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  1. Book ; Thesis: Therapieergebnisse der refraktären und rezidivierten Akuten Lymphatischen Leukämie (ALL) bei Erwachsenen

    Weinberg, Gereon-Matthias

    2018  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Gereon-Matthias Weinberg aus Bad Honnef
    Language German
    Size XII, 154 Seiten, Diagramme, 21 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2019
    Note Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 131-138
    HBZ-ID HT020461310
    Database Catalogue ZB MED Medicine, Health

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  2. Book: The management of psoriasis in the age of biologics

    Weinberg, Jeffrey M.

    clinical update 2009

    (Journal of drugs in dermatology ; 8,10, Suppl.)

    2009  

    Author's details [ed. Jeffrey M. Weinberg ...]
    Series title Journal of drugs in dermatology ; 8,10, Suppl.
    Collection
    Language English
    Size 15 S. : graph. Darst.
    Publisher Journal of Drugs in Dermatology
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT016137211
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Treatment of psoriasis

    Weinberg, Jeffrey M.

    (MDT - Milestones in drug therapy)

    2008  

    Author's details ed. by Jeffrey M. Weinberg
    Series title MDT - Milestones in drug therapy
    Keywords Schuppenflechte ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Psoriasis vulgaris
    Language English
    Size X, 183 S.
    Publisher Birkhäuser
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015392839
    ISBN 978-3-7643-7722-9 ; 3-7643-7722-4
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Alleviating the burden of herpes zoster through vaccination

    Weinberg, Jeffrey M.

    (Journal of the American Academy of Dermatology ; 57,6, Suppl.)

    2007  

    Author's details guest ed.: Jeffrey M. Weinberg
    Series title Journal of the American Academy of Dermatology ; 57,6, Suppl.
    Collection
    Language English
    Size 6A S., S. S109 - S150 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015382096
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Advances in psoriasis

    Weinberg, Jeffrey M. / Lebwohl, Mark G.

    a multisystemic guide

    2014  

    Author's details Jeffrey M. Weinberg ; Mark Lebwohl ed
    Keywords Psoriasis
    Subject code 616.526
    Language English
    Size XVIII, 332 S. : Ill., graph. Darst., 26 cm
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018393225
    ISBN 978-1-4471-4431-1 ; 1-4471-4431-7 ; 9781447144328 ; 1447144325
    Database Catalogue ZB MED Medicine, Health

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  6. Book: TNF-alpha inhibitors

    Weinberg, Jeffrey M.

    (Milestones in drug therapy)

    2006  

    Author's details ed. by J.M. Weinberg
    Series title Milestones in drug therapy
    Keywords Tumor-Nekrose-Faktor ; Inhibitor
    Subject Hemmstoff ; Kachektin ; TNF
    Language English
    Size IX, 133 S. : Ill., graph. Darst.
    Publisher Birkhäuser
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT014753729
    ISBN 978-3-7643-7248-4 ; 3-7643-7248-6
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: An Evaluation of Anatomic Referencing for Femoral Component Sizing Using Computed Tomography-Based Computer Modeling.

    Campbell, Brett / Weinberg, Max / Bischoff, Jeffrey / Scuderi, Giles R

    The journal of knee surgery

    2024  

    Abstract: One of the critical steps in total knee arthroplasty is femoral component positioning and sizing. Historically, there was wider variability between femoral component sizes, necessitating the concepts of anterior referencing (AR) and posterior referencing ...

    Abstract One of the critical steps in total knee arthroplasty is femoral component positioning and sizing. Historically, there was wider variability between femoral component sizes, necessitating the concepts of anterior referencing (AR) and posterior referencing (PR). With the introduction of smaller increments between sizes, the concept of anatomic referencing has been introduced to replace AR and PR. The intent of this study was to validate the concept of anatomic referencing and show that with 2 mm increments in femoral sizes, the femoral component can be placed flush to the anterior cortex while maintaining posterior condylar offset (PCO). Digital surface models were created using 515 femurs from an established computed tomography database. Virtual bone resections, component sizing and placement were performed assuming neutral mechanical axis and a cartilage thickness of 2 mm. The appropriately sized femoral component, which had 2 mm incremental sizes, was placed flush with the anterior cortex with restoration of the PCO. The anterior-posterior distance from the posterior surface of the component to the medial and lateral surfaces of the posterior condylar cartilage were measured. The medial condyle was the limiting condyle in the majority of cases (73%). The average medial gap after appropriate femoral component matching was 0.6 mm (0.39-1.41 mm) across all sizes. The overall average condylar gap was 1.02 mm. The most common femoral component was a size 7 (57.2 mm) and the average femoral AP width was 55.9 mm. Anatomic referencing with an implant system that has 2-mm increments in femoral component sizing provides an alternative to AR and PR without compromise. Anatomic referencing allows for perfect alignment of the anterior flange of the femoral component to the anterior cortex of the femur while restoring the native PCO to within 1 mm. This avoids having to choose between AR or PR when in between femoral sizes.
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2075354-8
    ISSN 1938-2480 ; 1538-8506 ; 0899-7403
    ISSN (online) 1938-2480
    ISSN 1538-8506 ; 0899-7403
    DOI 10.1055/a-2240-3566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anatomic Referencing of the Distal Femur in Total Knee Arthroplasty: The impact of Orientation on Femoral Component Size.

    Campbell, Brett / Weinberg, Max / Bischoff, Jeffrey / Scuderi, Giles R

    The Journal of arthroplasty

    2024  

    Abstract: Background: Anatomic referencing in total knee arthroplasty places the femoral component flush to the anterior cortex while maintaining posterior condylar offset (PCO). The intent of this study was to evaluate how component position influences the ... ...

    Abstract Background: Anatomic referencing in total knee arthroplasty places the femoral component flush to the anterior cortex while maintaining posterior condylar offset (PCO). The intent of this study was to evaluate how component position influences the femoral component size.
    Methods: Digital surface models were created using 446 femora from an established computed tomography (CT) database. Virtual bone resections, component sizing, and component placement were performed assuming neutral (0°) flexion and neutral (3°) rotation relative to the posterior condyles. The appropriately sized femoral component, which had 2 mm incremental sizes, was placed flush with the anterior cortex for optimal restoration of the PCO. Sizing and placement were repeated using 3 and 6° flexion and 0, 5, and 7° external rotation (ER).
    Results: At 0° flexion, decreasing ER from 3 to 0° resulted in an average decreased anterior-posterior height (APH) of 1.9 mm, corresponding to a component size decrease of 1 for 88% of patients. At 7° ER, component size increased by an average of 2.5 mm, corresponding to a size increase for 80% of patients. Flexing the femoral component to 3° with ER at 3° resulted in a decrease in APH of 2.2 mm (1 size decrease in 93% of patients). At 3° flexion and 3° ER, 86% had the same component size as 0° flexion and 0° ER. Increasing ER at 3° flexion increased APH by 1.2 mm at 5° and 3.1 mm at 7° on average, relative to 3° ER. Increasing flexion from 3 to 6° extended this effect.
    Conclusions: Flexion decreases the APH when the ER is held constant. The ER of the femoral component increases the APH across all tested flexion angles, causing an increase in the ideal femoral component size to maintain PCO. With anatomic referencing, alterations in femoral component positioning and subsequent changes in component size can be accounted.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2024.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mandibular autorotation: a critical virtual parameter in clinical decision-making regarding maxilla-first versus mandible-first sequence.

    Andriola, F O / Weinberg, Y / Grosjean, L / Pagnoncelli, R M / Pottel, L / Swennen, G R J

    International journal of oral and maxillofacial surgery

    2024  

    Abstract: Large degrees of mandibular autorotation during intermediate splint design are prone to transfer error and decrease accuracy. The purpose of this study was to evaluate the amount of mandibular autorotation necessary to design intermediate splints for ... ...

    Abstract Large degrees of mandibular autorotation during intermediate splint design are prone to transfer error and decrease accuracy. The purpose of this study was to evaluate the amount of mandibular autorotation necessary to design intermediate splints for maxilla- and mandible-first sequences using virtual planning software, to help the clinical decision-making regarding the most adequate sequence for each patient. The influence of specific orthognathic movements (different vertical and sagittal changes at the Le Fort I level, cant correction) and the type of maxillofacial deformity (skeletal Class II, III, anterior open bite) were evaluated to identify those that would require higher levels of autorotation for each sequence. Three-dimensional virtual surgical planning data of 194 patients were reviewed (126 female, 68 male; mean age 26.5 ± 11.0 years; 143 skeletal Class II, 51 skeletal Class III) and subgroup analyses were conducted using the Kruskal-Wallis test and post-hoc pairwise comparisons. As an additional parameter (mandibular autorotation), maxilla-first is indicated for bimaxillary osteotomies with Le Fort I posterior intrusion, anterior open bite, and skeletal Class III, while mandible-first is recommended for Le Fort I global extrusion, especially with maxillary cant correction.
    Language English
    Publishing date 2024-02-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Long-term changes in heart rate and electrical remodeling contribute to alternans formation in heart failure: a patient-specific in silico study.

    Phadumdeo, Vrishti M / Mallare, Brianna L / Hund, Thomas J / Weinberg, Seth H

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 2, Page(s) H414–H431

    Abstract: Individuals with chronic heart failure (CHF) have an increased risk of ventricular arrhythmias, which has been linked to pathological cellular remodeling and may also be mediated by changes in heart rate. Heart rate typically fluctuates on a timescale ... ...

    Abstract Individuals with chronic heart failure (CHF) have an increased risk of ventricular arrhythmias, which has been linked to pathological cellular remodeling and may also be mediated by changes in heart rate. Heart rate typically fluctuates on a timescale ranging from seconds to hours, termed heart rate variability (HRV). This variability is reduced in CHF, and this HRV reduction is associated with a greater risk for arrhythmias. Furthermore, variations in heart rate influence the formation of proarrhythmic alternans, a beat-to-beat alternation in the action potential duration (APD), or intracellular calcium (Ca). In this study, we investigate how long-term changes in heart rate and electrical remodeling associated with CHF influence alternans formation. We measure key statistical properties of the RR-interval sequences from ECGs of individuals with normal sinus rhythm (NSR) and CHF. Patient-specific RR-interval sequences and synthetic sequences (randomly generated to mimicking these statistical properties) are used as the pacing protocol for a discrete time-coupled map model that governs APD and intracellular Ca handling of a single cardiac myocyte, modified to account for pathological electrical remodeling in CHF. Patient-specific simulations show that beat-to-beat differences in APD vary temporally in both populations, with alternans formation more prevalent in CHF. Parameter studies using synthetic sequences demonstrate that increasing the autocorrelation time or mean RR-interval reduces APD alternations, whereas increasing the RR-interval standard deviation leads to higher alternans magnitudes. Importantly, we find that although both the CHF-associated changes in heart rate and electrical remodeling influence alternans formation, variations in heart rate may be more influential.
    MeSH term(s) Humans ; Heart Rate/physiology ; Atrial Remodeling ; Arrhythmias, Cardiac ; Heart Failure ; Myocytes, Cardiac/physiology ; Action Potentials/physiology ; Calcium
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00220.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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