However, analysing neurodevelopmental outcomes by observed birthweight fails to differentiate between ...

Abstract	Background: Fetal growth restriction (FGR) is associated with a suboptimal intrauterine environment, which may adversely impact fetal neurodevelopment. However, analysing neurodevelopmental outcomes by observed birthweight fails to differentiate between true FGR and constitutionally small infants and cannot account for iatrogenic intervention. This study aimed to determine the relationship between antenatal FGR and mid-childhood (age 5 to 7 years) educational outcomes. Methods and findings: The Pregnancy Outcome Prediction Study (2008-2012) was a prospective birth cohort conducted in a single maternity hospital in Cambridge, United Kingdom. Clinicians were blinded to the antenatal diagnosis of FGR. FGR was defined as estimated fetal weight (EFW) <10th percentile at approximately 36 weeks of gestation, plus one or more indicators of placental dysfunction, including ultrasonic markers and maternal serum levels of placental biomarkers. A total of 2,754 children delivered at term were divided into 4 groups: FGR, appropriate-for-gestational age (AGA) with markers of placental dysfunction, healthy small-for-gestational age (SGA), and healthy AGA (referent). Educational outcomes (assessed at 5 to 7 years using UK national standards) were assessed with respect to FGR status using regression models adjusted for relevant covariates, including maternal, pregnancy, and socioeconomic factors. Compared to healthy AGA (N = 1,429), children with FGR (N = 250) were at higher risk of "below national standard" educational performance at 6 years (18% versus 11%; aOR 1.68; 95% CI 1.12 to 2.48, p = 0.01). By age 7, children with FGR were more likely to perform below standard in reading (21% versus 15%; aOR 1.46; 95% CI 0.99 to 2.13, p = 0.05), writing (28% versus 23%; aOR 1.46; 95% CI 1.02 to 2.07, p = 0.04), and mathematics (24% versus 16%; aOR 1.49; 95% CI 1.02 to 2.15, p = 0.03). This was consistent whether FGR was defined by ultrasound or biochemical markers. The educational attainment of healthy SGA children (N = 126) was comparable to healthy AGA, although this comparison may be underpowered. Our study design relied on linkage of routinely collected educational data according to nationally standardised metrics; this design allowed a high percentage of eligible participants to be included in the analysis (75%) but excludes those children educated outside of government-funded schools in the UK. Our focus on pragmatic and validated measures of educational attainment does not exclude more subtle effects of the intrauterine environment on specific aspects of neurodevelopment. Conclusions: Compared to children with normal fetal growth and no markers of placental dysfunction, FGR is associated with poorer educational attainment in mid-childhood.
MeSH term(s)	Child ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Child, Preschool ; Fetal Growth Retardation/diagnosis ; Prospective Studies ; Placenta ; Prenatal Diagnosis/methods ; Infant, Small for Gestational Age ; Pregnancy Outcome/epidemiology ; Gestational Age ; Educational Status
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185925-5
ISSN	1549-1676 ; 1549-1277
ISSN (online)	1549-1676
ISSN	1549-1277
DOI	10.1371/journal.pmed.1004225
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Article ; Online: Maternal high body mass index, but not gestational diabetes, is associated with poorer educational attainment in mid-childhood.

Olga, Laurentya / Sovio, Ulla / Wong, Hilary / Smith, Gordon C S / Aiken, Catherine E M

American journal of obstetrics and gynecology

2023

Abstract: Background: Previous studies suggest that gestational diabetes mellitus is associated with poorer cognitive outcomes in children. However, confounding factors, especially maternal body mass index, have been poorly accounted for.: Objective: This ... ...

Abstract	Background: Previous studies suggest that gestational diabetes mellitus is associated with poorer cognitive outcomes in children. However, confounding factors, especially maternal body mass index, have been poorly accounted for. Objective: This study aimed to examine the independent associations between maternal body mass index, gestational diabetes mellitus status, and educational outcomes. Study design: Antenatal data from a prospective birth cohort (Pregnancy Outcome Prediction Study, 2008-2012, Cambridge, United Kingdom) were linked to mid-childhood educational outcomes (Department for Education, United Kingdom). A total of 3249 children born at term were stratified by maternal gestational diabetes mellitus status and body mass index at booking (<25 vs ≥25 kg/m Results: No differences in educational attainment were found between children exposed to gestational diabetes mellitus and nonexposed children. Neither maternal glucose levels measured at 11 to 14 or 24 to 28 weeks, nor acceleration of the fetal abdominal circumference growth velocity were related to educational attainment at ages of 5 to 7 years. Children of mothers with booking body mass index ≥25 kg/m Conclusion: Mid-childhood educational attainment is not associated with maternal glucose status. This may provide important reassurance for pregnant women and clinicians. However, maternal body mass index is associated with lower childhood educational attainment and may be modifiable with intervention before or during pregnancy.
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2023.11.1227
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Article ; Online: Monitoring Emergency Department Visits From Puerto Rico in the Aftermath of Hurricane Maria Using Syndromic Surveillance - New York City, 2017.

Wong, Priscilla W / Parton, Hilary B

Disaster medicine and public health preparedness

2019 Volume 14, Issue 1, Page(s) 44–48

Abstract: Objective: Syndromic surveillance has been useful for routine surveillance on a variety of health outcomes and for informing situational awareness during public health emergencies. Following the landfall of Hurricane Maria in 2017, the New York City ( ... ...

Abstract	Objective: Syndromic surveillance has been useful for routine surveillance on a variety of health outcomes and for informing situational awareness during public health emergencies. Following the landfall of Hurricane Maria in 2017, the New York City (NYC) Department of Health and Mental Hygiene (DOHMH) implemented an enhanced syndromic surveillance system to characterize related emergency department (ED) visits. Methods: ED visits with any mention of specific key words ("Puerto," "Rico," "hurricane," "Maria") in the ED chief complaint or Puerto Rico patient home Zip Code were identified from the DOHMH syndromic surveillance system in the 8-week window leading up to and following landfall. Visit volume comparisons pre- and post-Hurricane Maria were performed using Fisher's exact test. Results: Analyses identified an overall increase in NYC ED utilization relating to Puerto Rico following Hurricane Maria landfall. In particular, there was a small but significant increase in visits involving a medication refill or essential medical equipment. Visits for other outcomes, such as mental illness, also increased, but the differences were not statistically significant. Conclusions: Gaining this situational awareness of medical service use was informative following Hurricane Maria, and, following any natural disaster, the same surveillance methods could be easily established to aid an effective emergency response.
MeSH term(s)	Cyclonic Storms/statistics & numerical data ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/statistics & numerical data ; Humans ; New York City ; Patient Acceptance of Health Care/psychology ; Patient Acceptance of Health Care/statistics & numerical data ; Population Surveillance/methods ; Puerto Rico
Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2019.102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of group cognitive behavioral therapy for depression in adults: a systematic review and meta-analysis of delivery by different healthcare professionals.

Wong, Cecil Pak Shun / Yeung, Jacky Tsz Kit / Fong, Daniel Yee Tak / Smith, Robert David / Ngan, Angela Hoi Yan / Lam, Yanny Yin Ling / Chan, Kitty Siu Shan / Leung, Hilary Hau Yee / Wang, Man Ping / Wong, Janet Yuen Ha

Cognitive behaviour therapy

2024 Volume 53, Issue 3, Page(s) 302–323

Abstract: This study addresses the gap in understanding the varied effectiveness of group cognitive behavioral therapy (gCBT) delivered by different professionals. This study aims to address this gap by conducting a systematic review of randomized controlled ... ...

Abstract	This study addresses the gap in understanding the varied effectiveness of group cognitive behavioral therapy (gCBT) delivered by different professionals. This study aims to address this gap by conducting a systematic review of randomized controlled trials (RCTs) that evaluate gCBT and compare it to inactive controls in adults with a clinical diagnosis of depression. A total of 33 RCTs were included for analysis. In the overall analysis, 'profession of gCBT deliverer' was not a significant moderator in the meta-regression model (
MeSH term(s)	Adult ; Humans ; Depression/therapy ; Cognitive Behavioral Therapy/methods ; Health Personnel ; Comorbidity ; Delivery of Health Care
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2076060-7
ISSN	1651-2316 ; 1650-6073
ISSN (online)	1651-2316
ISSN	1650-6073
DOI	10.1080/16506073.2024.2313741
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Article ; Online: Environmental Outcomes Associated With Transition From In-Person to a Virtual Oncology Conference During the COVID-19 Pandemic.

Lichter, Katie E / Drew, Taylor / Demeulenaere, Sasha / Wong, Emily / Mohamad, Osama / Yom, Sue S / Bagshaw, Hilary P

JAMA oncology

2022 Volume 8, Issue 9, Page(s) 1351–1352

MeSH term(s)	COVID-19 ; Humans ; Medical Oncology ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.1925
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Article ; Online: Humidity gradients in the air spaces of leaves.

Wong, Suan Chin / Canny, Martin J / Holloway-Phillips, Meisha / Stuart-Williams, Hilary / Cernusak, Lucas A / Márquez, Diego A / Farquhar, Graham D

Nature plants

2022 Volume 8, Issue 8, Page(s) 971–978

Abstract: Stomata are orifices that connect the drier atmosphere with the interconnected network of more humid air spaces that surround the cells within a leaf. Accurate values of the humidities inside the substomatal cavity, ... ...

Abstract	Stomata are orifices that connect the drier atmosphere with the interconnected network of more humid air spaces that surround the cells within a leaf. Accurate values of the humidities inside the substomatal cavity, w
MeSH term(s)	Carbon Dioxide ; Diffusion ; Humidity ; Photosynthesis/physiology ; Plant Leaves/physiology ; Temperature
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ISSN	2055-0278
ISSN (online)	2055-0278
DOI	10.1038/s41477-022-01202-1
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