LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1003

Search options

  1. Article ; Online: Speed reading the epigenome and genome.

    George, James M / Chinnaiyan, Arul M

    Nature biotechnology

    2023  Volume 41, Issue 10, Page(s) 1392–1393

    MeSH term(s) Epigenome ; Genome/genetics ; Epigenesis, Genetic/genetics
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-01757-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A Pragmatic Approach to Prostate Cancer Screening.

    Tosoian, Jeffrey J / Penson, David F / Chinnaiyan, Arul M

    JAMA

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.4089
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients.

    Gondal, Mahnoor N / Cieslik, Marcin / Chinnaiyan, Arul M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Immune checkpoint blockade (ICB) therapies have emerged as a promising avenue for the treatment of various cancers. Despite their success, the efficacy of these treatments is variable across patients and cancer types. Numerous single-cell RNA-sequencing ( ...

    Abstract Immune checkpoint blockade (ICB) therapies have emerged as a promising avenue for the treatment of various cancers. Despite their success, the efficacy of these treatments is variable across patients and cancer types. Numerous single-cell RNA-sequencing (scRNA-seq) studies have been conducted to unravel cell-specific responses to ICB treatment. However, these studies are limited in their sample sizes and require advanced coding skills for exploration. Here, we have compiled eight scRNA-seq datasets from nine cancer types, encompassing 174 patients, and 90,270 cancer cells. This compilation forms a unique resource tailored for investigating how cancer cells respond to ICB treatment across cancer types. We meticulously curated, quality-checked, pre-processed, and analyzed the data, ensuring easy access for researchers. Moreover, we designed a user-friendly interface for seamless exploration. By sharing the code and data for creating these interfaces, we aim to assist fellow researchers. These resources offer valuable support to those interested in leveraging and exploring single-cell datasets across diverse cancer types, facilitating a comprehensive understanding of ICB responses.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.576110
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: I am therefore I think.

    Anavekar, Nandan S / Chinnaiyan, Kavitha M / Kalra, Ankur

    European heart journal

    2023  Volume 44, Issue 36, Page(s) 3401–3402

    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad451
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: MiR-205-5P AS POTENTIAL BIOMARKER AND THERAPEUTIC TARGET IN HEAD AND NECK SQUAMOUS CELL CARCINOMA.

    Babu, S / Krishnan, M / Chinnaiyan, M / Daniel, P / Solomon, A

    Experimental oncology

    2023  Volume 44, Issue 4, Page(s) 337–338

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; MicroRNAs ; Carcinoma, Squamous Cell/pathology ; Biomarkers ; Head and Neck Neoplasms ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Proliferation ; Cell Movement
    Chemical Substances MicroRNAs ; Biomarkers ; MIRN205 microRNA, human
    Language English
    Publishing date 2023-03-08
    Publishing country Ukraine
    Document type Journal Article
    ZDB-ID 2176927-8
    ISSN 1812-9269 ; 0204-3564
    ISSN 1812-9269 ; 0204-3564
    DOI 10.32471/exp-oncology.2312-8852.vol-44-no-4.19059
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2355: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A comprehensive review on therapeutic application of mesenchymal stem cells in neuroregeneration.

    Babu, Shyamaladevi / Krishnan, Madhan / Panneerselvam, Arjunkumar / Chinnaiyan, Mayilvanan

    Life sciences

    2023  Volume 327, Page(s) 121785

    Abstract: Each year, thousands of people suffer from traumatic peripheral nerve lesions, which impair mobility and sensibility and frequently have fatal outcomes. The recovery of peripheral nerves on its own is frequently insufficient. In this regard, cell therapy ...

    Abstract Each year, thousands of people suffer from traumatic peripheral nerve lesions, which impair mobility and sensibility and frequently have fatal outcomes. The recovery of peripheral nerves on its own is frequently insufficient. In this regard, cell therapy is currently one of the most cutting-edge techniques for nerve healing. The purpose of this review is to highlight the properties of various types of mesenchymal stem cells (MSCs) that are critical for peripheral nerve regeneration after nerve injury. The Preferred Reporting term used to review the available literature are "nerve regeneration," "stem cells," "peripheral nerve damage," "rat," and "human" were combined. In addition, using the phrases "stem cells" and "nerve regeneration" in PubMed, a "MeSH" search was conducted. This study describes the features of the most often utilized MSCs, as well as its paracrine potential, targeted stimulation, and propensity for differentiation into Schwann-like and neuronal-like cells. For the repair of peripheral nerve lesions, ADSCs appear to be the most relevant and promising MSCs, because of their ability to sustain and increase axonal growth, as well as their outstanding paracrine activity, putative differentiation potential, low immunogenicity, and excellent post-transplant survival rate.
    MeSH term(s) Rats ; Animals ; Schwann Cells/metabolism ; Peripheral Nerves ; Mesenchymal Stem Cells ; Nerve Regeneration/physiology ; Peripheral Nerve Injuries/pathology ; Sciatic Nerve/injuries
    Language English
    Publishing date 2023-05-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121785
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A Systematic Overview of Single-Cell Transcriptomics Databases, their Use cases, and Limitations.

    Gondal, Mahnoor N / Shah, Saad Ur Rehman / Chinnaiyan, Arul M / Cieslik, Marcin

    ArXiv

    2024  

    Abstract: Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we systematically ... ...

    Abstract Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we systematically examined large-scale scRNA-seq databases, categorizing them based on their scope and purpose such as general, tissue-specific databases, disease-specific databases, cancer-focused databases, and cell type-focused databases. Next, we discuss the technical and methodological challenges associated with curating large-scale scRNA-seq databases, along with current computational solutions. We argue that understanding scRNA-seq databases, including their limitations and assumptions, is crucial for effectively utilizing this data to make robust discoveries and identify novel biological insights. Furthermore, we propose that bridging the gap between computational and wet lab scientists through user-friendly web-based platforms is needed for democratizing access to single-cell data. These platforms would facilitate interdisciplinary research, enabling researchers from various disciplines to collaborate effectively. This review underscores the importance of leveraging computational approaches to unravel the complexities of single-cell data and offers a promising direction for future research in the field.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Role of stress management for cardiovascular disease prevention.

    Chinnaiyan, Kavitha M

    Current opinion in cardiology

    2019  Volume 34, Issue 5, Page(s) 531–535

    Abstract: Purpose of review: Despite the significant decline in cardiovascular disease (CVD) rates owing to recognition of risk factors, timely and appropriate therapy for acute events, and improved medical therapy, it remains the leading cause of death globally. ...

    Abstract Purpose of review: Despite the significant decline in cardiovascular disease (CVD) rates owing to recognition of risk factors, timely and appropriate therapy for acute events, and improved medical therapy, it remains the leading cause of death globally. Novel risk factors and modifications must be considered in the development and progression of CVD. The purpose of this review is to delineate the association between psychological and mental stress and CVD.
    Recent findings: Stress has been implicated as a significant risk factor in both the acceleration of atherosclerosis and a trigger for acute CVD events. In the last decade, a growing body of evidence has been accumulated on the biological, neuroanatomical, and neurophysiological effects of stress and the benefits of cultivating resilience. The pathophysiology of stress is complex and involves the brain, autonomic nervous system, and the endocrine system, with associated metabolic, inflammatory, and hemostatic abnormalities.
    Summary: Most practice guidelines do not recognize the importance of screening for stress in primary and secondary CVD prevention. There is a paucity of large, scalable, and cost-effective approaches for stress intervention. Two potential strategies are required for reducing stress: strategies that are population-based, and narrower targeted strategies for clinical practice.
    MeSH term(s) Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/psychology ; Humans ; Mass Screening ; Mental Disorders/complications ; Mental Disorders/physiopathology ; Resilience, Psychological ; Risk Factors ; Stress, Psychological/complications ; Stress, Psychological/diagnosis ; Stress, Psychological/physiopathology ; Stress, Psychological/therapy
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000649
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2556: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Bhagavad Gita, dichotomy of control and metric medicine: the conflict of burnout.

    Kalra, Ankur / Chinnaiyan, Kavitha M / Lala, Anuradha

    European heart journal

    2022  Volume 43, Issue 46, Page(s) 4769–4771

    MeSH term(s) Humans ; Burnout, Psychological ; Burnout, Professional/prevention & control ; Medicine
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac545
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Is Universal Next-Generation Sequencing Testing of Patients With Advanced Cancer Ready for Prime Time?-Reply.

    Cobain, Erin F / Chinnaiyan, Arul M

    JAMA oncology

    2021  

    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.1907
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top