Article ; Online: The case of complement inhibitors.
Advances in biological regulation
2021 Volume 81, Page(s) 100822
Abstract: Severe COVID-19 is characterized by lung and multiorgan inflammation and coagulation in the presence of overactivation of the complement system. Complement is a double edged-sward in SARS-Cov-2 infection. On one hand, it can control the viral infection ... ...
Abstract | Severe COVID-19 is characterized by lung and multiorgan inflammation and coagulation in the presence of overactivation of the complement system. Complement is a double edged-sward in SARS-Cov-2 infection. On one hand, it can control the viral infection in milder cases, on the other hand in cases with severe and prolonged infection massive complement activation occurs, which can intensify lung and systemic inflammation and promote a procoagulant and prothrombotic state. Several uncontrolled studies and controlled clinical trials with different complement inhibitors have been performed and others are ongoing. Results are promising in some but negative in others. Further studies are required to elucidate the benefit to risk profile of complement inhibitors in COVID-19 patients at different stages of the disease and to clarify the best targets in the complement cascade. |
---|---|
MeSH term(s) | COVID-19/blood ; Complement Activation/drug effects ; Complement Inactivating Agents/therapeutic use ; Complement System Proteins/metabolism ; Humans ; Lung/metabolism ; Lung/pathology ; SARS-CoV-2/metabolism ; Severity of Illness Index ; COVID-19 Drug Treatment |
Chemical Substances | Complement Inactivating Agents ; Complement System Proteins (9007-36-7) |
Language | English |
Publishing date | 2021-08-19 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 2667413-0 |
ISSN | 2212-4934 ; 2212-4926 |
ISSN (online) | 2212-4934 |
ISSN | 2212-4926 |
DOI | 10.1016/j.jbior.2021.100822 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Uc I Zs.364: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.