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Article ; Online: Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in the development of antidiabetic drugs via inhibition of α-amylase and DPP4 activity.

Chahal, Sandhya / Rani, Payal / Shweta / Goel, Kapil Kumar / Joshi, Gaurav / Singh, Rajvir / Kumar, Parvin / Singh, Devender / Sindhu, Jayant

Bioorganic chemistry

2024 Volume 147, Page(s) 107363

Abstract: Environment-benign, multicomponent synthetic methodologies are vital in modern pharmaceutical research and facilitates multi-targeted drug development via synergistic approach. Herein, we reported green and efficient synthesis of pyrano[2,3-c]pyrazole ... ...

Abstract	Environment-benign, multicomponent synthetic methodologies are vital in modern pharmaceutical research and facilitates multi-targeted drug development via synergistic approach. Herein, we reported green and efficient synthesis of pyrano[2,3-c]pyrazole fused spirooxindole linked 1,2,3-triazoles using a tea waste supported copper catalyst (TWCu). The synthetic approach involves a one-pot, five-component reaction using N-propargylated isatin, hydrazine hydrate, ethyl acetoacetate, malononitrile/ethyl cyanoacetate and aryl azides as model substrates. Mechanistically, the reaction was found to proceed via in situ pyrazolone formation followed by Knoevenagel condensation, azide alkyne cycloaddition and Michael's addition reactions. The molecules were developed using structure-based drug design. The primary goal is to identifying anti-oxidant molecules with potential ability to modulate α-amylase and DPP4 (dipeptidyl-peptidase 4) activity. The anti-oxidant analysis, as determined via DPPH, suggested that the synthesized compounds, A6 and A10 possessed excellent anti-oxidant potential compared to butylated hydroxytoluene (BHT). In contrast, compounds A3, A5, A8, A9, A13, A15, and A18 were found to possess comparable anti-oxidant potential. Among these, A3 and A13 possessed potential α-amylase inhibitory activity compared to the acarbose, and A3 further emerged as dual inhibitors of both DPP4 and α-amylase with anti-oxidant potential. The relationship of functionalities on their anti-oxidant and enzymatic inhibition was explored in context to their SAR that was further corroborated using in silico techniques and enzyme kinetics.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2024.107363
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Article ; Online: Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function.

Singla, Bhupesh / Aithabathula, Ravi Varma / Kiran, Sonia / Kapil, Shweta / Kumar, Santosh / Singh, Udai P

Cells

2022 Volume 11, Issue 11

Abstract: The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the ... ...

Abstract	The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases.
MeSH term(s)	Endothelial Cells/metabolism ; Lymphangiogenesis ; Lymphatic System ; Lymphatic Vessels ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11111750
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Article ; Online: Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

Bhupesh Singla / Ravi Varma Aithabathula / Sonia Kiran / Shweta Kapil / Santosh Kumar / Udai P. Singh

Cells, Vol 11, Iss 1750, p

2022 Volume 1750

Abstract	The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases.
Keywords	lymphatic vessels ; lymphangiogenesis ; reactive oxygen species ; superoxide anion ; hydrogen peroxide ; nitric oxide ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design of experiment based methodical optimization and green syntheses of hybrid patchouli oil coated silver nanoparticles for enhanced antibacterial activity

Ankush Parmar / Shikha Kapil / Shilpee Sachar / Shweta Sharma

Current Research in Green and Sustainable Chemistry, Vol 3, Iss , Pp 100016- (2020)

2020

Abstract: The current monologue reports the facile synthesis of hybrid Patchouli oil (P. cablin) coated silver nanoparticles (P-Ag-NPs) using hyacinth bean (L. purpureus) seed extract as a reducing agent. Design of experiment (DoE) based methodical optimization of ...

Abstract	The current monologue reports the facile synthesis of hybrid Patchouli oil (P. cablin) coated silver nanoparticles (P-Ag-NPs) using hyacinth bean (L. purpureus) seed extract as a reducing agent. Design of experiment (DoE) based methodical optimization of the formulation parameters such as metallic salt concentration, and pH resulted in the successful accomplishment of the desired attributes i.e. morphology, and particle size. State of art spectroscopic (UV–Vis, DLS, ATR-FTIR, EDS), and microscopic techniques (HR-TEM, FE-SEM mapping) based characterization of the attained nanoparticles was carried out.The outcome of the respective UV–Vis analysis ascertained the biogenic synthesis, as the absorption maxima of the obtained particles (~415 nm) lied within characteristic SPR region of the Ag-NPs. DLS analysis revealed that the fabricated nanoparticles were nanosized (110 nm), and possessed a significantly high surface charge (−20.73 mV). ATR-FTIR spectra illustrated the presence of varied functional groups which confirmed the imperious role played by the phytoconstituents in reducing and capping of the synthesized P-Ag-NPs. Electron microscopic analysis further strengthened these findings, as no signs of intermittent agglomeration were present, and the P-Ag-NPs were uniformly distributed.HR-TEM also illustrated that the synthesized hybrid metallic nanoparticles were spherical, and encompassed a coating of essential oil on the halo of the as-synthesized NPs. FE-SEM-Mapping confirmed the phase purity of the Ag-NPs and showed that the particles primarily comprised of the elemental silver in nano form. DPPH and antibacterial assay revealed a significantly high antioxidant (i.e. 2.76 fold) and antibacterial (i.e. 3 fold) potential of the P-Ag-NPs as compared to its counterparts, respectively. The present work thus paves a gallant and promising pathway to eradicate the unsurmountable predicament of microbial pathogenesis.
Keywords	Quality by design ; Green syntheses ; Patchouli oil ; Hyacinth bean ; Hybrid silver nanoparticles ; Antioxidant ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Design of experiment based methodical optimization and green syntheses of hybrid patchouli oil coated silver nanoparticles for enhanced antibacterial activity

Parmar, Ankush / Kapil, Shikha / Sachar, Shilpee / Sharma, Shweta

Current research in green and sustainable chemistry. 2020 June, v. 3

2020

Abstract	The current monologue reports the facile synthesis of hybrid Patchouli oil (P. cablin) coated silver nanoparticles (P-Ag-NPs) using hyacinth bean (L. purpureus) seed extract as a reducing agent. Design of experiment (DoE) based methodical optimization of the formulation parameters such as metallic salt concentration, and pH resulted in the successful accomplishment of the desired attributes i.e. morphology, and particle size. State of art spectroscopic (UV–Vis, DLS, ATR-FTIR, EDS), and microscopic techniques (HR-TEM, FE-SEM mapping) based characterization of the attained nanoparticles was carried out.The outcome of the respective UV–Vis analysis ascertained the biogenic synthesis, as the absorption maxima of the obtained particles (~415 nm) lied within characteristic SPR region of the Ag-NPs. DLS analysis revealed that the fabricated nanoparticles were nanosized (110 nm), and possessed a significantly high surface charge (−20.73 mV). ATR-FTIR spectra illustrated the presence of varied functional groups which confirmed the imperious role played by the phytoconstituents in reducing and capping of the synthesized P-Ag-NPs. Electron microscopic analysis further strengthened these findings, as no signs of intermittent agglomeration were present, and the P-Ag-NPs were uniformly distributed.HR-TEM also illustrated that the synthesized hybrid metallic nanoparticles were spherical, and encompassed a coating of essential oil on the halo of the as-synthesized NPs. FE-SEM-Mapping confirmed the phase purity of the Ag-NPs and showed that the particles primarily comprised of the elemental silver in nano form. DPPH and antibacterial assay revealed a significantly high antioxidant (i.e. 2.76 fold) and antibacterial (i.e. 3 fold) potential of the P-Ag-NPs as compared to its counterparts, respectively. The present work thus paves a gallant and promising pathway to eradicate the unsurmountable predicament of microbial pathogenesis.
Keywords	Lablab purpureus ; Pogostemon cablin ; absorption ; antibacterial properties ; antioxidants ; chemical constituents of plants ; essential oils ; green chemistry ; nanosilver ; oils ; pH ; particle size ; pathogenesis ; research ; salt concentration ; seed extracts ; silver
Language	English
Dates of publication	2020-06
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2666-0865
DOI	10.1016/j.crgsc.2020.100016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depression, Schizophrenia, and Obsessive-Compulsive Disorder: An Umbrella Meta-Analysis.

Patel, Shweta / Silvi, Suraiya / Desai, Saral / Rahman, Fayaz / Depa, Nishitha / Hanif, Sarah / Rizvi, Syeda / Hsieh, Ya-Ching / Malik, Preeti / Patel, Urvish / Mansuri, Zeeshan / Mercy, Rana Prathap / Aedma, Kapil / Parikh, Tapan

The primary care companion for CNS disorders

2023 Volume 25, Issue 5

MeSH term(s)	Humans ; Schizophrenia/therapy ; Depressive Disorder, Major/therapy ; Transcranial Magnetic Stimulation/methods ; Depression ; Obsessive-Compulsive Disorder/therapy ; Treatment Outcome
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.22r03423
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Article ; Online: An investigation to the prolonged requirement (>7 days) of vasopressors in cervical spinal cord injury patients-a retrospective analysis.

Mishra, Rajeeb Kumar / Goyal, Keshav / Bindra, Ashish / Singh, Gyaninder Pal / Kumar, Niraj / Sokhal, Navdeep / Soni, Kapil Dev / Kedia, Shweta / Barman, Sagar Dev

Spinal cord series and cases

2021 Volume 7, Issue 1, Page(s) 96

Abstract: Study design: Retrospective chart review.: Objectives: The primary aim was to identify the number of patients requiring vasopressors beyond the first week of cervical spinal cord injury (SCI). Secondary objectives were to note the type, duration and ... ...

Abstract	Study design: Retrospective chart review. Objectives: The primary aim was to identify the number of patients requiring vasopressors beyond the first week of cervical spinal cord injury (SCI). Secondary objectives were to note the type, duration and doses of vasopressors and any association between prolonged vasopressors use and outcome. Setting: Neurosurgical intensive care of a tertiary trauma care centre. Methods: After Ethical approval we retrospectively collected the data of patients of isolated cervical SCI admitted to neurosurgical intensive care from January to December 2017. Vasopressor requirement for sepsis or cardiac arrest was excluded. Results: Out of 80 patients analysed, 54 (67.5%) received vasopressors. The prolonged requirement of vasopressors was observed in 77.7%. Our preferred agent was dopamine (64.8%). We found out that longer requirement (in days) of high dose of dopamine was associated with higher survival (p = 0.03). Conclusion: Our results describe a significant portion of cervical SCI patients need ongoing vasopressor to maintain a mean arterial pressure >65 mm of Hg beyond first week. We observed patients who required longer duration of high dose dopamine had a higher chance of survival suggesting some unknown mechanism of high dose of dopamine. This is first such observation, further studies are needed to substantiate.
MeSH term(s)	Cervical Cord ; Humans ; Retrospective Studies ; Spinal Cord Injuries/drug therapy ; Vasoconstrictor Agents/therapeutic use
Chemical Substances	Vasoconstrictor Agents
Language	English
Publishing date	2021-11-02
Publishing country	England
Document type	Journal Article
ISSN	2058-6124
ISSN (online)	2058-6124
DOI	10.1038/s41394-021-00459-6
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Article: Milky urine: A real cause of concern.

Dhansura, Tasneem S / Gandhi, Shweta P / Patil, Kapil

Indian journal of anaesthesia

2013 Volume 57, Issue 3, Page(s) 327

Language	English
Publishing date	2013-08-02
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0019-5049
ISSN	0019-5049
DOI	10.4103/0019-5049.115609
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Article ; Online: Clinical characteristics of COVID-19 in solid organ transplant recipients following COVID-19 vaccination: A multicenter case series.

Saharia, Kapil K / Anjan, Shweta / Streit, Judy / Beekmann, Susan E / Polgreen, Philip M / Kuehnert, Matthew / Segev, Dorry L / Baddley, John W / Miller, Rachel A

Transplant infectious disease : an official journal of the Transplantation Society

2022 Volume 24, Issue 2, Page(s) e13774

Abstract: Background: Solid organ transplant recipients (SOTR) have diminished humoral immune responses to COVID-19 vaccination and higher rates of COVID-19 vaccine breakthrough infection than the general population. Little is known about COVID-19 disease ... ...

Abstract	Background: Solid organ transplant recipients (SOTR) have diminished humoral immune responses to COVID-19 vaccination and higher rates of COVID-19 vaccine breakthrough infection than the general population. Little is known about COVID-19 disease severity in SOTR with COVID-19 vaccine breakthrough infections. Methods: Between 4/7/21 and 6/21/21, we requested case reports via the Emerging Infections Network (EIN) listserv of SARS-CoV-2 infection following COVID-19 vaccination in SOTR. Online data collection included patient demographics, dates of COVID-19 vaccine administration, and clinical data related to COVID-19. We performed a descriptive analysis of patient factors and evaluated variables contributing to critical disease or need for hospitalization. Results: Sixty-six cases of SARS-CoV-2 infection after vaccination in SOTR were collected. COVID-19 occurred after the second vaccine dose in 52 (78.8%) cases, of which 43 (82.7%) occurred ≥14 days post-vaccination. There were six deaths, three occurring in fully vaccinated individuals (7.0%, n = 3/43). There was no difference in the percentage of patients who recovered from COVID-19 (70.7% vs. 72.2%, p = .90) among fully and partially vaccinated individuals. We did not identify any differences in hospitalization (60.5% vs. 55.6%, p = .72) or critical disease (20.9% vs. 33.3%, p = .30) among those who were fully versus partially vaccinated. Conclusions: SOTR vaccinated against COVID-19 can still develop severe, and even critical, COVID-19 disease. Two doses of mRNA COVID-19 vaccine may be insufficient to protect against severe disease and mortality in SOTR. Future studies to define correlates of protection in SOTR are needed.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-01-31
Publishing country	Denmark
Document type	Journal Article ; Multicenter Study
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13774
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Article: Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC)

Singh, Prithvi / Rai, Arpita / Verma, Amit Kumar / Alsahli, Mohammed A. / Rahmani, Arshad Husain / Almatroodi, Saleh A. / Alrumaihi, Faris / Dev, Kapil / Sinha, Anuradha / Sankhwar, Shweta / Dohare, Ravins

Biology. 2021 Aug. 08, v. 10, no. 8

2021

Abstract: Head and neck squamous cell carcinoma (HNSC) is one of the most common malignant tumors worldwide with a high rate of morbidity and mortality, with 90% of predilections occurring for oral squamous cell carcinoma (OSCC). Cancers of the mouth account for ... ...

Abstract	Head and neck squamous cell carcinoma (HNSC) is one of the most common malignant tumors worldwide with a high rate of morbidity and mortality, with 90% of predilections occurring for oral squamous cell carcinoma (OSCC). Cancers of the mouth account for 40% of head and neck cancers, including squamous cell carcinomas of the tongue, floor of the mouth, buccal mucosa, lips, hard and soft palate, and gingival. OSCC is the most devastating and commonly occurring oral malignancy, with a mortality rate of 500,000 deaths per year. This has imposed a strong necessity to discover driver genes responsible for its progression and malignancy. In the present study we filtered oral squamous cell carcinoma tissue samples from TCGA-HNSC cohort, which we followed by constructing a weighted PPI network based on the survival of patients and the expression profiles of samples collected from them. We found a total of 46 modules, with 18 modules having more than five edges. The KM and ME analyses revealed a single module (with 12 genes) as significant in the training and test datasets. The genes from this significant module were subjected to pathway enrichment analysis for identification of significant pathways and involved genes. Finally, the overlapping genes between gene sets ranked on the basis of weighted PPI module centralities (i.e., degree and eigenvector), significant pathway genes, and DEGs from a microarray OSCC dataset were considered as OSCC-specific hub genes. These hub genes were clinically validated using the IHC images available from the Human Protein Atlas (HPA) database.
Keywords	biomarkers ; data collection ; databases ; genes ; head and neck squamous cell carcinoma ; humans ; microarray technology ; morbidity ; mortality ; mucosa ; palate ; squamous cell carcinoma ; tongue
Language	English
Dates of publication	2021-0808
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10080760
Database	NAL-Catalogue (AGRICOLA)

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