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  1. Book: Advances in radiotherapy

    Williams, Terence M.

    (Surgical oncology clinics of North America ; volume 32, number 3 (July 2023))

    2023  

    Author's details editor Terence M. Williams
    Series title Surgical oncology clinics of North America ; volume 32, number 3 (July 2023)
    Collection
    Language English
    Size xvi Seiten, Seite 400-629, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT030059865
    ISBN 978-0-443-18213-6 ; 0-443-18213-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1339 -32,3- not available for loan Lesesaal EG

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  2. Article ; Online: Advances in Radiotherapy.

    Williams, Terence M

    Surgical oncology clinics of North America

    2023  Volume 32, Issue 3, Page(s) xv–xvi

    MeSH term(s) Humans ; Radiation Oncology ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stereotactic body radiation therapy in advanced NSCLC.

    Williams, Terence M

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19, Issue 7, Page(s) 439–441

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Radiosurgery/methods ; Tumor Microenvironment/radiation effects
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: BRAF

    Williams, Terence M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2019  Volume 25, Issue 21, Page(s) 6557

    MeSH term(s) DNA ; Humans ; Oncogenes ; Proto-Oncogene Proteins B-raf/genetics ; Thyroid Neoplasms/genetics
    Chemical Substances DNA (9007-49-2) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-2705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Targeting oncogenic

    Yang, Linlin / Li, Zhefeng / Binzel, Daniel W / Guo, Peixuan / Williams, Terence M

    Molecular therapy. Nucleic acids

    2023  Volume 33, Page(s) 559–571

    Abstract: ... ...

    Abstract KRAS
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.07.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neoadjuvant Therapy Versus Immediate Surgery for Resectable Pancreas Cancer: Still Open for Debate.

    Cloyd, Jordan M / Williams, Terence M

    American journal of clinical oncology

    2020  Volume 43, Issue 10, Page(s) 752–754

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604536-4
    ISSN 1537-453X ; 0277-3732
    ISSN (online) 1537-453X
    ISSN 0277-3732
    DOI 10.1097/COC.0000000000000728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector

    Fadel, Amen N / Ibrahim, Sulaiman S / Sandeu, Maurice M / Tatsinkou, Claudine Grâce Maffo / Menze, Benjamin D / Irving, Helen / Hearn, Jack / Nagi, Sanjay C / Weedall, Gareth D / Terence, Ebai / Tchapga, Williams / Wanji, Samuel / Wondji, Charles S

    Evolutionary applications

    2024  Volume 17, Issue 2, Page(s) e13641

    Abstract: Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms ... ...

    Abstract Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2405496-3
    ISSN 1752-4563 ; 1752-4571
    ISSN (online) 1752-4563
    ISSN 1752-4571
    DOI 10.1111/eva.13641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer.

    Prasad, Rahul N / Williams, Terence M

    Translational lung cancer research

    2020  Volume 9, Issue 5, Page(s) 2040–2050

    Abstract: Despite declining smoking rates, lung cancer remains the second most common malignancy in the United States and the leading cause of cancer-related mortality. Non-small cell lung cancer (NSCLC) comprises roughly 85% of cases, and patients tend to present ...

    Abstract Despite declining smoking rates, lung cancer remains the second most common malignancy in the United States and the leading cause of cancer-related mortality. Non-small cell lung cancer (NSCLC) comprises roughly 85% of cases, and patients tend to present with advanced disease. Historically, concurrent chemoradiotherapy (CRT) has been the standard of care for stage III unresectable NSCLC but outcomes even with multimodal therapy have remained relatively poor. Efforts to improve outcomes through radiation dose escalation with conventional dose fractionation were unsuccessful with RTOG 0617, demonstrating significantly decreased overall survival (OS) with high dose radiation with respect to standard therapy. The recent PACIFIC trial established a new role for consolidative immune checkpoint blockade therapy after CRT using the programmed death ligand 1 (PD-L1) inhibitor durvalumab, by demonstrating significantly improved progression free survival and OS. Although promising, the addition of immunotherapy to multimodal therapy has generated debate regarding the most effective immune pathways to target, appropriate sequencing of therapy, most effective radiation techniques, and toxicity-related concerns. This review will highlight recent and ongoing trials in unresectable, locally advanced NSCLC that incorporate chemotherapy, radiation, and immunotherapy with an emphasis on analysis of treatment-related toxicities and implications for future study design.
    Language English
    Publishing date 2020-11-19
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-20-638
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: The Emerging Role of Radiotherapy in Oligoprogressive Non-Small Cell Lung Cancer.

    Tam, Andrew / Eustace, Nicholas / Kassardjian, Ari / West, Howard / Williams, Terence M / Amini, Arya

    Surgical oncology clinics of North America

    2023  Volume 32, Issue 3, Page(s) 497–514

    Abstract: Oligoprogressive disease (OPD) is an emerging concept that describes patients who have progression of disease in a limited number of metastatic sites while on systemic therapy. Growing evidence has suggested the integration of local ablative therapy with ...

    Abstract Oligoprogressive disease (OPD) is an emerging concept that describes patients who have progression of disease in a limited number of metastatic sites while on systemic therapy. Growing evidence has suggested the integration of local ablative therapy with systemic agents in patients with OPD further improves survival. In oligoprogressive non-small cell lung cancer, stereotactic body radiotherapy may have an important role in the effective local control of selective progressing metastases, which may translate to better patient outcomes. This review explores the treatment paradigm of this subset of patients and provides an update on the current existing literature on this topic.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/pathology ; Disease Progression ; Radiosurgery
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: RAS-RAF-miR-296-3p signaling axis increases Rad18 expression to augment radioresistance in pancreatic and thyroid cancers.

    Wolfe, Adam R / Feng, Haihua / Zuniga, Oscar / Rodrigues, Henrique / Eldridge, Daniel E / Yang, Linlin / Shen, Changxian / Williams, Terence M

    Cancer letters

    2024  Volume 591, Page(s) 216873

    Abstract: Oncogenic RAS and RAF signaling has been implicated in contributing to radioresistance in pancreatic and thyroid cancers. In this study, we sought to better clarify molecular mechanisms contributing to this effect. We discovered that miRNA 296-3p (miR- ... ...

    Abstract Oncogenic RAS and RAF signaling has been implicated in contributing to radioresistance in pancreatic and thyroid cancers. In this study, we sought to better clarify molecular mechanisms contributing to this effect. We discovered that miRNA 296-3p (miR-296-3p) is significantly correlated with radiosensitivity in a panel of pancreatic cancer cells, and miR-296-3p is highly expressed in normal cells, but low in cancer cell lines. Elevated expression of miR-296-3p increases radiosensitization while decreasing the expression of the DNA repair enzyme RAD18 in both pancreatic and thyroid cancer cells. RAD18 is overexpressed in both pancreatic and thyroid tumors compared to matched normal controls, and high expression of RAD18 in tumors is associated with poor prognostic features. Modulating the expression of mutant KRAS in pancreatic cancer cells or mutant BRAF in thyroid cancer cells demonstrates a tight regulation of RAD18 expression in both cancer types. Depletion of RAD18 results in DNA damage and radiation-induced cell death. Importantly, RAD18 depletion in combination with radiotherapy results in marked and sustained tumor regression in KRAS mutant pancreatic cancer orthotopic tumors and BRAF mutant thyroid heterotopic tumors. Overall, our findings identify a novel coordinated RAS/RAF-miR-296-3p-RAD18 signaling network in pancreatic and thyroid cancer cells, which leads to enhanced radioresistance.
    Language English
    Publishing date 2024-04-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2024.216873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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