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Article: ECT for depression with amnesia.

Hirose, Shigehiro

2002 Volume 18, Issue 1, Page(s) 60

MeSH term(s)	Amnesia/etiology ; Amnesia/therapy ; Depressive Disorder/complications ; Depressive Disorder/therapy ; Electroconvulsive Therapy/adverse effects ; Humans ; Male ; Middle Aged ; Treatment Outcome
Language	English
Publishing date	2002-03-28
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1426385-3
ISSN	1533-4112 ; 1095-0680
ISSN (online)	1533-4112
ISSN	1095-0680
DOI	10.1097/00124509-200203000-00016
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Article: The causes of underdiagnosing akathisia.

Hirose, Shigehiro

Schizophrenia bulletin

2003 Volume 29, Issue 3, Page(s) 547–558

Abstract: This article reviews what causes clinicians to overlook or underdiagnose akathisia. The causes are considered to be related to both the patient's symptoms and the clinician's attitude toward akathisia. The patient factors include mild severity of ... ...

Abstract	This article reviews what causes clinicians to overlook or underdiagnose akathisia. The causes are considered to be related to both the patient's symptoms and the clinician's attitude toward akathisia. The patient factors include mild severity of akathisia, lack of apparent motor restlessness, no voluntary expression of inner restlessness, no clear communication of inner restlessness, restlessness in body parts other than the legs, atypical expressions of inner restlessness, other prominent psychic symptoms, and absence of other extrapyramidal signs. The clinician factors include emphasis on objective restlessness, failure to consider akathisia during antipsychotic therapy, failure to fully implement antiakathisia treatments in ambiguous cases, and strict adherence to research diagnostic criteria. Akathisia is likely to be overlooked or underdiagnosed when both patient and clinician factors are present. Currently, there may be two major problems with underdiagnosis: (1) symptoms that fulfill the diagnostic criteria for akathisia are overlooked, and (2) conditions that do not fulfill the diagnostic criteria but can still benefit from antiakathisia measures are underdiagnosed.
MeSH term(s)	Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Benzodiazepines/therapeutic use ; Cholinergic Antagonists/therapeutic use ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Mental Disorders/drug therapy ; Psychomotor Agitation/diagnosis ; Psychomotor Agitation/drug therapy ; Psychomotor Agitation/etiology ; Severity of Illness Index
Chemical Substances	Antipsychotic Agents ; Cholinergic Antagonists ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2003-07-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/oxfordjournals.schbul.a007027
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Article ; Online: Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.

Journal of medicinal chemistry

2022 Volume 65, Issue 20, Page(s) 13852–13865

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 3C-like protease ( ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 3C-like protease (3CL
MeSH term(s)	Humans ; SARS-CoV-2 ; Coronavirus 3C Proteases ; COVID-19/drug therapy ; Peptide Hydrolases ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Protease Inhibitors/chemistry ; Cysteine ; Cysteine Endopeptidases/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; Peptides/chemistry
Chemical Substances	Coronavirus 3C Proteases (EC 3.4.22.28) ; Peptide Hydrolases (EC 3.4.-) ; Protease Inhibitors ; Cysteine (K848JZ4886) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Antiviral Agents ; Peptides
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c01081
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Article ; Online: Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset

Vasanthan Jayakumar / Osamu Nishimura / Mitsutaka Kadota / Naoki Hirose / Hiromi Sano / Yasuhiro Murakawa / Yumiko Yamamoto / Masataka Nakaya / Tomoyuki Tsukiyama / Yasunari Seita / Shinichiro Nakamura / Jun Kawai / Erika Sasaki / Masatsugu Ema / Shigehiro Kuraku / Hideya Kawaji / Yasubumi Sakakibara

Scientific Data, Vol 8, Iss 1, Pp 1-

2021 Volume 9

Abstract: Measurement(s) sequence_assembly • genome • DNA Technology Type(s) sequence assembly process • DNA sequencing Sample Characteristic - Organism Macaca fascicularis • Callithrix jacchus Machine-accessible metadata file describing the reported data: https:// ...

Abstract	Measurement(s) sequence_assembly • genome • DNA Technology Type(s) sequence assembly process • DNA sequencing Sample Characteristic - Organism Macaca fascicularis • Callithrix jacchus Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.14665314
Keywords	Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset.

Jayakumar, Vasanthan / Nishimura, Osamu / Kadota, Mitsutaka / Hirose, Naoki / Sano, Hiromi / Murakawa, Yasuhiro / Yamamoto, Yumiko / Nakaya, Masataka / Tsukiyama, Tomoyuki / Seita, Yasunari / Nakamura, Shinichiro / Kawai, Jun / Sasaki, Erika / Ema, Masatsugu / Kuraku, Shigehiro / Kawaji, Hideya / Sakakibara, Yasubumi

Scientific data

2021 Volume 8, Issue 1, Page(s) 159

Abstract: Cynomolgus macaque (Macaca fascicularis) and common marmoset (Callithrix jacchus) have been widely used in human biomedical research. Long-standing primate genome assemblies used the human genome as a reference for ordering and orienting the assembled ... ...

Abstract	Cynomolgus macaque (Macaca fascicularis) and common marmoset (Callithrix jacchus) have been widely used in human biomedical research. Long-standing primate genome assemblies used the human genome as a reference for ordering and orienting the assembled fragments into chromosomes. Here we performed de novo genome assembly of these two species without any human genome-based bias observed in the genome assemblies released earlier. We assembled PacBio long reads, and the resultant contigs were scaffolded with Hi-C data, which were further refined based on Hi-C contact maps and alternate de novo assemblies. The assemblies achieved scaffold N50 lengths of 149 Mb and 137 Mb for cynomolgus macaque and common marmoset, respectively. The high fidelity of our assembly is also ascertained by BAC-end concordance in common marmoset. Our assembly of cynomolgus macaque outperformed all the available assemblies of this species in terms of contiguity. The chromosome-scale genome assemblies produced in this study are valuable resources for non-human primate models and provide an important baseline in human biomedical research.
MeSH term(s)	Animals ; Callithrix/genetics ; Chromosomes ; Contig Mapping ; Gene Order ; Macaca fascicularis/genetics
Language	English
Publishing date	2021-06-28
Publishing country	England
Document type	Dataset ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-021-00935-6
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Article ; Online: Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

bioRxiv

Abstract: The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). The 3C-like protease (3CL ... pro ... ) is a promising target for ... ...

Abstract	The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). The 3C-like protease (3CL<sup>pro</sup>) is a promising target for COVID-19 treatment. Here, we report the new class of covalent inhibitors for 3CL<sup>pro</sup> possessing chlorofluoroacetamide (CFA) as a cysteine reactive warhead. Based on the aza-peptide scaffold, we synthesized the series of CFA derivatives in enantiopure form and evaluated their biochemical efficiencies. The data revealed that 8a (YH-6) with R configuration at the CFA unit strongly blocks the SARS-CoV-2 replication in the infected cells and this potency is comparable to that of nirmatrelvir. The X-ray structural analysis shows that 8a (YH-6) forms a covalent bond with Cys145 at the catalytic center of 3CL<sup>pro</sup>. The strong antiviral activity and sufficient pharmacokinetics property of 8a (YH-6) suggest its potential as a lead compound for treatment of COVID-19.
Keywords	covid19
Language	English
Publishing date	2022-06-06
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2022.06.05.494897
Database	COVID19

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Article ; Online: Millennial-scale northern Hemisphere Atlantic-Pacific climate teleconnections in the earliest Middle Pleistocene.

Hyodo, Masayuki / Bradák, Balázs / Okada, Makoto / Katoh, Shigehiro / Kitaba, Ikuko / Dettman, David L / Hayashi, Hiroki / Kumazawa, Koyo / Hirose, Kotaro / Kazaoka, Osamu / Shikoku, Kizuku / Kitamura, Akihisa

Scientific reports

2017 Volume 7, Issue 1, Page(s) 10036

Abstract: Suborbital-scale climate variations, possibly caused by solar activity, are observed in the Holocene and last-glacial climates. Recently published bicentennial-resolution paleoceanic environmental records reveal millennial-scale high-amplitude ... ...

Abstract	Suborbital-scale climate variations, possibly caused by solar activity, are observed in the Holocene and last-glacial climates. Recently published bicentennial-resolution paleoceanic environmental records reveal millennial-scale high-amplitude oscillations postdating the last geomagnetic reversal in the Marine Isotope Stage (MIS) 19 interglacial. These oscillations, together with decoupling of post-reversal warming from maximum sea-level highstand in mid-latitudes, are key features for understanding the climate system of MIS 19 and the following Middle Pleistocene. It is unclear whether the oscillations are synchronous, or have the same driver as Holocene cycles. Here we present a high resolution record of western North Pacific submarine anoxia and sea surface bioproductivity from the Chiba Section, central Japan. The record reveals many oxic events in MIS 19, coincident with cold intervals, or with combined cold and sea-level fall events. This allows detailed correlations with paleoceanic records from the mid-latitude North Atlantic and Osaka Bay, southwest Japan. We find that the millennial-scale oscillations are synchronous between East and West hemispheres. In addition, during the two warmest intervals, bioproductivity follows the same pattern of change modulated by bicentennial cycles that are possibly related to solar activity.
Language	English
Publishing date	2017-08-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-10552-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Immediate effect of intravenous diazepam in neuroleptic-induced acute akathisia: an open-label study.

Hirose, Shigehiro / Ashby, Charles R

The Journal of clinical psychiatry

2002 Volume 63, Issue 6, Page(s) 524–527

Abstract: Background: Neuroleptic-induced akathisia can be severely distressing to some patients. and rapid treatment would be preferable. However, there have been relatively few studies conducted regarding the rapid treatment of akathisia. The effect of ... ...

Abstract	Background: Neuroleptic-induced akathisia can be severely distressing to some patients. and rapid treatment would be preferable. However, there have been relatively few studies conducted regarding the rapid treatment of akathisia. The effect of intravenous diazepam at the beginning of treatment for akathisia was studied in an open clinical trial. Method: The subjects were 18 patients with schizophrenia or bipolar I disorder (DSM-IV criteria) who developed neuroleptic-induced acute akathisia during antipsychotic medication and who required immediate relief from the distress of akathisia. Diazepam was given intravenously to the patients at a rate of 5 mg per 30 seconds. Results: All 18 subjects experienced immediate relief from akathisia after the injection of diazepam (mean +/- SD dose = 12.6 +/- 2.6 mg; range, 10-17 mg). They reported no serious adverse effects. Conclusion: The results suggest that intravenous diazepam could be used in the treatment of patients with severely distressing akathisia who require immediate relief.
MeSH term(s)	Acute Disease ; Adult ; Akathisia, Drug-Induced/drug therapy ; Akathisia, Drug-Induced/etiology ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Diazepam/administration & dosage ; Diazepam/therapeutic use ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Schizophrenia/drug therapy ; Treatment Outcome
Chemical Substances	Anti-Anxiety Agents ; Antipsychotic Agents ; Diazepam (Q3JTX2Q7TU)
Language	English
Publishing date	2002-07-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/jcp.v63n0610
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Article: An open pilot study combining risperidone and a selective serotonin reuptake inhibitor as initial antidepressant therapy.

Hirose, Shigehiro / Ashby, Charles R

The Journal of clinical psychiatry

2002 Volume 63, Issue 8, Page(s) 733–736

Abstract: Background: Atypical antipsychotics such as risperidone or olanzapine have been reported to be effective when added to a selective serotonin reuptake inhibitor (SSRI) in cases of depression in which treatment with an SSRI alone is not effective. It is ... ...

Abstract	Background: Atypical antipsychotics such as risperidone or olanzapine have been reported to be effective when added to a selective serotonin reuptake inhibitor (SSRI) in cases of depression in which treatment with an SSRI alone is not effective. It is possible that the combination of an SSRI and an atypical antipsychotic may be efficacious as an initial treatment for major depression. Method: Thirty-six subjects who fulfilled DSM-IV diagnostic criteria for major depressive disorder were given fluvoxamin, 50 or 75 mg/day, with risperidone, 0.5 or 1 mg/day, at the start of treatment. The dose of fluvoxamine was increased to 100 or 150 mg/day on the fourth day of the treatment and maintained thereafter. Hamilton Rating Scale for Depression (HAM-D) scores were obtained at base-line and every week for 6 weeks. Remission and response were defined, respectively, as > or = 75% and 50%-74% reduction from baseline in HAM-D score. Results: Of 30 subjects who completed the 6-week study, 23 (76%) achieved remission, 5 (17%) achieved response, and 2 (7%) were nonresponsive. Of the 6 patients who did not complete the study, 3 showed remission, 1 showed response, and 2 showed minimal or no response by the time of dropout. The reported adverse effects were mild, and none of the 36 subjects enrolled in the study manifested or reported extrapyramidal symptoms, nausea, or vomiting. Conclusion: The results suggest that the combination of risperidone and fluvoxamine from the beginning of antidepressant therapy enhances the therapeutic response rate in depression.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Ambulatory Care ; Antipsychotic Agents/therapeutic use ; Depressive Disorder/diagnosis ; Depressive Disorder/drug therapy ; Drug Administration Schedule ; Female ; Fluvoxamine/therapeutic use ; Humans ; Male ; Middle Aged ; Pilot Projects ; Psychiatric Status Rating Scales ; Risperidone/therapeutic use ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Serotonin Uptake Inhibitors ; Risperidone (L6UH7ZF8HC) ; Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	2002-10-01
Publishing country	United States
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/jcp.v63n0812
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Article ; Online: Millennial-scale northern Hemisphere Atlantic-Pacific climate teleconnections in the earliest Middle Pleistocene

Masayuki Hyodo / Balázs Bradák / Makoto Okada / Shigehiro Katoh / Ikuko Kitaba / David L. Dettman / Hiroki Hayashi / Koyo Kumazawa / Kotaro Hirose / Osamu Kazaoka / Kizuku Shikoku / Akihisa Kitamura

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 9

Abstract: Abstract Suborbital-scale climate variations, possibly caused by solar activity, are observed in the Holocene and last-glacial climates. Recently published bicentennial-resolution paleoceanic environmental records reveal millennial-scale high-amplitude ... ...

Abstract	Abstract Suborbital-scale climate variations, possibly caused by solar activity, are observed in the Holocene and last-glacial climates. Recently published bicentennial-resolution paleoceanic environmental records reveal millennial-scale high-amplitude oscillations postdating the last geomagnetic reversal in the Marine Isotope Stage (MIS) 19 interglacial. These oscillations, together with decoupling of post-reversal warming from maximum sea-level highstand in mid-latitudes, are key features for understanding the climate system of MIS 19 and the following Middle Pleistocene. It is unclear whether the oscillations are synchronous, or have the same driver as Holocene cycles. Here we present a high resolution record of western North Pacific submarine anoxia and sea surface bioproductivity from the Chiba Section, central Japan. The record reveals many oxic events in MIS 19, coincident with cold intervals, or with combined cold and sea-level fall events. This allows detailed correlations with paleoceanic records from the mid-latitude North Atlantic and Osaka Bay, southwest Japan. We find that the millennial-scale oscillations are synchronous between East and West hemispheres. In addition, during the two warmest intervals, bioproductivity follows the same pattern of change modulated by bicentennial cycles that are possibly related to solar activity.
Keywords	Medicine ; R ; Science ; Q
Subject code	550
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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