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  1. Article: Liver transplantation in colorectal metastases. Is there an indication for this procedure?

    Cienfuegos, Javier A / Zozaya, Gabriel / Rotellar, Fernando

    Revista espanola de enfermedades digestivas

    2024  Volume 116, Issue 2, Page(s) 59–62

    Abstract: Almost 25 % of patients with colorectal cancer present metastases at the time of diagnosis and 50 % go on to develop metastases in the course of the disease. Surgical resection is the only curative treatment although only between 20 % and 30 % of ... ...

    Abstract Almost 25 % of patients with colorectal cancer present metastases at the time of diagnosis and 50 % go on to develop metastases in the course of the disease. Surgical resection is the only curative treatment although only between 20 % and 30 % of patients present resectable lesions. Although liver transplantation is contraindicated in unresectable metastases of colorectal cancer, ever since the publication of the results of a pilot study there has been renewed interest in transplantation in these patients. In two consecutive trials overall and recurrence-free 5-year survival rates of 83 % and 35 % respectively, have been reported, Currently several trials are ongoing which are expected to allow the patient selection criteria for the indication of liver transplantation to be refined.
    MeSH term(s) Humans ; Liver Transplantation/methods ; Liver Neoplasms ; Pilot Projects ; Hepatectomy ; Colorectal Neoplasms/pathology
    Language English
    Publishing date 2024-02-20
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9873/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neoadjuvant treatment in localized and resectable cancer of the pancreas: a new therapeutic paradigm.

    Martí-Cruchaga, Pablo / Cienfuegos, Javier A / Rotellar, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2022  Volume 114, Issue 7, Page(s) 371–374

    Abstract: Ductal carcinoma of the pancreas (DCP) is one of the most devastating tumors and ranks fourth among the causes of death from cancer. It is estimated that by 2030 it will be among the top three "cancer killers", along with lung cancer and hepatocarcinoma. ...

    Abstract Ductal carcinoma of the pancreas (DCP) is one of the most devastating tumors and ranks fourth among the causes of death from cancer. It is estimated that by 2030 it will be among the top three "cancer killers", along with lung cancer and hepatocarcinoma. Overall survival at five years from diagnosis is 5-10% in centers with experience. At the time of diagnosis, only 10-15% of patients present tumors localized to the pancreas and which are susceptible to curative resection (R0) (resectable tumors). Fifty percent present with systemic disease (stage IV) and 30-35% present borderline or locally advanced tumors which are generally not resectable due to vascular invasion.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/surgery ; Humans ; Neoadjuvant Therapy ; Pancreas/pathology ; Pancreatectomy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2022-05-31
    Publishing country Spain
    Document type Editorial
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2022.8925/2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acute pancreatitis: an opportunity for gastroenterology hospitalists?

    Cienfuegos, Javier A / Valentí, Víctor / Rotellar, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2022  Volume 114, Issue 2, Page(s) 73–75

    Abstract: Acute pancreatitis (AP) is the third most frequent cause of hospital admissions for digestive disorders in the US and Europe after digestive bleeding and cholelithiasis/cholecystitis. The incidence of AP ranges from 15 to 100 cases per 100,000 ... ...

    Abstract Acute pancreatitis (AP) is the third most frequent cause of hospital admissions for digestive disorders in the US and Europe after digestive bleeding and cholelithiasis/cholecystitis. The incidence of AP ranges from 15 to 100 cases per 100,000 inhabitants per year, and has been steadily increasing in recent years. In Spain, the reported incidence is 72 patients per 100,000 inhabitants per year. The most frequent cause is biliary lithiasis (50 %-60 % of cases); fortunately, 80 % of patients have only mild symptoms-as defined by the revised Atlanta Classification-and progress favorably, although mortality rate is 4.2 %. Clinical guidelines explicitly indicate that laparoscopic cholecystectomy should be performed during the first 48-72 hours or at the time of hospital admission in mild cases of biliary origin.
    MeSH term(s) Acute Disease ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Gallstones/complications ; Gastroenterology ; Hospitalists ; Humans ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/etiology ; Retrospective Studies
    Language English
    Publishing date 2022-03-25
    Publishing country Spain
    Document type Journal Article ; Comment
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2022.8573/2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Learning From Technical Details With Effect on Postoperative Pancreatic Fistula.

    Cienfuegos, Javier A / Valenti, Victor / Rotellar, Fernando

    JAMA surgery

    2021  Volume 156, Issue 12, Page(s) 1183

    MeSH term(s) Humans ; Pancreas/surgery ; Pancreatic Fistula/etiology ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.3750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: COVID-19 and the digestive system: implications for transforming care delivery.

    Cienfuegos, Javier A / Pérez-Cuadrado, Enrique

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 113, Issue 2, Page(s) 83–84

    Abstract: The pandemic caused by SARS-CoV-2 has posed an unprecedented challenge to health systems, leading in many countries to the collapse of health care and a lack of preventive measures both for the most vulnerable sections of the population and among ... ...

    Abstract The pandemic caused by SARS-CoV-2 has posed an unprecedented challenge to health systems, leading in many countries to the collapse of health care and a lack of preventive measures both for the most vulnerable sections of the population and among healthcare professionals.
    MeSH term(s) COVID-19 ; Delivery of Health Care ; Digestive System Diseases/therapy ; Humans
    Language English
    Publishing date 2021-01-11
    Publishing country Spain
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.7774/2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pancreatic injury and acute pancreatitis in COVID-19 patients.

    Cienfuegos, Javier A / Almeida, Ana / Aliseda, Daniel

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 113, Issue 5, Page(s) 389

    Abstract: Apart from pulmonary manifestations, there is an increased incidence of pancreatic involvement and acute pancreatitis (AP) reported in COVID-19 patients. In January 2021, a PubMed search using the terms "Acute Pancreatitis, COVID-19" yielded a result ... ...

    Abstract Apart from pulmonary manifestations, there is an increased incidence of pancreatic involvement and acute pancreatitis (AP) reported in COVID-19 patients. In January 2021, a PubMed search using the terms "Acute Pancreatitis, COVID-19" yielded a result including 94 studies. Most of the studies refer to isolated cases or limited series, with the added difficulty that some authors have considered AP as elevated lipase and/or amylase levels without the diagnostic criteria for AP being met, as highlighted by Chivato et al. in relation to the case they report. Pancreatic involvement has been reported in 17 % of COVID-19 patients and AP in 1.8-2.0 % of these patients.
    MeSH term(s) Acute Disease ; COVID-19 ; Humans ; Pancreas/diagnostic imaging ; Pancreatitis ; SARS-CoV-2
    Language English
    Publishing date 2021-02-10
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.7807/2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Small pancreatic neuroendocrine tumors: observing and monitoring or prompt surgical resection.

    Cienfuegos, Javier A / Hurtado-Pardo, Luis / Rotellar, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 114, Issue 1, Page(s) 1–4

    Abstract: Over recent decades there has been a significant increase in the annual incidence of neuroendocrine tumors of the pancreas (PanNETs), from 0.4 to 0.8 per 100,000 inhabitants, due to a more widespread use of more sensitive imaging techniques (cross- ... ...

    Abstract Over recent decades there has been a significant increase in the annual incidence of neuroendocrine tumors of the pancreas (PanNETs), from 0.4 to 0.8 per 100,000 inhabitants, due to a more widespread use of more sensitive imaging techniques (cross-sectional and functional imaging).
    MeSH term(s) Cross-Sectional Studies ; Humans ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/surgery ; Pancreas/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2021-11-15
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.8419/2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hepatic injury and COVID-19: pathogenic mechanisms or epiphenomena?

    Cienfuegos, Javier A / Valentí, Víctor / Rotellar, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 113, Issue 7, Page(s) 554–555

    Abstract: Ampuero J et al. analyzed the relationship between liver injury and clinical progression of the disease in a meta-analysis of over 5,000 COVID-19 patients. The authors reported an association between increased aspartate aminotransferase (AST), alanine ... ...

    Abstract Ampuero J et al. analyzed the relationship between liver injury and clinical progression of the disease in a meta-analysis of over 5,000 COVID-19 patients. The authors reported an association between increased aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels with mortality, admission to Intensive Care and the development of complications, respectively.
    MeSH term(s) Alanine Transaminase ; Aspartate Aminotransferases ; COVID-19 ; Humans ; Liver ; SARS-CoV-2
    Chemical Substances Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2021-02-10
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.7851/2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pathogenesis of pneumoperitoneum in a COVID-19 patients.

    Cienfuegos, Javier A / Almeida, Ana / Aliseda, Daniel / Rotellar, Fernando

    Cirugia espanola

    2021  Volume 99, Issue 6, Page(s) 476–477

    MeSH term(s) COVID-19 ; Humans ; Injections, Intraperitoneal ; Insufflation ; Pneumoperitoneum/etiology ; SARS-CoV-2
    Language English
    Publishing date 2021-03-24
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2021.03.012
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  10. Article ; Online: Etiopatogenia de neumoperitoneo en pacientes COVID-19.

    Cienfuegos, Javier A / Almeida, Ana / Aliseda, Daniel / Rotellar, Fernando

    Cirugia espanola

    2021  Volume 99, Issue 6, Page(s) 476–477

    Title translation Pathogenesis of pneumoperitoneum in a COVID-19 patients.
    Language Spanish
    Publishing date 2021-01-21
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 730701-9
    ISSN 1578-147X ; 0009-739X
    ISSN (online) 1578-147X
    ISSN 0009-739X
    DOI 10.1016/j.ciresp.2021.01.012
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